On January 16, 2020 I-Mab ("I-Mab" or the "Company") (NASDAQ: IMAB), a clinical stage biopharmaceutical company committed to the discovery, development and commercialization of novel or highly differentiated biologics to treat diseases with significant unmet medical needs, particularly cancers and autoimmune disorders, reported the pricing of its initial public offering of 7,407,400 American Depositary Shares ("ADSs"), each ten (10) ADSs representing twenty-three (23) ordinary shares of the Company, par value US$0.0001 per share, at US$14.00 per ADS, assuming the underwriters do not exercise their option to purchase additional ADSs (Press release, I-Mab Biopharma, JAN 16, 2020, View Source [SID1234553310]). The ADSs will begin trading on January 17, 2020 on the Nasdaq Global Market under the symbol "IMAB."

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The Company has granted the underwriters an option to purchase up to an additional 1,111,110 ADSs within 30 days from the date of the final prospectus at US$14.00 per ADS. The total gross proceeds of the offering are expected to be approximately US$ 103,703,600, assuming the underwriters do not exercise their option to purchase additional ADSs, or approximately US$ 119,259,140, if the underwriters choose to exercise their option to purchase additional ADSs in full.

Jefferies LLC and China International Capital Corporation Hong Kong Securities Limited are acting as joint book-running managers for this offering. China Renaissance Securities (Hong Kong) Limited and Huatai Securities (USA), Inc. are acting as lead managers for this offering.

The Company’s registration statement related to the offering has been filed with, and declared effective by, the U.S. Securities and Exchange Commission (the "SEC"). This press release does not constitute an offer to sell or a solicitation of an offer to buy the securities described herein, nor shall there be any sale of these securities in any state or jurisdiction in which such an offer, solicitation, or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

Copies of the prospectus related to the offering may be obtained from (i) Jefferies LLC, Attn: Equity Syndicate Prospectus Department, 520 Madison Avenue, 2nd Floor, New York, New York 10022, by telephone at (877) 821-7388 or by e-mail at [email protected] or (ii) China International Capital Corporation Hong Kong Securities Limited, Attn: Rita Li, 29th One International Finance Center, One Harbour View Street, Central, Hong Kong, by telephone at (852) 2872-2000 or by e-mail at [email protected].

On January 16, 2020, Genprex, Inc. (the "Company") reported that it has entered into a securities purchase agreement (the "Securities Purchase Agreement") with an accredited investor identified on the signature page thereto (the "Purchaser") pursuant to which the Company agreed to issue and sell to the Purchaser an aggregate of 961,000 shares (the "Shares") of its common stock, par value $0.001 per share (the "Common Stock"), in a registered direct offering (the "Registered Direct Offering") (Filing, 8-K, Genprex, JAN 16, 2020, View Source [SID1234553309]). The Shares were offered by the Company pursuant to its shelf registration statement on Form S-3 (File No. 333-233774) filed with the Securities and Exchange Commission (the "Commission") on September 16, 2019, as amended on October 4, 2019 (as amended, the "Registration Statement") and declared effective on October 28, 2019.

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The purchase price for one Share in the Registered Direct Offering was $0.24. The closing of the Registered Direct Offering is anticipated to occur on January 21, 2020. The Company expects the aggregate net proceeds from the Offerings, after deducting estimated offering expenses, to be approximately $200,000. The Company intends to use the aggregate net proceeds for working capital and other general corporate purposes.

The Securities Purchase Agreement contains customary representations, warranties and agreements by the Company and customary conditions to closing.

The foregoing description of the material terms of the Securities Purchase Agreement does not purport to be complete and is qualified in its entirety by reference to the full text of the Securities Purchase Agreement, a copy of which is filed herewith as Exhibit 10.1 and is incorporated herein by reference.

The representations, warranties and covenants contained in the Securities Purchase Agreement were made only for purposes of such agreement and as of specific dates, were solely for the benefit of the parties to the Securities Purchase Agreement and may be subject to limitations agreed upon by the contracting parties. Accordingly, the Securities Purchase Agreement is incorporated herein by reference only to provide investors with information regarding the terms of the Securities Purchase Agreement and not to provide investors with any other factual information regarding the Company or its business, and should be read in conjunction with the disclosures in the Company’s periodic reports and other filings with the Commission.

The legal opinion, including the related consent, of Sheppard Mullin Richter & Hampton, LLP relating to the issuance and sale of the Shares is filed as Exhibit 5.1 hereto.

This Current Report on Form 8-K does not constitute an offer to sell, or the solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or jurisdiction.

