Almac Sciences and Irish Manufacturing Research Collaborate to Enhance Flow Chemistry Expertise

On November 2, 2021 Almac Sciences, a member of the Almac Group, reported that it has initiated a new flow chemistry collaboration with Irish Manufacturing Research (IMR) to design and 3D print novel flow reactors and static mixers (Press release, Almac, NOV 2, 2021, View Source [SID1234594653]). The planned project takes advantage of the design freedom of Additive Manufacturing (AM, an industrialised approach to 3D printing) to make bespoke reactors allowing previously unobtainable chemistry plausible.

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Flow chemistry is gaining momentum in its application within the pharma industry by unlocking reaction chemistry not possible in traditional batch mode. At Almac, exploiting continuous flow technology aims to offer clients the best available technology to meet their demanding processing needs of today whilst securing manufacture for the future, by expediting the development of processes where the target chemistry is inherently difficult to scale due to safety concerns.

IMR is a leading manufacturing Research and Technology Organisation (RTO) with labs and industrial pilot lines in Ireland. IMR’s ambition is to accelerate the implementation of key elements of Ireland’s industrial strategy and enable Irish based manufacturers to be early adopters of new technology.

Lead collaborator at IMR, Tristan McCallum said: "I am very excited about our collaboration with Almac Sciences where, with our expertise at IMR, we can support Irish industry to design and produce AM reactors and mixers locally; using the advanced additive manufacturing capability here in Ireland."
Dr Megan Smyth, Team Leader, Custom and Flow Chemistry at Almac Sciences commented: "This collaboration enables us to move to the next step of our flow chemistry service allowing immediate access to printed reactors with unique properties. This project will ensure we continue to offer our customers best-in-class technical solutions to address the many challenges that contract chemistry brings. As an industry, we need to develop innovative manufacturing routes that opens up access to new raw material supply chains with more secure and mature options. Flow chemistry can assist with this and we are delighted to be progressing it with IMR."

Earlier this year, Almac Sciences invested over £5million to establish its R&D centre to support increased client demand for its established biocatalysis, flow chemistry and peptides solutions. "

10-Q – Quarterly report [Sections 13 or 15(d)]

MacroGenics has filed a 10-Q – Quarterly report [Sections 13 or 15(d)] with the U.S. Securities and Exchange Commission .

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Biofrontera is setting the path for further expansion in the world’s largest pharmaceutical market with the IPO of its US subsidiary Biofrontera Inc.

On November 2, 2021 Biofrontera AG (NASDAQ: BFRA; Frankfurt Stock Exchange: B8F) Biofrontera AG (ISIN: DE0006046113) has reported the closing of the successful IPO of its US subsidiary Biofrontera Inc. on Nasdaq (see also ad hoc announcement of November 2, 2021) (Press release, Biofrontera, NOV 2, 2021, View Source [SID1234594327]).

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The successfully completed IPO provides Biofrontera Inc. with the financial resources necessary to expand its marketing and sales activities. In addition, the listing on Nasdaq offers U.S. companies the opportunity to flexibly exploit market opportunities and respond rapidly to market risks.

Similar financing opportunities cannot be created by Biofrontera AG, which is restricted in many respects by the German capital market and corporate law regulations.

Professor Dr. Hermann Lübbert, founder and CEO of Biofrontera AG, commented: "The IPO and the associated access to one of the largest technology markets, together with the growth-oriented US corporate law, provides Biofrontera Inc. with the opportunity for further financing independently of Biofrontera AG. The high trading volumes already on the first two trading days indicate solid investor interest."

In the U.S., the current market share of Ameluz within the Photodynamic Therapy (PDT) sector is about 24%. Considering the still limited total market share of less than 2% for PDT in the treatment of actinic keratoses, our company’s declared goal is the exploitation of the growth potential through increased investments in marketing and sales. Furthermore, Biofrontera Inc. is strengthening the marketing of its second product Xepi, a topical antibiotic that is approved for the treatment of impetigo, a highly infectious bacterial skin infection, and effective even against antibiotic-resistant bacteria.

Biofrontera AG will directly benefit from the PDT sales growth of Biofrontera Inc. through a license and supply agreement. Under this agreement, Biofrontera Inc. acquires Ameluz and the PDT lamp BF-RhodoLED from Biofrontera AG. Up to annual Ameluz sales of USD 30 million, Biofrontera Inc. pays 50% of sales as a transfer price. This share decreases to 40% for sales from 30 to 50 Mio. USD and to 30% above 50 Mio. USD in sales, respectively, accounting for the associated higher sales costs.

Patents, drug approvals and all sales outside the USA, as well as future research results outside the further development of Ameluz will be exclusively owned by Biofrontera AG. Following the successful IPO of Biofrontera Inc., Biofrontera AG will be able to focus its financial resources on research and development and on marketing its products on the European and other international markets.

CorMedix Inc. to Report Third Quarter 2021 Financial Results and Provide a Corporate Update on November 9

On November 2, 2021 CorMedix Inc. (Nasdaq: CRMD), a biopharmaceutical company focused on developing and commercializing therapeutic products for the prevention and treatment of infectious and inflammatory disease, reported that it will report its financial results for the third quarter ended September 30, 2021, after the market close on Tuesday, November 9, 2021, and will host a corporate update conference call at 4:30pm Eastern Time (Press release, CorMedix, NOV 2, 2021, View Source [SID1234594326]).

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Pfizer reports third-quarter 2021 results

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