On October 12, 2018 Nordic Nanovector ASA (OSE: NANO) reported that the Company and its collaborators will present data and analyses from its non-clinical and clinical studies with Betalutin (177Lu-lilotomab satetraxetan) at the 32nd Annual Congress of the European Association of Nuclear Medicine (13-17 October 2018, Düsseldorf, Germany) (Press release, Nordic Nanovector, OCT 12, 2018, View Source [SID1234553493]).

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The presentations are:

Therapeutic efficacy of 177Lu-lilotomab satetraxetan in non-Hodgkin B-cell Lymphoma is controlled by G2/M cell cycle progression

Authors: A. Pichard et al.

Session: 305 – M2M: Therapy Effects, Preclinical

Abstract No. OP-069

Format: Oral presentation

Date/time: Sunday 14 October, 11:30-12:45 CEST

Tumor Absorbed Dose and Changes in FDG PET Parameters in Non-Hodgkin Lymphoma Patients Treated with 177Lu-lilotomab satetraxetan

Authors: A. Løndalen et al.

Session: 608 – Clinical Oncology – Rapid Fire Session: It’s in the Blood!

Abstract No. OP-252

Format: Oral presentation

Date/time: Monday 15 October, 08:00-09:30 CEST

On October 10, 2018, the Company delivered notice to Cantor Fitzgerald & Co. ("Cantor") terminating the Controlled Equity OfferingSM Sales Agreement, dated February 1, 2013 (the "Sales Agreement"), with Cantor effective as of October 20, 2018 (Filing, 8-K, Celsion, OCT 12, 2018, View Source [SID1234530287]). The Sales Agreement permitted the Company to sell additional shares of our Common Stock having an aggregate offering price of up to $25 million through "at the market" equity offerings from time to time. From February 2013 through the date of termination, the Company sold 1,784,396 shares of Common Stock under the Sales Agreement generating gross proceeds of $12.8 million. The Company has no further obligations under the Sales Agreement.

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On October 12, 2018 Oncopeptides AB (Nasdaq Stockholm: ONCO) reported that they will present at Jefferies London Healthcare Conference on November 14th at 3.20 PM local time (GMT), the presentation will be webcasted (Press release, Oncopeptides, OCT 12, 2018, View Source [SID1234530258]).

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Oncopeptides is a research and development stage pharmaceutical company developing drugs for the treatment of cancer. Since the founding of the company, the focus has primarily been on the development of the lead product candidate melflufen (Ygalo), an alkylating peptide, belongs to a novel class of peptidase-enhanced compounds (PEnCs), intended for effective and focused treatment of hematological cancers, and in particular multiple myeloma.

Melflufen (Ygalo) has been used to treat late-stage RRMM patients in the phase II clinical study called O-12-M1 that is completed with favorable results which have been reported previously. Currently, Oncopeptides conduct four clinical trials with melflufen for the treatment of multiple myeloma. These are HORIZON, OCEAN, ANCHOR and BRIDGE.

The current clinical study program is intended to demonstrate better results from treatment with melflufen (Ygalo) compared to established alternative drugs for patients with late-stage multiple myeloma. This could potentially provide physicians with a new treatment option for patients suffering from this serious disease.

For further information, please contact:

Rein Piir, Head of Investor Relations at Oncopeptides AB
E-mail: [email protected]

This information was submitted for publication at 09.00 CET October 12, 2018

On October 12, 2018 The imaging agent 5-Aminolevulinic Acid (5-ALA), which helps neurosurgeons see the edges of a tumor more clearly to improve removal, was used in brain cancer surgery at University Hospitals Seidman Cancer Center today for the first time since the FDA approved it for use in the United States (Press release, University Hospitals, OCT 12, 2018, View Source [SID1234530230]). Although the drug has long been a standard of care in Germany and much of Europe, it was only approved by the FDA for use in the U.S. in 2017.

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Andrew Sloan, MD, Director, Brain Tumor and Neuro-Oncology Center at UH Seidman and UH Cleveland Medical Center, who has been doing clinical trials with the drug for almost a decade based on his own FDA-approved IND clinical trial, was the first neurosurgeon in the U.S. to use the drug on a patient with brain cancer since FDA approval.

Several published studies — including those from Dr. Sloan — have shown that removing more tumor results in improved survival. However, this often is difficult.

"Glioblastoma are tumors which derive from the brain itself. They look like brain tissue, they feel like brain tissue, and at times, it’s hard to determine where tumor ends and inflamed brain tissue begins," said Dr. Sloan.

To help identify the difference between the border of tumors and healthy tissue and improve tumor removal, Dr. Sloan used 5-ALA during surgery so that the tumor cells glowed hot pink when illuminated with a special blue light incorporated into his operating microscope.

This novel technique enabled him to see the edges of the tumors more clearly, allowing him to remove them more completely from the brain.

On October 12, 2018 Sutro Biopharma, Inc. (NASDAQ: STRO), reported that it has been granted Orphan Drug Designation by the United States Food and Drug Administration (FDA) for STRO-001 for the treatment of multiple myeloma (Press release, Sutro Biopharma, OCT 12, 2018, View Source [SID1234529894]). STRO-001 is a potential first-in-class antibody drug conjugate (ADC) targeting CD74, a protein highly expressed in B-cell malignancies such as multiple myeloma.

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"There is a growing need for new treatment options for patients with multiple myeloma," commented Bill Newell, Sutro’s Chief Executive Officer. "This Orphan Drug Designation is a great step towards advancing our uniquely designed STRO-001 that could bring new treatment options to patients in need."

STRO-001 was developed with Sutro’s proprietary cell-free protein synthesis and site-specific conjugation platform, XpressCF+, which facilitate precision design and rapid empirical optimization of ADCs. Sutro’s technology enables design and manufacture of a highly optimized single molecular species within the product, rather than the usual mixture of imprecisely conjugated antibodies that comprise an ADC development product made by conventional cell-based manufacturing platforms.

"STRO-001 was designed to directly target cancer cells to deliver a cytotoxic payload. Building upon our XpressCF+ platform we plan to develop better options to treat tumors with greater precision," Bill Newell added.

STRO-001 is currently being studied in a Phase 1 clinical trial enrolling separate dose escalation cohorts for myeloma and B-cell lymphoma.

About Orphan Drug Designation

The Orphan Drug Designation Program provides orphan status to drugs and biologics which are defined as those intended for the safe and effective treatment, diagnosis or prevention of rare diseases/disorders that affect fewer than 200,000 people in the U.S., or that affect more than 200,000 persons but are not expected to recover the costs of developing and marketing a treatment drug.