On January 3, 2018 Syntimmune, Inc., a clinical-stage biotechnology company focused on FcRn biology, reported that the company has appointed Jean-Paul Kress, M.D., as President and Chief Executive Officer. Dr. Kress, who will also serve as a director of the company, brings senior leadership experience in pharmaceutical and biotechnology firms, with a focus on operations and commercialization of innovative products addressing unmet medical needs across diverse disease indications (Press release, Syntimmune, JAN 3, 2018, View Source [SID1234522846]). David de Graaf, Ph.D., has stepped down from his position as CEO and resigned from the company’s Board of Directors. Syntimmune co-founder Laurence Blumberg, M.D., will continue to serve as Syntimmune’s Chief Operating Officer and as a member of the Board.

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"Jean-Paul possesses decades of experience bringing to market therapies based on breakthrough science," stated Burt Adelman, M.D., Syntimmune’s lead independent director and advisor to the company. "We are very pleased to welcome this industry veteran at the helm of Syntimmune. We believe Jean-Paul’s leadership brings vision and expertise that will be transformational as the company matures toward becoming a late-stage development organization and continues to rapidly advance therapies targeting FcRn biology to patients."

Dr. Blumberg added, "We are grateful for David de Graaf’s many contributions during a period of substantial progress at Syntimmune, during which we initiated two mid-stage clinical trials of our lead candidate, SYNT001, and completed a successful Series B financing that has positioned us well for further advancement."

Prior to joining Syntimmune, Dr. Kress served as Executive Vice President and President, International, and Head of Global Therapeutic Operations at Biogen Inc., overseeing the company’s rare and specialty disease teams. Previously, Dr. Kress was Senior Vice President, Head of North America at Sanofi Genzyme, where he was instrumental in launching several therapeutic products, including dupilumab, the first biologic agent approved in atopic dermatitis. Prior to this, he was President and Chief Executive Officer of Sanofi Pasteur MSD, a vaccines joint venture of Sanofi and Merck & Co. Dr. Kress also held leadership roles at Gilead, serving as Vice President, US Sales and Marketing, and Vice President, General Manager for France. He began his industry career with Eli Lilly in France and held commercial and business development roles in the US and Europe at Abbott (now AbbVie). Dr. Kress received an M.D. degree from Faculté Necker-Enfants Malades in Paris, and graduate and post-graduate degrees in pharmacology and immunology from École Normale Supérieure in Paris.

"I am excited to join the accomplished team at Syntimmune, which possesses world-class expertise in immunology and FcRn biology applicable to a broad range of autoimmune diseases," said Dr. Kress. "Syntimmune has made important strides in advancing its clinical development pipeline, and I look forward to the progress of the company’s ongoing Phase 1b/2a clinical trials of SYNT001 in pemphigus and warm autoimmune hemolytic anemia, as well as the anticipated commencement of clinical studies in additional indications."

On January 3, 2018 Siamab Therapeutics, Inc., a biopharmaceutical company developing novel cancer therapeutics, reported that Jeff Behrens, president and chief executive officer, will present at the 10th annual Biotech Showcase conference in San Francisco on Tuesday, January 9, 2018 at 1:45 p.m. PT (Press release, Siamab Therapeutics, JAN 3, 2018, View Source [SID1234522845]). The conference will be held January 8-10, 2018, at the Hilton San Francisco Union Square.

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"We look forward to presenting an overview of our glycan-targeting platform to treat solid tumors"

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Mr. Behrens will provide an overview of the company, its proprietary technology platform and its development pipeline, including the ST1 program. ST1, Siamab’s lead monoclonal antibody (mAb) therapeutic, is in late stage preclinical development formatted as an antibody drug conjugate (ADC) for the treatment of solid tumors expressing Sialyl-Tn (STn). Mr. Behrens will also present new data on targeting STn+ myeloid-derived suppressor cells (MDSCs), major regulators of the tumor anti-immune response that act by suppressing T cells. Siamab has for the first time identified and utilized the presence of STn on MDSCs to target and deplete MDSCs in vivo, providing a potential new therapeutic approach for the treatment of solid tumors.

"We look forward to presenting an overview of our glycan-targeting platform to treat solid tumors," said Mr. Behrens. "We will be focusing on promising new data from the ST1 program that points to STn+ MDSCs as an exciting and untapped immune-oncology target. ST1 has demonstrated excellent efficacy and safety in multiple IND-enabling tumor models as a direct anti-cancer therapy, and it may also have the potential to deplete MDSCs, which are known to be potent suppressors of tumor immunity."

Siamab’s proprietary technology platform enables the development of highly specific mAb therapeutics, including ADCs, bi-specific antibodies and CAR-T cell therapies, targeting cancer cell surface glycans called tumor-associated carbohydrate antigens (TACAs). TACAs are an emerging set of tumor antigens that are implicated in immune suppression, chemoresistance and a cancer stem cell (CSC) phenotype. The elevated presence of STn—a key TACA observed in a number of solid tumors, including ovarian, prostate, pancreatic, gastric, and colon—is associated with metastatic disease, poor prognosis, and reduced overall survival. Elevation of STn expression is linked to chemotherapy resistance and enables tumors to evade the host immune system. In addition, STn is expressed on multiple biomarkers including the CSC biomarkers CD44 and MUC1, which reside on both CSCs and mature malignant cells in some cancer types.

