On May 18, 2017 Merck, a leading science and technology company, reported significantly increased both net sales and EBITDA pre in the first quarter of 2017 (Press release, Merck KGaA, MAY 18, 2017, View Source [SID1234519246]).

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In addition, the company today confirmed and specified its outlook for the full year.

"For Merck, 2017 is another year of many challenges as well as tremendous opportunities. I am confident that we will seize these opportunities by further driving our clear growth strategy for our three business sectors forward," said Stefan Oschmann, Executive Board Chairman and CEO of Merck. "We again achieved profitable growth in the first quarter. Two approvals for our immuno-oncology medicine Bavencio in the United States within a short period of time are a great success following long and hard work. We are also further developing our Life Science and Performance Materials business sectors with a targeted focus on innovative technologies. This will create long-term growth opportunities for us," said Oschmann.
Net sales rose by 5.3% to € 3.9 billion in the first quarter of 2017 (Q1 2016: € 3.7 billion). Merck grew in all three business sectors. Organically, Group sales increased by 3.1%, driven mainly by the Healthcare and Life Science business sectors. Currency effects had a positive effect of 2.6% on sales, while portfolio changes had a slightly negative impact. Accounting for 32% of Group sales, Asia-Pacific was the largest region.

EBITDA pre exceptionals, the key earnings indicator of the Group, rose by 14.5% to € 1.2 billion (Q1 2016: € 1.1 billion) thanks to the good operational performance of Healthcare and Life Science. Group EBIT fell by -11.1% to € 755 million (Q1 2016: € 849 million). This decline is due to an exceptional item in the year-earlier quarter when Merck sold its rights to Kuvan and realized a divestment gain of € 324 million.

Net income declined slightly in the first quarter of 2017 to € 521 million (Q1 2016: € 591 million) owing to the decrease in EBIT. Earnings per share decreased from € 1.36 to € 1.20. Earnings per share pre exceptionals rose in the first quarter of 2017 by 16.9% to € 1.80 (Q1 2016: € 1.54).

Merck reduced the net financial debt resulting from the Sigma-Aldrich acquisition by a further € 400 million to € 11.1 billion at the end of the first quarter, which compares with € 11.5 billion on December 31, 2016. As with major acquisitions in the past, Merck is aiming to rapidly and extensively reduce its debt. Merck had 51,480employees worldwide on March 31, 2017.

Healthcare starts off the year on a good strategic and financial footing
In the first quarter, the Healthcare business sector delivered solid organic sales growth of 4.4%. Including positive exchange rate effects of 2.0% and a negative portfolio impact of -1.0%, Healthcare increased sales by 5.4% to € 1.7 billion (Q1 2016: € 1.6 billion) in the first quarter of 2017.

Sales of the drug Rebif, which is used to treat relapsing forms of multiple sclerosis, saw an organic decline of -4.0% in the first quarter of 2017. Amid currency tailwinds of 2.4%, Rebif sales amounted to € 415 million (Q1 2016: € 422 million). In the first quarter, Merck generated organic sales growth of 4.3% with the oncology drug Erbitux. In addition, favorable exchange rate effects of 1.2% were incurred. Consequently, sales of Erbitux rose to € 218 million (Q1 2016: € 207 million). At € 171 million, Merck’s sales of the fertility medicine Gonal-f were lower than in the year-earlier quarter (Q1 2016: € 187 million). The organic sales decline of -9.6% resulted from the comparison with a strong year-earlier quarter and continued competitive pressure in Europe from biosimilars.

Despite higher marketing and selling expenses, EBITDA pre exceptionals of the Healthcare business sector rose in the first quarter by 24.5% to € 633 million (Q1 2016: € 508 million). The increase in EBITDA pre of Healthcare resulted from a one-time payment of € 116 million as compensation for future license payments (the year-earlier quarter included license income in the mid to high single-digit million euro range), higher royalty income for Avonex thanks to a patent granted in the United States in June 2016, as well as the milestone payment of € 37 million for the approval of Bavencio at the end of March.

