On May 18, 2016 Myriad Genetics, Inc. (NASDAQ:MYGN) reported it will present data from nine clinical studies with three different products at the 2016 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) annual meeting to be held June 3-7, 2016 in Chicago, Ill (Press release, Myriad Genetics, MAY 18, 2016, View Source [SID:1234512587]). Key podium presentations will highlight the safety and validity of the Myriad myRisk Hereditary Cancer multigene panel test in assessing hereditary cancer risk. Abstracts of the Company’s presentations are available at: abstracts.asco.org.

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"We’re excited that the studies with myRisk Hereditary Cancer being presented at ASCO (Free ASCO Whitepaper) will advance the state-of-the-art of hereditary cancer testing," said Johnathan Lancaster, M.D., Ph.D., chief medical officer, Myriad Genetic Laboratories. "In particular, our new data provide additional evidence for expanding testing to a broader set of patients at risk for developing hereditary cancers, and for understanding the risks associated with mutations."

Myriad’s presentations are listed below. Follow Myriad on Twitter via @MyriadGenetics to stay informed about news and updates from the Company.

myRisk Hereditary Cancer Presentations
Podium Presentations

Title: Yield of multiplex panel testing exceeds expert opinion and validated prediction models.
Presenter: Gregory Idos
Date: Sunday, June 5, 2016, 9:45 – 9:57 a.m.
Location: S404, Abstract:1509

Title: Ovarian cancer (OC) risk associated with mutations detected by multiple-gene germline sequencing in 95,561 women.
Presenter: Allison Kurian
Date: Monday, June 6, 2016, 10:09 – 10:21 a.m.
Location: E450ab, Abstract: 5510

Title: Safety of multiplex gene testing for inherited cancer risk: interim analysis of a clinical trial.
Presenter: Allison Kurian
Date: Tuesday, June 7, 2016, 8:36 – 8:48 a.m.
Location: S102, Abstract:1503

Title: Prevalence of germline mutations in cancer risk genes among unselected colorectal cancer (CRC) patients (pts).
Presenter: Matthew Yurgelun
Date: Tuesday, June 7, 2016, 8:12 – 8:24 a.m.
Location: S102, Abstract:1501

Poster Presentations

Title: Genetic heterogeneity and survival among pancreatic adenocarcinoma (PDAC) patients with positive family history.
Presenter: Gloria Petersen
Date: Saturday, June 4, 2016, 8:00 – 11:30 a.m.
Location: Hall A, Abstract:4108, Poster Board 100

Title: Detection of somatic variants in peripheral blood lymphocytes using a next generation sequencing multigene cancer panel.
Presenter: Bradford Coffee
Date: Monday, June 6, 2016, 8:00 – 11:30 a.m.
Location: Hall A, Abstract:1580, Poster Board 403

Poster Discussion Presentation

Title: Magnitude of invasive breast cancer (BC) risk associated with mutations detected by multiple-gene germline sequencing in 95,561 women.
Presenter: Michael Hall
Date: Monday, June 6, 2016, 8:00 — 11:30 a.m., Discussion 1:15 — 2:30 p.m.
Location: S404, Abstract:1512, Poster Board 335

myChoice HRD: Poster Presentation

Title: Clinical significance of homologous recombination deficiency (HRD) score testing in endometrial cancer patients.
Presenter: Jean Hansen
Date: Monday, June 6, 2016, 1:00 – 4:00 p.m.
Location: Hall A, Abstract: 5584, Poster Board 407

Prolaris Abstract Publication

Title: Reduction in therapeutic burden from use of CCP test in treatment decisions among newly diagnosed prostate cancer patients independent of Charlson Comorbidity Index.
Presenter: Neal Shore
Abstract: e16572

About Myriad myRisk Hereditary Cancer Testing
The Myriad myRisk Hereditary Cancer test uses an extensive number of sophisticated technologies and proprietary algorithms in an 850 step laboratory process to evaluate 25 clinically significant genes associated with eight hereditary cancer sites including: breast, colon, ovarian, endometrial, pancreatic, prostate and gastric cancers and melanoma. For more information visit: View Source

About myChoice HRD
Myriad’s myChoice HRD is the first homologous recombination deficiency test that can detect when a tumor has lost the ability to repair double-stranded DNA breaks, resulting in increased susceptibility to DNA-damaging drugs such as platinum drugs or PARP inhibitors. High myChoice HRD scores reflective of DNA repair deficiencies are prevalent in all breast cancer subtypes, ovarian and most other major cancers. In previously published data, Myriad showed that the myChoice HRD test predicted drug response to platinum therapy in certain patients with triple-negative breast and ovarian cancers. It is estimated that 1.8 million people in the United States and Europe who are diagnosed with cancers annually may be candidates for treatment with DNA-damaging agents.

