On November 4, 2020 SOFIE Biosciences, Inc. ("SOFIE"), an established radiopharmaceutical supplier and worldwide radiopharmaceutical contract manufacturing organization, and Jubilant Radiopharma, a business division of Jubilant Pharma Limited, reported that both the organizations have entered into a strategic partnership (Press release, Jubilant Radiopharma, NOV 4, 2020, View Source;therapeutics-301165832.html [SID1234569908]). Under the terms of the partnership, Jubilant Pharma, via one of its wholly owned subsidiaries, with 25% of equity holding shall be a strategic partner to SOFIE, enabling SOFIE to continue to grow production capacity, advance its theranostic pipeline, and support novel PET diagnostic manufacturing and distribution within the U.S.

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"SOFIE is a beacon of innovation, and with Jubilant’s deep experience, uncompromised quality and customer-centric operations, we will bring game-changing theranostic solutions to nuclear medicine," stated Sergio Calvo, President of Jubilant’s Radiopharmaceuticals Division.

"With this new relationship, SOFIE achieves another milestone in our innovation strategy," Philipp Czernin, SOFIE’s Chief Revenue Officer, remarked. "By engaging a well-established industry partner such as Jubilant Radiopharma, SOFIE will leverage the combined market presence and astute organizational structure to deliver breakthrough compounds to the nuclear medicine community. With respective distribution capabilities and the highly complementary product portfolio of SPECT and PET radiopharmaceuticals, both companies are well poised to create a single-vendor opportunity in select geographies."

As part of the agreement, Jubilant Radiopharma will invest US $25m into SOFIE Biosciences. This funding will help accelerate the readiness timelines for SOFIE’s state-of-the-art Theranostics Center of Excellence Manufacturing Facility in Totowa, New Jersey, as well as advance the development of their Fibroblast Activation Protein Inhibitor (FAPI) program. Patrick Phelps, SOFIE’s President and Chief Executive Officer stated, "Under this strategic partnership, SOFIE is excited to meet the growing need to manufacture highly specialized radiopharmaceuticals, as well as become the first theranostic production center for FAPI in the US. FAPI has received worldwide acclaim for its value as a key next-generation theranostic agent with the ability to greatly enhance the detection and treatment of a wide variety of oncology diseases, and we believe with Jubilant Radiopharma’s investment and support, we can accelerate the development and commercialization of this exciting family of compounds."

"This agreement is yet another demonstration of Jubilant Radiopharma’s long term commitment to the global Nuclear Medicine community. Our teams are dedicated to bringing to market the next generation of breakthrough products and industry-leading services to healthcare providers across the globe as part of our mission of improving lives through Nuclear Medicine," stated Pramod Yadav, CEO Jubilant Pharma Limited.

On November 4, 2020 Biocept, Inc. (Nasdaq: BIOC), a leading commercial provider of molecular diagnostic tests and services for physicians treating cancer patients, reported that it will release financial results for the three and nine months ended September 30, 2020 after the market closes on Thursday, November 12, 2020 (Press release, Biocept, NOV 4, 2020, View Source [SID1234569907]). The Company will host a conference call for the investment community to discuss the results and answer questions at 4:30 p.m. Eastern time (1:30 p.m. Pacific time).

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We encourage participants to pre-register for the conference call using the following link: View Source Callers who pre-register will be given a conference passcode and unique PIN to gain immediate access to the call and bypass the live operator. Participants may pre-register at any time, including up to and after the call start time.

Those who choose not to pre-register can access the live conference by dialing (855) 656-0927 for domestic callers, (855) 669-9657 for Canadian callers, or (412) 902-4109 for other international callers. Those interested in listening to a webcast of the live conference call may do so by visiting View Source

A replay of the conference call will be available for 48 hours following the conclusion of the call by dialing (877) 344-7529 for domestic callers, (855) 669-9658 for Canadian callers, or (412) 317-0088 for other international callers, and entering the replay access code 10149217. A webcast replay will be available for 90 days at http://ir.biocept.com/events.cfm.