On March 23, 2017, Merck received approval from the U.S. Food and Drug Administration (FDA) for its immuno-oncology drug Bavencio for the treatment of metastatic Merkel cell carcinoma (mMCC) in the United States. This was followed on May 9, 2017, by the approval of Bavencio to treat a common form of advanced bladder cancer. Moreover, on March 9, 2017, Merck announced that it is in advanced stages of negotiations to divest its Biosimilars business. On April 24, 2017, Merck then announced the divestment of its Biosimilars business to Fresenius. The decision was in line with the strategy of the Healthcare business sector of focusing on the discovery and development of innovative pharmaceuticals.
Life Science drives integration forward and increases profitability further
The Life Science business sector grew in the first quarter of 2017 organically by 3.3%, to which all regions and business areas contributed. In addition, exchange rate effects of 2.4% had a favorable impact, as did portfolio effects of 0.4%. In the first quarter of 2017, sales by the Life Science business sector thus rose overall by 6.1% to € 1.5 billion (Q1 2016: € 1.4 billion).

The Process Solutions business area, which markets products for the entire pharmaceutical production value chain, delivered organic sales growth of 4.8%. The Research Solutions business area, which focuses on academia and pharmaceutical research institutions, generated an organic sales increase of 1.0%. Sales by Applied Solutions, which serves clinical and diagnostic testing laboratories as well as the food and environmental industries, grew organically by 4.4%.

EBITDA pre exceptionals of the Life Science business sector rose in the first quarter by 13.3% to € 445 million (Q1 2016: € 393 million). Merck continued to make good progress with the integration of Sigma-Aldrich in the first quarter. The ongoing realization of synergies from the Sigma-Aldrich acquisition and good organic sales performance led to higher profitability. The EBITDA pre exceptionals margin of Life Science improved to 30.1% (Q1 2016: 28.1%).

In January, Merck announced the acquisition of BioControl Systems Inc., a global leader in food safety testing. BioControl’s established rapid detection technology and third-party validated testing platforms complement the portfolio of the Applied Solutions business area within Life Science.

Performance Materials: OLED materials business continues to generate strong growth
In the first quarter, net sales of the Performance Materials business sector grew by 3.6% to € 645 million (Q1 2016: € 622 million). A slight organic sales decline of
-0.9% was more than offset by positive foreign exchange effects of 4.5%. The organic decline, which stemmed from the Display Materials business, was compensated for by the positive organic development of the other three Performance Materials business units.

In the Display Materials business unit, the double-digit growth of the business with the innovative liquid crystal technology UB-FFS marked a new sales record in the first quarter. However, this could not fully offset the typical price declines and the normalization of market shares. Nevertheless, Merck maintained its leadership position. The Pigments & Functional Materials business unit delivered solid organic growth. The Integrated Circuit Materials business unit, which includes the business with materials used to manufacture integrated circuits as well as the SAFC Hitech business of Sigma-Aldrich, generated good organic sales growth. The strong sales increase in the Advanced Technologies business unit was primarily due to continued growth in the OLED materials business.

EBITDA pre exceptionals of Performance Materials fell in the first quarter by -3.7% to € 263 million (Q1 2016: € 273 million).

Merck is working to apply its liquid crystals expertise also in areas beyond displays, for instance liquid crystal windows. At the same time, Merck intends to sustainably secure its market and technology leadership in display materials.

Merck confirms and specifies outlook for 2017
With the publication of the results of 2016, Merck had provided an initial forecast of the development of net sales, EBITDA pre exceptionals and business free cash flow for the Merck Group and the individual business sectors in 2017. Following a solid first quarter, Merck forecasts net sales to increase to between € 15.5 billion and € 16.0 billion in 2017. Organically, Merck continues to expect a slight to moderate increase in comparison with the previous year, yet now assumes that currency changes will have a slightly positive effect of probably 1% to 2% on net sales. For 2017, Group EBITDA pre exceptionals is expected to be in a range of between € 4.4 billion and € 4.6 billion.

