On June 12, 2020 AbbVie (NYSE:ABBV) reported that it has been notified that TRC Capital Investment Corporation (TRC Capital) has commenced an unsolicited "mini-tender" offer, dated June 1, 2020, to purchase up to 1,500,000 shares of AbbVie common stock at $88.05 per share (Press release, AbbVie, JUN 12, 2020, View Source [SID1234561068]). The offer price is approximately 4.99 percent below the closing price of the AbbVie common stock on May 29, 2020 ($92.67), the last trading day before the date of the offer. AbbVie is not associated in any way with TRC Capital, its mini-tender offer, or the offer documentation.

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AbbVie does not endorse TRC Capital’s offer. This mini-tender offer is at a price below the closing price for AbbVie’s shares (as of the day prior to the offer) and is subject to numerous conditions. AbbVie recommends that shareholders obtain current quotes for the shares, review terms and conditions, and consult with their broker.

AbbVie shareholders who have already tendered may withdraw their shares by providing the written notice described in the TRC Capital offering documents prior to the expiration of the offer, which is currently scheduled at 12:01 a.m. New York City time on June 30, 2020.

AbbVie encourages brokers, dealers, and other investors to review the SEC’s letter regarding broker-dealer mini-tender offer dissemination and disclosure, which can be found here: View Source

AbbVie requests that a copy of this news release be included with all distribution of materials related to TRC Capital’s offer for shares of AbbVie common stock.

On June 12, 2020 Foundation Medicine, Inc., reported that it has completed the acquisition of Lexent Bio, Inc., a precision oncology company located in California, developing novel multiomics liquid biopsy platforms to advance cancer care (Press release, Foundation Medicine, JUN 12, 2020, View Source [SID1234561067]). This acquisition will accelerate Foundation Medicine’s research and development strategy and expand its existing liquid biopsy platforms to advance cancer care for patients. The technology developed by Lexent Bio complements Foundation Medicine’s existing efforts and partnerships aimed at developing advanced diagnostics for physicians, as well as genomically evaluating disease progression and informing treatment decisions at earlier stages of disease.

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"Lexent Bio’s platforms align well with our liquid biopsy research and development strategy, which ultimately aims to bring the latest research innovations into routine clinical use in metastatic disease and at potentially earlier stages of patient care," said Cindy Perettie, chief executive officer at Foundation Medicine. "They bring with them an accomplished group of clinicians, scientists and engineers who share our patient-centric, science-first mission to transform cancer care. We’re thrilled to welcome them to our team and look forward to their contributions to our research and development efforts to deliver new breakthroughs that advance precision medicine and patient care."

Lexent Bio’s novel monitoring platform is currently in development and is based on low-pass whole genome sequencing (WGS) and DNA methylation analysis. Foundation Medicine plans to further incorporate WGS and methylation into new assay platforms to support treatment decision-making across all stages of disease. Methylation analysis has been shown to reveal important aspects of underlying cancer biology and allows oncologists to identify patients at high risk of disease progression, potentially intervene sooner and improve patient outcomes in earlier stages of disease.1,2 These collective capabilities will enable the expansion of Foundation Medicine’s current tumor-informed personalized cancer monitoring initiatives into universal tumor-agnostic approaches in the future.

This technology adds to Foundation Medicine’s portfolio of tissue and liquid biopsy platforms and will aim to support new approaches for developing targeted therapies, from discovery research through clinical development. With this acquisition and the integration of Lexent Bio’s monitoring platform, Foundation Medicine will expand its capabilities to support adaptive clinical trial designs and accelerate therapeutic development in both early and late stage disease, ultimately bringing new options to oncologists and patients.

"Our team is passionate about changing the way we understand and treat cancer. We’ve spent years building a platform that, once developed and available, will help guide oncologists to identify patients at higher risk for disease progression, and to make better treatment decisions earlier in patient care," said Ken Nesmith, co-founder of and chief executive officer at Lexent Bio. "The team is pleased to join Foundation Medicine and work collaboratively to bring these capabilities to physicians and their patients."

On June 12, 2020 NOXXON Pharma N.V. (Paris:ALNOX), a biotechnology company focused on improving cancer treatments by targeting the tumor microenvironment (TME), reported that it has issued the third and fourth tranche of Convertible Bonds under the financing agreement published on April 23, 2020 (Press release, NOXXON, JUN 12, 2020, View Source [SID1234561066]).

