On January 6, 2021 Harpoon Therapeutics, Inc. (Nasdaq: HARP), reported the pricing of an underwritten public offering of 5,882,352 shares of its common stock at a price to the public of $17.00 per share (Press release, Harpoon Therapeutics, JAN 6, 2021, View Source [SID1234573634]). Harpoon Therapeutics expects that the gross proceeds from the sale of the shares will be approximately $100.0 million, before deducting underwriting discounts and commissions and offering expenses payable by Harpoon Therapeutics. In addition, Harpoon Therapeutics has granted the underwriters in the offering a 30-day option to purchase up to 882,352 additional shares of common stock at the public offering price. The offering is expected to close on January 11, 2021, subject to customary closing conditions.

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Harpoon Therapeutics plans to use the net proceeds of the offering, together with other available funds, to fund the continued clinical development of HPN424 in metastatic castration-resistant prostate cancer, HPN536 in ovarian cancer and other solid tumors, HPN217 in multiple myeloma, and HPN328 for the treatment of small cell lung cancer and other neuroendocrine tumors expressing Delta-like canonical Notch ligand 3; to advance the development of other pipeline candidates, including HPN601; and for working capital and general corporate purposes.

SVB Leerink and Piper Sandler are acting as joint bookrunning managers for the offering. Baird and Truist Securities are acting as co-lead managers for the offering. Roth Capital Partners is acting as co-manager for the offering.

The shares of common stock are being offered pursuant to a "shelf" registration statement previously filed with and declared effective by the Securities and Exchange Commission (SEC). Harpoon Therapeutics has filed a preliminary prospectus supplement and the accompanying prospectus related to the offering with the SEC, which are available on the SEC’s website, located at www.sec.gov. Copies of the final prospectus supplement relating to this offering, when available, and the accompanying prospectus may be obtained from: SVB Leerink LLC, Attention: Syndicate Department, One Federal Street, 37th Floor, Boston, MA 02110, by telephone at (800) 808-7525, ext. 6132 or by email at [email protected] or Piper Sandler & Co., Attention: Prospectus Department, 800 Nicollet Mall, J12S03, Minneapolis, MN 55402, by telephone at (800) 747-3924 or by email at [email protected].

This press release shall not constitute an offer to sell, or a solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction. Any offer, if at all, will be made only by means of a prospectus supplement and accompanying prospectus, which are a part of the effective registration statement.

On January 6, 2021 Evotec SE (Frankfurt Stock Exchange: EVT, MDAX/TecDAX, ISIN: DE0005664809) reported its management will be presenting at and attending the following upcoming conferences in the first quarter of 2021 (Press release, Evotec, JAN 6, 2021, View Source;announcements/press-releases/p/evotec-to-attend-upcoming-investor-conferences-6016 [SID1234573623]):

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J.P. Morgan 39th Annual Healthcare Conference 2021
Date: Monday, 11 January – Thursday, 14 January 2021, Presentation: Tuesday, 12 January, 7.30 am EST (1.30 pm CET, 12.30 pm GMT, 4.30 am PST)
Venue: Virtual
Attendee: Werner Lanthaler, Chief Executive Officer
Commerzbank German Investment Seminar
Date: Wednesday, 13 January 2021
Venue: Virtual
Attendee: Werner Lanthaler, Chief Executive Officer
UniCredit Kepler Cheuvreux German Corporate Conference
Date: Wednesday, 20 January 2021, Presentation: Wednesday, 20 January, 12 pm CET
Venue: Virtual
Attendee: Werner Lanthaler, Chief Executive Officer
BioCapital Europe
Date: Thursday, 11 March 2021
Venue: Virtual
Attendee: Enno Spillner, Chief Financial Officer

On January 6, 2021 Erasca, a company whose mission is to erase cancer, reported that Wei Lin, M.D., has joined as chief medical officer (Press release, Erasca, JAN 6, 2021, View Source [SID1234573622]). David Chacko, M.D., previously Erasca’s chief business officer, has been appointed as chief financial officer, assuming the role from Gary Yeung, who has departed from the company to pursue other opportunities.

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"Attracting top talent like Wei to Erasca positions the company to aggressively pursue clinical development of our burgeoning pipeline so we can bring new therapeutics that aim to erase cancer for the many patients who await better treatment options," said Jonathan E. Lim, M.D., Erasca’s chairman, CEO and co-founder. "In the past year, we have significantly advanced our pipeline, including having multiple programs that are now in the clinic. We are grateful that Wei has joined us at this critical juncture to help accelerate our clinical development activities for the potential benefit of patients. He is an exceptional clinician and strategic thinker with deep expertise in oncology drug development."