Forecast for FY 2017
€ million
Net sales
EBITDA pre exceptionals
Earnings per share pre exceptionals
Merck Group
~ 15,500 – 16,000
~ 4,400 – 4,600
€ 6.15 – 6.50
Healthcare
Slight organic growth,
low portfolio effect due to the divestment of the business in Pakistan
~ 1,900 – 2,000
Life Science
Solid organic sales growth, low portfolio effect due to the acquisition of BioControl
~ 1,780 – 1,850
Performance Materials
Slight organic sales decline
~ 1,050 – 1,130
Corporate and Other
–
~ -350 – -400

Merck Group – Key figures
€ million
Q1 2017
Q1 2016
Change
Net sales
3,861
3,665
5.3%
Operating result (EBIT)
755
849
-11.1%
Margin (% of net sales)
19.5%
23.2%
EBITDA
1,203
1,282
-6.2%
Margin (% of net sales)
31.2%
35.0%
EBITDA pre exceptionals
1,240
1,084
14.5%
Margin (% of net sales)
32.1%
29.6%
Earnings per share (€)
1.20
1.36
-11.8%
Earnings per share pre exceptionals (€)
1.80
1.54
16.9%
Net income
521
591
-11.8%
March 31, 2017
Dec. 31, 2016
Net financial debt
11,113
11,513
-3.5%

On May 18, 2017 Novartis reported it will present data from across its oncology portfolio at the upcoming 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper), being held June 2-6 in Chicago; the 14th International Conference on Malignant Lymphoma (ICML), being held June 14-17 in Lugano, Switzerland; and the 22nd Annual Congress of the European Hematology Association (EHA) (Free EHA Whitepaper), being held June 22-25 in Madrid (Press release, Novartis, MAY 18, 2017, View Source [SID1234519243]). With more than 75 abstracts accepted, data will highlight research across 34 compounds in key disease areas, including breast and lung cancers, melanoma, leukemia and other blood disorders, and myeloproliferative neoplasms (MPNs).

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"Our presence at key medical congresses this year is marked by our innovation in targeted therapies and immuno-oncology in difficult to treat cancers," said Bruno Strigini, CEO, Novartis Oncology. "We are particularly excited to show the first data from the JULIET trial, which evaluates the use of CTL019 in relapsed/refractory diffuse large B-cell lymphoma. These results, along with the data that led to our filing for CTL019 in relapsed/refractory pediatric and young adult patients with B-cell acute lymphoblastic leukemia, demonstrate our commitment to research in this area."

Novartis data at the 2017 ASCO (Free ASCO Whitepaper) Annual Meeting will highlight the following:

Update on outcomes with Kisqali* (ribociclib) in postmenopausal women with hormone receptor positive, human epidermal growth factor receptor-2 negative (HR+/HER2-) advanced breast cancer:

Updated Results from MONALEESA-2, a Phase 3 Trial of First-Line Ribociclib + Letrozole in Hormone Receptor-Positive (HR+), HER2-Negative (HER2-), Advanced Breast Cancer (ABC) [Abstract #1038; Sunday, June 4, 8:00 AM CDT]
Health-Related Quality of Life (HRQoL) of Postmenopausal Women with Hormone Receptor-Positive (HR+), Human Epidermal Growth Factor Receptor 2-Negative (HER2-) Advanced Breast Cancer (ABC) Treated with Ribociclib + Letrozole: Results from MONALEESA-2 [Abstract #1020; Sunday, June 4, 8:00 AM CDT]

Data showing patient-reported quality of life outcomes for CTL019** (tisagenlecleucel), an investigational chimeric antigen receptor T cell (CAR-T) therapy, in relapsed/refractory pediatric and young adult patients with B-cell acute lymphoblastic leukemia (ALL):

