On October 26, 2020 Vaccinex, Inc. (Nasdaq: VCNX), a clinical-stage biotechnology company pioneering a differentiated approach to treating cancer and neurodegenerative disease through the inhibition of SEMA4D, reported that members of management will participate in the Virtual Investor KOL Roundtable on Tuesday, October 27, 2020 at 10:00 AM ET (Press release, Vaccinex, OCT 26, 2020, View Source [SID1234569968]).

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Participating in the KOL Roundtable discussion will be Maurice Zauderer, Ph.D., President and Chief Executive Officer of Vaccinex and Eric Siemers, MD, President, Siemers Integrations LLC and Former Distinguished Medical Fellow for Eli Lilly and Company’s Alzheimer’s Disease Global Development Team. Drs Zauderer and Siemers will discuss how the results of the completed SIGNAL phase 2 study in Huntington’s disease may inform further studies in both Huntington’s and Alzheimer’s disease and Dr. Zauderer will review Vaccinex’s program to test the combination of its pepinemab anti-SEMA4D antibody with Keytruda to treat Head & Neck Cancer.

A live video webcast of the KOL roundtable discussion will be available on the Events page of the Investors section of the Company’s website (www.vaccinex.com). A webcast replay will be available two hours following the live presentation.

In addition to the KOL roundtable discussion, members of the management team will be available for one-on-one meetings with qualified members of the investment community. To schedule a one-on-one call with management, please submit a request through the conference website virtualinvestorco.com, or contact the conference at [email protected]. For more information about the event, please visit virtualinvestorco.com.

On October 26, 2020 Theralase Technologies Inc. ("Theralase" or the "Company")(TSXV: TLT) (OTCQB: TLTFF), a clinical stage pharmaceutical company dedicated to the research and development of light activated Photo Dynamic Compounds ("PDC") and associated drug formulations reported that it has released the Company Quarterly Newsletter (Press release, Theralase, OCT 26, 2020, View Source [SID1234569761]).

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The Newsletter provides updates on the previous quarter and progress on the Phase II Non-Muscle Invasive Bladder Cancer ("NMIBC") Clinical Study.

The Newsletter can be found on the Company’s website www.theralase.com/quarterly-newsletters/.

On October 26, 2020 RhoVac AB ("RhoVac") reported that the publication of the article on RhoVac’s Phase I/II study is set to be published in November (Press release, RhoVac, OCT 26, 2020, View Source [SID1234569083]).

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As previously disclosed, the article elaborating on the results of RhoVac’s Phase I/II study in prostate cancer including the 12-month follow-up period, has been accepted for publication in the Journal for ImmunoTherapy of Cancer (JITC). The publication now indicates that the release of the article will take place in November, a few weeks later than previously suggested. The article will feature an elaboration on the mode of action of RV001, but also a discussion on the PSA data findings indicating possibilities of delaying disease progression, for which RhoVac’s currently ongoing phase IIb study is aimed at providing substantial evidence.

RhoVac’s CEO, Anders Månsson, comments: "Despite the minor delay, I am very happy about the confirmation on the publication of this article. We have waited for this publication a long time, and now and I am excited to address its findings with our potential partners."

This disclosure contains information that RhoVac is obliged to make public pursuant to the EU Market Abuse Regulation (EU nr 596/2014). The information was submitted for publication, through the agency of the contact person, on 26-10-2020 08:30 CET.

On October 26, 2020 RhoVac AB ("RhoVac") reported that it is participating this week in the partnering event BIO Europe 2020 Digital (Press release, RhoVac, OCT 26, 2020, View Source [SID1234569082]).

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This week the digital version of the massive pharmaceutical partnering conference BIO Europe is held with participation from RhoVac. The program features plenum sessions on contemporary common interest topics in the industry, but the emphasis is on partnering.

RhoVac’s CEO, Anders Månsson, comments: "RhoVac certainly maintains a regular dialogue with its potential partners also outside of digital congresses, but digital conferences like BIO Europe obviously provides us with an opportunity to `mass market’ our company and the RV001, and there is certainly a great interest out there."

On October 26, 2020 NBE-Therapeutics, a Swiss-based company developing best-in-class cancer therapies based on its proprietary, highly differentiated Antibody-Drug Conjugate (ADC) platform, reported that it has commenced first-in-human studies of its lead program NBE-002 targeting ROR1, for triple negative breast cancer (TNBC) and other solid tumors (Press release, NBE Therapeutics, OCT 26, 2020, View Source [SID1234569081]).

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This phase 1/2, open label study will evaluate the recommended dose for further clinical development, safety, tolerability, anti-tumor activity, immunogenicity, pharmacokinetics and pharmacodynamics of NBE-002, a novel anti-ROR1 antibody-drug conjugate, in patients with advanced solid tumors. Initial results from the study are expected in 2021.

The clinical study (NCT04441099) is being led by globally renowned investigators in the fields of oncology and antibody-drug conjugates, including: Anthony W Tolcher, MD from NEXT Oncology, San Antonio, Texas; Funda Meric-Bernstam, MD from The University of Texas MD Anderson Cancer Center, Houston, Texas; and Meredith McKean, MD from Sarah Cannon Research Institute – TN Oncology, Nashville, Tennessee.

NBE-Therapeutics’ best-in-class iADC platform creates highly potent, safe and immune-stimulatory ADCs with a novel anthracycline payload, which have been shown to induce a long-lasting anti-tumor immunity in pre-clinical models of solid tumors. Lead candidate NBE-002 has shown a remarkable therapeutic index (a measure of extremely high safety and tolerability) during non-clinical development.

Bertrand Damour, CEO of NBE-Therapeutics, said: "The first patient was enrolled in July 2020 and we are already at the third dose level. l am very pleased that the trial is progressing so well. Our goal is to develop best-in-class oncology treatments to increase survival, with the potential to cure solid tumors and to improve quality of life for cancer patients worldwide. The start of this trial represents an important milestone for NBE-Therapeutics to clinically demonstrate that our ADC platform has a highly favorable safety profile alongside significant efficacy in multiple pipeline programs. We look forward to continued progress with our ADCs in advanced solid tumors."

Dr. Ulf Grawunder, Founder, COO & CDO of NBE-Therapeutics, said: "We consider NBE-002 the best-in-class ROR1 targeting ADC in development, and are excited it has entered the clinic. In pre-clinical, solid tumor studies NBE’s novel iADC platform has shown unparalleled safety and efficacy, together with induction of anti-tumor immune memory. This immune-oncology function also prevented tumor re-growth upon tumor re-challenge, after complete regression had been achieved in preclinical tumor models. If this dual function translates into clinical benefit, NBE’s iADC platform could transform cancer medicine."

To read more: Clinicaltrials.gov NCT number: NCT04441099

About ROR1

ROR1 is receptor tyrosine kinase-like orphan receptor 1. It is a cell-surface protein that is expressed during embryofetal development but disappears before birth and is usually not expressed on normal cells in children or adults. ROR1 can, however, reappear on malignant tissues and may be expressed across a broad variety of cancer types including solid tumors. By addressing ROR1 cancer-fighting therapeutics can be selectively targeted to tumor cells, while sparing normal cells.