UPDATE: Heat Biologics to Host Analyst and Investor Event February 28, 2018, to Present Results from its Phase 2 Lung Cancer Study

On February 26, 2018 Heat Biologics, Inc. (NASDAQ: HTBX), a biopharmaceutical company developing drugs designed to activate a patient’s immune system against cancer, is hosting an analyst and investor event to present Phase 2 results from its HS-110 (viagenpumatucel-L) study in combination with the Bristol-Myers Squibb checkpoint inhibitor, nivolumab (Opdivo), in patients with advanced non-small cell lung cancer (NSCLC) whose cancers have progressed after treatment with one or more lines of therapy (Press release, Heat Biologics, FEB 26, 2018, View Source [SID1234524164]).

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The presentation will take place at 8 a.m., Wednesday, Feb. 28, 2018, at the Lotte New York Palace Hotel in New York City. To register and watch a live webcast of the event, visit View Source

The event follows the first formalized Independent Data Monitoring Committee ("IDMC") meeting review of the most recent Phase 2 interim data from the trial. The presentation will include data generated from the first 35 patients enrolled in the study, specifically:

Clinical efficacy measures of treatment response
The correlation of immune response from blood samples with positive clinical outcome
Safety data evaluation and analysis
Speakers include Roger B. Cohen, MD, Professor of Medicine at the University of Pennsylvania and Associate Director for Clinical Research for the Abramson Cancer Center, who will discuss the current treatment landscape for NSCLC, and the emerging role of combination immunotherapy treatments. Following Dr. Cohen’s presentation, George Peoples, MD, Chief Medical Officer for Heat, will discuss the latest Phase 2 results from the HS-110 study. Heat management will also provide an outline of the company’s planned development strategy for HS-110 based on the trial data, as well as the recent outcome of its Type C meeting with the FDA.

Endocyte Announces Phase 3 VISION Trial and Provides Update on Corporate Strategy and Reports Fourth Quarter and Year End 2017 Financial Results

On February 26, 2018 Endocyte, Inc. (NASDAQ:ECYT), a biopharmaceutical company developing targeted therapeutics for personalized cancer treatment, today provided an update on its corporate strategy and reported its financial results for the fourth quarter and full year ending Dec. 31, 2017 (Press release, Endocyte, FEB 26, 2018, View Source [SID1234524163]).

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"Following a successful End of Phase 2 meeting with the FDA, we are excited to launch the VISION trial, a phase 3 registration trial of 177Lu-PSMA-617 in patients with prostate cancer," said Mike Sherman, president and CEO of Endocyte. "After extensive collaboration with prostate cancer specialists around the world, the robust and sophisticated VISION trial design will be attractive to patients and physicians when we begin enrollment in the second quarter of 2018."

"In addition, we were pleased that Caryn Barnett and Theresa Bruce recently joined our team, both seasoned leaders with strong track records of executing late stage oncology development programs," added Mr. Sherman. "We expect 2018 to be a critical year of execution for us, as we will not only initiate VISION, but also bring our adaptor-controlled chimeric antigen receptor t-cell (CAR T-cell) program into the clinic in the fourth quarter of 2018."

177Lu-PSMA-617Phase 3 VISION Trial Design Finalized

Following a successful End of Phase 2 meeting with the U.S. Food and Drug Administration (FDA), Endocyte finalized the phase 3 VISION trial design for 177Lu-PSMA-617. The trial will include two interim assessments of efficacy, which could potentially lead to an early approval for 177Lu-PSMA-617.