On November 4, 2020 BioMarin Pharmaceutical Inc. (NASDAQ: BMRN) reported that Jean-Jacques Bienaimé, Chairman and Chief Executive Officer, and Brian Mueller, Executive Vice President, Chief Financial Officer, will participate in the Credit Suisse 29th Annual Virtual Healthcare Conference on November 10, 2020 at 12:30pm ET (Press release, BioMarin, NOV 4, 2020, View Source [SID1234569906]). An audio webcast of the presentation will be available live. You can access the webcast at: View Source An archived version of the remarks will also be available through the Company’s website for a limited time following the conference.

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On November 4, 2020 Evogene Ltd. (NASDAQ: EVGN), (TASE: EVGN), a leading computational biology company focused on revolutionizing product discovery and development in multiple life-science based industries, including human health and agriculture, reported that it has closed the previously announced registered direct offering pursuant to which the company entered into a definitive securities purchase agreement with an existing institutional shareholder and certain Israeli institutional investors providing for the issuance of an aggregate of (i) 3.92 million ordinary shares at a purchase price of $2.50 per share, and (ii) 883,534 pre-funded warrants each to purchase one ordinary share ("Pre-Funded Warrants") (Press release, Evogene, NOV 4, 2020, View Source [SID1234569905]). The Pre-Funded Warrants were sold at a price of $2.49 each, with an exercise price of $0.01 per ordinary share. The Pre-Funded Warrants are exercisable at any time after the date of issuance upon payment of the exercise price.

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Cantor Fitzgerald & Co. acted as placement agent in the offering.

The ordinary shares and Pre-Funded Warrants offered in the registered direct offering described above were offered by Evogene pursuant to its shelf registration statement on Form F-3 (File No.333-240249) previously filed and declared effective by the Securities and Exchange Commission (the "SEC") on August 10, 2020. A prospectus supplement and accompanying prospectus relating to the offering have been filed with the SEC and is available on the SEC’s website at View Source

This press release is for informational purposes only and should not be construed as investment advice and does not constitute an offer to sell or the solicitation of an offer to buy these securities, nor will there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

On November 4, 2020 Shuttle Pharmaceuticals, Inc (Shuttle Pharma) a clinical stage, Maryland-based, biopharmaceutical company developing new drugs for cancer treatment in combination with radiation therapy, reported that it was awarded patent number 10,745,352 by the U.S. Patent and Trademark Office (Press release, Shuttle Pharmaceuticals, NOV 4, 2020, View Source [SID1234569904]). These novel compounds enable cancer treatment by the combination of an inhibitory epigenetic mechanism and a stimulatory DNA repair activation process using a single molecule. The patent is the first issued based on Shuttle Pharma’s platform technology linking an ATM activating domain to an HDAC inhibitory domain for cancer treatment and protection of normal tissue. Shuttle Pharma holds the exclusive rights for development of this drug platform.

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Lead inventor Scott Grindrod, PhD describes histone deacetylase (HDAC) inhibitors as a novel class of drugs targeting enzymes involved in regulation of gene expression. HDACs regulate gene expression by changing the conformation of chromatin in cells into a tightly coiled and transcriptionally inactive form. However, acetylated chromatin is more open and supports transcription. Inhibitors of HDAC enzymes can inhibit cell growth, regulate tubulin stability, turn on transcription of tumor suppressor genes, and activate cellular immunity. These are key target functions for cancer treatment.

Ataxia-telangiectasia is a human genetic disease characterized by extreme radiation sensitivity, neurological immune impairment, and premature aging. The mutated gene product (ATM) regulates the responses of cells to DNA damaging agents. In normal cells, ATM protein activation enables efficient repair of radiation damage to protect the genome and promote cell survival.

There are 12 HDAC enzymes with important functions for maintaining health. Clinical applications of pan-HDAC inhibitors have been limited by off target toxicities. Shuttle Pharma has focused its discovery platform technology on HDAC enzyme selectivity. According to Dr. Anatoly Dritschilo, Shuttle Pharma’s CEO, the interest in immunotherapy to treat cancers in combination with other modalities has focused particular attention on HDAC6 selective inhibitors.