On August 19, 2020 Maverick Therapeutics, Inc., a private biopharmaceutical company pioneering conditionally active bispecific T cell targeted immunotherapies, reported the presentation of preclinical data from its lead COBRA programs, MVC-101 and MVC-280, at the 2nd Annual Cell Engager Summit taking place virtually from August 18 to August 20, 2020 (Press release, Maverick Therapeutics, AUG 19, 2020, View Source [SID1234563878]).
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Chad May Ph.D., Senior Vice President, Research & Development, Maverick Therapeutics, will reveal new preclinical data characterizing the conditional and potent activity of its second program candidate, MVC-280, a COBRA that targets B7H3, during a presentation titled "Protease Dependent COBRATM Activity Regresses Established Tumors in Mice." The preclinical data demonstrate that MVC-280 regresses established solid tumors in mice and increases tolerability relative to inherently active T cell engagers. Dr. May is also scheduled to participate in a panel discussion on the opportunities within the tumor microenvironment to widen the therapeutic index.
"The preclinical data from MVC-280 are extremely encouraging and highlight the therapeutic potential for COBRAs to pursue more broadly expressed and validated targets," said Chad May, Ph.D., Senior Vice President, Research & Development, Maverick Therapeutics. "The binding kinetics of the MVC-280 COBRA also gave us a unique opportunity to assess tolerability and efficacy within the same in vivo model and enabled the calculation of a therapeutic index, which we consider to be 30 to 100x greater than that of an inherently active T cell engager."
Highlights of the presentation include:
MVC-101 regressed established solid tumors expressing EGFR in mice
MVC-280 regressed established solid tumors expressing B7H3 in mice
Half-life extended COBRAs are cleared more rapidly after proteolytic activation
Regression of established solid tumors is dependent on tumor mediated linker cleavage and COBRA activation
The COBRA design increases the therapeutic window
Presentation Schedule
Panel Discussion:
Title: Exploiting the High Protease Concentration in the Tumor Microenvironment to Reduce Toxicity
Date & Time: Wednesday, August 19, 2020 at 11:30AM ET
Presentation:
Title: Protease Dependent COBRA Activity Regresses Established Tumors in Mice
Session: Analyzing Tumor Target Selection to Maximize Efficacy Whilst Minimizing Toxicity
Date & Time: Thursday, August 20, 2020 at 9:30AM ET
About the COBRA Platform
Maverick Therapeutics’ COBRA platform is the most mature conditionally active bispecific T cell engaging platform designed to safely target a broad range of solid tumors with highly specific and potent activity while limiting on-target toxicities in normal tissues. By nature of its highly innovative design, the COBRA platform reflects a novel approach to T cell engaging immunotherapies where T cell activation and resulting cell killing only take place where it is needed – in tumors. This unique design delivers the long sought trifecta in cancer care; high specificity, high potency and reduced toxicity.
About MVC-101
Maverick Therapeutics’ lead program candidate, MVC-101, is a proprietary COBRA molecule designed to target the Epidermal Growth Factor Receptor (EGFR), a protein expressed on both malignant and healthy tissues. MVC-101 regressed established human tumors in several preclinical models. Exposures of MVC-101 at efficacious relative to tolerated doses in safety studies demonstrates an increased therapeutic index compared to standard T cell engagers. MVC-101 is designed to be a universal solution for patients with EGFR expressing solid tumor cancers. EGFR is expressed on a wide range of solid tumor cancers, including but not limited to colorectal, head & neck, renal, pancreatic, cervical and non-small cell lung cancers. Maverick expects to initiate a Phase 1/2, Open Label, Dose Escalation Study of MVC-101 in Q1 2021.
About MVC-280
Maverick Therapeutics’ second program candidate, MVC-280, is a proprietary COBRA molecule designed to target B7H3 (CD276). B7H3 is expressed in a broad range of malignant and healthy tissues, similar to EGFR. MVC-280 regressed established tumors in several preclinical models. It is cross-reactive to its target protein expressed on mouse tissues, creating an opportunity to measure both efficacy and relative safety in the same preclinical model and use that data to calculate a therapeutic index. MVC-280 is designed to be a universal solution for patients with B7H3 expressing solid tumor cancers. B7H3 is expressed on a wide range of solid tumor cancers, including but not limited to prostate, renal, triple negative breast, head & neck, ovarian and urothelial cancers. Maverick expects to initiate a Phase 1/2, Open Label, Dose Escalation Study of MVC-280 in H2 2021.