The VISION trial is an international, prospective, open-label, multicenter, randomized phase 3 study of 177Lu-PSMA-617 for the treatment of patients with progressive prostate specific membrane antigen (PSMA)-positive metastatic castration-resistant prostate cancer (mCRPC), who have received at least one novel androgen axis drug (NAAD) and at least one taxane regimen. VISION will enroll up to 750 patients with PSMA-positive scans, randomized in a 2:1 ratio to receive either 177Lu-PSMA-617 and best supportive care alone or in combination with a NAAD (physician’s choice), versus best supportive care alone or in combination with a NAAD (physician’s choice). Best supportive care alternatives are palliative in nature. Patients treated with 177Lu-PSMA-617 will receive 7.4 gigabecquerel (GBq) intravenously every six weeks for a maximum of six cycles. The trial will be stratified by the physician’s choice of using a NAAD or not, so the use of NAAD’s will be balanced between trial arms.

The primary endpoint of the study will be overall survival (OS). Secondary endpoints include radiographic progression free survival, response evaluation criteria in solid tumors (RECIST) response, and time to first symptomatic skeletal event. Interim efficacy analyses of OS will be conducted at 50% and 70% of the 489 targeted events.

Enrollment of the trial is expected to begin in the second quarter of 2018 and is expected to be completed in 18-24 months. The first interim assessment of OS could occur as early as the second half of 2019.

Announced Agreement for Clinical Supply of Lutetium with ITM

Endocyte also announced an agreement with ITM Isotopen Technologien München AG, which will provide clinical supply of no-carrier-added Lutetium for the manufacturing of 177Lu-PSMA-617.

Added Experienced Clinical Trial Professionals to Ensure Strong Execution

In addition, today Endocyte announced that it recently added key capabilities to support the success of its clinical programs.

Caryn Barnett joined Endocyte as Senior Director, Clinical Operations with global responsibility for Endocyte clinical trials. She has over 22 of years’ experience in the pharmaceutical industry, most recently as Director of Clinical Operations, North America Oncology at Eli Lilly and Company. Caryn’s accomplishments include her recent leadership in executing four simultaneous global oncology registration programs, each of which were subsequently approved by the FDA.

Theresa Bruce joined Endocyte as Head of European Clinical Operations following 25 years in the field of clinical research, with the last 20 dedicated to oncology. Theresa brings a significant understanding of the regulatory landscape, particularly in Europe. Additionally, she played a lead role in developing next generation prostate cancer therapeutics in these regions, with her involvement in the operational execution of several phase 3 prostate cancer studies including, most notably, the development of abiraterone (Zytiga) from early-stage trials through registration.

CAR T-Cell Therapy Expected to Begin Clinical Development in the Fourth Quarter of 2018

Endocyte has also finalized plans for the clinical development of its adaptor-controlled CAR T-cell therapy in patients with osteosarcoma. Endocyte’s approach utilizes an autologous CAR T-cell targeting fluorescein isothiocyanate (FITC), an agent otherwise not present in the human body. With the administration of CAR T adaptor molecules (CAMs) which bind to tumor targets and to the CAR T-cells, the approach potentially enables controlled engagement of the CAR T-cells. This control over the antigen target differentiates the approach to earlier generation CAR T programs. In collaboration with Michael Jensen, MD of Seattle Children’s Research Institute, pre-clinical evaluations have been completed and clinical evaluation is expected to begin in the fourth quarter of 2018.

In this trial, patients will be selected based on the presence of folate receptor positive disease. Following administration of the FITC-targeted CAR T-cells, the protocol provides for intra-patient dose escalation of CAMs. Patients will be monitored following each CAM dose to assess immune response, providing for rapid feedback on activity and safety of the therapy. This innovative design is intended to gradually build the immune response, thereby allowing for the potential to maximize antitumor activity with the intent to avoid severe cytokine release syndrome as well as CAR T-cell exhaustion.

Through Endocyte’s collaboration with Purdue University, multiple additional CAMs are in pre-clinical development, directed against distinct targets including, potentially, carbonic anhydrase 9, cholecystokinin-2 receptor (CCK2R), neurokinin-1 receptor (NK1R), among others.