On May 18, 2016 Novartis rreported that it will highlight the strength of its oncology research programs at the upcoming 52nd Annual Meeting of the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper), being held June 3-7 in Chicago (Press release, Novartis, MAY 18, 2016, View Source [SID:1234512583]). Data will demonstrate advances across several of the company’s core disease areas of focus including leukemias and lung, melanoma and breast cancers.

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"We are particularly excited to share the results from the Tasigna Treatment-free Remission trials as these represent our unwavering commitment to further understand management approaches for Philadelphia chromosome-positive chronic myeloid leukemia," said Bruno Strigini, President of Novartis Oncology. "These and other data at ASCO (Free ASCO Whitepaper) 2016 underscore our drive to advance cancer research for the benefit of patients."

Novartis data at the 2016 ASCO (Free ASCO Whitepaper) Annual Meeting will highlight the following:

The potential for some patients with Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML), treated with Tasigna (nilotinib), to achieve a sustained deep level of molecular response and maintain a major molecular response after stopping therapy – a concept called Treatment-free Remission (TFR):

Treatment-free remission (TFR) in patients (pts) with chronic myeloid leukemia in chronic phase (CML-CP) treated with frontline nilotinib: Results from the ENESTFreedom study [Abstract #7001; Saturday, June 4, 3:12 PM CDT]
Treatment-free remission (TFR) in patients (pts) with chronic myeloid leukemia in chronic phase (CML-CP) treated with second-line nilotinib (NIL): First results from the ENESTop study [Abstract #7054; Monday, June 6, 8:00 AM CDT]

Update on the efficacy and safety of Tafinlar (dabrafenib) and Mekinist (trametinib) combination therapy in patients with BRAF V600-mutated cancers, including potential indications under investigation:

Genomic analysis and 3-y efficacy and safety update of COMBI-d: A Phase III study of dabrafenib (D) + trametinib (T) vs D monotherapy in patients with unresectable or metastatic BRAF V600E/K-mutant cutaneous melanoma [Abstract #9502; Monday, June 6, 1:39 PM CDT]
An open-label Phase II trial of dabrafenib (D) in combination with trametinib (T) in patients with previously treated BRAF V600E-mutant advanced non-small cell lung cancer (NSCLC; BRF113928) [Abstract #107; Monday, June 6, 9:57 AM CDT]
ROAR: A Phase II, open-label study in patients with BRAF V600E-mutated rare cancers to investigate the efficacy and safety of dabrafenib (D) and trametinib (T) combination therapy [Abstract # TPS2604; Sunday, June 5, 8:00 AM CDT]
Update on CTL019, an investigational Chimeric Antigen Receptor T cell (CAR T) therapy, in relapsed/refractory pediatric acute lymphoblastic leukemia (ALL):

Sustained remissions with CD19-specific chimeric antigen receptor (CAR)-modified T cells in children with relapsed/refractory ALL [Abstract #3011; Monday, June 6, 4:54 PM CDT]
Ongoing investigation of established and pipeline therapies for patients with unmet needs:

Long-term outcomes of ruxolitinib (RUX) therapy in patients with myelofibrosis (MF): 5-year update from COMFORT-I [Abstract #7012; Monday, June 6, 11:30 AM CDT]**
Phase I study of the safety and efficacy of the cMET inhibitor capmatinib (INC280) in patients (pts) with advanced cMET+ non-small cell lung cancer (NSCLC) [Abstract #9067; Saturday, June 4, 8:00 AM CDT]
Additional notable data from Novartis’ core disease areas of focus include:

Breast Cancer:

A randomized trial (MA.17R) of extending adjuvant letrozole for 5 years after completing an initial 5 years of aromatase inhibitor therapy alone or preceded by tamoxifen in postmenopausal women with early-stage breast cancer [Abstract #LBA1; Sunday, June 5, 1:40 PM CDT]
Patient-reported outcomes from MA.17R: A randomized trial of extending adjuvant letrozole for 5 years after completing an initial 5 years of aromatase inhibitor therapy alone or preceded by tamoxifen in postmenopausal women with early-stage breast cancer [Abstract #LBA506; Monday, June 6, 3:15 PM CDT]
Correlation of PIK3CA mutations in cell-free DNA (cfDNA) and efficacy of everolimus (EVE) in metastatic breast cancer: Results from BOLERO-2 [Abstract #519; Sunday, June 5, 11:30 AM CDT]
Prevention of everolimus/exemestane (EVE/EXE) stomatitis in postmenopausal (PM) women with hormone receptor-positive (HR+) metastatic breast cancer (MBC) using a dexamethasone-based mouthwash (MW): Results of the SWISH trial [Abstract #525; Sunday, June 5, 8:00 AM CDT]
Evaluation of lapatinib as a component of neoadjuvant therapy for HER2+ operable breast cancer: 5-year outcomes of NSABP protocol B-41 [Abstract #501; Monday, June 6, 1:27 PM CDT]
Ribociclib (LEE011) and letrozole in estrogen receptor-positive (ER+), HER2-negative (HER2-) advanced breast cancer (aBC): Phase Ib safety, preliminary efficacy and molecular analysis [Abstract #568; Sunday, June 5, 8:00 AM CDT]

Lung Cancer:

Genetic landscape of ALK+ non-small cell lung cancer (NSCLC) patients and response to ceritinib in ASCEND-1 [Abstract #9064; Saturday, June 4, 8:00 AM CDT]
Phase II safety and efficacy results of a single-arm Ph Ib/II study of capmatinib (INC280) + gefitinib in patients with EGFR-mutated (mut), cMET-positive (cMET+) non-small cell lung cancer (NSCLC) [Abstract #9020; Saturday, June 4, 3:00 PM CDT]
Hematology:

PILLAR-2: A randomized, double-blind, placebo-controlled, Phase III study of adjuvant everolimus (EVE) in patients (pts) with poor-risk diffuse large B-cell lymphoma (DLBCL) [Abstract #7506; Sunday, June 5, 11:45 AM CDT]
ReTHINK: A randomized, double-blind, placebo-controlled, multicenter, Phase III study of ruxolitinib in early myelofibrosis patients [Abstract #TPS7080; Monday, June 6, 8:00 AM CDT]**
Patient reported outcomes (PROs) of multiple myeloma (MM) patients treated with panobinostat (PAN) after >=2 lines of therapy based on the international Phase III, randomized, double-blind, placebo-controlled, PANORAMA-1 trial [Abstract #8054; Monday, June 6, 8:00 AM CDT]
Other Tumor Types:

A first-in-human phase I study of the anti-PD-1 antibody PDR001 in patients with advanced solid tumors [Abstract #3060; Sunday, June 5, 8:00 AM CDT]
BERIL-1: A Phase II, placebo-controlled study of buparlisib (BKM120) plus paclitaxel vs placebo plus paclitaxel in patients with platinum-pretreated recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) [Abstract #6008; Sunday, June 5, 10:12 AM CDT]
BERIL-1: Biomarker results from targeted sequencing of circulating tumor DNA (ctDNA) and archival tissue in a randomized Phase II study of buparlisib (BKM120) or placebo + paclitaxel in patients with head and neck squamous cell carcinoma (HNSCC) [Abstract #6045; Saturday, June 4, 1:00 PM CDT]
A Phase II study of the efficacy and safety of the cMET inhibitor capmatinib (INC280) in patients (pts) with advanced hepatocellular carcinoma (HCC) [Abstract #4074; Saturday, June 4, 8:00 AM CDT]
Everolimus (EVE) in advanced, nonfunctional, well-differentiated neuroendocrine tumors (NET) of gastrointestinal (GI) or lung origin: Second interim overall survival (OS) results from the RADIANT-4 study [Abstract #4090; Saturday, June 4, 8:00 AM CDT]
Genomic mutation profiling (GMP) and clinical outcome in patients (pts) treated with ribociclib (CDK4/6 inhibitor) in the Signature program [Abstract 2528; Sunday, June 5, 8:00 AM CDT]
Throughout the 2016 ASCO (Free ASCO Whitepaper) Annual Meeting, Novartis Oncology will host dedicated content on the company website (View Source) that will feature unique insights and perspectives on emerging areas of cancer care and research.

Product Information
Approved indications for products vary by country and not all indications are available in every country. The product safety and efficacy profiles have not yet been established outside the approved indications. Because of the uncertainty of clinical trials, there is no guarantee that compounds will become commercially available with additional indications.

For full prescribing information, including approved indications and important safety information about marketed products, please visit
View Source .

