On October 16, 2020 IMV Inc. (TSX: IMV; NASDAQ: IMV) (the "Company" or "IMV"), a clinical-stage biopharmaceutical company, reported that it has entered into an equity distribution agreement, dated October 16, 2020, with Piper Sandler & Co. ("Piper Sandler") as agent, pursuant to which the Company may, from time to time sell, through "at-the-market" offerings (the "ATM Offering") with Piper Sandler acting as sales agent, on the Nasdaq Capital Market (the "Nasdaq") such number of common shares as would have an aggregate offering price of up to US$50 million under the ATM Prospectus Supplement (as defined below) (Press release, IMV, OCT 16, 2020, View Source [SID1234568587]).

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Piper Sandler, at IMV’s discretion and instruction, will use its commercially reasonable efforts to sell the common shares at market prices from time to time. No offers or sales of common shares will be made in Canada or through the facilities of the Toronto Stock Exchange (the "TSX"). The ATM Offering will be made by way of a prospectus supplement (the "ATM Prospectus Supplement") to the Company’s Canadian final base shelf prospectus, as amended, and the Company’s United States final base shelf prospectus, as amended, which is contained in the Company’s U.S. registration statement on Form F-10 (File No. 333-249493) (the "Registration Statement"), dated October 16, 2020. The Registration Statement was declared effective by the United States Securities and Exchange Commission (the "SEC") on October 16, 2020.

The ATM Prospectus Supplement has been filed with the Nova Scotia Securities Commission, as principal regulator in Canada, and in the United States with the SEC. The TSX has conditionally approved the Offering.

The Company plans to use the net proceeds from this offering for general corporate purposes, including but not limited to working capital expenditures, capital expenditures, research and development expenditures, COVID-19 vaccine candidate expenditures, and clinical trial expenditures.

Copies of the ATM Prospectus Supplement and the accompanying final base shelf prospectus, as amended, relating to the offered common shares may be obtained for free from the offices of Piper Sandler & Co., Attention: Prospectus Department, 800 Nicollet Mall, J12S03, Minneapolis, MN 55402, via telephone at (800) 747-3924 or via email at [email protected].

This press release shall not constitute an offer to sell or a solicitation of an offer to buy, nor shall there be any sale of these common shares in any jurisdiction in which an offer, solicitation or sale would be unlawful prior to registration or qualifications under the securities laws of any such jurisdiction.

On October 16, 2020 Guardant Health, Inc. (Nasdaq: GH) reported it will report financial results for the third quarter 2020 after market close on Thursday, November 5, 2020 (Press release, Guardant Health, OCT 16, 2020, View Source [SID1234568586]). Company management will be webcasting a corresponding conference call beginning at 1:30 p.m. Pacific Time / 4:30 p.m. Eastern Time.

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Live audio of the webcast will be available on the "Investors" section of the company website at: www.guardanthealth.com. The webcast will be archived and available for replay after the event.

On October 16, 2020 Mevion Medical Systems reported that it has shipped the accelerator module for the MEVION S250i Proton Therapy System to Kunshan, China (Press release, Mevion Medical Systems, OCT 16, 2020, View Source [SID1234568585]). The 15-ton compact accelerator, the heart of the proton therapy system, is the smallest of its kind and will be the first in China.

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According to the Global Cancer Observatory, there were 4,285,033 new cancer cases recorded in China in 2018. However, with only 2 proton therapy centers in clinical operation in Mainland China, there is a large cohort of patients without access to this cutting-edge technology.

Proton therapy is a superior form of radiation therapy that can reduce the risk of unnecessary radiation exposure to surrounding healthy tissue and organs at risk. Many types of cancer can benefit from proton therapy, such as lung, breast, and prostate cancer. Pediatric patients with cancers in the brain and central nervous system can significantly benefit from this powerful treatment option.

"This shipment to China, the first of many, is part of Mevion’s mission to provide this life-saving technology to as many patients as possible," said Tina Yu, Ph.D., chief executive officer of Mevion Medical Systems. "We are proud to achieve this milestone and open the door to affordable and innovative proton therapy to underserved patients in China."

Single-room proton therapy systems, the dominant global system of choice in recent years, enable more cancer centers in large cities and rural areas the ability to offer this advanced cancer treatment to their patients. With the first shipment from Mevion, China embarks on a new era of single-room proton therapy.

The enormous expenditures and space requirements needed by other single-room or multi-room proton technologies have been a notable impediment to proton therapy adoption worldwide. Mevion changed proton therapy by creating the first and smallest single-room proton therapy system that can be embedded directly into a radiation oncology department and scaled to add additional treatment rooms with the growth of patient volume. This efficient approach will allow cancer centers to share existing resources, give patients access to a collection of cancer-fighting therapies under one roof, and ensures new protons centers’ financial success in the expanding Chinese market.