Expected 2018 Milestones

Phase 3 registration VISION trial of 177Lu-PSMA-617 in mCRPC first patient visit (2Q 2018)
50-patient response rate data readout of investigator initiated trial of 177Lu-PSMA-617 in mCRPC at Peter MacCallum Cancer Centre in Melbourne, Australia at the Annual Meeting of the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) (June 2018)
Publications on other ongoing investigator initiated clinical trials of 177Lu-PSMA-617 in prostate cancer patients (2018)
CAR T phase 1 first patient visit in osteosarcoma (4Q 2018)
Fourth Quarter 2017 Financial Results

Endocyte reported a net loss of $8.6 million, or $0.18 per basic and diluted share, for the fourth quarter of 2017, compared to a net loss of $11.1 million, or $0.26 per basic and diluted share for the same period in 2016.

Research and development expenses were $5.1 million for the fourth quarter of 2017, compared to $8.2 million for the same period in 2016. The decrease was primarily attributable to: a decrease of $1.4 million in compensation expense as a result of employee terminations since December 31, 2016, including those resulting from the company’s restructuring in June 2017; a decrease of $1.0 million in manufacturing expense for EC1169; a decrease of $0.7 million in expenses related to trial and manufacturing costs for EC1456; and a decrease of $0.6 million in expenses related to pre-clinical work and general research, including the development of EC2629. These decreases were partially offset by: an increase of $0.6 million in expenses related to consulting fees for PSMA-617 and in expenses related to our CAR T-cell therapy program

General and administrative expenses were $3.7 million for the fourth quarter of 2017, compared to $3.1 million for the same period in 2016. The increase was primarily attributable to an increase in expenses related to legal and professional fees and an increase in compensation expense, including stock compensation expense.

Cash, cash equivalents and investments were $97.5 million at Dec. 31, 2017, compared to $103.1 million at Sept. 30, 2017, and $138.2 million at Dec. 31, 2016.

Financial Expectations

The company anticipates its cash, cash equivalents and investments balance at the end of 2018 to exceed $50 million. Endocyte has sufficient cash to fund its activities into the second half of 2019 through many important milestones.

Conference Call

Endocyte management will host a conference call today at 8:30 a.m. EST.
U.S. and Canadian participants: (877) 845-0711
International: (760) 298-5081

A live, listen-only webcast of the conference call and accompanying slides may be accessed by visiting the Investors & News section of the Endocyte website, www.endocyte.com.

The webcast will be recorded and available on the company’s website for 90 days following the call.

Website Information
Endocyte routinely posts important information for investors on its website, www.endocyte.com, in the "Investors & News" section. Endocyte uses this website as a means of disclosing material information in compliance with its disclosure obligations under Regulation FD. Accordingly, investors should monitor the "Investors & News" section of Endocyte’s website, in addition to following its press releases, SEC filings, public conference calls, presentations and webcasts. The information contained on, or that may be accessed through, Endocyte’s website is not incorporated by reference into, and is not a part of, this document.

Eagle Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2017 Results

On February 26, 2018 Eagle Pharmaceuticals, Inc. ("Eagle" or "the Company") (Nasdaq: EGRX) reported its financial results for the three- and twelve-months ended December 31, 2017 (Press release, Eagle Pharmaceuticals, FEB 26, 2018, View Source [SID1234524162]). Highlights of and subsequent to the fourth quarter of 2017 include:

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Business and Recent Highlights:

Agreed on a path forward with the FDA for RYANODEX for EHS and plans to conduct an additional clinical trial in August 2018 during the Hajj pilgrimage, similar to the Eagle study conducted during the Hajj in 2015;
Completed randomization of 600 subjects in the fulvestrant clinical study ahead of schedule during the first quarter of 2018;
Filed an ANDA for Eagle’s first of two ANDA product candidates in 2018; awaiting FDA acceptance;
Settled $48mm in potential Arsia milestone obligations in exchange for $15 million in cash, for a total investment in Eagle Biologics of $45 million.
Financial Highlights:

