On May 19, 2020 BioMarin Pharmaceutical Inc. (Nasdaq: BMRN) reported that the initial purchasers of the previously announced offering of its 1.25% Senior Subordinated Convertible Notes due 2027 in a private placement to qualified institutional buyers pursuant to Rule 144A under the Securities Act of 1933, as amended elected to exercise in full their 13-day option to purchase an additional $50 million aggregate principal amount of the notes (the "Additional Notes") (Press release, BioMarin, MAY 19, 2020, View Source;301062041.html [SID1234558294]). The sale of the Additional Notes closed today.

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The Additional Notes have identical terms to the 1.25% Senior Subordinated Convertible Notes due 2027 sold on May 14, 2020 (the "Original Notes" and, together with the Additional Notes, the "Notes") and, following today’s closing, there is a total of $600 million aggregate principal amount of Notes outstanding. The aggregate net proceeds from the offering of the Notes was approximately $585.8 million after deducting the initial purchasers’ discounts and commissions and estimated expenses payable by BioMarin. BioMarin used approximately $50.0 million of the net proceeds from the offering to repurchase shares of its common stock concurrently with the offering of the Original Notes in privately negotiated transactions with purchasers of the notes effected through one of the initial purchasers or its affiliate, as BioMarin’s agent. BioMarin intends to use a majority of the net proceeds from the offering of the Notes to repay, repurchase or settle in cash some or all of its 1.50% senior subordinated convertible notes due in 2020, although it did not effect any such repayment, repurchase or settlement concurrently with the offering. BioMarin intends to use the remainder of the net proceeds for general corporate purposes.

The offer and sale of the Notes and the shares of BioMarin common stock issuable upon conversion of the Notes have not been registered under the Securities Act or any state securities laws, and unless so registered, the Notes and such shares may not be offered or sold in the United States absent registration or an applicable exemption from, or in a transaction not subject to, the registration requirements of the Securities Act and other applicable securities laws.

This press release is neither an offer to sell nor a solicitation of an offer to buy any securities, nor shall it constitute an offer, solicitation or sale of the securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such jurisdiction.

On May 19, 2020 Cryoport, Inc. (NASDAQ: CYRX) ("Cryoport") reported its intention to offer, subject to market and other conditions, $100.0 million in aggregate principal amount of convertible senior notes due 2025 (the "notes") in a private offering to investors reasonably believed to be qualified institutional buyers pursuant to Rule 144A under the Securities Act of 1933, as amended (the "Securities Act") (Press release, Cryoport, MAY 19, 2020, View Source [SID1234558293]). Cryoport also expects to grant the initial purchasers of the notes a 30-day option to purchase up to an additional $15.0 million in principal amount of notes.

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The notes will be senior, unsecured obligations of Cryoport, will accrue interest payable semi-annually in arrears and will mature on June 1, 2025, unless earlier repurchased, redeemed or converted. At any time before the close of business on the scheduled trading day immediately before the maturity date, noteholders may convert their notes at their option into shares of Cryoport’s common stock, together, if applicable, with cash in lieu of any fractional share, at the then-applicable conversion rate. The notes will not be redeemable at Cryoport’s election before June 5, 2023. The notes will be redeemable, in whole and not in part, for cash at Cryoport’s option at any time on or after June 5, 2023, but only if (1) the last reported sale price per share of Cryoport’s common stock exceeds 130% of the conversion price for a specified period of time and (2) a registration statement covering the resale of the shares of Cryoport’s common stock issuable upon conversion of the notes is effective and available for use. The redemption price will be equal to the principal amount of the notes to be redeemed, plus accrued and unpaid interest, if any, to, but excluding, the redemption date. The interest rate, initial conversion rate and other terms of the notes will be determined at the pricing of the offering.

Cryoport intends to use the net proceeds from the offering primarily for working capital, inventory development, global infrastructure buildout and facilities expansion, sales and marketing and, potentially, acquisitions with strategic impact.

The offer and sale of the notes and the shares of common stock issuable upon conversion of the notes have not been registered under the Securities Act or any other securities laws, and unless so registered, may not be offered or sold except pursuant to an exemption from, or in a transaction not subject to, the registration requirements of the Securities Act and any other applicable securities laws. This press release does not constitute an offer to sell, or the solicitation of an offer to buy, the notes or the shares of common stock issuable upon conversion of the notes, nor will there be any sale of the notes or such shares, in any state or other jurisdiction in which such offer, sale or solicitation would be unlawful.