Patient-Reported Quality of Life (QOL) Following CTL019 in Pediatric and Young Adult Patients (pts) with Relapsed/Refractory (r/r) B-cell Acute Lymphoblastic Leukemia (B-ALL) [Abstract #10523; Sunday, June 4, 8:00 AM CDT]
New data evaluating long-term outcomes with Tafinlar (dabrafenib) and Mekinist (trametinib) combination therapy in patients with BRAF V600-mutated unresectable or metastatic melanoma as well as data from patients with other tumor types:

Five-Year Overall Survival (OS) Update from a Phase II, Open-Label Trial of Dabrafenib (D) and Trametinib (T) in Patients (pts) with BRAF V600-Mutant Unresectable or Metastatic Melanoma (MM) [Abstract #9505; Sunday, June 4, 9:24 AM CDT]
COMBI-MB: A Phase II Study of Combination Dabrafenib (D) and Trametinib (T) in Patients with BRAF V600-Mutant (mut) Melanoma Brain Metastases (MBM) [Abstract #9506; Sunday, June 4, 10:00 AM CDT]
Updated Survival of Patients (pts) with Previously Treated BRAF V600E-Mutant Advanced Non-Small Cell Lung Cancer (NSCLC) who Received Dabrafenib (D) or D + Trametinib (T) in the Phase II BRF113928 Study [Abstract #9075; Saturday, June 3, 8:00 AM CDT]
Efficacy of Dabrafenib (D) and Trametinib (T) in Patients (pts) with BRAF V600E-Mutated Anaplastic Thyroid Cancer (ATC) [Abstract #6023; Monday, June 5, 1:15 PM CDT]
New data on Zykadia (ceritinib) as well as the investigational compound EGF816 which highlight continued investigations in the treatment of mutation-driven lung cancer:

Ceritinib Plus Nivolumab (NIVO) in Patients (pts) with Anaplastic Lymphoma Kinase Positive (ALK+) Advanced Non-Small Cell Lung Cancer (NSCLC) [Abstract #2502; Saturday, June 3, 1:39 PM CDT]
Genomic Profiling of Resistant Tumor Samples Following Progression on EGF816, a Third Generation, Mutant-Selective EGFR Tyrosine Kinase Inhibitor (TKI), in Advanced Non-Small Cell Lung Cancer (NSCLC) [Abstract #11506; Sunday, June 4, 9:48 AM CDT]
Adjuvant treatment of renal cell carcinoma (RCC) and safety and efficacy of combination therapy in treatment of advanced RCC:

Randomized Phase III Trial of Adjuvant Pazopanib Versus Placebo After Nephrectomy in Patients with Locally Advanced Renal Cell Carcinoma (RCC) (PROTECT) [Abstract #4507; Monday, June 5, 10:12 AM CDT]
A Phase I/II Study to Assess the Safety and Efficacy of Pazopanib (PAZ) and Pembrolizumab (PEM) in Patients (pts) with Advanced Renal Cell Carcinoma (aRCC) [Abstract #4506; Monday, June 5, 9:36 AM CDT]
Additional data presented at ASCO (Free ASCO Whitepaper) include:

Phase III Study of Lapatinib (L) Plus Trastuzumab (T) and Aromatase Inhibitor (AI) vs T+AI vs L+AI in Postmenopausal Women (PMW) with HER2+, HR+ Metastatic Breast Cancer (MBC): ALTERNATIVE [Abstract #1004; Saturday, June 3, 2:27 PM CDT]
Everolimus (EVE) Plus Endocrine Therapy in Patients with Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor 2-Negative (HER2-) Advanced Breast Cancer (BC): First and Second-Line Data from the BOLERO-4 Study [Abstract #1010; Sunday, June 4, 8:00 AM CDT]
Cognitive Technology Addressing Optimal Cancer Clinical Trial Matching and Protocol Feasibility in a Community Cancer Practice [Abstract #6501; Monday, June 5, 8:12 AM CDT]
Sandoz, a Novartis division, the pioneer and global leader in biosimilars, will present data for Zarxio, the company’s filgrastim biosimilar:

