On October 16, 2018 Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) reported that it will report its third quarter 2018 financial results on Wednesday, October 24, 2018 after the financial markets close (Press release, Vertex Pharmaceuticals, OCT 16, 2018, View Source [SID1234529948]). The company will host a conference call and webcast at 4:30 p.m. ET. To access the call, please dial (866) 501-1537 (U.S.) or +1 (720) 545-0001 (International).

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The conference call will be webcast live and a link to the webcast can be accessed through Vertex’s website at www.vrtx.com in the "Investors" section. To ensure a timely connection, it is recommended that participants register at least 15 minutes prior to the scheduled webcast. An archived webcast will be available on the company’s website

On October 16, 2018 Alkermes plc (Nasdaq: ALKS) reported that it will host a conference call and webcast presentation at 8:30 a.m. ET (1:30 p.m. BST) on Tuesday, Oct. 23, 2018, to discuss the company’s third quarter 2018 financial results (Press release, Alkermes, OCT 16, 2018, View Source;p=irol-newsArticle&ID=2371934 [SID1234529947]). Management will also provide an update on the company.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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The webcast player and accompanying slides may be accessed on the Investors section of Alkermes’ website at www.alkermes.com. The conference call may be accessed by dialing +1 888 424 8151 for U.S. callers and +1 847 585 4422 for international callers. The conference call ID number is 6037988.

A replay of the conference call will be available from 11:00 a.m. ET (4:00 p.m. BST) on Tuesday, Oct. 23, 2018, through 5:00 p.m. ET (9:00 p.m. GMT) on Tuesday, Oct. 30, 2018, and may be accessed by visiting Alkermes’ website or by dialing +1 888 843 7419 for U.S. callers and +1 630 652 3042 for international callers. The replay access code is 6037988.

On October 16, 2018 Diplomat Pharmacy, Inc. (NYSE: DPLO), reported that it will release its third-quarter 2018 operating results after market close Tuesday, Nov. 6, with a conference call to follow at 5 p.m. ET (Press release, Diplomat Speciality Pharmacy, OCT 16, 2018, View Source [SID1234529937]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Shareholders and interested participants can listen to a live broadcast by calling 833.286.5805 (647.689.4450 for international callers) and entering participation code 7553049, starting about 15 minutes before the call. A live webcast of the conference call will be available on the investor relations section of Diplomat’s website at ir.diplomat.is. The site will host an audio recording and supplemental investor information for 90 days.

On October 16, 2018 Athenex, Inc. (NASDAQ: ATNX), a global biopharmaceutical company dedicated to the discovery, development and commercialization of novel therapies for the treatment of cancer and related conditions, reported that results of the Oraxol (oral paclitaxel and HM30181A) pharmacokinetics and phase II clinical trial in the treatment of breast cancer patients who failed previous chemotherapies will be presented on October 21, 2018 at a Poster Discussion in the European Society for Medical Oncology (ESMO) (Free ESMO Whitepaper) Congress in Munich, Germany (Press release, Athenex, OCT 16, 2018, View Source;p=RssLanding&cat=news&id=2371846 [SID1234529936]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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This study has completed patient recruitment and encouraging positive efficacy and safety data will be reported. Oraxol was granted the Promising Innovative Medicine Designation by the United Kingdom Medicines and Healthcare Products Regulatory Agency in December 2017.

Details on the Poster Discussion session are listed below.

Title: Oral paclitaxel and HM30181A demonstrate clinical activity in metastatic breast cancer (MBC) patients
Presentation Number: 287PD
Presenter: Ming-Shen Dai (Taipei, TW)
Session Name: Poster Discussion session – Breast cancer, metastatic
Date / Time / Location: October 21, 2018; 9:15 AM – 10:30 AM (local time); ICM – Room 1, ICM München
The Poster presentation at ESMO (Free ESMO Whitepaper) will be available on the ESMO (Free ESMO Whitepaper) website at 12:00 CEST on Friday, October 19, 2018.

On October 16, 2018 BioMarin Pharmaceutical Inc. (Nasdaq: BMRN) reported that the Company earned $15 million in milestone payments from Pfizer Inc (Press release, BioMarin, OCT 16, 2018, View Source [SID1234529934]). These milestone payments were triggered by the U.S. Food and Drug Administration (FDA) approval of Talzenna (talazoparib) for the treatment of adult patients with deleterious or suspected deleterious germline BRCA (gBRCA)-mutated, HER2-negative locally advanced (LA) or metastatic breast cancer (MBC). Patients are selected for therapy based on an FDA-approved companion diagnostic. These milestone payments are part of an agreement made with Medivation, Inc. when Medivation purchased talazoparib. Medivation was acquired by Pfizer.

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In August 2015, Medivation, Inc. and BioMarin Pharmaceutical Inc. entered into an asset purchase agreement under which Medivation acquired all worldwide rights to Talzenna (talazoparib), a once-daily, oral poly ADP ribose polymerase (PARP) inhibitor. Under the agreement, Medivation, acquired by Pfizer, is responsible for all research, development, regulatory and commercialization activities for all indications on a global basis.

Under the terms of the agreement, Medivation paid BioMarin $410 million upfront, and BioMarin was entitled to receive up to an additional $160 million (in aggregate) upon the achievement of regulatory and sales-based milestones, of which $35 million has been earned to date, as well as mid-single digit royalties for Talzenna (talazoparib). In June of this year, the European Medicines Agency accepted the Marketing Application for talazoparib for this patient population and is currently reviewing the application.