MilliporeSigma Announces $65 Million Antibody-Drug Conjugate Manufacturing Expansion

On September 9, 2020 MilliporeSigma reported a $65 million expansion of its HPAPI and ADC manufacturing capabilities and capacity at its facility near Madison, Wisconsin (Press release, MilliporeSigma, SEP 9, 2020, View Source [SID1234564898]). This investment will allow large-scale manufacturing of increasingly potent compounds that have the potential to treat cancer. Completion is expected by mid-2022 and should add approximately 50 full-time jobs starting in 2021.

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MilliporeSigma is expanding its ADC manufacturing capabilities. ADCs are an emerging class of medicines designed for high-specificity targeting and destruction of cancer cells, while preserving healthy ones.
"ADCs have posted incredible growth over the last decade and regulatory agencies’ approval in recent years demonstrate their promise as a targeted therapy," said Andrew Bulpin, head of Process Solutions at MilliporeSigma. "With more than 35 years of experience in this space, we have been a frontrunner in the development and manufacturing of biologics, conjugation processes and small molecules. This investment underscores our commitment to working with innovators to bring new treatments to patients quickly and more efficiently."

MilliporeSigma’s new 70,000-square-foot commercial building will be one of the largest dedicated HPAPI manufacturing facilities specifically designed to handle single-digit nanogram occupational exposure limit materials. The facility will incorporate containment areas to produce next-generation linker and payload materials for ADCs. The project is an addition to the company’s Madison campus, which was the first commercial ADC facility in North America designed to handle highly active materials. It will join MilliporeSigma’s established campus in St. Louis, Missouri, which specializes in ADC bio-conjugation, active pharmaceutical ingredients, excipient and adjuvants manufacturing.

ADCs are an emerging class of medicines designed for high-specificity targeting and destruction of cancer cells, while preserving healthy cells. There are now only nine ADCs approved globally. However, the ADC industry is delivering strong growth and is expected to reach $15 billion by 20301.

While ADCs can provide many benefits compared with other therapeutic options, they also present a unique set of challenges. Their development is complex, necessitating stringent containment infrastructure, and their structural exceptionality requires expertise in a number of different technologies for small and large molecules, as well as analytical capabilities. Due to these challenges, more than 70 percent of ADC projects are outsourced to contract development and manufacturing organizations2.

With more than 35 years of experience in the development and manufacturing of small molecules, biologics and ADC technologies, MilliporeSigma offers extensive experience in both clinical and commercial manufacturing. The company’s comprehensive service portfolio combines the steps of drug development and production — from pre-clinical to commercial — from a single source. This consolidation helps reduce risk and streamlines the process of getting therapies to patients faster.

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Aethlon Medical to Present at the H.C. Wainwright 22nd Annual Global Investment Conference

On September 9, 2020 Aethlon Medical, Inc. (Nasdaq: AEMD), a medical device technology company focused on developing products to diagnose and treat life and organ threatening diseases, reported that Timothy C. Rodell, M.D., Chief Executive Officer, is scheduled to provide an overview of the Company on Monday, Sept. 14, at 2:00 p.m. EDT (Press release, Aethlon Medical, SEP 9, 2020, https://www.prnewswire.com/news-releases/aethlon-medical-to-present-at-the-hc-wainwright-22nd-annual-global-investment-conference-301124812.html [SID1234564896])

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Replays of the presentation will be aired live and available for 90 days. The reply can be accessed at View Source and the investor relations section of Aethlon Medical’s website at www.aethlonmedical.com.

Biocept to Present at the H.C. Wainwright Global Investment Virtual Conference on September 14

On September 9, 2020 Biocept, Inc. (Nasdaq: BIOC), a leading commercial provider of molecular diagnostics designed to provide physicians with clinically actionable information to improve the patient outcomes, reported that President and CEO Michael Nall will present at the H.C. Wainwright 22nd Annual Global Investment Conference on Monday, September 14, 2020 at 3:30 p.m. Eastern time (12:30 p.m. Pacific time) (Press release, Biocept, SEP 9, 2020, View Source [SID1234564894]).

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The live presentation can be accessed here and will be archived on the Investor Relations section of the Biocept website.

Viracta Therapeutics to Present at the H.C. Wainwright 22nd Annual Global Investment Conference

On September 9, 2020 Viracta Therapeutics, Inc. (the "Company"), a precision oncology company targeting virus-associated malignancies, reported that Ivor Royston, MD, President and Chief Executive Officer of Viracta, will present a corporate overview at the H.C. Wainwright 22nd Annual Global Investment Conference on Tuesday, September 15, 2020 at 3:00 pm ET (Press release, Viracta Therapeutics, SEP 9, 2020, https://www.prnewswire.com/news-releases/viracta-therapeutics-to-present-at-the-hc-wainwright-22nd-annual-global-investment-conference-301125916.html [SID1234564892]).

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Arcadia Biosciences (RKDA) to Present at H.C. Wainwright’s 22nd Annual Global Investment Conference September 14-16, 2020

On September 9, 2020 Arcadia Biosciences, Inc. (Nasdaq: RKDA), a leader in science-based approaches to enhancing the quality and nutritional value of crops and food ingredients, reported that it will be featured as a presenting company at the 22nd Annual Global Investment Conference sponsored by H.C Wainwright (Press release, Arcadia Biosciences, SEP 9, 2020, https://www.prnewswire.com/news-releases/arcadia-biosciences-rkda-to-present-at-hc-wainwrights-22nd-annual-global-investment-conference-september-14-16-2020-301126240.html [SID1234564890]). The conference is being held virtually on September 14-16, 2020.

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Matthew Plavan, Arcadia’s president and CEO will present a business overview at 2:00 p.m. EDT on Wednesday, September 16, 2020 and will be available for one-on-one web meetings with investors. Institutional investors may request a meeting by registering for the conference at www.hccwevents.com.

The presentation will be webcast live here, and a replay will be available in the Investors section of the company’s website.