On September 20, 2018 OncoMed Pharmaceuticals Inc. (NASDAQ: OMED), a clinical-stage biopharmaceutical company focused on discovering and developing novel anti-cancer therapeutics, reported that Celgene has notified OncoMed that due to strategic product portfolio considerations Celgene has decided not to exercise its option to license OncoMed’s bispecific antibody navicixizumab (anti-DLL4/VEGF bispecific, OMP-305B83) (Press release, OncoMed, SEP 20, 2018, View Source [SID1234529495]). Celgene continues to retain its options to license OncoMed’s etigilimab (anti-TIGIT monoclonal antibody, OMP-313M32) and rosmantuzumab (anti-RSPO3, OMP-131R10) under the collaboration. OncoMed and Celgene are working to formalize the termination of the collaboration agreement with respect to navicixizumab, and OncoMed expects to retain worldwide rights to navicixizumab.

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"While we are disappointed in Celgene’s decision, we thank them for the productive interactions in evaluating navicixizumab, and we respect their decision given their pipeline prioritization and focus," said John Lewicki, Ph.D., President and Chief Executive Officer of OncoMed. "With the global development and commercialization of navicixizumab remaining under our control, we are evaluating potential opportunities for the program and will continue to assess the data as it evolves for navicixizumab in combination with paclitaxel in heavily pretreated platinum-resistant ovarian cancer patients."

OncoMed is currently conducting a Phase 1b clinical trial of navicixizumab in combination with paclitaxel in patients with platinum-resistant late-stage ovarian cancer. Interim Phase 1b data will be presented in a poster presentation on October 20, 2018 at the European Society of Medical Oncology (ESMO) (Free ESMO Whitepaper) meeting to be held in Munich.

About Navicixizumab
OncoMed’s anti-DLL4/VEGF bispecific antibody, navicixizumab, is designed to inhibit the function of both DLL4 and VEGF and thereby induce potent anti-tumor responses while mitigating certain angiogenic-related toxicities. Navicixizumab was developed utilizing OncoMed’s BiMAb bispecific platform technology, which enables the design of bispecific antibodies comparable to traditional monoclonal antibodies but possessing dual target-binding specificity. In preclinical studies, navicixizumab demonstrated robust in vivo anti-tumor efficacy across a range of solid tumor xenografts, including colon, ovarian, lung and pancreatic cancers, among others. Further, in preclinical studies dual inhibition of DLL4 and VEGF appeared to exhibit synergistic anti-tumor activity at doses where blockade of either target alone elicited sub-optimal activity.

On September 19, 2018 AngioDynamics, Inc. (NASDAQ: ANGO), a leading provider of innovative, minimally invasive medical devices for vascular access, peripheral vascular disease, and oncology, reported that Michael C. Greiner, Executive Vice President and Chief Financial Officer, will present at the Cantor Global Healthcare Conference at 8:35 a.m. ET on Tuesday, October 2, 2018 in New York, NY (Press release, AngioDynamics, SEP 19, 2018, View Source [SID1234529494]).

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A live webcast of the presentation will be accessible through the "Investors" section of the Company’s website at www.angiodynamics.com and will be available for replay following the event.

On September 19, 2018 AskAt Inc. reported that AskAt received the decision to grant a European patent dated September 13, 2018 from the European Patent Office (EPO) in connection with the Application No. 15182580.9, a use patent of EP4 receptor antagonist for the treatment of Cancer (Press release, AskAt, SEP 19, 2018, View Source [SID1234535046]).

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On September 19, 2019 Cotinga Pharmaceuticals Inc. (TSX Venture: COT; OTCQB: COTQF) ("Cotinga" or the "Company"), a clinical-stage pharmaceutical company advancing a pipeline of targeted therapies for the treatment of cancer, reported that Richard Ho, M.D., Ph.D., Chief Scientific Officer, will present data on COTI-2, Cotinga’s lead compound currently in a Phase 1b/2a trial, at the 11th International Symposium on Translational Research in Oncology taking place September 27-29, 2018 in Dublin, Ireland (Press release, Cotinga, SEP 19, 2018, View Source [SID1234533151]).

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Presentation Title: COTI-2: preclinical and early clinical results from an orally available small molecule targeting mutant p53
Presentation Date and Time: Saturday, September 29, 2018 11:45 AM – 12:15 PM Irish Standard Time
Presentation Location: Landsdowne Suite, Herbert Park Hotel, Ballsbridge, D4

Phase 1b/2a Trial of COTI-2
The ongoing trial focuses on evaluating COTI-2 as a combination therapy for the potential treatment of a wide spectrum of cancers. In 2017, the Company announced top-line data from the gynecological malignancies arm of the trial demonstrating monotherapy with COTI-2 was generally safe and well-tolerated. Monotherapy with COTI-2 also exhibited an encouraging pharmacokinetic/pharmacodynamic profile and signals of efficacy.

Primary outcome measures will evaluate safety and tolerability and determine the maximum tolerated dose and recommended Phase 2 dose for COTI-2 as a combination therapy. Secondary and exploratory outcome measures will evaluate pharmacokinetics and various signals of efficacy. Additional details are available on clinicaltrials.gov.

On September 19, 2018 Molecular Templates, Inc. (Nasdaq:MTEM) reported an agreement with Takeda Pharmaceutical Company Limited (Takeda) for the joint development of CD38-targeted engineered toxin bodies (ETBs) for the treatment of patients with diseases such as multiple myeloma (Press release, Molecular Templates, SEP 19, 2018, View Source [SID1234529616]). The lead development candidate is a CD38-targeted ETB that resulted from a previous discovery collaboration between the two companies.

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The parties developed preclinical stage ETBs targeting CD38 under the prior discovery collaboration. Takeda and Molecular Templates will further develop the ETBs for the treatment of multiple myeloma under this new license, development and commercialization agreement.

"This collaboration builds on Takeda’s deep history and commitment to the study of blood cancers, including multiple myeloma," said Philip Rowlands, Ph.D., Head, Oncology Therapeutic Area Unit at Takeda. "Throughout our research collaboration with Molecular Templates, we have seen the promise of its ETB platform for the discovery and development of new therapies. As we expand our relationship and continue to explore next-generation modalities, our hope is to bring forth new and important treatment options for patients."

Under the terms of the agreement, Takeda will make an upfront payment of $30 million and Molecular Templates is eligible to receive development, regulatory and commercial milestone payments of up to $632.5 million if Molecular Templates exercises its co-development option or $337.5 million if Molecular Templates does not exercise or opts out of its co-development option. Takeda has also agreed to pay royalties on sales of the commercial product developed through the collaboration. Molecular Templates and Takeda will share equally in the development costs.

"We have worked closely with Takeda’s scientific team since October 2016 to develop CD38-targeted ETBs with substantial improvements over our own internal program, MT-4019," said Eric Poma, Ph.D., Molecular Templates’ Chief Executive and Scientific Officer. "Takeda’s expertise in multiple myeloma and strong antibody capabilities allowed us to develop CD38-targeted ETBs that, of the ones tested to date, are the most potent ETBs we have created with our platform. We look forward to moving this program into the clinic."

Multiple myeloma cells widely express the CD38 protein, making it an increasingly important target in the development of therapeutics for multiple myeloma. CD38-targeted ETBs recognize the protein and deliver a modified bacterial toxin that enters the myeloma cells and destroys them through the enzymatic and irreversible destruction of ribosomes. Unlike other CD38-targeted therapies, ETBs are not reliant on the body’s own immune system for effectiveness, offering the potential of broader and deeper responses.