On March 27, 2018 -InteRNA Technologies reported that the company will present a poster on its lead microRNA development candidate INT-1B3 at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting, to be held in Chicago, IL, on April 14-18, 2018 (Press release, InteRNA Technologies, MAR 27, 2018, View Source [SID1234525017]). The proof-of-concept data highlight INT-1B3’s unique ability to target multiple hallmarks of cancer as a single agent, demonstrating immune system activation, tumor regression and pronounced long term immunity. InteRNA will announce the complete results through a press release following the presentation.

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Poster Information:
Title: Pharmacologic profile of INT-1B3: a novel synthetic microRNA 193a-3p mimic for therapeutic intervention in Oncology (Abstract #4405)
Presenters: Drs. Sanaz Yahyanejad (Senior Research Scientist) and Michel Janicot (Chief Development Officer)
Session Name: Molecular and Cellular Biology / Genetics – MicroRNA Therapeutics
Date & Time: Tuesday, April 17, 2018; 1:00 pm -5:00 pm Central Standard Time
Location: McCormick Place South, Exhibit Hall A, Poster Section 19, Poster Board Number:6

On March 27, 2018 Bavarian Nordic A/S (OMX: BAVA, OTC: BVNRY) reported that Paul Chaplin, President & Chief Executive Officer will provide a corporate presentation at Needham & Company’s 17th Annual Healthcare Conference in New York City on Tuesday, March 27, 2018 at 4:00 PM EDT (Press release, Bavarian Nordic, 27 27, 2018, View Source [SID1234525016]).

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A live and archived webcast of the presentation will be available at http://bit.ly/2DZQgOi.

Contacts
U.S.: Seth Lewis, Vice President, Investor Relations. Phone: +1 978 341 5271
Europe: Rolf Sass Sørensen, Vice President Investor Relations & Communications. Phone +45 61 77 47 43

On March 27, 2018 RedHill Biopharma Ltd. (NASDAQ:RDHL) (Tel-Aviv Stock Exchange:RDHL) ("RedHill" or the "Company"), a specialty biopharmaceutical company primarily focused on late clinical-stage development and commercialization of proprietary drugs for gastrointestinal diseases and cancer, reported that two abstracts1 related to the successful Phase III study with BEKINDA (RHB-102)2 24 mg for acute gastroenteritis and gastritis (the GUARD study) have been accepted for oral presentations at the Society for Academic Emergency Medicine (SAEM) 2018 Annual Meeting, May 16-17, 2018, at the JW Marriott Hotel in Indianapolis, IN (Press release, RedHill Biopharma, MAR 27, 2018, View Source [SID1234525013]).

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The randomized, double-blind, placebo-controlled Phase III GUARD study with BEKINDA 24 mg successfully met its primary endpoint of efficacy in the treatment of acute gastroenteritis and gastritis, and BEKINDA 24 mg was found to be safe and well tolerated in this indication3. If approved for marketing by the FDA, BEKINDA 24 mg could become the first 5-HT3 antiemetic drug in the U.S. indicated for the treatment of acute gastroenteritis and gastritis.

The first presentation, entitled ‘Treatment of Acute Gastroenteritis-Related Emesis with Bimodal Release Ondansetron (RHB-102)’, will be presented by Robert Silverman, MD, MS, Associate Professor of Emergency Medicine, Zucker School of Medicine at Hofstra/Northwell; Northwell Health, and Lead Investigator of the BEKINDA Phase III GUARD study, on Wednesday, May 16, 2018, at 3:00 PM EDT. The abstract concludes that the Phase III GUARD study is the first study of acute gastroenteritis-related emesis showing benefit from any ondansetron preparation in adolescents and adults and suggests that acute gastroenteritis can be treated with a long-acting, bimodal release tablet, potentially avoiding the need for intravenous access.

The second presentation, entitled ‘A 24 mg bimodal-release ondansetron pill (RHB-102) shows no evidence of QT interval prolongation’, will be presented by Joseph Miller, MD, MS, Associate Clinical Professor, Emergency Medicine, Henry Ford Hospital and Investigator of the BEKINDA Phase III GUARD study, on Thursday, May 17, 2018, from 9:00 AM EDT. The abstract concludes that in patients with normal baseline corrected QT interval (QTc), 24 mg bimodal extended-release ondansetron caused no QTc prolongation in comparison to placebo.

About BEKINDA (RHB-102):
BEKINDA is a proprietary, bimodal extended-release (24 hours) oral pill formulation of ondansetron, covered by several issued and pending patents and targets several gastrointestinal indications. A first Phase III clinical study with BEKINDA 24 mg for the treatment of acute gastroenteritis and gastritis (the GUARD study) successfully met its primary endpoint. A Phase II study with BEKINDA 12 mg for the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D) successfully met its primary endpoint.

On March 27, 2018 Moleculin Biotech, Inc., (NASDAQ: MBRX) ("Moleculin" or the "Company"), a clinical stage pharmaceutical company focused on the development of oncology drug candidates, all of which are based on license agreements with The University of Texas System on behalf of the M.D. Anderson Cancer Center, reported that it has entered an agreement with The University Hospitals Cleveland Medical Center, which includes the Seidman Cancer Center and the Cleveland Clinic, to participate in its U.S. Phase I/II clinical trial of Annamycin for the treatment of relapsed or refractory acute myeloid leukemia (AML) and that patient enrollment has begun (Press release, Moleculin, MAR 27, 2018, View Source [SID1234525011]).

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"This is an important milestone in establishing the efficacy of Annamycin in the treatment of AML in a U.S. trial," commented Walter Klemp, Chairman and CEO of Moleculin. "Coupled with the impending Annamycin clinical trial in Poland, we believe we are at an important inflection point to demonstrate the safety and effectiveness of our leading drug candidate. We have worked hard to get to this point, and we are gratified with the opportunities to move Annamycin forward."

On March 27, 2018 Five Prime Therapeutics, Inc. (Nasdaq:FPRX), a clinical-stage biotechnology company focused on discovering and developing innovative immuno-oncology protein therapeutics, reported that Charles D. Kaplan, Director of Immuno-Oncology Research at Five Prime, has been invited to give an oral presentation at the 2018 American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting, being held April 14 – 18, 2018, in Chicago (Press release, Five Prime Therapeutics, MAR 27, 2018, View Source [SID1234525010]).

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Presentation Title: FPA150: A recombinant, afucosylated, fully human IgG1 monoclonal antibody for the treatment of malignancies that express high levels of B7-H4
Presenter Name: Charles D. Kaplan
Session Type: Drug Development Track – Special Session
Session Title: New Drugs on the Horizon 1
Session Start Time: April 15, 20181:00 PM
Location: Room S103 – McCormick Place South (Level 1)

About FPA150

FPA150 is a novel, fully human, afucosylated monoclonal antibody targeting B7-H4. B7-H4 expression is observed in multiple solid tumors, including breast, bladder and gynecologic cancers, and has been documented to correlate with poor prognosis. FPA150 is designed with a dual mechanism of action: blocking the T cell checkpoint activity of B7-H4 as well as delivering potent antibody-dependent cell-mediated cytotoxicity against tumor cells expressing B7-H4. Five Prime anticipates initiating Phase 1 development of FPA150 during the first half of 2018.