Selecta Biosciences Secures Up To $35 Million Debt Financing with Oxford Finance LLC and Silicon Valley Bank

On September 1, 2020 Selecta Biosciences, Inc. (NASDAQ: SELB), a clinical-stage biotechnology company focused on unlocking the full potential of biologic therapies based on its immune tolerance platform, ImmTORTM, reported that it has entered into a debt financing facility for up to $35 million with Oxford Finance and Silicon Valley Bank (SVB) (Press release, Selecta Biosciences, SEP 1, 2020, View Source [SID1234564219]). Proceeds from the financing will be used to retire $12.6 million of existing debt, advance Selecta’s ImmTOR pipeline in gene therapy and autoimmune diseases, and for selected business development activities.

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"This partnership with Oxford Finance and SVB bolsters our financial position and extends our cash runway as we look to accelerate the development of our ImmTOR pipeline in gene therapy and autoimmune diseases," said Brad Dahms, Chief Financial Officer of Selecta. "We are pleased to continue our relationship with SVB and are excited to partner with Oxford Finance on this facility at such an important time for Selecta."

"We are thrilled to support Selecta’s efforts to continue development of its ImmTOR platform," said Christopher A. Herr, Senior Managing Director at Oxford Finance. "The potential for ImmTOR in gene therapy and autoimmune diseases align with our strategy of funding innovative life sciences companies".

"Selecta is driving important advancements in biologic therapies through its ImmTOR platform," said Ryan Roller, Director of Life Science and Healthcare at Silicon Valley Bank. "We are pleased to expand our relationship with the Selecta team and have the opportunity to support the Company’s next phase of growth."

Under the terms of the financing agreement, Oxford Finance and Silicon Valley Bank will provide Selecta with up to $35 million of borrowing capacity available in two tranches: $25 million at closing, and an additional $10 million available through September 30, 2021 upon the achievement of two development milestones: enrollment of the first patient in the Phase 1 clinical trial of Selecta’s gene therapy program in methylmalonic acidemia, and the enrollment of the first patient in each of the two Phase 3 clinical trials of SEL-212 in chronic refractory gout. The facility will require Selecta to make only interest payments through at least April 1, 2022. If the development milestones are met, the interest-only period will be extended to October 1, 2022. The entire facility matures on August 1, 2025. There are no financial covenants in the agreement.

Incyte to Present at Upcoming Investor Conference

On September 1, 2020 Incyte (Nasdaq:INCY) reported that it will present at the Morgan Stanley 18th Annual Global Healthcare (Virtual) Conference on Wednesday, September 16, 2020 at 9:30 a.m. EDT (Press release, Incyte, SEP 1, 2020, View Source [SID1234564218]).

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The presentation will be webcast live and can be accessed at Investor.Incyte.com and will be available for replay for 30 days.

Invitae to Participate in the Morgan Stanley Virtual Global Healthcare Conference

On September 1, 2020 Invitae Corporation (NYSE: NVTA), a leading medical genetics company, reported that members of its management team will virtually participate in a fireside chat at the 18th Annual Morgan Stanley Global Healthcare Conference on Monday, September 14, 2020 at 4:30 p.m. Eastern / 1:30 p.m. Pacific (Press release, Invitae, SEP 1, 2020, View Source [SID1234564217]).

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Invitae’s (NVTA) mission is to bring comprehensive genetic information into mainstream medical practice to improve the quality of healthcare for billions of people. www.invitae.com (PRNewsFoto/Invitae Corporation)

The live webcast of the fireside chat may be accessed by visiting the investors section of the company’s website at ir.invitae.com. A replay of the webcast will be available shortly after the conclusion of the fireside chat.

Invitation to presentation of Oasmia’s Q1 report 2020/2021 on September 9, 2020

On September 1, 2020 Oasmia Pharmaceutical reported that it will publish its Q1 report on September 9, 2020, at 08.00 am CEST (Press release, Oasmia, SEP 1, 2020, View Source [SID1234564215]).

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The company will hold a conference call and an online presentation on the same day at 10.00 am CET. The call will be hosted by Francois Martelet, CEO, and Michael af Winklerfelt, CFO. The presentation will be in English.

DCprime and PCI Biotech Announce a Research Collaboration to Explore Novel Cancer Vaccination Concepts

On September 1, 2020 DCprime, the front-runner in the field of relapse vaccines, and PCI Biotech (OSE: PCIB), a cancer focused biopharmaceutical company with a unique intracellular delivery technology via PhotoChemical Internalisation, reported an extensive research collaboration (Press release, DCPrime, SEP 1, 2020, View Source [SID1234564214]). Within the collaboration, DCprime and PCI Biotech will combine their know-how and technology platforms to pursue the development of novel cancer vaccination concepts based on tumor-independent antigens (TIAs). The collaboration builds on preclinical proof-of-concept results previously presented by DCprime at the 34th Annual Meeting of the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) in November 2019 and on PCI Biotech fimaVacc and fimaNAc technologies.

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The partnership is governed by a research collaboration agreement, under which the collaborators will perform an extensive evaluation of technology compatibility and synergy based on preclinical studies. The companies will evaluate results achieved from this research collaboration and then explore the potential for further development and partnership.

"We continue to innovate the cancer vaccine space and look forward to working closely with PCI Biotech on a ground-breaking off-the shelf vaccination concept for solid tumors addressing the huge need for novel antigen targets in oncology," said Erik Manting, CEO of DCprime. " Having access to PCI Biotech’s intracellular antigen delivery platforms and expertise will accelerate the development of therapeutic approaches based on the unique and novel principle we developed using tumor-independent antigens. This complements DCprime’s existing pipeline of relapse vaccines progressing through clinical trials in haematological malignancies."

"We are very pleased to collaborate with DCprime. This collaboration could reinforce the fimaVacc positive results obtained during a phase I study presented at the European Society for Medical Oncology (ESMO) (Free ESMO Whitepaper) Immuno-Oncology Congress 2019, and the preclinical promising results obtained with fimaNAc, the PCI-mediated intracellular delivery of various types of "naked" mRNA molecules. Combining the complementary technologies of DCprime and PCI Biotech could lead to entirely new therapeutic clinical applications," commented Per Walday, CEO of PCI Biotech.