Jazz Pharmaceuticals to Report 2019 Second Quarter Financial Results on August 6, 2019

On July 23, 2019 Jazz Pharmaceuticals plc (Nasdaq: JAZZ) reported that it will report its 2019 second quarter financial results on Tuesday, August 6, 2019, after the close of the financial markets (Press release, Jazz Pharmaceuticals, JUL 23, 2019, View Source [SID1234537684]). Company management will host a live audio webcast immediately following the announcement at 4:30 p.m. EDT/9:30 p.m. IST to discuss second quarter 2019 financial results and provide a business and financial update.

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Interested parties may access the live audio webcast via the Investors section of the Jazz Pharmaceuticals website at www.jazzpharmaceuticals.com. Please connect to the website prior to the start of the conference call to ensure adequate time for any software downloads that may be necessary to listen to the webcast. A replay of the webcast will be archived on the website for at least one week.

Audio webcast/conference call:
U.S. Dial-In Number: +1 855 353 7924
International Dial-In Number: +1 503 343 6056
Passcode: 5590569

A replay of the conference call will be available through August 13, 2019 and accessible through one of the following telephone numbers, using the passcode below:

Replay U.S. Dial-In Number: +1 855 859 2056
Replay International Dial-In Number: +1 404 537 3406
Passcode: 5590569

Immix Receives FDA Authorization to Expand Clinical Trial under US IND

On July 23, 2019 Immix Biopharma, Inc–a clinical-stage biopharmaceutical company developing next-generation cancer therapies–reported that it received a letter from the FDA authorizing it to proceed with expanding its phase 1b/2a clinical trial of IMX-110 to the United States under an IND (Press release, Immix Biopharma, JUL 23, 2019, View Source [SID1234537683]).

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To-date, interim readouts from the phase 1b/2a trial in Australia are 100% CBR / DCR for all patients who completed the 5th cohort and at least 2 cycles, as scheduled – with the longest duration of response being 8-months of stable disease. No treatment-related serious adverse events have been observed to-date in any cohorts and dose escalation is continuing.

Immix’ Interim Medical Director and CEO Ilya Rachman, MD, PhD noted, "We were quite surprised and incredibly happy to see real clinical benefits of the drug at such an early stage in the trial. We are excited to explore the extent of this drug’s potential as we progress with dose escalation and approach the expected optimal therapeutic dose of the drug."

At present, Immix is finalizing selection of US clinical sites that will participate in this Phase 1b/2a multinational trial for advanced solid tumors.

Immix is also opening a call for investigator initiated studies where the company will provide its lead compound Imx-110 at no charge and is expanding its Series A financing to add more patients to the ongoing phase 1b/2a study.

About IMX-110
Imx-110 is a first-in-class combination therapy designed to inhibit cancer resistance and evolvability while inducing apoptosis. Imx-110 contains NF-kB/Stat3/pan-kinase inhibitor curcumin combined with a small amount of doxorubicin encased in a nano-sized delivery system for optimal tumor penetration. The nanoparticle is tunable in that it can be bound to various targeting moieties, allowing it to deliver even more payload to tumors or other cell populations of interest, if needed. Imx-110 showed preclinical efficacy in glioblastoma, multiple myeloma, triple-negative breast, colorectal, ovarian, and pancreatic tumor models — with the mechanism of action being a 5x increase in cancer cell apoptosis compared to doxorubicin alone, and a wholesale shift in the tumor microenvironment post administration.

Seattle Genetics Announces Proposed Public Offering of Common Stock

On July 23, 2019 Seattle Genetics, Inc. (Nasdaq: SGEN) reported that it has commenced an underwritten public offering of 6,000,000 shares of its common stock (Press release, Seattle Genetics, JUL 23, 2019, View Source [SID1234537682]). All of the shares are being offered by Seattle Genetics. In addition, Seattle Genetics expects to grant the underwriters of the offering a 30-day option to purchase up to an additional 900,000 shares of its common stock solely to cover overallotments at the public offering price, less the underwriting discounts and commissions. The offering is subject to market and other conditions, and there can be no assurance as to whether or when the offering will be completed, or as to the actual size or terms of the offering.