On May 19, 2020 ADC Therapeutics SA (NYSE: ADCT), a late clinical-stage oncology-focused biotechnology company pioneering the development and commercialization of highly potent and targeted antibody drug conjugates for patients suffering from hematological malignancies and solid tumors, reported the closing of its initial public offering of 14,082,475 shares of its common shares at a price of $19.00 per share, which included the exercise in full by the underwriters of their option to purchase 1,836,844 additional common shares (Press release, ADC Therapeutics, MAY 19, 2020, View Source [SID1234558292]). The gross proceeds from the offering, before deducting underwriting discounts and commissions and estimated offering expenses payable by ADC Therapeutics, are approximately $267.6 million. The shares began trading on the New York Stock Exchange on May 15, 2020 under the ticker symbol "ADCT."

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Morgan Stanley, BofA Securities and Cowen acted as joint book-running managers for the offering.

The offering is being made only by means of a prospectus. Copies of the prospectus relating to the offering may be obtained from Morgan Stanley & Co. LLC, Attn: Prospectus Department, 180 Varick Street, 2nd Floor, New York, NY 10014, by telephone at (866) 718-1649 or by email at [email protected]; BofA Securities, Inc., NC1-004-03-43, 200 North College Street, 3rd floor, Charlotte, NC 28255-0001, Attn: Prospectus Department, or by email at [email protected]; or Cowen and Company, LLC, c/o Broadridge Financial Solutions, Attn: Prospectus Department, 1155 Long Island Avenue, Edgewood, NY 11717, by telephone at (833) 297-2926 or by email at [email protected].

A registration statement relating to these securities has been filed with, and declared effective by, the U.S. Securities and Exchange Commission. This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction. There is no intention or permission to publicly offer, solicit, sell or advertise, directly or indirectly, any securities of ADC Therapeutics SA, such as the common shares, in or into Switzerland within the meaning of the Swiss Financial Services Act ("FinSA") and these securities will not be listed or admitted to trading on the SIX Swiss Exchange or on any other regulated trading venue (exchange or multilateral trading facility) in Switzerland. Neither this document nor any other offering or marketing material relating to these securities, such as the common shares, constitutes or will constitute a prospectus pursuant to the FinSA, and neither this document nor any other offering or marketing material relating to the common shares constitutes a prospectus pursuant to the FinSA, and neither this document nor any other offering or marketing material relating to the common shares may be publicly distributed or otherwise made publicly available in Switzerland.

In addition, ADC Therapeutics announced today the receipt of the initial $65.0 million disbursement, before deducting fees and expenses payable by ADC Therapeutics, of senior secured convertible term loans under its previously announced Convertible Credit Facility with Deerfield Partners, L.P. and certain of its affiliates (collectively, Deerfield) and the issuance to Deerfield of $65.0 million aggregate principal amount of senior secured convertible notes.

On May 19, 2020 Deep Lens, a software company reported on a groundbreaking approach to faster recruitment of the best-suited cancer patients to clinical trials, has integrated proprietary molecular data parsing and management technology into the company’s award-winning clinical trial screening and enrollment platform, VIPER (Press release, Deep Lens, MAY 19, 2020, View Source [SID1234558291]). This breakthrough integration will enable cancer care teams, clinical trial sponsors, and trial coordinators to immediately and automatically match patients based on the genetic profile of their cancers to the best precision therapies and oncology clinical trials.

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The company worked with the University of Miami Office of Technology Transfer to exclusively license the technology. A team from Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, and UHealth Information Technology developed an engine to leverage new ways of consuming and normalizing molecular genetic test results from companies, such as Caris Life Sciences, Foundation Medicine, Guardant Health, NeoGenomics, Tempus, and more, to automate and expedite the patient screening process.

"Our office facilitates transfer of university innovations for the benefit of the university community and the public," said Bin Yan, Ph.D., J.D., Director of the Office of Technology Transfer. "So, it was a natural fit to work with Deep Lens and integrate our two differentiated technologies to solve a real problem in clinical trial recruitment: limited time and resources for physicians and care teams."

In the past, the genetic test results were sent to healthcare providers, where a trained specialist or physician would analyze the results for therapy decisions. But, clinical trial coordinators often do not have access to this data or the ability to extract information from it when matching patients to clinical trials, leading to inconsistencies in the screening process and missed opportunities to leverage the data. Now, with integration into the VIPER platform, molecular test results from any lab vendor, across all patients can be quickly searched and easily analyzed by cancer care teams and clinical trial coordinators immediately and automatically match patients to the best precision-based clinical trials available.

"Deep Lens’ VIPER has already made a big improvement to the patient screening process for our precision trials," said Jim Langford, Vice President of Clinical Operations, Aivita Biomedical in Irvine, California. "With the addition of automated molecular-based patient matching, we see VIPER giving us much greater granularity into how we work with our provider sites to drive greater patient engagement."

The collaboration between Deep Lens and the University of Miami not only provides Deep Lens with additional, differentiated technology in precision medicine but establishes the University of Miami as a collaboration partner for future genomics technology development and project work.