On January 16, 2020 Biovica, active in cancer diagnostics, reported that the scientific journal Clinical Cancer Research has published data from the TREnd study, demonstrating the benefits of using DiviTum when evaluating palbociclib treatment outcome in women with metastatic breast cancer (Press release, Biovica, JAN 16, 2020, View Source [SID1234553300]).

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"We are very pleased that these results, which were initially presented at the AACR (Free AACR Whitepaper) annual meeting 2019, are published in the renowned journal Clinical Cancer Research. The data shows that DiviTum can be used to evaluate the treatment efficacy of a CDK 4/6 inhibitor in metastatic breast cancer." said Anders Rylander, CEO of Biovica. "This data is an important part of our clinical efficacy data. DiviTum has been evaluated in more than ten studies including more than 1 700 breast cancer patients."

The TREND-study evaluated blood samples from 45 women with metastatic breast cancer treated with palbociclib with or without endocrine therapy. In the article "Plasma thymidine kinase activity as a biomarker in patients with luminal metastatic breast cancer treated with palbociclib within the TREnd trial", researchers demonstrated that patients with decreasing levels of DiviTum after only one month of therapy have a significant better outcome than patients with increasing levels, 9 vs 3.2 months’ time to progression.

Hence, change in TK levels during treatment provides important and early information for assessing treatment response. DiviTum levels measured at the point of progression on palbociclib correlated with clinical outcome on the next line of systemic treatment.

"The results from these studies provide the first evidence for DiviTum as a biomarker of efficacy of palbociclib in metastatic breast cancer and build upon prior evidence in the pre-operative setting." said Dr Luca Malorni, Prato Hospital, Italy, lead investigator of the study. "The results need confirmation in larger, ongoing studies, and are encouraging in terms of clinical value. Via this blood test we can potentially identify which patients will not have a benefit from these new treatments and should ideally be selected for alternative regimens."

On January 16, 2020 Bausch Health Companies Inc. (NYSE/TSX: BHC) ("Bausch Health") reported that it will release its fourth-quarter and full-year 2019 financial results on Wednesday, Feb. 19, 2020 (Press release, Bavarian Nordic, JAN 16, 2020, View Source [SID1234553299]). Bausch Health will host a conference call and live web cast at 8:00 a.m. ET to discuss the results and provide a business update. All materials will be made available on the Investor Relations section of the Bausch Health website prior to the start of the call.

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Conference Call Details

Date:

Wednesday, Feb. 19, 2020

Time:

8:00 a.m. ET

Webcast:

View Source

Participant Event Dial-in:

+1 (888) 317-6003 (United States)

+1 (412) 317-6061 (International)

+1 (866) 284-3684 (Canada)

Participant Passcode:

8170812

Replay Dial-in:

+1 (877) 344-7529 (North America)

+1 (412) 317-0088 (International)

+1 (855) 669-9658 (Canada)

Replay Passcode:

10138202 (replay available until Feb. 26, 2020)

On January 16, 2020 LUNGevity reported that it has issued a Request for Applications (RFA) for translational research for Career Development Awards that will be granted in 2020 (Press release, LUNGevity Foundation, JAN 16, 2020, View Source [SID1234553298]). The RFA is available on the LUNGevity website at www.LUNGevity.org/CDA-RFA and is also posted on the proposalCENTRAL website at proposalcentral.com.

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LUNGevity’s Career Development Awards for Translational Research program was created to support future research leaders who will keep the field of lung cancer research vibrant with new ideas. Since 2002, LUNGevity has funded 130 projects at 59 institutions in 23 states, including 26 Career Development Awards.

Projects that will be funded in 2020 are expected to have a direct impact on the early detection of lung cancer and/or individualized lung cancer treatment, including through targeted therapy and immunotherapy.

Successful applicants may receive $100,000 per year for a possible period of three years and will participate as non-voting members of LUNGevity’s Scientific Advisory Board for the duration of the award. Applicants must be within the first five years of their first faculty appointment. The Career Development Awards are mentored awards, and a mentoring plan is part of the required submission.

"The 2020 awards will be the ninth round of LUNGevity Career Development Awards, and we are looking forward to this year’s applications," noted Dr. Upal Basu Roy, Vice President of Research. "This program has attracted outstanding young researchers who have gone on to become leaders in the lung cancer space. The impactful research we have supported has so far generated more than $27 million in follow-up funding, including independent NIH/NCI funding, indicating that the research and its findings have enough likelihood of benefiting patients to require additional funding."