Axial Therapeutics Promotes A. Stewart Campbell to Chief Executive Officer

On March 8, 2021 Axial Therapeutics Inc., a clinical-stage biopharmaceutical company focused on leveraging the gut-brain axis for the discovery and development of small molecule therapeutics with an initial focus on autism spectrum disorder (ASD) and Parkinson’s disease (PD), reported the appointment of A. Stewart Campbell, Ph.D. as Chief Executive Officer (CEO) (Press release, Axial Biotherapeutics, MAR 8, 2021, View Source [SID1234576204]). Dr. Campbell will also serve as a member on the Axial Board of Directors.

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"Stew is a proven executive leader with extensive experience in R&D innovation. His expertise across the drug development lifecycle, combined with his experience building results-focused teams makes him the right leader to take Axial forward," said Ronald C. Renaud, Axial Board Chair and Chief Executive Officer, Translate BIO. "His focus on bringing new therapies to patients will be critically important as he spearheads Axial’s efforts to advance new gut-targeted small molecule treatments for serious central nervous system (CNS) diseases and conditions."

Dr. Campbell is an accomplished executive with more than 25 years of experience building and leading teams that have strong track records of discovering and developing novel therapeutics, including numerous innovative product candidates that have progressed to the clinic. He is co-inventor on 20 issued patents.

He joined Axial in 2016 and has led the company’s research and development efforts, most recently serving as Senior Vice President, R&D. Prior to joining Axial, Dr. Campbell held various leadership roles at biopharmaceutical and chemical manufacturing companies including Ancora/CordenPharma, Surface Logix and Insmed Inc. He led the acquisition of Ancora by CordenPharma and subsequently served as Head of Product Management and Business Development for Carbohydrates and Lipids at CordenPharma. While at Surface Logix and Insmed, Dr. Campbell played an integral role in the discovery or development of five clinical stage drug candidates, including belumosudil and TAK-607. He holds a Ph.D. in Organic Chemistry from Queen’s University (Canada) and did post-doctoral research at Duke University.

"Axial is well-positioned for future growth with deep expertise in the gut-brain axis and cutting-edge science leading to the discovery of new drug targets and the development of safe and effective first-in-class therapies for CNS diseases and conditions, as well as oncology," said Dr. Campbell. "I look forward to working together with the leadership, the Board, and the dedicated Axial team to expand our pioneering drug discovery approach and advance our product candidates through the clinic."

Dr. Campbell succeeds David H. Donabedian, Ph.D., who served as CEO of Axial since co-founding the company in 2016. "We thank David for his commitment and tireless effort over the past four years, taking Axial from an idea to a company poised to enter Phase 2B in autism and with a robust pipeline of innovative programs in Parkinson’s disease and oncology," said Dr. Campbell.

Axial’s unique focus on targeting the gut as a means to treat CNS diseases and conditions is rooted in the groundbreaking research of its co-founder Dr. Sarkis Mazmanian at the California Institute of Technology establishing the biological link between the gut-brain axis and neurological disease.

The foundation of Axial’s approach is its innovative platform that leverages its proprietary in vivo models and "omics" capabilities as the scientific underpinning for the identification and validation of new disease targets followed by the design and delivery of gut-restricted, small molecule therapeutics. The company’s platform has significant potential for the development of novel therapies that mitigate underlying disease pathology, resulting symptoms, and disease progression in neurological diseases as well as oncology.

Axial’s lead product candidate is AB-2004, an oral compound poised to redefine the treatment of irritability in children with ASD, improving the lives of affected children and their families. In a Phase 1B/2A study, AB-2004 was shown to reduce metabolites implicated in ASD and improve key behaviors including irritability and anxiety. AB-2004 had no drug-related adverse events consistent with the large body of existing human safety data.

The company’s pipeline also includes small molecule, microbiome-inspired therapies in preclinical development for treatment of the underlying disease burden in PD.

Applied DNA to Participate in Upcoming Conferences

On March 8, 2021 Applied DNA Sciences, Inc. (NASDAQ: APDN) ("Applied DNA" or the "Company"), a leader in Polymerase Chain Reaction (PCR)-based DNA manufacturing, reported that it will be participating in the following virtual investor conferences (Press release, Applied DNA Sciences, MAR 8, 2021, View Source [SID1234576203]).

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March 9 – 10, 2021 – Dr. James A. Hayward, president and CEO, will present a company overview at the H.C. Wainwright Global Life Sciences Virtual Conference. Dr. Hayward and Beth Jantzen, chief financial officer, will also hold virtual investor meetings. Dr. Hayward’s pre-recorded presentation will be available for viewing beginning March 9 at 7:00 A.M. (ET). The presentation will also be available on Applied DNA’s website (link);
March 15 – 17, 2021 – Dr. Hayward will participate on a virtual panel at Roth Capital Markets’ 33rd Annual Conference titled ‘Therapeutics Against SARS-CoV-2 – Viral variants Will Not Fade Away’. The panel is scheduled for March 15, 2021 at 12:00pm ET and will be available to all Conference attendees, as well as on Applied DNA’s website (link). Management will also hold virtual investor meetings;
March 17 – 19, 2021 – Dr. Hayward will present at the Inaugural Emerging Growth Virtual Conference presented by M Vest LLC and Maxim Group LLC. The presentation will be available to all registered participants of the conference (link) on March 17th – 19th and will be posted on Applied DNA’s website (link) after March 19.

