Brickell Biotech, Inc. Announces Pricing of $20.1 Million Underwritten Public Offering

On June 17, 2020 Brickell Biotech, Inc. ("Brickell") (Nasdaq: BBI), a clinical-stage pharmaceutical company focused on developing innovative and differentiated prescription therapeutics for the treatment of debilitating skin diseases, reported the pricing of an underwritten public offering of 17,500,000 shares of common stock or common stock equivalents (which includes pre-funded warrants to purchase shares of common stock in lieu of shares of common stock) and investor warrants to purchase up to an aggregate of 17,500,000 shares of common stock (Press release, Vical, JUN 17, 2020, View Source [SID1234561204]). Each share of common stock (or pre-funded warrant in lieu thereof) is being sold together with one investor warrant to purchase one share of common stock at a combined offering price of $1.15, for total gross proceeds of approximately $20.1 million, before underwriting discounts and commissions and offering expenses payable by Brickell. The offering is expected to close on or about June 22, 2020, subject to the satisfaction or waiver of customary closing conditions.

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Brickell anticipates using the net proceeds from the offering for research and development, including clinical trials, working capital and general corporate purposes.
Oppenheimer & Co. Inc. is acting as the sole book-running manager in connection with the offering and Lake Street Capital Markets, LLC is acting as lead manager.
The securities will be offered pursuant to a registration statement on Form S-1 (File No. 333-238298), which was declared effective by the Securities and Exchange Commission (the "SEC") on June 17, 2020, and an additional registration statement filed with the SEC on June 17, 2020 pursuant to Rule 462(b) under the Securities Act of 1933, as amended. The offering is being made solely by means of a prospectus. A preliminary prospectus relating to and describing the terms of the offering has been filed with the SEC and is available on the SEC’s website at www.sec.gov. Copies of the preliminary prospectus and, when available, copies of the final prospectus relating to this offering can be obtained at the SEC’s website at www.sec.gov or from Oppenheimer & Co. Inc., Attention: Syndicate Prospectus Department, 85 Broad St., 26th Floor, New York, NY 10004, by telephone at (212) 667-8055 or by email at [email protected].
This press release does not constitute an offer to sell or the solicitation of an offer to buy, nor will there be any sales of these securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of such jurisdiction.

MannKind Corporation to Present at the June 2020 Lytham Partners Virtual Investor Growth Conference

On June 17, 2020 MannKind Corporation (NASDAQ:MNKD) reported that it will be featured in a virtual presentation and fireside chat at the June 2020 Lytham Partners Virtual Investor Growth Conference on Wednesday, June 24, 2020 at 12 pm ET (9 am PT) (Press release, Mannkind, JUN 17, 2020, View Source [SID1234561203]). Presenting from the Company will be its Chief Executive Officer, Michael Castagna, Pharm D.

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A webcast of the presentation will be posted under the investors section of MannKind’s website under events & presentations or can be accessed at www.lythampartners.com/virtual. A replay of the presentation will be available following the event.

Management will also be participating in virtual one-on-one meetings with institutional investors on June 24, 2020. To arrange a meeting, please contact Robert Blum of Lytham Partners at [email protected] or visit www.lythampartners.com/virtual.

Mallinckrodt to Present at the BMO Prescriptions for Success Healthcare Conference

On June 17, 2020 Mallinckrodt plc (NYSE: MNK), a global biopharmaceutical company, reported that it will present on Tuesday, June 23, 2020 at the BMO Prescriptions for Success Healthcare Conference (Press release, Mallinckrodt, JUN 17, 2020, View Source [SID1234561201]). Mark Trudeau, President and Chief Executive Officer, and Bryan Reasons, Executive Vice President and Chief Financial Officer, will represent the company in a fireside chat at 8:00 a.m. Eastern Time. To access the webcast, please refer to the webcast link posted on our site at: http://www.mallinckrodt.com/investors. A replay of the fireside chat will also be available following the meeting.

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Rigel to Present at the BMO 2020 Prescriptions for Success Healthcare Virtual Conference

On June 17, 2020 Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL) reported that Dean Schorno, the company’s chief financial officer, reported that to present a company overview at the BMO 2020 Prescriptions for Success Healthcare Virtual Conference on Tuesday, June 23, 2020 at 10:30 a.m. Eastern Time (Press release, Rigel, JUN 17, 2020, View Source [SID1234561200]).

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To access the live and subsequently archived webcast, go to the Investor Relations section of the company’s website at www.rigel.com. Please connect to Rigel’s website several minutes prior to the start of the live webcast to ensure adequate time for any software download that may be necessary.

Kangpu to Present Two Posters at the 2020 American Association for Cancer Research (AACR) Annual Meeting

On June 17, 2020 Kangpu Biopharmaceuticals, a clinical-stage company focused on the discovery and development of next-generation of immunomodulatory small molecules for the treatments of solid tumors, hematological malignancies, auto-immune diseases as well as inflammatory disorders, reported that two posters highlighting preclinical data of the company’s lead drug candidates, KPG-121 and KPG-818, will be presented at the 2020 American Association for Cancer Research (AACR) (Free AACR Whitepaper) Virtual Annual Meeting II to be held from June 22-24, 2020 (Press release, Kangpu Biopharmaceuticals, JUN 17, 2020, View Source [SID1234561199]).

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Details of the e-poster presentations on June 22-24 are as follows:

Abstract Title: KPG-121, A Novel Cereblon Modulator, Potently Inhibits Growth of Metastatic Castration Resistant Prostate Cancer in Combination with Androgen Receptor Inhibitors Both In Vitro and In Vivo
Abstract Number: 5300
Poster Number: 5327
Poster Session: Novel Antitumor Agents 2

KPG-121 is a novel modulator of the Cerebron (CRBN) E3 ubiquitin ligase complex CRL4CRBN targeting rapid ubiquitination and degradation of casein kinase 1A1 (CK1α) and transcription factors Aiolos and Ikaros. KPG-121 promotes anti-proliferation and anti-angiogenesis activities and enhances immunomodulatory properties. KPG-121 significantly improves anti-tumor efficacies when combined with androgen-receptor antagonists including Enzalutamide, Abiraterone Acetate, Apalutamide, or Darolutamide in xenograft models when compared to the androgen-receptor antagonist therapy alone. KPG-121 is currently being evaluated in a Phase I study in the US for the treatment of patients with metastatic and non-metastatic castration-resistant prostate cancer in combination with Enzalutamide, Abiraterone Acetate, or Apalutamide (NCT03569280 at www.clinicaltrials.gov).

Abstract Title: KPG-818, A Novel Cereblon Modulator, Inhibits Hematological Malignancies in Preclinical Models
Abstract Number: 5671
Poster Number: 6367
Poster Session: Novel Antitumor Agents 3

KPG-818 represents a novel generation of small molecule modulators of the CRBN E3 ubiquitin ligase complex CRL4CRBN and potently induces the ubiquitination and degradation of Aiolos (IKZF3) and Ikaros (IKZF1), two members of the Ikaros family of zinc-finger transcription factors critical in B-cell development. In preclinical studies, KPG-818 demonstrates outstanding in vitro anti-inflammatory properties and broad spectrum of anti-proliferative activities as well as remarkable in vivo efficacy in animal models of multiple blood cancers. KPG-818 is currently being developed in a Phase I study for the treatment of patients with hematological malignancies in the US (NCT04283097 at www.clinicaltrials.gov).

Abstracts and full session details can be found at www.aacr.org.