Fourth Quarter 2017

Total revenue for the fourth quarter of 2017 was $46.8 million, compared to $81.1 million in the fourth quarter of 2016, which included $40 million in license and other income;
Q4 2017 income before income tax provision was $9.9 million compared to $28.3 million in Q4 2016;
Q4 2017 net income was $9.1 million, or $0.61 per basic and $0.58 per diluted share, compared to net income of $57.3 million, or $3.75 per basic and $3.52 per diluted share in Q4 2016;
Q4 2017 Adjusted Non-GAAP net income was $15.6 million, or $1.05 per basic and $1.00 per diluted share, compared to Adjusted Non-GAAP net income of $17.2 million, or $1.12 per basic and $1.05 per diluted share in the prior year quarter.
Full Year 2017

Total revenue for the twelve months ending December 31, 2017 grew 25% to $236.7 million, compared to $189.5 million in 2016;
2017 income before income tax provision was $72.9 million, compared to $53.4 million in 2016;
2017 net income was $51.9 million, or $3.44 per basic and $3.27 per diluted share, compared to a net income of $81.5 million, or $5.24 per basic and $4.96 per diluted share in 2016;
2017 income tax expense was $21 million, compared to an income tax benefit of $28 million in 2016;
2017 Adjusted Non-GAAP net income was $69.0 million, or $4.57 per basic and $4.34 per diluted share, compared to Adjusted Non-GAAP net income of $45.9 million, or $2.96 per basic and $2.79 per diluted share in 2016. For a full reconciliation of Adjusted Non-GAAP net income to the most comparable GAAP financial measures, please see the tables at the end of this press release;
2017 EBITDA was $96.2 million, compared to $63.9 million in 2016;
At year end, Eagle had completed its $75 million Share Repurchase Program authorized in August 2016 and purchased an additional $5.8 million in Eagle common stock as part of its expanded $100 million share buyback program;
Cash and cash equivalents were $114.7 million, accounts receivable were $53.8 million, and debt was $48.8 million as of December 31, 2017; and,
2018 Expense Guidance:
R&D expense is expected to be in the range of $46 – $50 million ($39 – $43 million on a non-GAAP basis)
SG&A expense is expected to be in the range of $61 – $64 million ($45 – $48 million on a non-GAAP basis).
"Eagle had another record year in 2017, with revenue of $237 million and EBITDA of $96 million. We are excited about our positive meeting with the FDA that will enable us to advance RYANODEX for EHS, and are planning to conduct another clinical study at the Hajj in August of this year. And, our fulvestrant study randomization has now been completed ahead of schedule with 600 subjects. Pending positive data, we remain on track to file an NDA during the fourth quarter of 2018," stated Scott Tarriff, Chief Executive Officer of Eagle Pharmaceuticals.

"Importantly, we filed an ANDA for our first of two assets earlier this year and intend to file another during the second half of 2018. Combined branded sales for these assets are approximately $500 million, representing another significant opportunity to create value for patients and shareholders," added Tarriff.

"We remain focused on developing best-in-class injectables and driving value for shareholders. Given the strength of our pipeline and multiple upcoming catalysts in 2018, we believe we are well-positioned to continue to deliver strong results this year," concluded Tarriff.

Fourth Quarter 2017 Financial Results

Total revenue for the three months ended December 31, 2017 was $46.8 million, as compared to $81.1 million for the three months ended December 31, 2016. A summary of total revenue is outlined below:


Three Months Ended December 31,
2017 2016

Revenue:
Product sales $ 10,432 $ 9,080
Royalty income 36,353 32,015
License and other income — 40,046
Total revenue 46,785 81,141

Product sales were $10.4 million, driven by increases in Bendeka and Ryanodex, partially offset by a decrease in Argatroban. Royalty income increased to $36.4 million, as a result of the increased market share on Teva sales of Bendeka, as well as an increase in the royalty rate from 20% to 25%.

Research and development expenses decreased $6.8 million to $9.4 million for the three months ended December 31, 2017, compared to $16.2 million in the prior year quarter. The decrease was largely due to lower levels of API purchases.

