On November 20, 2019 CNS Pharmaceuticals, Inc. (NASDAQ: CNSP) ("Company"), a biotechnology company specializing in the development of novel treatments for brain tumors, reported Chief Executive Officer of CNS Pharmaceuticals, John M. Climaco, along with founder, Waldemar Priebe, PhD, and members of management, including, Chief Medical Officer, Sandra Silberman, MD, PhD, Chief Scientific Officer, Donald Picker, PhD, and scientific advisory board member, Sigmund Hsu, MD, PhD, will be attending the 24th Annual Meeting of the Society of Neuro-Oncology ("SNO") (Press release, CNS Pharmaceuticals, NOV 20, 2019, View Source [SID1234551548]). The event will take place November 20-24, 2019 at the JW Marriott Desert Ridge Resort in Phoenix, Arizona.

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"Following our recent IPO, we are looking forward to connecting with the scientific community at the world’s largest neuro-oncology conference," stated John Climaco. "We remain committed to further pursuing the advancement of our novel anthracycline, Berubicin, and to developing therapies for the treatment of glioblastoma."

About Berubicin
Berubicin is an anthracycline, a class of drugs among the most powerful chemotherapy drugs and effective against more types of cancer than any other class of chemotherapeutic agents. Anthracyclines are designed to damage the DNA of targeted cancer cells by interfering with the action of the topoisomerase II, a critical enzyme enabling cell proliferation. Berubicin was developed at the MD Anderson Cancer Center (MDACC), the world’s largest cancer research facility. Berubicin appeared to demonstrate one Durable Complete Response in a Phase I human clinical trial conducted by a prior developer.

On November 20, 2019 BioMed Inc. (OTCQB: QBIO), reported FDA approval of its contract manufacturer IsoTherapeutics Group LLC (ITG) (Press release, Q BioMed, NOV 20, 2019, View Source [SID1234551547]). ITG is now cleared to manufacture the Company’s FDA approved non-opioid cancer bone pain drug Strontium-89 Chloride USP.

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The long-awaited approval of the facility means that this important oncologic pain drug will soon be available to patients in the US and the rest of the world. Q BioMed is now the only FDA-approved source for this drug in the western world. The Company is activating its planned commercial operations to support marketing, sales, and distribution in the US and, soon, in the rest of the world.

Strontium-89 is an FDA-approved non-opioid radiopharmaceutical indicated for the treatment of painful skeletal metastases caused by cancer. The product is administered intravenously once every three months as an alternative to opioid analgesics and plays a critical role in the treatment of metastatic bone pain. The product has a long history of providing well-documented and significant pain relief for patients suffering from the excruciating pain associated with primary cancers that have spread to the bone, including breast, prostate, lung and others. This is the ideal time to be launching Strontium-89 given the current concerns with the over-use of opioid drugs. In addition, as more therapies come to market for the treatment of primary cancers, more people are living longer with metastatic disease. It is estimated that approximately two million patients experience debilitating bone pain from metastatic disease. The opportunity to provide significant pain relief to this group is substantial.

QBioMed CEO Denis Corin said, "We have been anticipating this critical regulatory step for a long time, certainly longer than we hoped, but we are thrilled that we can now move forward with certainty. This is the start of a new chapter in the evolution of our company, and we are looking forward to serving the needs of thousands of patients suffering from metastatic bone pain, providing them the chance to minimize their pain and positively impact life with metastatic disease. With millions of potential patients around the world, this is a major market opportunity for our company. In addition, we are investigating and planning expansion trials to provide additional indications for the drug and entry into an even larger therapeutic market."

On November 20, 2019 Medicenna Therapeutics Corp. ("Medicenna" or "the Company") (TSX: MDNA,OTCQB: MDNAF), a clinical stage Immuno-Oncology company, reported that it will host a Key Opinion Leader (KOL) call and webcast for the investment community on Monday, November 25, 2019 at 10:00 AM, ET (Press release, Medicenna Therapeutics, NOV 20, 2019, View Source [SID1234551546]).

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The KOL call will focus on Medicenna’s MDNA55 recurrent glioblastoma (rGBM) program and the latest Phase 2b clinical study results which will be presented by Dr. John Sampson on Sunday, November 24th, 2019 at the Annual Meeting of the Society of Neuro-Oncology being held from November 20 to 24 at the JW Marriott Desert Ridge Resort in Phoenix, Arizona.

Featured Speaker:

John H. Sampson, MD, PhD, MHSc, MBA Robert H. and Gloria Wilkins Distinguished Professor and Chair of Neurosurgery at Duke University in Durham, NC

Dr. Sampson is an internationally recognized leader in the field of brain cancer immunotherapy, experimental treatment of complex brain tumors and drug delivery to the brain using convection enhanced delivery (CED). He has authored more than 240 peer-reviewed publications documenting the development of multiple immunotherapeutic agents that have affected the standard of care in glioblastoma, the most malignant form of brain cancer. He has remained continuously funded by the National Institutes of Health since 2000. Dr. Sampson earned his medical degree from the University of Manitoba in Winnipeg, Canada and a PhD in neuro- immunology and brain tumor immunotherapy at Duke University. He completed his MBA at the Fuqua School of Business. Dr. Sampson was elected to the prestigious National Academy of Medicine as well as the Association of American Physicians.

