On August 20, 2019 GT Biopharma, Inc. (OTCQB:GTBP) (GTBP.PA) an immuno-oncology company focused on innovative treatments based on the Company’s proprietary NK cell engager (TriKE) platform and Multi-Target Directed Bispecific Drug Conjugate platform, reported that Jeffrey Miller, M.D. has been hired by the Company as its Consulting Chief Medical Officer (Press release, GT Biopharma , AUG 20, 2019, View Source [SID1234539510]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Dr. Miller is currently Professor of Medicine at the University of Minnesota, and is the Deputy Director of the University of Minnesota’s Masonic Comprehensive Cancer Center. Dr. Miller has more than 20 years of experience studying the biology of NK cells, and other immune effector cells and their use in clinical immunotherapy with over 170 peer-reviewed publications. Dr. Miller is a board certified physician specializing in hematological oncology. Dr. Miller is a member of numerous societies such as the American Society of Hematology (ASH) (Free ASH Whitepaper), the American Association of Immunologists, and has been a member of the American Society of Clinical Investigation since 1999. Dr. Miller serves on the editorial board for Blood, and is a reviewer for a number of journals and NIH grants.

Mr. Anthony Cataldo, the Chairman and Chief Executive Officer of GT Biopharma commented "we are pleased Jeff has agreed to become our Consulting Chief Medical Officer". Mr. Cataldo further stated "­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­Jeff is an outstanding physician and scientist, and is the inventor of our highly sought after TriKE platform technology".

About GTB-3550 Trispecific NK cell Engager (TriKE)

GTB-3550 (OXS-3550) is the Company’s first Tri-specific NK cell Engager (TriKE) product candidate being initially developed for the treatment AML. GTB-3550 is a single-chain, tri-specific scFv recombinant fusion protein conjugate composed of the variable regions of the heavy and light chains of anti-CD16 and anti-CD33 antibodies and a modified form of IL-15. The natural killer (NK) cell stimulating cytokine human IL-15 portion of the molecule provides a self-sustaining signal that activates NK cells and enhances their ability to kill. We intend to study GTB-3550 in CD33 positive leukemias such as acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and other CD33+ hematopoietic malignancies.

About GTB-1550 Multi-Target Directed Bispecific Drug Conjugate

GTB-1550 targets cancer cells expressing the CD19 receptor or CD22 receptor or both receptors thereby maximizing cancer cell recognition by binding to CD19+, CD22+ and CD19+/CD22+ cancer cells. When GTB-1550 binds to cancer cells, the cancer cells internalize GTB-1550, and are killed due to the action of drug’s cytotoxic diphtheria toxin payload.

On August 20, 2019, Synlogic, Inc. presented its corporate presentation (Presentation, Synlogic, AUG 20, 2019, View Source [SID1234538897]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

On August 20, 2019 Lannett Company, Inc. (NYSE: LCI) reported that it will report financial results for its fiscal 2019 fourth quarter and full year on Tuesday, August 27, 2019, after the market closes (Press release, Lannett, AUG 20, 2019, https://www.prnewswire.com/news-releases/lannett-to-report-fiscal-2019-fourth-quarter-full-year-financial-results-host-conference-call-on-tuesday-august-27-300903891.html [SID1234538892]). Lannett management will host a conference call that same afternoon at 4:30 p.m. Eastern Time to review the company’s performance and answer questions.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

The conference call will be available to interested parties by dialing 800-447-0521 from the U.S. or Canada, or 847-413-3238 from international locations, passcode 48926565. The call will be broadcast via the Internet at www.Lannett.com. Listeners are encouraged to visit the website at least 10 minutes prior to the start of the scheduled presentation to register, download and install any necessary audio software. A playback of the call will be archived and accessible on the same website for at least three months.

On August 20, 2019 Centene Corporation (NYSE: CNC) reported it will present at the Wells Fargo Securities 2019 Healthcare Conference, to be held September 4-5, at the Westin Copley Plaza in Boston (Press release, CENTENE, AUG 20, 2019, View Source [SID1234538891]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Centene will present on Wednesday, September 4th, at 9:05 a.m. Eastern Daylight Time (EDT). A simultaneous live audio webcast is also available at: View Source;tp_key=c91cdd2453.

A webcast replay of this presentation will be available afterwards via the Company’s website at www.centene.com under the Investors section.

On August 20, 2019 Q BioMed, Inc. (OTCQB: QBIO) and Chemveda Life Sciences are reported the successful chemical synthesis of a unique natural compound that has shown remarkable efficacy as a potential chemotherapy for the treatment of liver cancer (Press release, Q BioMed, AUG 20, 2019, View Source [SID1234538890]). This is a significant advancement for Q BioMed’s portfolio asset "Uttroside B" and the compound’s derivatives as a chemotherapeutic agent against, the most common form of liver cancer.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Additional confirmatory cell line efficacy data from current testing is expected to be completed in the next few weeks. The collaboration will advance the Q BioMed portfolio asset "Uttroside B" and its derivatives as a potential chemotherapeutic agent against hepatocellular carcinoma. The efficacy of Uttroside B, a potent saponin, against liver cancer was recently demonstrated in a preclinical study published in the November 2016 issue of Scientific Reports, a Nature journal.

The compound was isolated and characterized from the leaves of Solanum nigrum Linn, a plant widely used in traditional medicines. In the Scientific Reports study, researchers showed that in animal models, Uttroside B was ten times more cytotoxic to the HepG2 liver cancer cell line than sorafenib, the only drug approved by the Food and Drug Administration for liver cancer approved at the time and the current first line treatment for hepatocellular carcinoma. Sorafenib has been shown to increase survival by less than 3 months and has significant serious side effects, including hypertension, hemorrhage, and cardiovascular events including decreased blood flow to the heart and heart attacks.

Uttroside B drastically shrunk tumors in mice bearing human liver cancer xenografts. In addition, in pre-clinical experiments Uttroside B induced cytotoxicity in all liver cancer cell lines, and researchers were also able to confirm its biological safety, both by in vitro and in vivo studies.

Denis Corin, Q BioMed CEO said, "Having a synthetic molecule and several derivatives to work with now makes the ultimate production of a clinical drug candidate possible. Along with our collaborators in the project, the Oklahoma Medical Research Foundation and The Rajiv Gandhi Centre for Biotechnology, we will now advance the most promising candidates into preclinical testing and validation over the next few months in anticipation of an orphan drug application and an IND clinical program in early 2020."

Bheema Paraselli, President & CEO, Chemveda Life Sciences said, "Obtaining Uttroside B, even in milligram quantities, from its natural source is very challenging. Our Chemveda scientists achieved the first total synthesis of the molecule, which can now be scaled in large quantities for clinical development and ultimate drug product. Uttroside is one of the most complex natural products we have seen and worked on. We are very glad to have achieved this significant scientific milestone and look forward to ensuring its pre-clinical and clinical success in the fight against liver cancer."

Chemotherapeutic options for liver cancer are limited, and the prognosis of patients remains challenging. According to the Centers for Disease Control and Prevention, it is the second most common cause of cancer deaths worldwide, claiming approximately 750,000 lives each year. In the US, the American Cancer Society estimates that 42,000 people will be diagnosed with liver cancer in 2019 and that 32,000 will die from the disease this year. Liver cancer incidence has more than tripled since 1980 and deaths in the US have increased 56% since 2003.

The Uttroside B technology is covered by a provisional patent application. To see the full Scientific Reports study, go to: View Source

Please visit www.QBioMed.com for more information on our various pipeline products.