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Seattle Genetics anticipates using the net proceeds from the offering to fund ongoing commercialization of ADCETRIS in the United States and Canada, to fund its activities in preparation for the potential commercial launch of enfortumab vedotin, if approved by the FDA, to fund its research and development efforts designed to further expand the ADCETRIS label and to advance its pipeline of product candidates, as well as for general corporate purposes, including working capital. Seattle Genetics may also use a portion of the net proceeds to in-license, acquire or invest in complementary products, technologies, businesses or other assets or pursue other strategic opportunities although at this time Seattle Genetics has no material agreements or commitments with respect to any new in-license or acquisition opportunity.

J.P. Morgan Securities LLC, SVB Leerink LLC and Goldman Sachs & Co. LLC are acting as joint book-running managers for the offering.

A shelf registration statement relating to the shares was previously filed with and became effective by rule of the Securities and Exchange Commission. The offering is being made solely by means of a prospectus. A preliminary prospectus supplement and accompanying prospectus relating to the offering will be filed with the Securities and Exchange Commission and will be available on the Securities and Exchange Commission’s website located at View Source A copy of the preliminary prospectus supplement and accompanying prospectus relating to the offering, when available, may be obtained from: J.P. Morgan Securities LLC, Attention: Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, by telephone at (866) 803-9204 or by email at [email protected]; SVB Leerink LLC, Attention: Syndicate Department, One Federal Street, 37th Floor, Boston, MA 02110, by telephone at (800) 808-7525, ext. 6132, or by email at [email protected]; or Goldman Sachs & Co. LLC, Prospectus Department, 200 West Street, New York, NY 10282, by telephone at (866) 471-2526, by facsimile at (212) 902-9316 or by email at [email protected].

This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

AngioDynamics to Present at the Canaccord Genuity Growth Conference

On July 23, 2019 AngioDynamics, Inc. (NASDAQ: ANGO), a leading provider of innovative, minimally invasive medical devices for vascular access, peripheral vascular disease, and oncology, reported that Jim Clemmer, President and Chief Executive Officer, will present at the 39th Annual Canaccord Genuity Growth Conference at 10:30 a.m. ET on Wednesday, August 7, 2019 in Boston, MA (Press release, AngioDynamics, JUL 23, 2019, View Source [SID1234537681]).

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A live webcast of the presentation will be accessible through the "Investors" section of the Company’s website at www.angiodynamics.com and will be available for replay following the event.

OnKure Executes License and Option Agreement with KDAc Therapeutics

On July 23, 2019 OnKure, Inc., the leader in discovery and development of selective histone deacetylase inhibitors, reported that it entered into an exclusive license and option agreement with Massachusetts-based KDAc Therapeutics, Inc. to support the continued development of KDAc’s selective histone deacetylase 3 (HDAC3) inhibitor program (Press release, OnKure, JUL 23, 2019, View Source [SID1234537680]).

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The collaboration will focus on the continued advancement of KDAc’s lead candidate, KDAc-0001 (or OKI-422), which is licensed from the Broad Institute of MIT and Harvard. Histone deacetylase (HDAC) inhibitors are a class of anti-cancer agents that play important roles in epigenetic and non-histone protein regulation, including death, apoptosis, and cell cycle arrest in cancer cells. OKI-422 is designed to enhance the therapeutic benefit of targeted anti-cancer agents, including anti-checkpoint therapies through restoration of antigen presentation in genetically defined cancers driven by histone acetyl transferase (HAT) loss of function.

"KDAc’s experienced team and collaborative efforts resulted in the development of a very unique asset," said Tony Piscopio, Ph.D., Co-founder, President and Chief Executive Officer of OnKure. Piscopio added, "We are looking forward to adding KDAc-0001 to our portfolio of first in class and best in class drug candidates."

"OnKure’s experience and proven track record in epigenetic drug development synergize with KDAc’s insights in HDAC biology and discovery of highly selective inhibitors," said Edward Holson, Ph.D., Founder, Director and Chief Scientific Officer of KDAc.