On March 15, 2018 Transgene (Euronext Paris: TNG), a biotech company that designs and develops virus-based immunotherapies, reported that it will be presenting a poster with new and encouraging preclinical data on a novel viral vector (pseudocowpox, PCPV) at the AACR (Free AACR Whitepaper) (American Association for Cancer Research) Annual Meeting 2018, Chicago, IL, USA, April 14 – 18 (Press release, Transgene, MAR 15, 2018, View Source [SID1234621827]).

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The abstract was accepted for a late-breaking session of the congress and will be made available on the AACR (Free AACR Whitepaper) Online Itinerary Planner and Meeting App on April 13, 2018.

Poster title: Pseudocowpox: A next generation viral vector for cancer immunotherapy. A poxviral vector selected for its remarkable ability to induce IFN-alpha.

Single intratumoral injections of a NanoZolid formulated STING agonist has been proven to achieve significant effects on tumor growth reduction and overall survival (Press release, Lidds, MAR 15, 2018, View Source [SID1234555858]). These positive effects of the NanoZolid formulation with STING puts LIDDS in an exciting position in the immuno-oncology field having a technology to avoid frequent injections. The findings are now included in a patent application.

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The NanoZolid technology has in aggressive tumor models shown to enable a controlled release of a STING agonist intratumorally. With the NanoZolid drug delivery technology, a single injection of a NanoZolid formulated STING agonist (NZ-STING) could replace required multiple injections and thereby provide a safer, more convenient and potentially more effective treatment. The NZ-STING efficacy has been demonstrated in several preclinical animal studies where a single injection has shown effects on tumor growth and overall survival.

It is very exciting that NanoZolid with STING agonist has shown so positive results. STING agonists are agents that must be administered directly into tumors on at least a weekly basis. This is a perfect match for LIDDS as the NanoZolid technology can provide pharma companies with a competitive advantage avoiding these frequent injections. It is also interesting that big pharma companies are actively competing to develop this novel class of agents and deals with STING agonists has been rocketing lately as a result of this, says Monica Wallter, CEO of LIDDS.

STING agonists are novel immunotherapy agents, seen as one of the most promising agents for the treatment of cancers and consequently these are being aggressively researched and pursued by leading Big Pharma companies. Several deals with potential values up to 2 billion USD have been made despite the early stages of this therapeutic area. This highlights the competitiveness of the field to develop new and more effective cancer treatments.

Immuno-oncology is the fastest growing area in oncology, forecasted to reaching a market size over 100 billion USD by 2022.

On March 15, 2018 Massive Bio, Inc., a leader in providing simplified and affordable access to precision oncology to cancer patients treated at community-based oncology practices, reported that the first patient has been enrolled in a global registry for cancer patients evaluating the feasibility and clinical utility of an Artificial Intelligence-based precision oncology clinical trial matching tool powered by a virtual tumor board (VTB) program (Press release, Massive Bio, MAR 15, 2018, View Source [SID1234555208]). This registry will assess its clinical impact on world-wide patients with advanced cancer to facilitate clinical trial enrollment (CTE), as well as financial impact.

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The SYNERGY-AI registry is the first of its kind to combine artificial intelligence, genomic biomarkers and multi-variate analysis to accelerate clinical trial matching and promote access to promising cancer therapies. SYNERGY-AI is a part of Massive Bio’s global strategic collaboration with community-based oncology practices. Established in 2014, the goal of the collaboration is to promote precision oncology approaches at the point-of-care, and to ease access to clinical trials, while reducing patient and provider burden and overall cancer care costs.

"Today’s announcement marks a one-of-a-kind clinical program which utilizes a precision medicine approach to clinical trial matching that could potentially catalyze accelerated enrollment from a patient-driven perspective, while promoting access and innovation," said Dr. Arturo Loaiza-Bonilla, MD, MSEd, Chief Medical Advisor and Co-Founder of Massive Bio. "Initiation of this study also represents a significant milestone for Massive Bio, as we have the opportunity to help over 1,500 patients to enroll in therapeutic cancer trials. Most importantly, we believe this program has the potential to change the paradigm of how we approach clinical trial screening and enrollment and help many more patients in the future."

On March 15, 2018 Nordic Nanovector ASA (OSE: NANO) reported that it will present a poster reporting the anti-tumour effect of Humalutin (177Lu-conjugated humanized anti-CD37 antibody, 177Lu-NNV003) in preclinical models of non-Hodgkin’s lymphoma (NHL) at the American Association of Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2018 (Press release, Nordic Nanovector, MAR 15, 2018, View Source [SID1234553509]). The meeting takes place from 14-18 April in Chicago, USA.

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The preclinical data to be presented, described in an abstract published yesterday (link), demonstrate that:

In tumour cell lines:

• The unlabelled anti-CD37 antibody (NNV003) kills tumour cells mainly through an immunological process called antibody dependent cellular cytotoxicity

• Humalutin (177Lu-NNV003) was found to inhibit tumour cell growth.

In preclinical lymphoma models:

• Humalutin has shown significant tumour uptake and demonstrated an anti-tumour effect in all three NHL models (mantle cell lymphoma, diffuse large B-cell lymphoma and chronic lymphocytic leukaemia).

Jostein Dahle, Chief Scientific Officer commented: "The data is important for Nordic Nanovector as they provide an early demonstration of the potential that Humalutin has for treating different types of NHL. These encouraging data provide further support to the planned clinical development of Humalutin, for which Nordic Nanovector expects to launch a Phase I study in NHL in the second half of 2018."

Details for the poster presentation are as follows:

Poster Title: In vitro and in vivo evaluation of the beta-emitting lutetium-177 labeled anti-CD37 antibody radionuclide conjugate 177Lu-NNV003 in DLBCL, CLL and MCL models Session Date and Time: Sunday 15 April 2018, 1:00 PM – 5:00 PM (Central Time) Location: McCormick Place South, Exhibit Hall A, Poster Section 39, Poster Board Number: 11 Session Category: Experimental and Molecular Therapeutics Session Title: Modulators of Ionizing Radiation and Other Radiotherapeutics Permanent Abstract Number: 848

The poster will be available on 15 April 2018 on the company’s website at: www.nordicnanovector.com.

Vical has filed a 10-K – Annual report [Section 13 and 15(d), not S-K Item 405] with the U.S. Securities and Exchange Commission .

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