Today, new proton therapy centers in the United States are almost exclusively compact single-room systems. As the first company to innovate this approach, Mevion has over 50% market share of compact single-room systems in the U.S. and has been the preferred compact room provider of NCI-Designated Cancer Centers. To date, over 5,000 patients have been treated on Mevion proton therapy systems.

On October 16, 2020 Selexis SA, a JSR Life Sciences Company, reported the appointment of Dirk Lange to Chief Executive Officer (CEO) (Press release, Selexis
, OCT 16, 2020, View Source [SID1234568584]). Mr. Lange succeeds the company’s founding CEO, Dr. Igor Fisch, who had led the company since he co-founded it in 2001 and is departing to pursue other opportunities.

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As new Selexis CEO, Mr. Lange will help advance the continued market adoption of Selexis’ cell line development technologies and oversee the company’s operational and corporate strategy. He will also continue to serve in the role as CEO of JSR Life Sciences’ member company, KBI Biopharma, a leading contract development and manufacturing organization (CDMO). Under the JSR Life Sciences umbrella, Selexis and KBI’s integrated service offerings create the industry’s most robust biologics development package in the biopharmaceutical industry.

"We thank Igor for his years of leadership and service. He leaves behind a legacy of innovation, which contributed greatly to the ability of Selexis to play a role in the development of many of today’s most complex and difficult-to-express proteins," said Tim Lowery, president, JSR Life Sciences. "His foresight and belief in the power of the Chinese hamster ovary (CHO) cell as a premier manufacturing system of biologics has enabled countless companies to bring bispecifics, Fc fusions and other therapeutic proteins – as well as vaccines – to the clinic faster than ever."

Mr. Lange has served as president and CEO of KBI Biopharma since February 2020. Previously, he served as KBI’s chief operating officer following several roles of increasing responsibility, including senior vice president of operations; site head of KBI’s Boulder, Colorado facility; and vice president positions in operations and business development. Before moving to the United States in 2016, Mr. Lange was head of external supply operations at Novartis Biologics in Basel, Switzerland, and also held leadership positions in operations, program management and business development at Sandoz Oncology Injectables in Austria, and Rentschler Biopharma in Germany. He has also led several drug substance and drug product sites through successful health authority inspections by the U.S. Food and Drug Administration (FDA), European Medicines Agency (EMA) and Brazil’s regulatory agency, Agencia Nacional de Vigilancia Sanitaria (ANVISA). Mr. Lange received his Master Professional of Technical Management (CCI), an advanced training qualification of the German Chamber of Industry and Commerce (DIHK), in 2005, and his Bachelor Professional (CCI) of Pharmaceutical Technology degree in 2002. He also taught economics and operations management at the Chamber of Commerce and Industry in Ulm, Germany.

Commented Mr. Lange, "While I now oversee both Selexis and KBI Biopharma, life sciences companies will have the freedom to choose their partner of choice as they consider working with us for biologics and vaccine cell line development and/or manufacturing. I look forward to working with the talented team at Selexis to improve and uncover new and powerful ways to support our partners in their mission to help patients."

On October 16, 2020 Aptorum Group Limited (Nasdaq: APM; Euronext Paris: APM) (the "Company", "Aptorum Group" or "Aptorum"), a biopharmaceutical company focused on novel technologies including the targeting of infectious diseases, reported it will hold its 2020 annual general meeting of shareholders at its Hong Kong office located at 17/F, Guangdong Investment Tower, 148 Connaught Road Central, Hong Kong at 8:00 p.m. Hong Kong Time on December 9, 2020 (7:00 a.m. Eastern Standard Time on December 9, 2020 / 12:00 p.m. Greenwich Mean Time on December 9, 2020 / 1:00 p.m. Central European Time on December 9, 2020) (Press release, Aptorum, OCT 16, 2020, View Source [SID1234568583]).

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Shareholders of record as of October 12, 2020 are entitled to receive notice of and vote at the annual general meeting. The Company filed its annual report on Form 20-F, including its audited financial statements for the fiscal year ended December 31, 2019, with the U.S. Securities and Exchange Commission (the "SEC") on April 29, 2020. Aptorum Group’s annual report on Form 20-F can be accessed in the investor section of the Company’s website at www.aptorumgroup.com, as well as on the SEC’s website at www.sec.gov. Shareholders may request a meeting notice, proxy statement and hard copy of the annual report on Form 20-F free of charge by contacting [email protected].