BioCure Technology Inc. Announces Closing of Financing

On October 14, 2020 BioCure Technology Inc. (CSE: CURE) ("BioCure" or the "Company") reported that it will close a non-brokered private placement (the "Private Placement" on October 15th, 2020 consisting of 1,786,725 Units at a price of $0.14 cents per Unit for gross proceeds of $250,142 (Press release, Biocure Technology, OCT 14, 2020, View Source [SID1234628751]).

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Each Unit is comprised of one common share (the "Shares) and one share purchase warrant (the "Warrants") of the Company, where each whole Warrant entitles the holder to purchase an additional share for a period of two years from closing at a price of $0.21 per Warrant share (the "Warrant Shares").

The Company also agreed to pay a finder’s fee of $3,360 ("Finders Cash") and 24,000 finder warrants ("Finder Warrants") for the proceeds raised by the finders ("Finders") in connection with the private placement. The Finder Warrants are exercisable for a period of one year from closing at a price of $0.21 per share.

The net proceeds from the non-brokered private placement are intended to be used for general working capital and research and development.
All securities issuance in the Private Placement will be subject to a hold period expiring on February 15, 2021.

Plus Therapeutics to Announce Third Quarter 2020 Financial Results and Host Conference Call on October 22, 2020

On October 14, 2020 Plus Therapeutics, Inc. (Nasdaq: PSTV) (the "Company"), a clinical-stage company focused on making a positive impact on patients’ lives, reported that the company will report 2020 third quarter financial results on Thursday, October 22, 2020, after market close (Press release, PLUS THERAPEUTICS, OCT 14, 2020, View Source [SID1234572292]). Subsequently, Plus Therapeutics’ management team will host a conference call and webcast at 5:00 p.m. Eastern Time to discuss the financial results and provide a corporate update.

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A live webcast will be available at ir.plustherapeutics.com/events

Please refer to the information below for conference call dial-in information. Callers should dial in approximately 10 minutes prior to the start of the call.

Conference Call Name: Plus Therapeutics Third Quarter 2020 Financial Results Conference Call
Following the live call, a replay will be available on the Company’s website under the ‘Investors Relations’ section. The webcast will be available on the Company’s website for 90 days following the live call.

Entry into a Material Definitive Agreement

On October 14, 2020, Sorrento Therapeutics, Inc. ("Sorrento") and ACEA Therapeutics, Inc. ("ACEA") reported that entered into a binding term sheet (the "Binding Term Sheet") setting forth the terms and conditions by which Sorrento will, through a subsidiary, purchase all of the issued and outstanding equity of ACEA (the "Acquisition") (Filing, 8-K, Sorrento Therapeutics, OCT 14, 2020, View Source [SID1234568573]). Contingent upon the execution of a definitive agreement between the parties (the "Definitive Agreement") and subject to certain conditions, Sorrento will, at the closing of the Acquisition (the "Closing"), make an initial payment of $38,000,000, subject to certain adjustments (the "Initial Consideration").

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In addition to the Initial Consideration, Sorrento shall issue contingent value rights to the equityholders of ACEA representing the right to receive the following payments: (i) the amounts that would otherwise be due to ACEA under that certain License Agreement, dated July 13, 2020 (the "License Agreement"), between Sorrento and ACEA (as previously disclosed in Sorrento’s Current Report on Form 8-K filed with the Securities and Exchange Commission on July 17, 2020), (ii) with respect to specified royalty-bearing products, five percent of the annual net sales thereof in a manner consistent with the royalty payment terms of the License Agreement, and (iii) up to $265,000,000 in additional payments, subject to the receipt of certain regulatory approvals and achievement of certain net sales targets with respect to the assets acquired pursuant to the Acquisition.

Under the Binding Term Sheet, ACEA has agreed to negotiate exclusively with Sorrento with respect to the Acquisition for a period of 90 days.

The final terms of the Acquisition are subject to the negotiation and finalization of the Definitive Agreement and any other agreements relating to the Acquisition, and the material terms of the Acquisition may differ from those set forth in the Binding Term Sheet. In addition, the Closing will be subject to various customary and other closing conditions, including the approval of ACEA’s equityholders.

The foregoing description of terms of the Binding Term Sheet does not purport to be complete and is qualified in its entirety by reference to the full text of the (i) Binding Term Sheet that will be filed with the Securities and Exchange Commission as an exhibit to an amendment to this Current Report on Form 8-K or to Sorrento’s Annual Report on Form 10-K for the fiscal year ending December 31, 2020, and (ii) the License Agreement that will be filed with the Securities and Exchange Commission as an exhibit to Sorrento’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2020.