Safety and Efficacy of Alternating Treatment with EP2006, a Filgrastim Biosimilar, and Reference Filgrastim for the Prevention of Severe Neutropenia, in Patients with Breast Cancer Receiving Myelosuppressive Chemotherapy [Abstract #10116; Saturday, June 3, 1:15 PM CDT]
Novartis data at the 14th Meeting of ICML will highlight data from the multi-center Phase II JULIET study evaluating the efficacy and safety of CTL019 in adult patients with r/r diffuse large B-cell lymphoma (DLBCL):

Global Pivotal Phase 2 Trial of the CD19-Targeted Therapy CTL019 in Adult Patients with Relapsed or Refractory (R/R) Diffuse Large B-cell Lymphoma (DLBCL) – An Interim Analysis [Abstract #007; Wednesday, June 14, 3:40 PM CEST]
Novartis data at the 2017 EHA (Free EHA Whitepaper) Annual Congress will highlight the following:

Data evaluating CTL019** outcomes in r/r pediatric and young adult patients with B-ALL:

Global Registration Trial of Efficacy and Safety of CTL019 in Pediatric and Young Adult Patients with Relapsed/Refractory (R/R) Acute Lymphoblastic Leukemia (ALL): Update to the Interim Analysis [Abstract #S476; Saturday, June 24, 4:00 PM CEST]
Analysis of Safety Data from 2 Multicenter Trials of CTL019 in Pediatric and Young Adult Patients with Relapsed/Refractory (R/R) B-Cell Acute Lymphoblastic Leukemia (B-ALL) [Abstract #P517; Saturday, June 24, 5:30 PM CEST]
CTL019 Clinical Pharmacology and Biopharmaceutics in Pediatric Patients (pts) with Relapsed or Refractory (R/R) Acute Lymphoblastic Leukemia (ALL) [Abstract #S477; Saturday, June 24, 4:15 PM CEST]
New analyses of ENESTfreedom and ENESTop evaluating Treatment-free Remission (TFR) at 96-week follow-up in patients meeting rigorous criteria for treatment discontinuation:

Durable Treatment-free Remission (TFR) After Stopping Second-line Nilotinib (NIL) in Patients (Pts) with Chronic Myeloid Leukemia in Chronic Phase (CML-CP): ENESTop 96-Wk Update [Abstract #P257; Friday, June 23, 5:15 PM CEST]
Durable Treatment-free Remission (TFR) Following Frontline Nilotinib in Patients (Pts) with Chronic Myeloid Leukemia in Chronic Phase (CML-CP): ENESTfreedom 96-Wk Update [Abstract #P601; Saturday, June 24, 5:30 PM CEST]

Pooled survival analysis of two clinical trials evaluating Rydapt (midostaurin) in adult patients with advanced systemic mastocytosis:

Pooled Survival Analysis of Midostaurin Clinical Study Data (D2201 + A2213) in Patients with Advanced Systemic Mastocytosis (ADVSM) Compared with Historical Controls [Abstract #S788; Sunday, June 25, 9:00 AM CEST]
New data in myeloproliferative neoplasms, including a long-term analysis evaluating Jakavi (ruxolitinib)*** in patients with inadequately controlled polycythemia vera in a less advanced phase of the disease:

Ruxolitinib For The Treatment Of Inadequately Controlled Polycythemia Vera Without Splenomegaly: 80-Week Follow-Up From The RESPONSE-2 Trial [Abstract #S784; Sunday, June 25, 8:00 AM CEST]
Comparing The Safety And Efficacy Of Ruxolitinib (Rux) In Patients (Pts) With DIPSS Low/Intermediate-1-, Intermediate-2-, And High-Risk Myelofibrosis (MF) In JUMP, A Phase 3b, Expanded-Access Study [Abstract #E1333; Friday, June 23, 9:30 AM CEST]
Treatment and Management Of Patients With MPNs – Findings From the International MPN LANDMARK Survey [Abstract #P706; Saturday, June 24, 5:30 PM CEST]
Perception Of Symptom Burden and Treatment Goals Between Physicians and Patients With MPNs: An Analysis From the International MPN LANDMARK Survey [Abstract #E1320; Friday, June 23, 9:30 AM CEST]
Additional data presented at EHA (Free EHA Whitepaper) include:

Mediation by Patient-Reported Outcomes on the Association Between Film-Coated versus Dispersible Formulations of Deferasirox and Serum Ferritin Reduction: A Post-Hoc Analysis of the ECLIPSE Trial [Abstract #P286; Friday, June 23, 5:15 PM CEST]
Crizanlizumab, a P-selectin Inhibitor, Increases the Likelihood of Not Experiencing a Sickle Cell-Related Pain Crisis While on Treatment: Results from the Phase II SUSTAIN Study [Abstract #S454; Saturday, June 24, 12:15 PM CEST]

Throughout the 2017 ASCO (Free ASCO Whitepaper) Annual Meeting, ICML meeting and EHA (Free EHA Whitepaper) Annual Meeting, Novartis Oncology will host dedicated content on the Novartis Oncology website (View Source) that will feature unique insights and perspectives on emerging areas of cancer care and research.

Product Information
Approved indications for products vary by country and not all indications are available in every country. The product safety and efficacy profiles have not yet been established outside the approved indications. Because of the uncertainty of clinical trials, there is no guarantee that compounds will become commercially available with additional indications.

For full prescribing information, including approved indications and important safety information about marketed products, please visit
View Source

EGF816, CTL019 and crizanlizumab (SEG101, formerly SelG1) are investigational compounds. Efficacy and safety have not been established. There is no guarantee these compounds will become commercially available.

On May 18, 2017 Verastem, Inc. (NASDAQ:VSTM), focused on discovering and developing drugs to improve the survival and quality of life of cancer patients, reported an abstract featuring long-term follow up data from the DYNAMO study evaluating duvelisib in patients with follicular lymphoma (FL) has been selected for oral presentation at the 22nd Congress of the European Hematology Association (EHA) (Free EHA Whitepaper) being held June 22-25, 2017 in Madrid, Spain (Press release, Verastem, MAY 18, 2017, View Source [SID1234519242]).

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In addition, an abstract describing Phase 2 data, also from the DYNAMO study, evaluating duvelisib in patients with small lymphocytic lymphoma (SLL) has been selected for an e-poster presentation at the meeting. DYNAMO is a Phase 2 clinical trial evaluating the safety and efficacy of duvelisib in patients with indolent non-Hodgkin lymphoma (iNHL) that are double refractory to both rituximab and chemotherapy.

"In the previously reported Phase 2 DYNAMO study results, duvelisib monotherapy demonstrated statistically significant clinical activity in iNHL patients, acheiving the primary endpoint with a 46% overall response rate, and was generally well tolerated with a manageable safety profile with appropriate risk mitigation," said Hagop Youssoufian, MSc, MD, Head of Hematology and Oncology Development at Verastem. "We look forward to presenting the long-term follow up data in June."