"Integrating this molecular data parsing and management technology into VIPER and continuing to work with University of Miami on integrating future genomics advancements will ensure that we have the leading and most up-to-date information and technologies," stated TJ Bowen, Ph.D., co-founder and Chief Scientist at Deep Lens. "Now, cancer care teams, clinical trial sponsors, and trial coordinators can leverage an AI-enabled workflow platform that aggregates all relevant data sources for even faster automation and improved patient matching to increase clinical trial enrollment."

Patient recruitment for clinical trials remains a time-intensive, costly barrier to the execution of drug development programs. More than 14,000 oncology clinical trials are actively recruiting patients; yet estimates put the rate of participation as low as three percent of potential trial candidates, which can lead to enrollment delays of months, if not years.

"With this new functionality, VIPER will facilitate even greater patient access to cutting-edge treatments. By identifying eligible patients for clinical trials based on their digital and molecular biomarkers, VIPER is exactly what is needed to improve trial enrollment numbers," said David Braxton, M.D., Head of Molecular Pathology at a California cancer center that uses the VIPER platform. "Patients deserve access to the most promising treatments and getting access should not be a burden for care teams and patients."

On May 19, 2020 BostonGene Corporation, a biomedical software company focused on defining optimal, precision medicine-based therapies for cancer patients, reported that, as a result of its strategic collaborations, seven abstracts have been accepted to the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting (Press release, BostonGene, MAY 19, 2020, View Source [SID1234558290]). All abstracts to be published in the Journal of Clinical Oncology supplement for the ASCO (Free ASCO Whitepaper) Annual Meeting Proceedings.

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"We are honored to have multiple abstracts accepted by ASCO (Free ASCO Whitepaper) 2020. The studies demonstrate the clinical utility of BostonGene‘s advanced precision medicine capabilities and our commitment to transform the lives of cancer patients," said Andrew Feinberg, President & CEO at BostonGene.

Details of abstract presentations are as follows:

1.Abstract Number: 8055*

Title: "Multi-omics analysis of mantle cell lymphoma reveals an immune-cold tumor microenvironment associated with ibrutinib resistance"

Session: Hematologic Malignancies—Lymphoma and Chronic Lymphocytic Leukemia

Presenter: Krystle Nomie, PhD, BostonGene

Poster: 388

Tumor-immune molecular programs were characterized from over 200 mantle cell lymphoma samples and correlated with response to ibrutinib.

Research conducted with The University of Texas MD Anderson Cancer Center

2.Abstract Number: 6561*

Title: "Immune functional portraits of head and neck cancer using next generation sequencing"

Session: Head and Neck Cancer

Presenter: Susan Raju Paul, MBBS, Vaccine and Immunotherapy Center, Massachusetts General Hospital

Poster: 222

BostonGene’s comprehensive, integrated analysis of WES and RNAseq was used to characterize the cellular composition and functional state of over 1,400 head and neck tumors and their tumor microenvironment.

Research conducted with Massachusetts General Hospital

3.Abstract Number: 8054*

Title: "Identification of Predicted Neoantigen Vaccine Candidates in Follicular Lymphoma Patients"

Session Hematologic Malignancies—Lymphoma and Chronic Lymphocytic Leukemia

Presenter: Cody Ramirez at Washington University in St Louis

Poster: 387

Tumor-specific mutant antigens (TSMAs) that can be targeted by vaccination were studied in follicular lymphoma patients and led to a first-in-human pilot trial of a personalized TSMA vaccine combined with immunotherapy.

Research conducted with Washington University in St Louis

4.Abstract Number: e20065

Title: "Correlation of PI3K upregulation with NOTCH2 mutations in ibrutinib-resistant mantle cell lymphoma"

First Author: Krystle Nomie, PhD, BostonGene

Research conducted with The University of Texas MD Anderson Cancer Center

5.Abstract Number: e21026

Title: "Non-small cell lung cancer: Analysis using mass cytometry and next generation sequencing reveals new opportunities for the development of personalized therapies"

First Author: Susan Raju Paul, MBBS, Vaccine and Immunotherapy Center, Massachusetts General Hospital

Research conducted with Massachusetts General Hospital

6.Abstract Number: e17106

Title: "Integrated single-cell spatial multi-omics of intratumor heterogeneity in renal cell carcinoma"

First Author: James Hsieh, MD, PhD at Washington University in St. Louis

Research conducted with Washington University in St Louis

7.Abstract Number: e17506

Title: "Integrated-omics of MRI-visible and -invisible prostate cancer identifies molecular correlations with clinical outcome"

First Author: Eric H. Kim, MD at Washington University in St. Louis

Research conducted with Washington University in St Louis

*Abstracts to be presented as posters at the 2020 ASCO (Free ASCO Whitepaper) Annual Virtual Meeting from May 29-31, 2020