Because INC280, CTL019, LEE011, BKM120 and PDR001 are investigational compounds, the safety and efficacy profiles have not yet been fully established. Access to these investigational compounds is available only through carefully controlled and monitored clinical trials. These trials are designed to better understand the potential benefits and risks of the compound. Because of the uncertainty of clinical trials, there is no guarantee that INC280, CTL019, LEE011, BKM120 and PDR001 will ever be commercially available anywhere in the world.

On May 18, 2016 Merrimack Pharmaceuticals, Inc. (Nasdaq:MACK) reported that it will present on its extensive oncology pipeline at the 2016 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting, June 3-7, 2016 at McCormick Place, Chicago, Illinois (Press release, Merrimack, MAY 18, 2016, View Source [SID:1234512580]). Final results from a Phase 1 study evaluating the safety, pharmacology and initial efficacy of MM-151 will be presented in a Poster Discussion Session. Merrimack will also present on the results from its Phase 3 NAPOLI-1 study of ONIVYDE, as well as on multiple therapeutic candidates from its antibody engineering and antibody-directed nanotherapeutic (ADN) technology platforms in six poster sessions.

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Poster Discussion Session:

Final results of a first-in-human study evaluating the safety, pharmacology and initial efficacy of MM-151, an oligoclonal anti-EGFR antibody in patients with refractory solid tumors (Abstract 2518)
Session Title: Poster Discussion Session, Developmental Therapeutics – Clinical Pharmacology and Experimental Therapeutics
Sunday, June 5, 2016, 11:30 AM – 12:45 PM CT
Location: Arie Crown Theater

Poster Sessions:

Updated overall survival (OS) analysis of NAPOLI-1: Phase 3 study of nanoliposmal irinotecan (nal-IRI, MM-398), with or without 5-fluorouracil and leucovorin (5-FU/LV), vs 5-FU/LV in metastatic pancreatic cancer (mPAC) previously treated with gemcitabine-based therapy (Abstract 4126)
Session Title: Gastrointestinal (Noncolorectal) Cancer
Saturday, June 4, 2016, 8:00 AM – 11:30 AM CT
Location: Hall A

Randomized Phase 2 study of paclitaxel (PTX), trastuzumab (T) with or without MM-111 in HER2 expressing gastroesophageal cancers (GEC) (Abstract 4043)
Session Title: Gastrointestinal (Noncolorectal) Cancer
Saturday, June 4, 2016, 8:00 AM – 11:30 AM CT
Location: Hall A

A Phase 1b/2 study combining MM-151 + nal-IRI + 5-FU + leucovorin in RAS-wild type metastatic colorectal cancer (mCRC) (Abstract TPS3633)
Session Title: Gastrointestinal (Colorectal) Cancer
Saturday, June 4, 2016, 8:00 AM – 11:30 AM CT
Location: Hall A

SHERLOC: A Phase 2 study of seribantumab (MM-121) in combination with docetaxel or pemetrexed versus docetaxel or pemetrexed alone in patients with heregulin positive (HRG+), locally advanced or metastatic non-small cell lung cancer (NSCLC) (Abstract TPS9110)
Session Title: Lung Cancer – Non-Small Cell Metastatic
Saturday, June 4, 2016, 8:00 AM – 11:30 AM CT
Location: Hall A

HERMIONE: A Phase 2, randomized, open label trial comparing MM-302 plus trastuzumab with chemotherapy of physician’s choice plus trastuzumab, in anthracycline naive HER2-positive, locally advanced/metastatic breast cancer patients previously treated with pertuzumab and ado-trastuzumab emtansine (T-DM1) (Abstract TPS631)
Session Title: Breast Cancer – HER2/ER
Sunday, June 5, 2016, 8:00 AM – 11:30 AM CT
Location: Hall A

A Phase 1 biomarker-directed multi-arm study evaluating the co-administration of MM-151 with MM-121, MM-141, or trametinib in EGFR-driven cancers (Abstract TPS11619)
Session Title: Tumor Biology
Monday, June 6, 2016, 1:00 PM – 4:30 PM CT
Location: Hall A

On May 18, 2016 ImmunoGen, Inc. (Nasdaq: IMGN), a biotechnology company developing novel antibody-drug conjugate (ADC) cancer therapeutics, reported the clinical data from a 46-patient Phase 1 cohort evaluating the efficacy and safety of mirvetuximab soravtansine as single-agent therapy for platinum-resistant, folate receptor alpha (FRα)-positive ovarian cancer (Press release, ImmunoGen, MAY 18, 2016, View Source [SID:1234512578]). These results have informed the Company’s selection of the patient population and primary endpoint for a Phase 3 study scheduled to begin before year-end.