Entry into a Material Definitive Agreement

On October 14, 2020, X4 Pharmaceuticals, Inc. (the "Company"), reported that it entered into a common stock purchase agreement (the "Purchase Agreement") with Aspire Capital Fund, LLC, an Illinois limited liability company ("Aspire Capital"), which provides that, upon the terms and subject to the conditions and limitations set forth therein, Aspire Capital is committed to purchase up to an aggregate of $50.0 million of shares of the Company’s common stock at the Company’s request from time to time during the 36-month term of the Purchase Agreement (Filing, 8-K, X4 Pharmaceuticals, OCT 14, 2020, View Source [SID1234568572]). Concurrently with entry into the Purchase Agreement, the Company also entered into a registration rights agreement with Aspire Capital (the "Registration Rights Agreement"), pursuant to which the Company filed with the Securities and Exchange Commission ("SEC") a prospectus supplement to the Company’s effective shelf registration statement on Form S-3 (File No. 333-242372), which registers the issuance and sale of the shares of common stock that the Company may offer to Aspire Capital from time to time under the Purchase Agreement.

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Under the Purchase Agreement, on any trading day selected by the Company, the Company has the right, in its sole discretion, to present Aspire Capital with a purchase notice (each, a "Regular Purchase Notice") directing Aspire Capital (as principal) to purchase up to 30,000 shares of the Company’s common stock (not to exceed $1,000,000 worth of shares unless the Company and Aspire Capital agree otherwise) per business day, up to an aggregate of $50.0 million of the Company’s common stock at a per share price (the "Purchase Price") equal to the lesser of:


the lowest sale price of the Company’s common stock on the Nasdaq Stock Market LLC ("Nasdaq") on the date of sale; or


the arithmetic average of the three (3) lowest closing sale prices for the Company’s common stock on Nasdaq during the ten (10) consecutive trading days ending on the trading day immediately preceding the purchase date.

In addition, on any date on which the Company submits a Regular Purchase Notice to Aspire Capital in an amount equal to 30,000 shares, the Company also has the right, in its sole discretion, to present Aspire Capital with a volume-weighted average price purchase notice (each, a "VWAP Purchase Notice") directing Aspire Capital to purchase an amount of the Company’s common stock equal to up to 30% of the aggregate shares of the Company’s common stock traded on Nasdaq on the next trading day (the "VWAP Purchase Date"), subject to a maximum number of shares the Company may determine. The purchase price per share pursuant to such VWAP Purchase Notice is generally 97% of the volume-weighted average price for the Company’s common stock traded on Nasdaq on the VWAP Purchase Date.

The Purchase Agreement provides that the Company and Aspire Capital shall not effect any sales under the Purchase Agreement on any purchase date where the closing price of the Company’s common stock on Nasdaq is less than $0.25. In addition, the Company may not sell more than an aggregate of 3,255,700 shares of its common stock under the Purchase Agreement unless it obtains stockholder approval of the sale of additional shares or if after giving effect to a sale of additional shares, the average price paid for all shares then-issued under the Purchase Agreement would be equal to or greater than $6.76. There are no trading volume requirements or restrictions under the Purchase Agreement, and the Company will control the timing and amount of sales of the Company’s common stock to Aspire Capital. Aspire Capital has no right to require any sales by the Company but is obligated to make purchases from the Company as directed by the Company in accordance with the Purchase Agreement. There are no limitations on use of proceeds, financial or business covenants, restrictions on future financing transactions, rights of first refusal, participation rights, penalties or liquidated damages in the Purchase Agreement. The Purchase Agreement may be terminated by the Company at any time, at its discretion, without any cost to the Company. Aspire

Capital has agreed that neither it nor any of its agents, representatives and affiliates shall engage in any direct or indirect short-selling or hedging of the Company’s common stock during any time prior to the termination of the Purchase Agreement. Management currently expects to use any proceeds received by the Company under the Purchase Agreement to develop the Company’s product pipeline, for working capital and for general corporate purposes.

The foregoing description is not complete and is qualified in its entirety by reference to the full texts of the Purchase Agreement and the Registration Rights Agreement, copies of which are filed with as Exhibits 99.1 and 4.1, respectively, to this Current Report on Form 8-K and are incorporated herein by reference. The Company is filing the opinion of its counsel, Cooley LLP, relating to the legality of the shares of Common Stock offered and sold pursuant to the Purchase Agreement, as Exhibit 5.1 to this Current Report on Form 8-K.

