Zymeworks Files Preliminary Prospectus Supplements for Offering of Common Shares and Pre-Funded Warrants

On June 18, 2019 Zymeworks Inc. (NYSE/TSX: ZYME), a clinical-stage biopharmaceutical company developing multifunctional biotherapeutics, reported that it has filed a preliminary prospectus supplement (the "Canadian Supplement") to its Canadian short form base shelf prospectus dated March 6, 2019 (the "Base Prospectus") in connection with an offering of its common shares and pre-funded warrants to purchase its common shares (the "Offering") (Press release, Zymeworks, JUN 18, 2019, View Source [SID1234537146]). The Canadian Supplement was filed with the securities regulatory authorities in each of the provinces and territories of Canada. A preliminary prospectus supplement (the "U.S. Supplement," together with the Canadian Supplement, the "Supplements") was also filed with the U.S. Securities and Exchange Commission (the "SEC") as part of a registration statement on Form S-3, as amended, including a prospectus which became effective January 31, 2019 (the "Registration Statement"), pursuant to which the securities will be offered in the United States.

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The Company also expects to grant to the underwriters a 30-day over-allotment option to purchase up to an additional 15% of the number of common shares offered in the Offering. The Offering is expected to be priced in the context of the market, with the final terms of the Offering to be determined at the time of pricing. There can be no assurance as to whether or when the Offering may be completed, or as to the actual size or terms of the Offering. The closing of the Offering will be subject to customary closing conditions, including the listing of the common shares on the TSX and NYSE and any required approvals of each exchange. The pre-funded warrants will not be listed on the TSX or the NYSE.

The Offering is expected to raise total gross proceeds of approximately US$150.0 million, before deducting underwriting discounts and commissions and estimated offering expenses. The Company intends to use the net proceeds of the Offering (i) to accelerate and expand the global development of ZW25 both as a single agent and in combination with other anti-cancer agents in a variety of HER2-expressing tumors, including gastroesophageal, breast and other underserved cancers; (ii) to accelerate and expand the clinical development of ZW49; (iii) to advance other novel preclinical programs, including those involving non-HER2-expressing tumors; and (iv) for general corporate purposes.

J.P. Morgan Securities, LLC is acting as active book-running manager for the Offering. Wells Fargo Securities, LLC and Stifel, Nicolaus & Company, Incorporated are acting as passive book-running managers, Raymond James Ltd. is acting as co-lead manager and Ladenburg Thalmann & Co. Inc. is acting as co-manager.

The Supplements and the Registration Statement contain important detailed information about the Offering. A copy of the Canadian Supplement can be found on SEDAR at www.sedar.com and www.sec.gov, and a copy of the U.S. Supplement and the related Registration Statement can be found on EDGAR at www.sec.gov. Copies of the Supplements may also be obtained from J.P. Morgan Securities, LLC, Attention; Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, or by telephone at (866) 803-9204; Wells Fargo Securities, LLC, Attention; Equity Syndicate Department, 375 Park Avenue, New York, NY 10152, by telephone at (800) 326-5897, or by email at [email protected]; or Stifel, Nicolaus & Company, Incorporated, Attention: Syndicate, One Montgomery Street, Suite 3700, San Francisco, CA 94104, by telephone at (415) 364-2720, or by email at [email protected]. Prospective investors should read the Supplements and the Registration Statement before making an investment decision.

This news release shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of these securities in any province, state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such province, state or jurisdiction.

ArQule to Present at the BMO Prescriptions for Success Healthcare Conference on June 25, 2019

On June 18, 2019 ArQule, Inc. (Nasdaq: ARQL) reported that Marc Schegerin, Chief Financial Officer and Head of Strategy, will present at the BMO Prescriptions for Success Healthcare Conference on June 25, 2019 at 8:00 a.m. ET at the The Mandarin Oriental New York, New York (Press release, ArQule, JUN 18, 2019, View Source [SID1234537145]).

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The live webcast of the presentation will be available via the "Investors & Media" section of ArQule’s website, www.arqule.com, under "Events & Presentations." A replay of the webcast will be available shortly after the conclusion of the presentation.

Physicians’ Education Resource® Releases Agenda for 20th Annual International Lung Cancer Congress®

On June 18, 2019 Physicians’ Education Resource (PER), a worldwide leading resource for continuing medical education, reported the full agenda for the 20th Annual International Lung Cancer Congress (Press release, Physicians’ Education Resource, JUN 18, 2019, View Source [SID1234537144]). The congress will be held July 25-27 at the Hyatt Regency Huntington Beach in California.

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"We are so proud to be celebrating 20 years of educational excellence at this year’s congress," said Phil Talamo, president of PER. "This is a major milestone for PER, and we wouldn’t be able to become one of the most comprehensive and detailed educational lung cancer meetings in the world without the support of our national and international faculty members and participants who attend our International Lung Cancer Congress every year."