Conference call and webcast details:
Date: November 25, 2019
Time: 10:00 am ET

To access the conference audio:
Local dial in: 416-764-8609
North American Toll Free: 1-888-390-0605
Conference ID No.: 38917905

To access the webcast and slide presentation:

View Source

Following the event, the archived webcast and Medicenna presentation will be available on the Company’s website at www.medicenna.com.

On November 20, 2019 Phoenix Molecular Designs (PhoenixMD), a clinical stage biotechnology company developing precise cancer therapeutics targeting essential kinases, reported that it has dosed the first patient in its Phase 1/1b study of PMD-026, the company’s lead product candidate (Press release, PhoenixMD, NOV 20, 2019, View Source [SID1234551545]). PMD-026 is a proprietary first-in-class orally-available RSK (kinase) inhibitor for the potential treatment of patients with metastatic breast cancer and, more specifically, triple-negative breast cancer (TNBC).

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"Dosing the first patient in this newly initiated clinical trial is a paramount milestone for PhoenixMD," said Andrew Dorr, M.D., chief medical officer of Phoenix Molecular Designs. "We believe PMD-026 to be a promising new approach to treat advanced breast cancer and we look forward to building upon this momentum in the pursuit of a potential treatment option for individuals living with advanced forms of breast cancer."

The company’s Phase 1/1b clinical trial will be conducted at leading medical centers across United States and it will evaluate safety, tolerability, pharmacokinetics and anti-tumor activity of PMD-026 in patients with metastatic breast cancer in the dose escalation as well as in women with TNBC in Phase 1b. Importantly, this trial will include a CAP/CLIA (College of American Pathologists/Clinical Laboratory Improvement Amendments) certified companion diagnostic (CDx) designed to detect RSK2 activation in breast tumors and to then correlate it with response to PMD-026. Activated RSK2 is prevalent in breast cancer as it is highly expressed in 89 percent of primary tumors and is found in metastatic disease. In TNBC, early data indicates that approximately 42 percent of patients have extremely high levels of RSK2 activation. Targeting of RSK2, which drives breast cancer proliferation, by PMD-026 creates a distinct precision medicine approach to treating breast cancer.

"Metastatic breast cancer, including TNBC, is a devastating disease with poor prognosis and few impactful treatment options," said Murali Beeram, M.D., lead investigator of South Texas Accelerated Research Therapeutics (START). "Our team is eager to evaluate RSK2 inhibition in advanced breast cancers and play an integral role, alongside PhoenixMD, in the exploration of new medicines for patients."

About PMD-026
PhoenixMD’s lead candidate, PMD-026, is the first RSK inhibitor being developed for the treatment of TNBC. PMD-026 was precisely designed for TNBC because RSK2 was specifically identified as the key kinase, out of 519 kinases, that drives the growth of this breast cancer subtype. Preclinical data shows the potential for PMD-026 to be effective alone or in combination with conventional chemotherapies. It has the potential to be a platform technology for chemotherapy, hormone therapy and/or immunotherapy sensitization for a wide range of refractory cancers in the future. PMD-026 is currently in Phase 1/1b testing.

On November 20, 2019 IOTA Pharmaceuticals Ltd (Cambridge, UK) and the Experimental Therapeutic Unit of the Neurology Department of Massachusetts General Hospital (Neurology, MGH, Boston, USA) reported the creation of a new Glioblastoma drug screening pipeline, PHOENIX (Press release, IOTA Pharmaceuticals, NOV 20, 2019, View Source [SID1234551544]).

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Based on IOTA’s GBM Drug Bank1 and MGH’s Glioblastoma patient-derived cell screening platforms2, PHOENIX will translate IOTA’s preclinical work on drug-induced gene expression in established GBM cell lines into a clinic-facing pipeline of effective drug combinations that could form the basis for personalised glioblastoma treatments.

The establishment of PHOENIX and the initial findings which have informed the platform will be reported at the American Society for Neuro Oncology meeting being held later this week in Phoenix, Arizona.

PHOENIX has been created with funds received from The Brain Tumour Charity (UK).

1 GBM Drug Bank-a new resource for glioblastoma drug discovery and informatics research.
2 Patient-Derived Glioma Models: From Patients to Dish to Animals.

Information on the PHOENIX pipeline, and how you can participate, can be obtained from Prof Bakhos Tannous at MGH ([email protected]) and Dr David Bailey at IOTA ([email protected]).