On August 27, 2020 Odonate Therapeutics, Inc. (NASDAQ: ODT), a pharmaceutical company dedicated to the development of best-in-class therapeutics that improve and extend the lives of patients with cancer, reported the pricing of an underwritten public offering of 5,614,036 shares of its common stock, offered at a price of $14.25 per share (Press release, Odonate Therapeutics, AUG 27, 2020, View Source [SID1234564117]). In addition, Odonate has granted the underwriters a 30-day option to purchase up to an additional 842,105 shares of its common stock on the same terms and conditions. All shares of common stock sold in the offering are being sold by Odonate. The offering is expected to close on or about September 1, 2020, subject to customary closing conditions.

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The gross proceeds from the proposed underwritten public offering are expected to be $80 million before deducting customary underwriting discounts and offering expenses. Odonate intends to use the proceeds from the proposed underwritten public offering of its shares of common stock for development, regulatory and commercial preparation activities relating to tesetaxel, as well as for working capital and general corporate purposes.

Jefferies is acting as book-running manager, and LifeSci Capital is acting as lead manager for the offering.

The securities described above are being offered pursuant to a shelf registration statement (File No. 333‑233990), which became effective on October 18, 2019.

A final prospectus supplement and accompanying base prospectus relating to and describing the terms of the offering will be filed with the U.S. Securities and Exchange Commission (SEC). The securities described above have not been qualified under any state blue sky laws. This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction. The offering can be made only by means of a prospectus supplement and an accompanying base prospectus, copies of which may be obtained at the SEC’s website at www.sec.gov, or by request to Jefferies LLC (Attention: Equity Syndicate Prospectus Department, 520 Madison Avenue, 2nd Floor, New York, New York 10022; telephone: 877-821-7388; email: [email protected]).

On August 27, 2020 Oncternal Therapeutics, Inc. (Nasdaq: ONCT), a clinical-stage biopharmaceutical company focused on the development of novel oncology therapies, reported that it has entered into an underwriting agreement with H.C. Wainwright & Co., LLC under which the underwriter has agreed to purchase on a firm commitment basis 1,666,667 shares of common stock of the Company, at a price to the public of $2.10 per share, less underwriting discounts and commissions (Press release, Oncternal Therapeutics, AUG 27, 2020, View Source [SID1234564116]). The closing of the offering is expected to occur on or about September 1, 2020, subject to satisfaction of customary closing conditions.

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H.C. Wainwright & Co. is acting as the sole book-running manager for the offering.

The Company also has granted to the underwriter a 30-day option to purchase up to an additional 250,000 shares of common stock at the public offering price, less underwriting discounts and commissions. The gross proceeds to Oncternal, before deducting underwriting discounts and commissions and offering expenses and assuming no exercise of the underwriter’s option to purchase additional common stock, are expected to be approximately $3.5 million. The Company intends to use the net proceeds from this offering for general corporate purposes, including expenses related to the clinical and preclinical development of cirmtuzumab and TK216, preclinical development of its ROR1 CAR-T program, and for working capital.

The shares of common stock are being offered by Oncternal pursuant to a "shelf" registration statement on Form S-3 (File No. 333-222268) previously filed with the Securities and Exchange Commission (the "SEC") on December 22, 2017 and declared effective by the SEC on January 5, 2018. The offering of the shares of common stock is made only by means of a prospectus, including a prospectus supplement, forming a part of the effective registration statement. A preliminary prospectus supplement and accompanying prospectus relating to the shares of common stock being offered will be filed with the SEC. Electronic copies of the preliminary prospectus supplement and accompanying prospectus may be obtained, when available, on the SEC’s website at View Source or by contacting H.C. Wainwright & Co., LLC at 430 Park Avenue, 3rd Floor, New York, NY 10022, by phone at (646) 975-6996 or e-mail at [email protected].

This press release shall not constitute an offer to sell or a solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction.