The 20th Annual International Lung Cancer Congress is a three-day program for surgical, medical and radiation oncologists interested in the treatment of patients with lung cancer. During this meeting, the activity co-chairs—Drs. David R. Gandara and Roy S. Herbst—will be joined by renowned international and national experts who will present a series of cutting-edge lectures, case-based panel and interactive discussions, a molecular tumor board and several Medical Crossfire programs on how oncologists can incorporate the latest data on targeted agents, immunotherapy, surgery and radiation oncology in the clinic. Additionally, Gandara and Herbst will present the 12th annual Bonnie J. Addario Lung Cancer Foundation keynote lecture and award at this year’s congress.

Magellan Rx Management Pioneers Novel Drug Wastage Program, Savings Exceed $46 Million in First Year, While Promoting High Quality Care for Members

On June 18, 2019 Magellan Rx Management, the pharmacy benefit management (PBM) division of Magellan Health, Inc. (NASDAQ: MGLN), reported that it has launched an innovative solution to control spend for high-cost infusible drugs, while promoting high quality care for members (Press release, Magellan Health Services, JUN 18, 2019, View Source [SID1234537143]). Payers are often faced with challenges like limited vial size options and availability that can lead to excessive spend in categories such as oncology and autoimmune conditions. The Magellan Rx drug wastage program leverages prior authorization and dosing protocols, in collaboration with providers, to identify clinically-appropriate opportunities to reduce waste.

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Since the drug wastage program launched in early 2018, participating health plans have saved over $46 million and savings continue to grow. This reduction in waste is also critical to improving the efficiency of healthcare throughout the United States and is a key component to providing high quality care.

Effective Strategies to Combat Expensive Drug Wastage

When a portion of a medication is unused and discarded due to vial size limitations, payers are billed for product that wasn’t actually administered to the patient. Depending on the drug, this can equate to tens of thousands of dollars wasted per patient over the course of treatment. Drug wastage is an established problem, especially in oncology where research has estimated that nearly $3 billion is wasted annually in cancer medicines that are discarded.1 High-cost medications used to treat autoimmune conditions such as rheumatoid arthritis can also contribute to substantial drug wastage. Given the top five Commercial medical benefit drugs by spend fall within the oncology, oncology support, or autoimmune categories2, there is an opportunity to leverage drug wastage strategies to combat rising drug spend.

"It is imperative for payers and patients to be aware of these market dynamics and medical benefit drug spend and trend—which, historically, has gone unmanaged—in order to implement timely strategies that will mitigate escalating drug costs," said Steve Cutts, senior vice president and general manager, specialty. "At Magellan Rx, we equip our customers with the knowledge to make better decisions and provide clinically-appropriate interventions for their members directed at reducing drug waste, resulting in significant dollars saved for the plan as well as downstream reductions in member cost share."

Clinical pharmacists at Magellan Rx teamed up with expert key opinion leaders and health plan customers to develop and implement a program that identifies opportunities to reduce drug wastage, targeting high-cost medications. Once identified, providers are given the option to prescribe a clinically-equivalent dose that would minimize the amount of drug waste. Provider validation has been excellent to date, with nearly 50 percent of providers agreeing to the use of more efficient vials.

For over 14 years, Magellan Rx has delivered cost-effective and leading-edge strategies for medical benefit drug management, offering flexible solutions that can also operate outside of the traditional payer-PBM relationship. Health plans can plug in to the extensive clinical expertise and experience at Magellan Rx by delegating specialty and medical drug management services while retaining a separate PBM. Through innovative, targeted initiatives like the drug wastage program, combined with other clinical solutions such as utilization management, site of service, and biosimilar management, Magellan Rx helps customers reduce their drug spend for highly complex and costly medical benefit drugs while promoting high quality care for their members.

"We are focused on reducing cost of care while maintaining a high quality of care for our members," said Scott McClelland, vice president of commercial and specialty pharmacy programs at Florida Blue. "That’s why we collaborate with Magellan Rx to find solutions, like the drug waste prevention program, that help curb rising specialty spend on the medical benefit. The success of this partnership has helped us save money for our members while ensuring they get the care they need."

For more on trends in medical drug management, get the latest updates from the Magellan Rx Report Spring 2019 Edition.

1. Harris, Gardiner. "Waste in Cancer Drugs Costs $3 Billion a Year, a Study Says." The New York Times 1 Mar. 2016. Web. 16 April 2019.

2. 2018 Magellan Rx Management Medical Pharmacy Trend ReportTM, ©2019.

Moderna to Present at BMO 2019 Prescriptions for Success Healthcare Conference

On June 18, 2019 Moderna, Inc., (Nasdaq: MRNA) a clinical stage biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines to create a new generation of transformative medicines for patients, reported that Pamela Cohen, M.D., Head, Clinical Oncology Development, will present at the BMO 2019 Prescriptions for Success Healthcare Conference on Tuesday, June 25, 2019 at 3:20 p.m. ET (Press release, Moderna Therapeutics, JUN 18, 2019, View Source [SID1234537142]).

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A live webcast of the presentation will be available under "Events and Presentations" in the Investors section of the Moderna website at View Source A replay of the webcast will be archived on Moderna’s website for 30 days following the presentation.