On August 6, 2020 ISA reported that it will present at the 6th Solebury Trout Summer 2020 Private Company Showcase, hosted by Piper Sandler and White & Case. You are welcome to tune in (Press release, ISA Pharmaceuticals, AUG 6, 2020, View Source [SID1234565550]).

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Date: Monday, 10 August 2020

Time: 5:00pm CET / 11:00am EDT.

Webcast: View Source

You may access the stream 15 minutes in advance and a replay of the webcast will be available for 60 days.

On August 6, 2020 ImmVira Group Company and Shanghai Pharmaceuticals Holding Co., Ltd reported a clinical collaboration and exclusive license agreement for ImmVira’s MVR-T3011 intratumoral oncolytic virus program for the commercialization of novel immunotherapies to treat solid malignant tumors (Press release, Immvira, AUG 6, 2020, View Source [SID1234563687]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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ImmVira’s MVR-T3011 oncolytic virus program has innovated with a genetically engineered oncolytic herpes simplex virus-1 (oHSV-1) to enhance the known oncolytic effects of oHSV-1. Through gene recombinant technologies, PD-1 antibody and interleukin-12 immune modulators are expressed within the virus. Oncolysis is achieved with additional immune response stimulation while keeping the boosted immune activity limited to the locality of MVR-T3011 to achieve a potentially favorable safety profile. The MVR-T3011 intratumoral program aims to target most solid malignant tumors with both remission rate improvement and safety improvement over immune modulator monotherapies. As part of the agreement, Shanghai Pharma will receive an exclusive license and gain access to ImmVira’s MVR-T3011 virus for clinical development, manufacturing and commercialization within certain fields of use in mainland China, Hong Kong, Macau and Taiwan (the Greater China region). ImmVira and Shanghai Pharma will collaborate on clinical trials in China with exclusive commercial rights for intratumoral therapies developed under the agreement assigned to Shanghai Pharma for the Greater China region. ImmVira retains full development and commercialization rights for regions outside of Greater China.

Under the terms of the agreement, ImmVira will receive from Shanghai Pharma an upfront payment and contingent milestone payments that would in the aggregate amount to RMB1.15 billion, as well as royalty payments of up to 12% of net revenues should Shanghai Pharma successfully commercialize a therapy from the collaboration.

"As we continue to lead in oncolytic virus research and development, we are delighted to collaborate with Shanghai Pharma on our first product pipeline," said Grace Zhou, chairman and chief executive officer of ImmVira. "This partnership represents an exceptional opportunity to leverage Shanghai Pharma’s leadership in immunotherapy research, clinical stage expertise, manufacture and countrywide distribution network. With a strong partner like Shanghai Pharma, we are more confident in the commercial success of MVR-T3011 and achieve our goal in engineering more effective yet safer remedies for cancer patients."

"ImmVira is a leader in providing best-in-class oncolytic virotherapy treatments for patients in need. We are pleased to collaborate with ImmVira and have MVR-T3011 intratumoral program join our market leading commercial pipeline. The MVR-T3011 design is a breakthrough novel approach to cancer treatment over monotherapies," said Zuo Min, Executive Director and President of Shanghai Pharma. "In-line with our dedication to providing innovative, safe and effective drugs against serious and chronic diseases, MVR-T3011 represents a sound scientific approach to cancer treatment. We are confident in its eventual commercial success not only as a first-in-class product but also a best-in-class product."

CTI BioPharma has filed a 10-Q – Quarterly report [Sections 13 or 15(d)] with the U.S. Securities and Exchange Commission .

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On August 6, 2020 WuXi Vaccines, a global leading company with world-class vaccine contract development and manufacturing organization (CDMO) capabilities, reported the appointment of Mr. Jian Dong as Chief Executive Officer (CEO) (Press release, WuXi Biologics, AUG 6, 2020, View Source [SID1234563468]). WuXi Vaccines is a joint venture established between WuXi Biologics and Shanghai-based Hile Bio-Technology.

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"We are delighted to announce Jian’s new appointment. He is a highly regarded leader with over 30 years of bio-pharmaceutical experience, including vaccine production, process development, as well as the design, construction, qualification and operation management of cGMP manufacturing facilities," said Dr. Chris Chen, Chairman of WuXi Vaccines, "We are confident that Jian will lead the company to establish a global high-quality system with outstanding vaccine CDMO capabilities. With a vision to accelerate and transform vaccine development and production, WuXi Vaccines will make substantial contributions to expedite vaccine development and ensure a robust supply chain."

"I am excited for the opportunity to lead WuXi Vaccines. By leveraging our robust capacities and state-of-the-art technologies, the company will further increase its unique presence in the vaccine industry to enable global partners and benefit patients worldwide." Commented Mr. Jian Dong.

Mr. Jian Dong joined WuXi Biologics in 2014, and had been responsible for global biomanufacturing, global engineering, and the overall operations of Wuxi site since 2015. Under the excellent leadership of Mr. Jian Dong, Wuxi site became the first GMP biologics Drug Substance (DS) and Drug Product (DP) facilities in China certified by both the US FDA and EMA. Prior to WuXi Biologics, Mr. Jian Dong spent decades in various roles with increasing responsibilities at Eli Lilly & Co. in the US, Shanghai United Cell Biotechnology and Shenzhen Kangtai Biological Products Co., Ltd. With extensive experience in vaccine manufacturing and facility qualification, he had made significant contributions to the tech transfer and large scale commercial production of recombinant hepatitis B vaccine in China.

In February, WuXi Vaccines completed modular lab installation of its vaccine manufacturing facility in Ireland, which represents a great milestone since the announcement of 240 million USD investment last November. With smooth progress made in the site construction, this integrated vaccine manufacturing facility is expected to be operational in 2021.

On August 6, 2020 Quanterix Corporation (Nasdaq: QTRX), a company digitizing biomarker analysis to advance the science of precision health, reported the pricing of its previously underwritten public offering of 2,651,108 shares of its common stock at a public offering price of $32.00 per share (Press release, Quanterix, AUG 6, 2020, View Source [SID1234563239]). All of the shares in the offering will be sold by Quanterix. Gross proceeds from the sale of the shares, before deducting underwriting discounts and commissions and offering expenses, are expected to be approximately $84.8 million. Quanterix has also granted the underwriters a 30-day option to purchase up to an additional 397,666 shares of common stock, at the public offering price less underwriting discounts and commissions.

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The offering is expected to close on August 11, 2020, subject to customary closing conditions.

SVB Leerink and Cowen are acting as joint bookrunning managers for the offering. Canaccord Genuity is acting as co-manager for the offering.

The public offering is being made pursuant to a shelf registration statement on Form S-3 that was previously filed with and declared effective by the Securities and Exchange Commission ("SEC"). A preliminary prospectus supplement and accompanying base prospectus relating to and describing the terms of the offering has been filed with the SEC and is available on the SEC’s website located at View Source Copies of the final prospectus supplement and the accompanying prospectus relating to this offering, when available, can be obtained from SVB Leerink LLC, Attention: Syndicate Department, One Federal Street, 37th Floor, Boston, MA, 02110, by telephone at (800) 808-7525, ext. 6218 or by e-mail at [email protected], or Cowen and Company, LLC, c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, Attention: Prospectus Department, by telephone at (833) 297-2926 or by email at [email protected].

This press release shall not constitute an offer to sell, or a solicitation of an offer to buy, nor will there be any sale of these securities in any state or other jurisdiction in which such an offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction.