On October 5, 2020 OncoMyx Therapeutics, a privately-held oncolytic immunotherapy company, reported that members of its senior management team will provide a company update today at 2:30 pm ET and host investor meetings at the Chardan Virtual 4th Annual Genetic Medicines Conference (Press release, OncoMyx Therapeutics, OCT 5, 2020, View Source [SID1234568113]). The conference is taking place virtually October 5th and 6th .

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"We are leveraging the unique advantages of myxoma virus to target mechanisms that are common to a number of cancers," said Steve Potts, Ph.D., MBA, founder and chief executive officer of OncoMyx. "With this pan-tumor approach, we are advancing a best-in-class pipeline of systemically-administered myxoma virotherapies in combination with checkpoint inhibitors and other immuno-oncology approaches that could boost the number of patients who could benefit from immunotherapies."

OncoMyx was founded on breakthrough research demonstrating the myxoma virus is highly immuno-interactive and can selectively infect and kill a broad range of cancer cell types. As a virus that is nonpathogenic to humans, myxoma does not have to overcome pre-existing immunity. With a large genome, myxoma is ideal for multi-arming, creating a precision medicine approach with a unique oncolytic virus that can activate the cancer immunity cycle and expand the therapeutic effectiveness of immunotherapies.

About the Chardan Virtual 4th Annual Genetic Medicines Conference

The conference will have presentations from more than 70 public and private companies who are leading the way in the genetic medicines space. The conference will feature presentations, fireside chats, panels, Q&A and 1×1’s. To learn more about the conference and the confirmed presenting companies, please contact [email protected].

On October 5, 2020 Eureka Therapeutics, Inc., a clinical stage biotechnology company developing novel T cell therapies to treat solid tumors, reported the Company has initiated a Phase I/II clinical trial of its ET140203 ARTEMIS T cell therapy in adult patients with hepatocellular carcinoma (HCC), the predominant type of liver cancer (Press release, Eureka Therapeutics, OCT 5, 2020, View Source [SID1234568112]). The Phase I portion of the ARYA-1 study is now open for enrollment.

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ET140203 follows on the experience gained from Eureka’s study of ET140202. ET140202 and ET140203 utilize Eureka’s proprietary ARTEMIS cell receptor platform engineered with a TCR-mimic antibody to target an alpha fetoprotein (AFP)-peptide/HLA-A2 complex on HCC cancer cells. ET140203 ARTEMIS T cells also incorporate Eureka’s proprietary tumor infiltration technology which has demonstrated a favorable safety profile and enhanced ability to infiltrate solid tumors in animal models – potentially leading to improved efficacy in patients.

"We are very excited to initiate our ET140203 ARYA-1 clinical trial," said Dr. Cheng Liu, President and CEO of Eureka Therapeutics. "We believe that poor infiltration of T cells into solid tumors is a significant barrier to developing T cell therapies with curative potential. ET140203 can potentially address this limitation associated with the current generation of CAR and TCR therapies, and we are pleased to be able to bring this therapy into the clinic."

The ARYA-1 study is a multi-center, open-label, dose escalation clinical trial of ARTEMIS T cell therapy to initially assess the safety and tolerability of ET140203 T cells in adult patients with AFP-positive HCC and to determine the recommended phase II dose (RP2D). The first site is at City of Hope, a world-renowned independent research and treatment center for cancer, diabetes and other life-threatening diseases, based in Duarte, California.

Liver cancer is the fourth leading cause of cancer death worldwide, accounting for an estimated 782,000 deaths in 2018. About 43,000 new cases, and 30,000 deaths from liver cancer are expected to occur in the U.S. in 2020. The rate of liver cancer diagnosis has more than tripled since 1980, according to the American Cancer Society. Patients with advanced HCC have a poor prognosis and limited treatment options.

On October 5, 2020 Exicure, Inc. (Nasdaq: XCUR), a pioneer in gene regulatory and immunotherapeutic drugs utilizing spherical nucleic acid (SNA) constructs, reported a presentation at the Chardan Virtual 4th Annual Genetic Medicines Conference on Monday, October 5, 2020 (Press release, Exicure, OCT 5, 2020, View Source [SID1234568111]).