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The investor, Atlas Special Opportunities, LLC, has received 967 Convertible Bonds (including 17 Convertible Bonds issued in relation to the transaction fee) with a nominal value of €1,000 each.

NOXXON maintains an updated summary table of issued convertible bonds in the Investors’ section of its website.

The characteristics, terms, conditions and dilutive potential of the financing may be found in the Annex to the press release published on April 23, 2020 available on the company’s website.

On June 12, 2020 Creatv Microtech, a privately-held biotechnology company reported that it has pioneered a blood test to predict treatment response in patients with stage II-III NSCLC treated with chemoradiation therapy (CRT) and consolidated immunotherapy (Press release, CREATV MICROTECH, JUN 12, 2020, View Source [SID1234561065]). Clinical data presented at the ASCO (Free ASCO Whitepaper) 2020 virtual annual meeting shows the ability to predict which NSCLC patients will benefit from anti-PD-L1/PD-1 immunotherapies . "We are delighted to present a method to stratify patients responding to immunotherapy by a single tube of blood collected after completion of CRT," said Dr. Cha-Mei Tang, CEO of Creatv. "Early identification of patients that do not respond to immunotherapy will reduce unnecessary patient suffering from ineffective and costly treatment, allowing patients to proceed to alternative therapies." Currently, no other blood test can predict immunotherapy treatment response for lung cancer.

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Creatv’s poster, Sequential Monitoring of Circulating Stromal Cells from Blood is Predictive of Progression in NSCLC patients undergoing anti-PD-L1 Therapy after Definitive Chemoradiation Therapy, Abstract ID: 3051, highlights the performance of the LifeTracDxTM test. In a completely novel concept, the test analyzes patients’ immune response to the presence of cancer, isolating stromal cells from cancer sites that have migrated into the blood stream. Creatv demonstrated that a particular subtype of circulating stromal cell, named Cancer Associated Macrophage-Like cells (CAMLs), can be used in patients with cancer to rapidly track response to new therapies. CAMLs are phagocytic myeloid cells derived from the patient’s immunological response to inflammation caused by active malignancy.

We have previously shown that in solid tumors, patients with CAMLs larger than 50µm in size have poorer prognosis, with shorter progression free survival (PFS) and overall survival (OS). In this poster, Creatv presents the findings from a two-year single blind prospective study of 104 NSCLC patients with Stage II-III or with locally recurrent disease treated with standard CRT, followed by anti-PD-L1 or PD-1 therapies (i.e. durvalumab, pembrolizumab, etc.). Blood draws were taken at baseline, directly after CRT completion and after approximately 2.5 months of anti-PD-L1/PD-1 therapy. The LifeTracDxTM tests at both time points were able to predict good PFS and OS by identifying patients responding well to the immunotherapy based on CAML size.

The poster is available here.

About LifeTracDxTM Blood Test

Creatv’s liquid biopsy assays (LifeTracDxTM) are commercialized Research Use Only tests designed for analysis of CAMLs and Circulating Tumor Cells (CTCs). LifeTracDxTM tests are applicable for cancer screening, companion diagnostics, prediction of treatment response including immunotherapy, prognosis, purified tumor DNA for sequencing, minimal residual disease, and early detection of cancer recurrence. LifeTracDxTM tests are currently being implemented in more than 20 clinical trials, from basic research to drug development. Creatv’s publications have shown that LifeTracDxTM can be used in multiple solid tumor cancers as an early predictor of patient response to therapy.

On June 12, 2020 Gamida Cell Ltd. (Nasdaq: GMDA), an advanced cell therapy company committed to cures for blood cancers and serious blood diseases, reported that Julian Adams, Ph.D., the company’s chief executive officer, will participate in a fireside chat at the JMP Securities Virtual Hematology and Oncology Forum on Thursday, June 18, 2020 at 2:00 p.m. ET (Press release, Gamida Cell, JUN 12, 2020, View Source [SID1234561064]).

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A live webcast of the presentation will be available on the Investors section of the Gamida Cell website, www.gamida-cell.com, and will be available for approximately 14 days following the event.