On September 24, 2020 IONpath, Inc., the leader in high-definition spatial proteomics, reported the close of a $18 million Series B financing led by Samsara BioCapital, and included participation from new investor Bruker Corporation, a global leader in mass spectrometry (Press release, IONpath, SEP 24, 2020, View Source [SID1234565594]). All existing major investors contributed to the round including Genoa Ventures, ND Capital, Paladin Partners Investments, Trancos IONpath Investors, Norwich Ventures, and Vertical Venture Partners Growth Fund.

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"Developed by pathologists for translational researchers, IONpath’s MIBI platform delivers a revolutionary way to visualize phenotypic profiles, enabling rich, sensitive spatial analysis of tissue microenvironments," said Mike Dybbs, Partner at Samsara BioCapital and IONpath Board member. "We are excited to support IONpath in its mission to advance precision medicine and we are proud to partner with Bruker and all the company’s investors on this financing."

IONpath’s MIBI (Multiplexed Ion Beam Imaging) technology is delivering on the promise of spatial proteomics by providing unprecedented insights for translational medicine researchers. Through highly multiplexed, quantitative protein imaging with unmatched sensitivity and true subcellular resolution down to 280 nm, only MIBI technology delivers actionable insights of single cells in their complex tissue microenvironment with the throughput and reproducibility required for clinical studies.

"Bruker is honored to support IONpath in the further development and commercialization of its MIBI technology, which is helping researchers solve some of the most complex problems in solid tumor oncology," said Dr. Rohan Thakur, Executive Vice President, Bruker Corporation. "We believe the synergies between label-free MALDI imaging for endogenous metabolites, lipids, and glycans, coupled to MIBI multiplexed sub-cellular protein imaging, will accelerate adoption of mass spectrometry approaches for pathology."

"We are seeing strong traction for our MIBI technology, both in our MIBIscope instrument and our end-to-end Research Services business. We are more convinced than ever that MIBI-enabled, high-definition spatial proteomics will be a key enabler for the deployment of precision medicine in the treatment of a wide range of diseases," said Sander Gubbens, PhD, CEO of IONpath. "We are grateful for the continued support of our investors and are honored to welcome Bruker as a new investor as we expand the availability of our MIBI technology and Research Services globally."

On September 24, 2020 PTC Therapeutics, Inc. (NASDAQ: PTCT) reported that management will present a company overview at the Jefferies Virtual Gene Therapy/Editing Summit on Thursday, October 1st at 9:00 a.m. ET (Press release, PTC Therapeutics, SEP 24, 2020, View Source [SID1234565593]).

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The presentation will be webcast live on the Events and Presentations page under the investor relations section of PTC Therapeutics’ website at www.ptcbio.com and will be archived for 30 days following the presentation. It is recommended that users connect to PTC’s website several minutes prior to the start of the webcast to ensure a timely connection.

On September 24, 2020 ONCOtracker, Inc and The Binding Site Group Ltd reported they have entered into an exclusive global license and collaboration agreement to develop a novel clinical laboratory test for measuring sBCMA, which has shown promise to monitor and predict outcomes for patients with common blood-based cancers including multiple myeloma (MM) and chronic lymphocytic leukemia (CLL) and other related conditions (Press release, OncoTracker, SEP 24, 2020, View Source [SID1234565592]).

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sBCMA was first discovered in 2011 by Dr. James Berenson and colleagues at The Institute for Myeloma and Bone Cancer Research (IMBCR). Dr. Berenson’s scientific and clinical research focuses on myeloma and has demonstrated that sBCMA is found at low levels in the serum of normal patients and is elevated among patients with MM and CLL in studies involving several thousand patients. Changes in sBCMA levels have also been found to occur rapidly and correlate with patients’ clinical status in response to treatment (Ghermezi et al. Haematologica 2017; Jew et al. Brit J Haematol 2020).

Under terms of the agreement, The Binding Site Group obtains a global exclusive license to develop and commercialize a sBCMA test for multiple myeloma, CLL and additional conditions. ONCOtracker which holds patented technology regarding the testing of this biomarker for multiple myeloma patients will continue to support The Binding Site’s sBCMA research and medical affairs efforts.