Details for the presentations at EHA (Free EHA Whitepaper) 2017 are:
Oral Presentation
Title: DYNAMO: A Phase 2 Study Demonstrating the Clinical Activity of Duvelisib in Patients with Double-Refractory Follicular Lymphoma
Presenter: Pier Luigi Zinzani, MD, PhD, University of Bologna Institute of Hematology
Abstract code: S777
Topic: Indolent Non-Hodgkin lymphoma – Clinical
Session title: Follicular lymphoma – Clinical
Location: Hall C
Date and time: Sunday, June 25, 2017, 8:45 – 9:00 CET
A copy of the oral presentation slides will be available here following the conclusion of the oral presentation.
E-Poster Presentation
Title: DYNAMO: The Clinical Activity of Duvelisib in Patients with Double-Refractory Small Lymphocytic Lymphoma in a Phase 2 Study
Abstract code: E1130
Topic: Indolent Non-Hodgkin lymphoma – Clinical
Location: e-poster screens
Date and time: Friday, June 23, 2017 from 9:30 CET to Saturday, June 24, 2017 at 19:00 CET

A copy of the e-poster presentation will be available here following the conclusion of the meeting.

About the Tumor Microenvironment
The tumor microenvironment encompasses multiple tumor and non-tumor cell populations and an extracellular matrix that support cancer cell survival. This includes immunosuppressive regulatory T-cells, myeloid-derived suppressor cells, tumor-associated macrophages, cancer-associated fibroblasts and extracellular matrix proteins that can hamper the entry and therapeutic benefit of cytotoxic T-cells and anti-cancer drugs. In addition to targeting the proliferative and survival signaling of cancer cells, Verastem’s product candidates, including duvelisib and defactinib, also target the tumor microenvironment to potentially improve a patient’s response to therapy.

About Duvelisib
Duvelisib is an investigational, dual inhibitor of phosphoinositide 3-kinase (PI3K)-delta and PI3K-gamma, two enzymes that are known to help support the growth and survival of malignant B-cells and T-cells. PI3K signaling may lead to the proliferation of malignant B-cells and is thought to play a role in the formation and maintenance of the supportive tumor microenvironment.1,2,3 Duvelisib is currently being evaluated in late- and mid-stage clinical trials, including DUO, a randomized, Phase 3 monotherapy study in patients with relapsed or refractory CLL,4 and DYNAMO, a single-arm, Phase 2 monotherapy study in patients with refractory iNHL that achieved its primary endpoint of ORR upon top-line analysis of efficacy data.5 Duvelisib is also being evaluated for the treatment of hematologic malignancies through investigator-sponsored studies, including T-cell lymphoma.6 Information about duvelisib clinical trials can be found on www.clinicaltrials.gov.

On May 18, 2017 TG Therapeutics, Inc. (NASDAQ:TGTX), reported that clinical abstracts featuring TG-1101 and TGR-1202 have been selected for presentation at the upcoming 22nd European Hematology Association (EHA) (Free EHA Whitepaper) annual congress, to be held June 22 – 25, 2017 in Madrid, Spain (Press release, TG Therapeutics, MAY 18, 2017, View Source [SID1234519240]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Details of the data presentations are outlined below.

Oral Presentation:

• Title: Chemo-free triplet combination of TGR-1202, ublituximab, and ibrutinib is well tolerated and highly active in patients with advanced CLL and NHL

Abstract Number: S772
Presentation Date & Time: Sunday, June 25, 2017 8:45 – 9:00 CEST
Session Title: Targeted therapies in relapsed chronic lymphocytic leukemia
Location: Hall A
Presenter: Loretta J. Nastoupil, MD, MD Anderson Cancer Center
Poster Presentation:

• Title: Combination of TGR-1202, Ublituximab, and bendamustine is safe and highly active in patients with advanced DLBCL and follicular lymphoma

Abstract Number: P563
Presentation Date & Time: Saturday, June 24, 2017 17:30 – 19:00 CEST
Session Title: Aggressive Non-Hodgkin Lymphoma- Relapsed/Refractory
Location: Poster Area Hall 7
Presenter: Matthew Lunning, DO, University of Nebraska Medical Center
The EHA (Free EHA Whitepaper) abstracts were made available today May 18, 2017 through the EHA (Free EHA Whitepaper) meeting website at www.ehaweb.org. Following each presentation, the data presented will be available on the Publications page, located within the Pipeline section, of the Company’s website at www.tgtherapeutics.com.