Alligator Bioscience to present new pre-clinical data for ADC-1013 and ATOR-1015 at PEGS conference in Boston, May 4

On April 28, 2017 Alligator’s reported that lead programme, ADC-1013, which has a pre-clinical profile indicating good safety and applicability in multiple tumor types, is currently being investigated in a second Phase I dose escalation trial (Press release, Alligator Bioscience, APR 28, 2017, View Source [SID1234538689]). The immuno-oncology antibody was out-licensed in August 2015 to Janssen Biotech Inc., an oncology company within the Johnson & Johnson group.

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Alligator’s wholly-owned product ATOR-1015 is a bispecific immuno-oncology compound that has the potential to be a first in class dual immune activating antibody.

"We are excited to be presenting these early data which provide further validation of the strength of our pipeline of tumor-directed immuno-oncology antibodies", says Per Norlén, Chief Executive Officer of Alligator Bioscience. "Alligator is deeply rooted in immuno-oncology and, as one of the first entrants into the scientific area in 2008, has successfully built a pipeline with the potential to provide much-needed treatments to patients suffering from multiple metastasizing cancers."

For further information, please contact:

Per Norlén, CEO
Telephone: + 46 46 286 42 80 (switchboard)
E-mail: [email protected]

Rein Piir, VP Investor Relations at Alligator
Telephone: +46 708 537292
E-mail: [email protected]

Per-Olof Schrewelius, CFO
Telephone: +46 46 286 42 85
E-mail: [email protected]

The information in the press release was submitted for publication at 1 p.m. CET on 28 April, 2017.

20-F – Annual and transition report of foreign private issuers [Sections 13 or 15(d)]

BeyondSpring Pharmaceuticals has filed a 20-F – Annual and transition report of foreign private issuers [Sections 13 or 15(d)] with the U.S. Securities and Exchange Commission (Filing, 20-F, BeyondSpring Pharmaceuticals, 2018, APR 28, 2017, View Source [SID1234527556]).

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10-K/A [Amend] – Annual report [Section 13 and 15(d), not S-K Item 405]

(Filing, 10-K, Galectin Therapeutics, 2016, APR 28, 2017, View Source [SID1234518742])

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10-K/A [Amend] – Annual report [Section 13 and 15(d), not S-K Item 405]

(Filing, 10-K, Threshold Pharmaceuticals, 2017, APR 28, 2017, View Source [SID1234518732])

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CEL-SCI RECEIVES INTENT TO GRANT NOTICE FOR NEW MULTIKINE PATENT FROM THE EUROPEAN PATENT OFFICE

On April 28, 2017 CEL-SCI Corporation (NYSE MKT: CVM) reported that it has been notified that it will be granted a new patent on Multikine* (Leukocyte Interleukin, Injection), its investigational cancer immunotherapy, from the European Patent Office (Press release, Cel-Sci, APR 28, 2017, View Source [SID1234518735]). The patent is titled: A METHOD FOR MODULATING HLA CLASS II TUMOR CELL SURFACE EXPRESSION WITH A CYTOKINE MIXTURE.

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The patent relates to a method for altering the composition of tumor infiltrating mononuclear cells, increasing CD4+/CD8+ ratio, increasing tumor stroma/epithelial ratio, and modulating HLA (Human Leukocyte Antigen) class II expression on a tumor cell surface with Multikine. CEL-SCI believes that this will result in the tumor becoming "visible" to the immune system, culminating in a more robust and sustainable anti-tumor immune response.

Geert Kersten, CEL-SCI Chief Executive Officer, said, "Our patent portfolio for Multikine consists of multiple patents issued in the United States, Europe, China and Japan. In addition to these patents that offer certain protections for Multikine, the method of manufacture for Multikine held by CEL-SCI as trade secret offers additional protections."

About Multikine

Multikine is designed to be a different type of therapy against cancer: one that appears to have the potential to work with the body’s natural immune system in the fight against tumors. Multikine is an investigational immunotherapeutic agent that is being tested in an open-label, randomized, controlled, global pivotal Phase 3 clinical trial as a potential first-line treatment for advanced primary squamous cell carcinoma of the head and neck. The Phase 3 study with Multikine, which remains on partial clinical hold for the enrollment of additional patients, has 928 patients enrolled.

Multikine is also being tested in a Phase 1 study at the University of California, San Francisco (UCSF), as a potential treatment for peri-anal warts in HIV/HPV co-infected men and women. Dr. Joel Palefsky, a world-renowned scientist and Key Opinion Leader in human papilloma virus (HPV) research and the prevention of anal cancer, is the Principal Investigator at UCSF.