Siamab scientists have demonstrated the safety and efficacy of their anti-STn antibody therapeutic in multiple preclinical studies. The company’s lead ST1 ADC was shown to inhibit tumor progression in cell line-derived and patient-derived xenograft (PDX) mouse models of ovarian and pancreatic cancer, with complete regression observed in some treatment arms. In addition, preclinical evaluation has demonstrated the compound’s safety across species, including in non-human primates.

Siamab is also utilizing STn-selective antibodies to develop both tissue- and serum-based biomarker assays with the potential to become companion diagnostics for both the stratification of patients as well as tools for assessing the pharmacodynamics action of the anti-STn therapeutic in the clinic.

On January 2, 2018 NanOlogy, a clinical stage pharmaceutical development company, reported that Gere diZerega, MD, VP of Medical Affairs, will present at Biotech Showcase, January 8, 2018, at 3:45 pm in Franciscan room D on the Ballroom Level of the Hilton San Francisco Union Square Hotel (Press release, NanOlogy, JAN 2, 2018, View Source [SID1234522843]).

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Dr. diZerega will present an update on the status of the NanOlogy clinical development programs. The company is developing a submicron particle technology platform for local delivery of chemotherapeutic agents in the treatment of cancer and related illnesses via intratumoral, intracystic, intraperitoneal, and topical administration.

Clinical Programs
NanOlogy has four Phase 2 clinical trials underway for NanoPac, a sterile suspension of submicron particle paclitaxel, in ovarian cancer (with orphan drug designation), prostate cancer, pancreatic cancer, and pancreatic mucinous cysts. NanOlogy also is conducting a Phase 2 trial of SOR007, submicron particle paclitaxel suspended in a topical anhydrous base, for cutaneous metastases, while NanOlogy affiliate, DFB Soria, has a Phase 2 trial of SOR007 nearing completion for actinic keratosis.

Preclinical
In addition, NanoPac for nebulized inhalation has shown tumor reduction in a preclinical lung cancer study after pharmacokinetic studies demonstrated more than 14 day retention of drug in lung tissue. In 2018, clinical trials are planned for NanoDoce, a sterile suspension of the submicron particle docetaxel, pending IND approval.

Patent Portfolio
The NanOlogy submicron particle technology platform is protected by an extensive intellectual property (IP) portfolio covering production processes, uses, formulations, and specifications, as well as composition under US patent 9,814,685 entitled Taxane Particles and Their Use granted on November 14, 2017 covering particle size, density, surface area, drug dissolution, and other aspects. "NanOlogy investigational drugs are being developed under FDA’s streamlined 505(b) 2 pathway" said Michael Baltezor, PhD, head of product development. "Coupled with a composition patent on our particles, we now enjoy NME [new molecular entity] – like IP advantages without the corresponding risk and time associated with NME development."

NanOlogy expects results from its clinical trials in 2018 and during this time will be identifying a pharmaceutical or strategic investment partner to progress its drug candidates to NDA submission, market approval, and commercial distribution.

On January 3, 2018 LabCorp (NYSE: LH) reported that it will participate at the 36th Annual J.P. Morgan Healthcare Conference (Press release, LabCorp, JAN 3, 2018, View Source;p=RssLanding&cat=news&id=2324630 [SID1234522842]). LabCorp’s presentation is scheduled for Tuesday, January 9, 2018 at 9:30 am (PT).

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A live audio webcast of the presentation will be available via the Company website at www.labcorp.com and archived for replay.

On January 3, 2018 Actinium Pharmaceuticals, Inc. (NYSE American: ATNM) ("Actinium" or "the Company") reported that the Company will be attending the Biotech Showcase 2018 being held January 8-10, 2018 at the Hilton San Francisco: Union Square in San Francisco, California (Press release, Actinium Pharmaceuticals, JAN 3, 2018, View Source [SID1234522841]). Representatives from Actinium’s business development, clinical development and executive teams will be attending the conference, and will be available for one-on-one meetings during the conference. To arrange an investor meeting with Actinium please contact, Steve O’Loughlin, Actinium’s Principal Financial Officer at [email protected] and to arrange a business development meeting please contact David Gould, M.D., Actinium’s Senior Vice President, Corporate Development & Corporate Affairs at [email protected]. Meetings can also be scheduled through the partneringONE system View Source

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Information for Actinium’s presentation are as follows:

Date: Monday, January 8, 2018
Time: 10:00 AM PT
Track: Yosemite – A (Ballroom Level)
Venue: Hilton San Francisco Union Square Hotel, 333 O’Farrell Street, San Francisco

About Biotech Showcase

Biotech Showcase, produced by Demy-Colton and EBD Group, is an investor and networking conference devoted to providing private and public biotechnology and life sciences companies with an opportunity to present to, and meet with, investors and pharmaceutical executives in one place during the course of one of the industry’s largest annual healthcare investor conferences, J.P. Morgan Annual Healthcare Conference.