"We are thrilled to partner with The Binding Site Group, the leader in myeloma diagnostics and manufacturer of Freelite, the diagnostic standard of care in multiple myeloma. They are the perfect collaborator to further develop and commercialize the sBCMA biomarker test and an ideal match for ONCOtracker," said James Berenson, MD, Founder and President of ONCOtracker.

"Binding Site has a history of collaborating with exceptional scientists and developing the utility of new markers and technologies to aid in monoclonal gammopathy patient management. With the introduction of the Freelite assay, more recently with our Mass Spectrometry collaboration and now as we seek to understand the developing role of serum BCMA measurements, we have always sought to collaborate with innovative and passionate scientists. Therefore we are delighted to announce this collaboration and excited to work with Dr. Berenson and the OncoTracker team as we add another tool to the monoclonal gammopathy patient management armamentarium," said Dr. Stephen Harding, Chief Scientific Officer of The Binding Site Group.

On September 24, 2020 Titan Pharmaceuticals, Inc. (NASDAQ: TTNP) reported it has entered into a share purchase agreement with certain accredited institutional investors to purchase 19,440,000 shares of its common stock in a registered direct offering at a purchase price of $0.14 per share (Press release, Titan Pharmaceuticals, SEP 24, 2020, View Source [SID1234565591]).

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Titan expects the net proceeds from the offering to be approximately $2.5 million after deducting the placement agent’s fees and other estimated offering expenses. The offering is expected to close on or about September 28, 2020, subject to the satisfaction of customary closing conditions.

Maxim Group LLC is acting as the sole placement agent in connection with the offering

The shares of common stock are being offered pursuant to a shelf registration statement on Form S-3 (File No. 333-230742), which was declared effective by the United States Securities and Exchange Commission ("SEC") on April 24, 2019.

This press release does not constitute an offer to sell or the solicitation of an offer to buy, nor will there be any sales of these securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of such jurisdiction. A prospectus supplement relating to the shares of common stock will be filed by Titan with the SEC. When available, copies of the prospectus supplement relating to the registered direct offering, together with the accompanying prospectus, can be obtained at the SEC’s website at www.sec.gov or from Maxim Group LLC, 405 Lexington Avenue, New York, NY 10174, Attention: Syndicate Department, or via email at [email protected] or telephone at (212) 895-3745.

On September 24, 2020 XiangXue Life Sciences (XLifeSc), a partner of GenScript ProBio, reported FDA allowance of its IND application for TCR-T program (TCRT-ESO-A2). GenScript ProBio extends congratulations on this (Press release, GenScript, SEP 24, 2020, View Source [SID1234565590]).

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This program is China’s first TCR-T program targeting solid tumors that are NY-ESO-1 positive in HLA-A*02:01 positive patients. On June 10, 2019, GenScript ProBio and XLifeSc announced an strategic partnership agreement with regard to the development and manufacturing of vectors for cell therapy. Under the agreement, as a major technical service provider for XLifeSc, GenScript will provide plasmid and virus process development, GMP plasmid and virus clinical samples, and commercial manufacturing services.

As the first product in XLifeSc’s pipeline, TAEST16001 enables autologous T-cell transduced with a replication incompetent lentiviral vector to express NY-ESO-1-specific TCR. According to a clinical study conducted by PI, reinfused T-cells have long-lasting effects on patients treated with TAEST16001. Phase 1 portion of an open, single arm and early clinical study of TAEST16001 in the treatment of solid tumor mainly containing soft tissue sarcoma with positive expression of tumor antigen NY-ESO-1 (HLA-A*02:01) is ongoing in Biotherapy Center/Melanoma and Sarcoma Medical Oncology Unit, Sun Yat-sen University Cancer Center.

GenScript ProBio congratulates XLifeSc on reaching an important milestone of TCR-T program.

"We congratulate XLifeSc on FDA allowance of its IND application for TCR-T program. TCR-T cell therapy has unprecedented potential for the treatment of solid tumor, which is a significant milestone for the immunotherapy field in China," said Dr. Brian Min, CEO of GenScript ProBio. "This is China’s first TCR-T program targeting the treatment of solid tumor. XLifeSc has entrusted TCR-T products with independent intellectual property rights to GenScript as the first collaborative program. We are honored to provide technology and production support for such great program. We will follow up on the clinical studies. We wish this program proceed smoothly in US and benefit patients with solid tumor soon."