On October 5, 2020 OncoHost, a global leader in host response profiling for improved personalized cancer therapy, reported that Professor Yuval Shaked, co-founder and Chief Scientific Advisor at OncoHost, and Professor of Cell Biology and Cancer Science at the Technion – Israel Institute of Technology, will deliver a presentation titled A Proteomics-Based Platform for Predicting Response to Immunotherapy and Personalizing Treatment Plans at the MAP 2020 Virtual Congress – ESMO (Free ESMO Whitepaper) this Friday, October 9th at 17:20 PM CEST (Press release, OncoHost, OCT 5, 2020, View Source;esmo-301145545.html [SID1234568128]).

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The presentation will show how through the analysis of host response profiles (i.e. the patient’s reaction), oncologists may be able to harness this information to better predict clinical outcomes and suggest the ideal combination treatment with immunotherapy.

"Despite major clinical success, immunotherapy treatments have demonstrated efficacy in only a small proportion of patients with non-small cell lung cancer (NSCLC)," said Prof. Yuval Shaked. "OncoHost’s studies have indicated that individual host response to anti-cancer treatment can generate pro-tumorigenic activities and support tumor re-growth and spread. It is therefore vital to analyze and earlier predict host response to treatment in order to improve outcomes and reduce unnecessary side effects experienced by so many patients."

Using machine learning (ML)-based analysis and algorithms to identify highly predictive cohort-based proteomic signatures in patients, personalized response prediction can be used to improve precision medicine in oncology. Personalized treatment plans can then be created through information based on cohort-based statistical analysis, personalized adaption and finally, translation to clinically relevant targets.

Prof. Shaked’s presentation will include a real-life case study on whom a Host Response profile analysis was performed, and will be followed by a live Q&A.

MAP is the leading congress in precision medicine in oncology in Europe, established by key opinion leaders in the field. The name of the Congress was recently changed into Molecular Analysis for Precision Oncology to better reflect its aims of focusing on science, translational research, education and collaboration. This year’s event will be held virtually on October 9-10.

On October 5, 2020 CARISMA Therapeutics Inc., a biopharmaceutical company focused on discovering and developing innovative immunotherapies, reported that the company will present at two virtual investor conferences in October 2020 (Press release, Carisma Therapeutics, OCT 5, 2020, View Source [SID1234568127]).

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Chardan 4th Annual Genetic Medicines Conference
Tuesday, October 6, 2020 at 11:00 am EST
7th Solebury Trout Private Company Showcase Co-Hosted by BMO and Davis Polk
Thursday, October 15, 2020 at 10:40 am EST

On October 5, 2020 Northwest Biotherapeutics (OTCQB: NWBO) ("NW Bio"), a biotechnology company developing DCVax personalized immune therapies for solid tumor cancers, reported that the database for the Phase III trial of DCVax-L for Gliobastoma has been locked (Press release, Northwest Biotherapeutics, OCT 5, 2020, View Source [SID1234568126]).

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With the database now locked, the independent service firms managing the Clinical Trial are arranging for the independent statisticians to have access to the unblinded raw data from the Trial. Neither the Company nor any party other than the independent statisticians will have access to any unblinded data at this stage.

The statisticians will proceed as quickly as possible with analyses of the raw data and prepare summaries of the Trial results for review by the Company, the Principal Investigator, the Steering Committee of the Trial, the Scientific Advisory Board, and a panel of independent brain cancer experts, who will analyze the data with the statisticians in preparation for public announcement and scientific publication.

"We are excited to be so close to the finish line now, after such a long road" commented Linda Powers, the Company’s CEO. "We are hopeful that DCVax-L can become an important new treatment option for patients who urgently need more and better treatments for Glioblastoma brain cancer."

"We are grateful to the independent service firms and the clinical trial sites who have worked so hard to complete the data collection and confirmation during many months of COVID restrictions and challenges," Ms. Powers continued. "We are also very grateful to our shareholders for their patience and support, which has made all this possible."

On October 5, 2020 Applied BioMath (www.appliedbiomath.com), the industry-leader in applying systems pharmacology and mechanistic modeling, simulation, and analysis to de-risk drug research and development, reported a two-year strategic partnership with Xilio Therapeutics (Press release, Applied BioMath, OCT 5, 2020, View Source [SID1234568125]). Applied BioMath will provide a variety of services related to mathematical modeling, simulation, analysis, and visualization, which include systems pharmacology, quantitative systems pharmacology, experiment prioritization and design, and traditional and mechanistic pharmacokinetic (PK) / pharmacodynamic (PD) modeling, in support of Xilio’s preclinical and clinical drug development projects. "We are thrilled to announce this next phase of our partnership with Xilio Therapeutics," said John Burke, PhD, Co-Founder, President, and CEO of Applied BioMath. "We really enjoy being part of the project teams, working on exciting projects and science, and helping to better inform decisions. We take pride in partnerships such as these as they are evidence that our prior collaborations with our partners provided high value."

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Applied BioMath employs a rigorous fit-for-purpose model development process which quantitatively integrates knowledge about therapeutics with an understanding of its mechanism of action in the context of human disease mechanisms. Applied BioMath’s approach employs proprietary algorithms and software that were designed specifically for systems pharmacology model development, simulation, and analysis. "Our previous collaborations with Applied BioMath informed the advancement of our preclinical candidates," said Jennifer O’Neil, PhD, Vice President, Translational Oncology at Xilio Therapeutics. "We look forward to continuing to work closely with Applied BioMath and incorporate their approach into more of our projects."

On October 5, 2020 IDEXX Laboratories, Inc. (NASDAQ: IDXX), a global leader in veterinary diagnostics, veterinary practice software and water microbiology testing, reported that it has scheduled the release of its 2020 third quarter financial results for Thursday, October 29, 2020 before the market opens (Press release, IDEXX Laboratories, OCT 5, 2020, View Source [SID1234568124]). The Company will conduct an analyst conference call beginning at 8:30 a.m. ET on that day.

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Individuals can access a live webcast of the conference call through a link on the IDEXX website, www.idexx.com/investors. An archived edition of the webcast will be available after 1:00 p.m. ET on that day via the same link and will remain available for one year.

The live call also will be accessible by telephone. To listen to the live conference call, please dial 1-888-771-4371 or 1-847-585-4405 and reference confirmation number 49967945.