On August 27, 2020 Arcus Biosciences, Inc. (NYSE:RCUS), an oncology-focused biopharmaceutical company working to create best-in-class cancer therapies, reported that management will present at the following upcoming virtual investor conferences (Press release, Arcus Biosciences, AUG 27, 2020, View Source [SID1234564115]):

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Citi 15th Annual BioPharma Virtual Conference, Wednesday, September 9 at 1:30 pm ET
2020 Cantor Global Virtual Healthcare Conference, Wednesday, September 16 at 4:40pm ET
Morgan Stanley Virtual 18th Annual Global Healthcare Conference, Friday, September 18 at 10:15 am ET
A live audio webcast of each presentation will be available by visiting the "Investors" section of the Arcus website at www.arcusbio.com. A replay of each webcast will be available for at least two weeks following the live event.

On August 27, 2020 Treadwell Therapeutics, a clinical-stage biotechnology company developing novel therapeutics for highly aggressive cancers, reported the initiation of three expansion cohorts in its ongoing Phase 1 study evaluating CFI-402257, a selective and highly potent oral inhibitor of tyrosine threonine kinase (TTK) (Press release, Treadwell Therapeutics, AUG 27, 2020, View Source [SID1234564114]). The expansion cohorts include ER+/HER2 breast cancer patients in combination with fulvestrant post CDK4/6 inhibitor failure, triple negative breast cancer patients and an additional cohort in solid tumors.

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"CFI-402257 is a potentially best-in-class, highly selective and potent inhibitor of TTK, a critical component of the cancer cell’s maintenance of genomic integrity and survival, which may be a key vulnerability of tumors that are resistant to CDK4/6 inhibitors," said Dr. Mark Bray, Treadwell Chief Scientific Officer and Co-Founder. "We are very encouraged by the compelling early signs of clinical activity of CFI-402257 as a monotherapy in the dose escalation portion of our Phase 1 study, and we look forward to continuing to evaluate the potential of our TTK inhibitor in combination therapy through our expansion cohorts."

"Patients with ER+/Her2- breast cancer face a high unmet medical need, as a majority of these patients become resistant to CDK4/6 inhibitors. We are very pleased by the initial indications of clinical activity in this patient segment and are excited to advance to the next phase of the study to evaluate the potential of CFI-402257 as a treatment for these patients," said Philippe Bedard, M.D., Princess Margaret Cancer Centre, primary investigator of the study.

The open-label Phase 1 trial of CFI-402257 is designed to assess the safety, tolerability, pharmacokinetics, and clinical benefit of treatment with CFI-402257. The study consists of two parts, the dose escalation portion, now completed, in which escalating doses were administered orally in patients with advanced cancer that was refractory to current treatment or for which no curative therapy exists. The dose expansion portion of the multi-center trial will enroll up to 52 patients across sites in Canada in three parallel arms: patients with ER+/HER2-negative breast cancer who have failed CDK4/6 inhibitors in combination with an approved endocrine treatment (fulvestrant); patients with triple negative breast cancer (TNBC); and patients with advanced solid tumors. Dr. Philippe Bedard of the Princess Margaret Cancer Centre is the primary investigator, and Dr. John Hilton (Ottawa Hospital Cancer Center) and Dr. Daniel Renouf (British Columbia Cancer Agency) are co-investigators of the study.

CFI-402257 is a potentially best-in-class inhibitor of TTK protein kinase. TTK is a dual-specificity serine-threonine kinase that is critical for the spindle assembly checkpoint (SAC), chromosome alignment and error correction. Inhibition of TTK kinase activity causes cells to prematurely exit mitosis with unattached chromosomes, resulting in severe chromosome missegregation, aneuploidy and eventually cell death. TTK is overexpressed in several tumors, and higher levels correlate with worse prognosis, and may contribute to the survival and proliferation of aneuploid cells. During initial preclinical screening studies, CFI-402257 demonstrated a desirable combination of potent inhibition of cancer cell growth and high oral bioavailability with robust suppression of tumour growth achieved upon at tolerated doses in in vivo studies.

On August 27, 2020 Median Technologies (Paris:ALMDT), The Imaging Phenomics Company, reported the publication date for its half year results 2020 (Press release, MEDIAN Technologies, AUG 27, 2020, View Source [SID1234564113]):

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Publication

Date

2020 half year results

October 14, 2020*