SG&A expenses decreased $4.2 million to $13.4 million in the fourth quarter of 2017 compared to $17.5 million in the three months ended December 31, 2016. The decrease was due to the expiration of the Spectrum promotion contract at the end of June 2017, as well as a reduction in marketing expenses. These reductions were partially offset by the increase in personnel-related expenses associated with the expansion of our sales force in the second quarter of 2017.

During the fourth quarter of 2017, Eagle recorded a tax expense of $854,000, compared to a tax benefit of $29 million during the fourth quarter of 2016. The tax provision in the fourth quarter of 2017 was decreased by the recognition of federal R&D tax credits, offset in part by an adjustment to Eagle’s net deferred tax asset to reflect the impact of the recently enacted federal tax reform legislation. The tax provision in the fourth quarter of 2016 was impacted by Eagle’s reversal of the valuation allowance against the Company’s net deferred tax asset.

Net income for the fourth quarter was $9.1 million, or $0.61 per basic share and $0.58 per diluted share, compared to net income of $57.3 million, or $3.75 per basic and $3.52 per diluted share in the three months ended December 31, 2016, due to the factors discussed above.

Adjusted Non-GAAP net income for the fourth quarter of 2017 was $15.6 million, or $1.05 per basic and $1.00 per diluted share, compared to Adjusted Non-GAAP net income of $17.2 million or $1.12 per basic and $1.05 per diluted share in the prior year quarter. For a full reconciliation of Adjusted Non-GAAP net income to the most comparable GAAP financial measures, please see the tables at the end of this press release.

Full Year 2017 Financial Results

Total revenue for the year ended December 31, 2017 was $236.7 million, as compared to $189.5 million for the year ended December 31, 2016. A summary of total revenue is outlined below:


Year Ended December 31,
2017 2016

Revenue:
Product sales $ 45,327 $ 40,646
Royalty income 153,880 99,040
License and other income 37,500 49,796
Total revenue 236,707 189,482

The increase in product sales in 2017 was driven primarily by the growth in Ryanodex sales. Royalty income increased by $54.8 million to $153.9 million in 2017 from $99.0 million in 2016, due to increased sales of Bendeka and an increase in the royalty rate from 20% to 25%. License and other income reflects payments received for achieving certain contractual milestones in connection with the Company’s Bendeka licensing agreement with Teva, as well as an upfront payment associated with the SymBio collaboration covering Japanese rights for bendamustine hydrochloride ready-to-dilute and rapid infusion injection products.

Gross margin expanded to 76% in 2017, as compared to 71% in 2016.

R&D expense increased to $32.6 million in 2017, compared to $28.3 million in 2016 as a result of development efforts to advance multiple product candidates. Excluding stock-based compensation and other non-cash and non-recurring items, 2017 R&D expense was $27.6 million.

SG&A expenses increased by $18.1 million to $71.4 million in 2017, compared to $53.3 million in 2016. The increase in SG&A expenses related primarily to: (i) increases in personnel-related expenses due to the expansion of our sales force in the second quarter of 2017; (ii) marketing expenses associated with pre-launch EHS disease state awareness initiatives; (iii) increased external legal expenses; and (iv) staff additions incurred to support expansion of the Company. These increases were partially offset by the expiration of the Spectrum promotion contract at the end of June 2017. Excluding stock-based compensation and other non-cash and non-recurring items, 2017 SG&A expense was $56.9 million.

For the full year, the Company recorded a tax expense of $21 million, compared to a benefit of $28 million in 2016. The tax provision in 2017 was decreased by the recognition of federal R&D tax credits and the impact of employee stock option exercises. These decreases were partially offset by an adjustment to Eagle’s net deferred tax asset to reflect the impact of the recently enacted federal tax reform legislation. The tax provision in 2016 was impacted by a reversal of a valuation allowance which had been carried against the Company’s net deferred tax assets. We anticipate that changes to the corporate tax code will positively impact Eagle’s tax expense beginning in 2018.

