On February 28, 2019 AdoRx Therapeutics, a UK based drug discovery company, reported that it has entered into a strategic collaboration with Johnson & Johnson Innovation LLC* and the Lung Cancer Initiative at Johnson & Johnson to develop novel therapeutics for the treatment of lung cancer (Press release, AdoRx Therapeutics, FEB 28, 2019, View Source;johnson-innovation-to-develop-novel-lung-cancer-therapeutics-300803519.html [SID1234554021]). Under terms of the agreement, AdoRx has granted an exclusive option to research, develop and commercialise novel antagonists within the AdoRx portfolio, and the groups will collaborate on drug discovery and preclinical development activities. Financial terms of the collaboration were not disclosed.

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Commenting, Pete Finan, CEO of AdoRx, said: "We are delighted to be teaming up with Johnson & Johnson and their Lung Cancer Initiative less than two years after the creation of AdoRx. The collaboration will facilitate the progression of AdoRx’s fit-for-purpose receptor antagonists into clinical development."

AdoRx was founded in 2017 by leading healthcare investor Epidarex Capital. The company announced further investment by Epidarex Capital and Sixth Element Capital which manages the oncology focused CRT Pioneer Fund (CPF) in June 2018.

*Johnson & Johnson Services, Inc is the legal entity to the agreement.

On February 28, 2019 Flow Pharma Inc., a San Francisco Bay Area biotechnology company focused on personalized vaccine development, reported that it has selected BGI Americas Inc. to provide the sequencing services required for all FlowVax neoantigen-based personalized therapeutic cancer vaccines under development by Flow Pharma (Press release, Flow Pharma, FEB 28, 2019, View Source [SID1234554003]).

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The first two Flow Pharma products under development are FlowVax HPV for the treatment of cervical cancer and FlowVax BreastCA for the treatment of breast cancer. FlowVax Breast CA will be a personalized therapeutic vaccine requiring patient-specific gene sequencing.

"The exciting new area of personalized therapeutic cancer vaccines requires rapid, accurate genomic and transcriptomic sequencing. BGI Americas is unique in providing next generation sequencing services using its own unique DNBseq sequencing technology based on combinatorial probe-anchor synthesis (cPAS), linear isothermal rolling-circle replication and DNA nanoball (DNB) technology," said Victor Zhang, Ph.D., CEO of BGI Americas. "BGI has a strong track record supporting the therapeutic and biomarker development of top biopharma and biotech companies. Our DNBseq technology has been validated by leading academic centers and industry users and will deliver strong value in our collaboration with Flow Pharma."

"In order to make a personalized therapeutic cancer vaccine, you have to know the genomic information of the patient’s tumor as well as that of the patient. Speed and accuracy are both critical. Once we have these gene sequences, we can use AI-augmented bioinformatics tools to quickly identify tumor targets for T-cell attack and then rapidly load these targets into a FlowVax vaccine customized for that particular patient." Said Lu Wang, Ph.D., Flow Pharma bioinformatics team leader

"We have spent a decade developing the FlowVax vaccine platform. FlowVax is optimized to simultaneously deliver multiple unmodified peptide targets for killer T-cell attack. Each of the chemical components used in the FlowVax platform are currently part of an FDA approved vaccine or pharmaceutical, simplifying our regulatory pathway," said Charles Herst, Ph.D., Flow Pharma chief science officer. "Personalized FlowVax therapeutic vaccines can be manufactured quickly and efficiently, keeping the cost down and getting the therapy in the hands of treating physicians soon after the diagnosis is made, for maximum efficacy."

"We believe that BGI’s DNBseq NGS platform is the best in class for the rigorous requirements of personalized therapeutic cancer vaccine development. The fact that BGI Americas provides professional and competitive genomic sequencing services along with experience and knowledge in supporting drug development, allows us to become a full-stack company in the space without the time and expense required to bring gene sequencing technology in-house," said Reid Rubsamen, M.D., CEO of Flow Pharma.

On February 28, 2019 Jounce Therapeutics, Inc. (NASDAQ: JNCE), a clinical-stage company focused on the discovery and development of novel cancer immunotherapies and predictive biomarkers, reported that it will report fourth quarter and full year 2018 financial results and provide a corporate update before market open on Wednesday, March 6, 2019 (Press release, Jounce Therapeutics, FEB 28, 2019, View Source [SID1234535389]). Jounce Therapeutics’ management team will host a live conference call and webcast at 8:00 a.m. ET.

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Conference Call and Webcast
To access the conference call, please dial (866) 916-3380 (domestic) or (210) 874-7772 (international) and refer to conference ID 8678456. The live webcast can be accessed under "Events & Presentations" in the Investors and Media section of the company’s website at www.jouncetx.com. The webcast will be archived and made available for replay on the company’s website approximately two hours after the call and will be available for 30 days thereafter.

On February 28, 2019 Astellas Pharma Inc. (TSE: 4503, President and CEO: Kenji Yasukawa, Ph.D., "Astellas") reported that the submission for a marketing authorisation application (MAA) for the oral once-daily therapy XOSPATA (gilteritinib) for the treatment of adult patients who have relapsed or refractory (resistant to treatment) acute myeloid leukaemia (AML) with a FLT3 mutation (FLT3mut+) has been accepted by the European Medicines Agency for regulatory review (Press release, Astellas, FEB 28, 2019, View Source [SID1234534621]).

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Astellas applied for and received accelerated assessment from the European Medicines Agency (EMA) for gilteritinib, which means the Committee for Medicinal Products for Human Use (CHMP) can reduce the timeframe for approval from 210 to 150 days.1

The MAA is based on data from the Phase 3 ADMIRAL trial investigating gilteritinib for the treatment of adult patients with FLT3mut+ relapsed or refractory AML. The full results of the ADMIRAL trial will be presented at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2019, March 29 – April 3 in Atlanta, USA.

AML is a cancer that impacts the blood and bone marrow, and its incidence increases with age.2 The incidence rate of AML is 3.7 per 100,000 per year in the European Union, resulting in an estimated 18,400 individuals diagnosed.3

On February 28, 2019 Bio-Path Holdings, Inc., (NASDAQ: BPTH), a biotechnology company leveraging its proprietary DNAbilize antisense RNAi nanoparticle technology to develop a portfolio of targeted nucleic acid cancer drugs, reported an upcoming poster presentation at the 2019 American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting, taking place from March 29 – April 3, 2019 in Atlanta, GA (Press release, Bio-Path Holdings, FEB 28, 2019, View Source [SID1234533906]).

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Details for the poster presentation are as follows:

Date: Wednesday, April 3, 2019
Presentation Time: 8:00 am – 12:00 pm Eastern Time
Location: Georgia World Congress Center, Exhibit Hall B
Session: Gene- and Vector-Based Therapy, Poster Section 12
Abstract: 4786
Title: "BP1003, A Novel Liposome-Incorporated STAT3 Antisense Oligodeoxynucleotide Inhibitor"