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This Phase 1 cohort, which was expanded from 20 to 46 patients to provide additional information for the design of subsequent trials, enrolled patients with platinum-resistant ovarian cancer who had received up to five previous treatment regimens. Patients also needed to have FRα expressed at or above a predefined level on at least 25% of tumor cells. Patients were classified as having low, medium, or high FRα expression based on the percent of tumor cells meeting this criterion (25-49%, 50-74%, and 75-100%, respectively). Among the 46 patients, 23 had high, 14 had medium, and 9 had low expression of FRα. All had previously received platinum and a taxane.

Among all 46 patients, the confirmed objective response rate (ORR) was 26% and median progression-free survival (PFS) was 4.8 months (95% confidence interval, 3.9-5.7 months). Among the 16 patients who received up to three prior regimens and had high or medium FRα expression – the population selected for the planned Phase 3 trial – the ORR was 44% and median PFS was 6.7 months (95% CI, 3.9-11.0 months). For the 30 patients with low FRα and/or who had received four or five prior regimens, ORR was 17% and median PFS was 4.2 months (95% CI, 2.6-5.5 months).

Current single-agent therapies for platinum-resistant ovarian cancer typically have an ORR of 15-20% and median PFS of 3-4 months, including in patients receiving no more than two prior regimens.1

Based upon the findings in this Phase 1 cohort, the planned Phase 3 trial assessing mirvetuximab soravtansine as single-agent therapy for platinum-resistant ovarian cancer will enroll patients who previously received up to three treatment regimens and whose cancer has high or medium FRα expression, with PFS as the primary endpoint.

"There is a significant need for new therapies for ovarian cancer," commented Dr. Kathleen Moore, Christy Everest Endowed Chair in Cancer Research and Director of the Oklahoma TSET Phase I Unit, Stephenson Cancer Center, University of Oklahoma HSC. "We’re excited about the findings with mirvetuximab soravtansine from this study and to be advancing this first-in-class agent into a Phase 3 trial for platinum-resistant ovarian cancer."

"We plan to have Phase 3 testing of mirvetuximab soravtansine up and running by year end," commented Dr. Charles Morris, ImmunoGen’s EVP and Chief Development Officer. "Now that we have the full results from the 46-patient ovarian cancer cohort, we’ve submitted a meeting request to the FDA to discuss our proposed path to approval. This meeting should take place early in 3Q2016, and we are targeting initiation of FORWARD I Phase 3 testing in 4Q2016."

Mirvetuximab soravtansine was generally well tolerated, with most side effects Grade 1 or 2 (least severe grades). Of particular note, incidence of blurred vision was reduced from 55%, mostly Grade 2, in the first 20 patients enrolled to 39%, mostly Grade 1, among the 26 patients added with the expansion of the cohort. Other side effects reported in more than 20% of patients were diarrhea, fatigue, nausea, vomiting, peripheral neuropathy, increased AST, keratopathy, and abdominal pain.

Data Presentation at ASCO (Free ASCO Whitepaper) 2016

"IMGN853 (mirvetuximab soravtansine), a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC): single-agent activity in platinum-resistant epithelial ovarian cancer patients" will be presented in the Gynecologic Cancer Poster Session (Poster Board #390) taking place on Monday, June 6, from 1:00-4:30 pm CT. (Abstract #5567).

About the Planned FORWARD I Phase 3 Trial

The FORWARD I Phase 3 trial is intended to support full marketing approval of mirvetuximab soravtansine for the treatment of patients with platinum-resistant ovarian cancer who previously received up to three treatment regimens for whom single-agent therapy is appropriate. The cancer also must have high or medium FRα expression. ImmunoGen estimates that 5,000-7,000 patients per year (US) meet these criteria.

Patients will be randomized 2:1 to mirvetuximab soravtansine or physician’s choice, which will include pegylated liposomal doxorubicin, topotecan, and weekly paclitaxel.

PFS will be the primary endpoint of the trial. This study also will be powered for separate assessment of the endpoint in the full study population and in the subset with high FRα expression and will include at least 300 patients.

About Mirvetuximab Soravtansine

Mirvetuximab soravtansine (IMGN853) is the first FRα-targeting ADC. It uses a FRα-binding antibody to target the ADC specifically to FRα-expressing cancer cells and a potent anti-tumor agent, DM4, to kill the targeted cancer cells.