Net income for the year ended December 31, 2017 was $51.9 million or $3.44 per basic and $3.27 per diluted share as compared to net income of $81.5 million or $5.24 per basic and $4.96 per diluted share for the year ended December 31, 2016, as a result of the factors discussed above.

Adjusted Non-GAAP net income for 2017 was $69.0 million, or $4.57 per basic and $4.34 per diluted share, compared to Adjusted Non-GAAP net income of $45.9 million, or $2.96 per basic and $2.79 per diluted share in 2016.

Liquidity

As of December 31, 2017, the Company had $114.7 million in cash and cash equivalents and $53.8 million in net accounts receivable, $40.0 million of which was due from Teva. In 2017, net cash provided by operating activities, excluding the increase in net accounts receivable, was $70.5 million. The Company had $48.8 million in outstanding debt.

As part of our stock repurchase plan, in 2017, we completed our $75 million Share Repurchase Program authorized in August 2016, and purchased an additional $5.8 million in Eagle common stock as part of our expanded $100 million share buyback program.

2018 Expense Guidance

2018 R&D expense is expected to be in the range of $46 – $50 million. This reflects ongoing expenses for the enrollment of fulvestrant and Ryanodex EHS clinical trials, as well as CMC outlays in expectation of the 2019 launch of fulvestrant, if approved. Excluding stock-based compensation and other non-cash and non-recurring items, R&D expense would be in the range of $39 – $43 million.

2018 SG&A expense is expected to be in the range of $61 – $64 million. Excluding stock-based compensation and other non-cash and non-recurring items, SG&A expense would be in the range of $45 – $48 million.

Conference Call

As previously announced, Eagle management will host its fourth quarter and full year 2017 conference call as follows:


Date Monday, February 26, 2018

Time 8:30 A.M. EST

Toll free (U.S.) 866-518-6930

International 203-518-9797

Webcast (live and replay)

www.eagleus.com, under the "Investor Relations" section

A replay of the conference call will be available for one week after the call’s completion by dialing 800-677-7320 (US) or 402-220-0666 (International) and entering conference call ID EGRXQ417. The webcast will be archived for 30 days at the aforementioned URL.

Athenex, Inc. to Report Fourth Quarter and Full Year 2017 Earnings Results on March 26, 2018

On February 26, 2018 Athenex, Inc. (Nasdaq:ATNX), a global biopharmaceutical company dedicated to the discovery, development and commercialization of novel therapies for the treatment of cancer and related conditions, reported that it will release fourth quarter and full year 2017 earnings results on March 26, 2018 (Press release, Athenex, FEB 26, 2018, View Source;p=RssLanding&cat=news&id=2334562 [SID1234524161]). The Company will host a conference call and audio webcast on Monday, March 26, 2018 at 9:00 a.m. Eastern Time.

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To participate in the call, dial (855) 227-0567 (domestic) or (612) 979-9912 (international) fifteen minutes before the conference call begins and reference the conference passcode 4156727. A replay will be available approximately one hour after the recording through Monday, April 2, 2018 and can be accessed by dialing (855) 859-2056. The live conference call and replay can also be accessed via audio webcast at the Investor Relations section of the Company’s website, located at www.athenex.com. An archive will be available at this website until April 26, 2018.

AbbVie to Present at the Barclays Global Healthcare Conference

On February 26, 2018 AbbVie (NYSE: ABBV) reported that it will participate in the Barclays Global Healthcare Conference on Thursday, March 15, 2018. Bill Chase, executive vice president and chief financial officer, will present at 8 a.m. Central time (Press release, AbbVie, FEB 26, 2018, View Source [SID1234524160]).

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A live audio webcast of the presentation will be accessible through AbbVie’s Investor Relations website at investors.abbvie.com. An archived edition of the session will be available later that day.