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Date: Monday, October 5, 2020

Time: 11:00 – 11:25 AM Eastern Time

Location: Virtual Webcast

The presentation will be available for live streaming via View Source

Replays of the webcast will be available on Exicure’s website for 30 days following the webcast.

On October 5, 2020 CohBar, Inc. (NASDAQ: CWBR), a clinical stage biotechnology company developing mitochondria based therapeutics to treat chronic diseases and extend healthy lifespan, reported that its Chief Executive Officer, Steven Engle, will present a company update at the BIO Investor Forum, being held virtually on October 13-15, 2020 (Press release, CohBar, OCT 5, 2020, View Source [SID1234568110]). This presentation will be available on demand for BIO Investor attendees.

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BIO is the world’s largest trade association representing biotechnology companies, academic institutions, state biotechnology centers and related organizations across the United States and in more than 30 other nations. BIO members are involved in the research and development of innovative healthcare, agricultural, industrial and environmental biotechnology products. BIO also produces the BIO International Convention, the world’s largest gathering of the biotechnology industry, along with industry-leading investor and partnering meetings held around the world.

On October 5, 2020 Odonate Therapeutics reported that the results of CONTESSA, a Phase 3 study of tesetaxel in the treatment of patients with metastatic breast cancer, have been selected for an oral presentation at the 2020 SABCS, to be held virtually December 8-11, 2020 (Press release, Odonate Therapeutics, OCT 5, 2020, View Source;a-phase-3-study-of-tesetaxel-in-the-treatment-of-patients-with-metastatic-breast-cancer–to-be-presented-at-the-2020-san-antonio-breast-cancer-symposium–sabcs–1463cc93-7e13-40a3-9d02-80a22baa098d [SID1234568109]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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The presentation details are as follows:

Date: December 11, 2020

Time: 9:00am CT

Session: General Session 4

Title: Results from CONTESSA: A phase 3 study of tesetaxel plus a reduced dose of capecitabine versus capecitabine alone in patients with HER2-, hormone receptor + (HR+) metastatic breast cancer (MBC) who have previously received a taxane

For more information, please visit View Source

About Tesetaxel

Tesetaxel is an investigational, orally administered chemotherapy agent that belongs to a class of drugs known as taxanes, which are widely used in the treatment of cancer. Tesetaxel has several pharmacologic properties that make it unique among taxanes, including: oral administration with a low pill burden; a long (~8‑day) terminal plasma half-life in humans, enabling the maintenance of adequate drug levels with relatively infrequent dosing; no history of hypersensitivity (allergic) reactions; and significant activity against chemotherapy‑resistant tumors. In patients with metastatic breast cancer, tesetaxel was shown to have significant, single‑agent antitumor activity in two multicenter, Phase 2 studies. Tesetaxel currently is the subject of three studies in breast cancer, including a multinational, multicenter, randomized, Phase 3 study in patients with metastatic breast cancer, known as CONTESSA.

About CONTESSA

CONTESSA is a multinational, multicenter, randomized, Phase 3 study of tesetaxel, an investigational, orally administered taxane, in patients with metastatic breast cancer (MBC). CONTESSA is comparing tesetaxel dosed orally at 27 mg/m2 on the first day of each 21‑day cycle plus a reduced dose of capecitabine (1,650 mg/m2/day dosed orally for 14 days of each 21‑day cycle) to the approved dose of capecitabine alone (2,500 mg/m2/day dosed orally for 14 days of each 21-day cycle) in 685 patients randomized 1:1 with human epidermal growth factor receptor 2 (HER2) negative, hormone receptor (HR) positive MBC previously treated with a taxane in the neoadjuvant or adjuvant setting. Capecitabine is an oral chemotherapy agent that is considered a standard‑of‑care treatment in MBC. Where indicated, patients must have received endocrine therapy with or without a cyclin‑dependent kinase (CDK) 4/6 inhibitor. The primary endpoint is progression-free survival (PFS) as assessed by an Independent Radiologic Review Committee (IRC). The secondary efficacy endpoints are overall survival (OS), objective response rate (ORR) as assessed by the IRC, and disease control rate (DCR) as assessed by the IRC.