ImmunoGen is advancing mirvetuximab soravtansine into Phase 3 testing as a single agent for the treatment of platinum-resistant ovarian cancer. The product candidate is also in Phase 1b/2 testing in combination regimens for ovarian cancer.

About Ovarian Cancer and FRα

This year, approximately 22,300 new cases of ovarian cancer will be diagnosed in the US and more than 14,200 women will die from the disease.2 ImmunoGen estimates that 40% of ovarian cancer cases have high FRα expression, 20% have medium, 20% have low, and 20% have very low levels of FRα.

Standard first-line therapy for ovarian cancer is a platinum-based regimen. Once the cancer becomes platinum-resistant, patients may receive single-agent therapy.

On May 19, 2016 Sumitomo Dainippon Pharma Co., Ltd. (Head Office: Osaka, Japan; President: Masayo Tada; hereinafter called "Sumitomo Dainippon Pharma") reported that clinical data of napabucasin (BBI608) and amcasertib (BBI503) will be presented at the 2016 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting in Chicago from June 3 to June 7, 2016 (Press release, Dainippon Sumitomo Pharma, MAY 18, 2016, View Source [SID:1234512577]).

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Napabucasin: 6 presentations
1. ABSTRACT #3564, Poster #261: Saturday, June 4 from 8:00 a.m. – 11:30 a.m.: BBI608-246: NCT02024607: Phase Ib extension study of cancer stemness inhibitor BB608 (Napabucasin) administered in combination with FOLFIRI +/- Bevacizumab (Bev) in patients (pts) with advanced colorectal cancer (CRC). The abstract is now available on the official website of ASCO (Free ASCO Whitepaper) (View Source)

2. ABSTRACT #4128, Poster #120: Saturday, June 4 from 8:00 a.m. – 11:30 a.m.: BBI608-118: NCT02231723: A Phase Ib extension study of cancer stemness inhibitor BB608 (Napabucasin) in combination with Gemcitabine and nab-Paclitaxel (nab-PTX) in patients (pts) with metastatic pancreatic cancer. The abstract is now available on the official website of ASCO (Free ASCO Whitepaper) (View Source)

3. ABSTRACT #9093, Poster #416: Saturday, June 4 from 8:00 a.m. – 11:30 a.m.: BBI608-201: NCT01325441: A Phase Ib/II Study of Cancer Stemness Inhibitor Napabucasin (BB608) Combined with Weekly Paclitaxel in Advanced Non-Small Cell Lung Cancer. The abstract is now available on the official website of ASCO (Free ASCO Whitepaper) (View Source)

4. ABSTRACT #1094, Poster #199: Sunday, June 5 from 8:00 a.m. – 11:30 a.m.:BBI608-201: NCT01325441: A Phase Ib/II Study of Cancer Stemness Inhibitor Napabucasin (BB608) Combined with Weekly Paclitaxel in Advanced Triple Negative Breast Cancer. 2 The abstract is now available on the official website of ASCO (Free ASCO Whitepaper) (View Source)

5. ABSTRACT #5578, Poster #401: Monday, June 6 from 1:00 p.m. – 4:30 p.m.:BBI608-118: NCT01325441: A Phase Ib/II Study of Cancer Stemness Inhibitor Napabucasin (BB608) Combined with Weekly Paclitaxel in Platinum Resistant Ovarian Cancer. The abstract is now available on the official website of ASCO (Free ASCO Whitepaper) (View Source)

6. ABSTRACT #TPS4144, Poster #129b: Saturday, June 4 from 8:00 a.m. – 11:30 a.m.:BBI608-336: NCT02178956: The BRIGHTER trial: A phase III randomized double-blind study of BBI-608 + weekly paclitaxel versus placebo (PBO) + weekly paclitaxel in patients (pts) with pretreated advanced gastric and gastro-esophageal junction (GEJ) adenocarcinoma.
The abstract is now available on the official website of ASCO (Free ASCO Whitepaper) (View Source)

Amcasertib: 1 presentation
1. ABSTRACT #6018, Poster #340: Saturday, June 4 from 1:00 p.m. – 4:30 p.m. (Poster Session) Saturday, June 4 from 4:45 p.m. – 6:00 p.m. (Poster Discussion Session):BBI503-101: NCT01781455: Phase I Extension Clinical Study of BB503, a First-in-Class Cancer Stemness Kinase Inhibitor, in Adult Patients with Advanced Head and Neck Cancer.
The abstract is now available on the official website of ASCO (Free ASCO Whitepaper) (View Source)