IMV to Announce Fourth Quarter and Fiscal 2020 Financial and Operational Results and Host Conference Call and Webcast on March 17, 2021

On March 8, 2021 IMV Inc. ("IMV" or the "Corporation") (Nasdaq: IMV; TSX: IMV), a clinical-stage biopharmaceutical company pioneering a novel class of immunotherapies, reported that it will hold a conference call and webcast on Wednesday, March 17, 2021 at 8:00 a.m. Eastern Time to discuss the Company’s 2020 fourth quarter and full year financial and operational results (Press release, IMV, MAR 8, 2021, View Source [SID1234576202]).

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Financial analysts are invited to join the conference call by dialing (866) 211-3204 (U.S. and Canada) or (647) 689-6600 (international) using the conference ID: 8998652.

Other interested parties will be able to access the live audio webcast at this link: View Source The webcast will be recorded and will then be available on the IMV website for 30 days following the call.

Pathios Therapeutics boosted by award of significant Innovate UK funding

On March 8, 2021 Pathios Therapeutics Limited ("Pathios"), an innovative biotech company focused on the development of first-in-class therapies for cancer, reported that it has been awarded £350K (approximately US$475K) in the form a Smart Grant from Innovate UK, the UK Government’s innovation agency, to accelerate their cancer immunotherapy programme targeting the innate immune checkpoint, GPR65 (Press release, Pathios Therapeutics, MAR 8, 2021, View Source [SID1234576201]). Pathios will collaborate on this project with researchers from the Department of Oncology at The University of Oxford to develop the key tools required to enable the rapid translation of small-molecule GPR65 inhibitors for treatment-resistant melanoma.

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The advent of immunotherapy agents targeting T-cell checkpoints (PD-1/CTLA-4) has brought about significant improvements in the long-term survival of many melanoma patients. However, only a subset of patients receive sustained benefit from these treatments and it remains an ongoing challenge to identify additional therapies for the remaining non-responsive population.

Recent ground-breaking science suggests a key reason that some melanoma patients that do not respond well to anti-PD-1 therapies relates to the disarming of innate immune cells called tumour-associated macrophages (TAMs) by the acidic microenvironment that is inherent to advanced tumours. Activation of the pH-sensing receptor, GPR65, on TAMs by acidic pH leads to the suppression of a host of pro-inflammatory genes thereby shifting the characteristics of these cells from immune-stimulating to immunosuppressive (1). The importance of the GPR65 pathway in cancer is underscored by a small proportion of the population with inactivating polymorphisms showing stratified association with survival when analysed in The Cancer Genome Atlas (TCGA). Pathios’ ‘Macrophage Conditioning’ approach aims to deploy small-molecule GPR65 inhibitors to reverse pH-dependent immunosuppressive signalling in the vast majority of patients who do not carry this genetic change.

With this grant, Pathios will develop a range of tools to expedite the translation of small molecule GPR65 inhibitors for use in cancer immunotherapy. This will include the development of early clinical target engagement biomarkers as well as employing a range of bioinformatics techniques to identify those patients most likely to benefit from Pathios’ GPR65-targeted approach.

Stuart Hughes, Chief Executive Officer of Pathios: "We are delighted to have secured this highly competitive funding from Innovate UK to accelerate our programme against GPR65 and to continue to build our scientific links with cancer researchers at The University of Oxford. This award boosts our ongoing programme and is a significant endorsement of our novel approach to targeting the innate immune system in hard-to-treat cancers. We look forward to developing the tools that will drive forward our GPR65-based ‘Macrophage Conditioning’ technology and help deliver on the company’s goal to provide a first-in-class treatment approach for those melanoma patients who currently have limited treatment options".

Lilly to Participate in Barclays Global Healthcare Conference

On March 8, 2021 Eli Lilly and Company (NYSE:LLY) reported that it will participate in the Barclays Global Healthcare Conference on Tuesday, March 9, 2021 (Press release, Eli Lilly, MAR 8, 2021, View Source [SID1234576200]). Patrik Jonsson, senior vice president, president of Lilly USA and chief customer officer, will participate in a virtual fireside chat at 9:45 a.m., Eastern Time.

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A live audio webcast will be available on the "Webcasts & Presentations" section of Lilly’s Investor website at View Source A replay of the presentation will be available on this same website for approximately 90 days.