This Current Report on Form 8-K contains forward-looking statements within the meaning of Private Securities Litigation Reform Act of 1995, as amended. These statements may be identified by the words "may," "will," "could," "would," "should," "expect," "plan," "anticipate," "intend," "believe," "estimate," "predict," "project," "potential," "continue," "target" or other similar terms or expressions that concern the Company’s expectations, strategy, plans or intentions. Forward-looking statements include, without limitation, statements related to the potential future sale of shares of the Company’s common stock, the price for such sales under the Purchase Agreement, and the Company’s expected use of proceeds from such sales. Any forward-looking statements in this Current Report on Form 8-K are based on management’s current expectations and beliefs. Actual events or results may differ materially from those expressed or implied by any forward-looking statements contained herein, including, without limitation, the risks and uncertainties described in the section entitled "Risk Factors" in the Company’s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (the "SEC") on August 4, 2020, and in subsequent filings the Company makes with the SEC from time to time. The Company undertakes no obligation to update the information contained in this Current Report on Form 8-K to reflect new events or circumstances, except as required by law.

Flagship Pioneering Announces Appointment of Tuyen Ong as CEO-Partner

On October 14, 2020 Flagship Pioneering, a unique life sciences innovation enterprise, reported that expanded and strengthened its executive leadership team with the appointment of Tuyen Ong, M.D. as CEO-Partner (Press release, Flagship Ventures, OCT 14, 2020, View Source [SID1234568547]). Dr. Ong will also serve as Chief Executive Officer at Ring Therapeutics, a Flagship Labs-founded company that promises to revolutionize gene therapy with its commensal virus platform.

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Dr. Ong is an accomplished biotechnology and pharmaceutical executive with a wealth of experience in research and development. He most recently served as Senior Vice President, Head of the Ophthalmology Franchise at Biogen.

"We are very excited to add Tuyen to our team of talented and experienced executives at Flagship, and to be able to further expand our group of CEO-Partners, a hybrid role unique to Flagship that assures maximum alignment and value creation for our breakthrough ventures," says Noubar Afeyan, Ph.D., founder and CEO of Flagship Pioneering and founding Chairman of Ring Therapeutics. "Tuyen’s extensive track record of building value for pharma and biotech, combined with his expertise in the development of gene therapies, will be tremendously beneficial to Ring and our other nucleic acid platform companies."

In his role as CEO-Partner of Flagship Pioneering, Dr. Ong joins the Flagship senior leadership team and will provide his knowledge and insights across the Flagship enterprise. He will also serve on the boards of directors of certain Flagship companies. Dr. Ong will also work as part of Flagship’s team to plan, drive, and achieve the highest possible value creation for Flagship and its companies.

As CEO of Ring Therapeutics, Dr. Ong will lead the development of the company’s groundbreaking nucleic acid therapy platform based on its large portfolio of commensal Anellovirus-based vectors.

"I’m delighted to join Flagship Pioneering’s outstanding executive leadership team and look forward to co-creating the next generation of innovative life sciences companies founded by Flagship," says Dr. Ong. "I am also thrilled to be joining Ring Therapeutics’ talented team of executives and scientists in its ambitious effort to develop transformational therapies using its multi-product platform by unlocking its unique knowledge of the human commensal virome and revolutionizing the nucleic acid medicine paradigm."

"I look forward to working closely with Tuyen to help realize the full potential of Ring," said Avak Kahvejian, Ph.D., Flagship Pioneering General Partner and Founding CEO of Ring Therapeutics. "Over the last two years, Ring has uncovered the largest collection of commensal, human viruses, and is leveraging these discoveries to develop the first potentially redosable and targetable gene therapy platform. We are very excited by the prospect of creating multiple breakthrough medicines from this platform."

About Tuyen Ong

Tuyen Ong is an experienced biotechnology and pharmaceutical executive with a passion for driving progress in medical sciences and bringing innovation to patients. Dr. Ong has deep expertise in R&D and gene therapy, having led the development of breakthrough treatments for retinopathies and rare diseases.

In his most recent role, Dr. Ong served as Senior Vice President, Head of the Ophthalmology Franchise at Biogen. Prior to the acquisition of Nightstar by Biogen in 2019, he served as Nightstar’s Chief Development Officer, where he defined the clinical and regulatory strategy for the company’s lead gene therapy programs. During his career, Dr. Ong has also held numerous senior leadership positions at PTC Therapeutics, Bausch and Lomb, and Pfizer, leading clinical development across multiple therapeutic disease areas of high-unmet need.

Dr. Ong holds an M.D. from University College London and an MBA from New York University Stern School of Business. He is a member of the Royal College of Ophthalmologists.