Dr. Lim further added, "On behalf of the entire company, I would like to thank Gary for his invaluable contributions to Erasca over the past two years, and we wish him all the best in his future endeavors. David’s broad experience as a management consultant, investor and operator will continue to contribute greatly to Erasca’s growth as a leading precision oncology company."

About Wei Lin, M.D.

Dr. Lin joins Erasca from Nektar Therapeutics, where he was senior vice president and head of development as well as a member of the executive committee. He was responsible for all development functions and the clinical development of Nektar’s pipeline, including advancing bempegaldesleukin into multiple registrational trials and achieving FDA breakthrough therapy designation in metastatic melanoma. Prior to Nektar, Dr. Lin held roles of increasing responsibility at Roche/Genentech, most recently as the global development lead in cancer immunotherapy for lung cancer and head and neck cancer. Under his leadership, his team completed five positive Phase III trials and achieved three US and EU regulatory approvals for Tecentriq, including the first advancement in first-line small cell lung cancer in three decades. He was also the site head for oncology product development for Roche China, where his team achieved multiple additional regulatory approvals for Avastin, Zelboraf and Tarceva. He is a past recipient of the ASCO (Free ASCO Whitepaper) Young Investigator Award and the AACR (Free AACR Whitepaper)-AstraZeneca Translational Lung Cancer Award. He was on faculty at MD Anderson Cancer Center, where he completed his medical oncology fellowship. He completed his internal medicine residency at Massachusetts General Hospital and received his M.D. from Harvard Medical School and his B.A. in physics from Haverford College.

About David Chacko, M.D.

Prior to joining Erasca, Dr. Chacko was a principal at Versant Ventures, where he held a dual investing/operating role, helping lead investment opportunities across multiple therapeutic areas. Operationally, he was intimately involved in advancing several Versant portfolio companies through company formation, fundraising, business development, and clinical and regulatory activities. Dr. Chacko joined Versant from Alcon, where, as chief of staff to the CEO, he worked alongside the executive leadership team to develop and implement high priority corporate initiatives to accelerate growth and innovation. Prior to Alcon, Dr. Chacko was an engagement manager at McKinsey, leading multiple teams serving pharmaceutical and medical device clients. Dr. Chacko received M.D. and MBA degrees concurrently from the University of Pennsylvania School of Medicine/Wharton School. Prior to that, he earned an MPhil from Oxford University, where he was a Marshall Scholar.

On January 6, 2021 C4 Therapeutics, Inc. (C4T) (Nasdaq: CCCC), a biopharmaceutical company pioneering a new class of small-molecule medicines that selectively destroy disease-causing proteins through degradation, reported key milestones for 2021, including C4T’s transition into a clinical-stage company and advancement of the Company’s pioneering targeted protein degrader portfolio (Press release, C4 Therapeutics, JAN 6, 2021, View Source [SID1234573605]).

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"C4T’s achievements in 2020, including the recent IND submission for our lead candidate, position us for considerable progress in 2021," said Andrew Hirsch, president and chief executive officer of C4 Therapeutics. "Pending FDA clearance, we look forward to initiating our first clinical trial, evaluating CFT7455 for the treatment of hematologic malignancies. In addition, leveraging the capabilities of our TORPEDO platform, we are advancing a broad portfolio of differentiated targeted protein degraders, which we believe have distinctive benefits over traditional small molecule approaches. This includes plans to submit an IND for CFT8634 and progress two additional BiDAC programs into IND-enabling studies, alongside continued investment in our discovery efforts. These strategic objectives keep us on track to deliver four programs into the clinic by the end of 2022."

"This is an exciting time for C4T as we embark on our first clinical study, advancing our mission to transform patient treatment through targeted protein degradation," said Marc Cohen, executive chairman and co-founder of C4 Therapeutics. "I would like to acknowledge the tremendous work of the entire C4T team over the last five years to get us to this inflection point."

2021 ANTICIPATED KEY MILESTONES

Initiate a Phase 1/2 clinical trial for CFT7455 in relapsed or refractory non-Hodgkin lymphomas and multiple myeloma in 1H 2021. CFT7455 is an orally bioavailable MonoDAC (Monofunctional Degradation Activating Compound) targeting IKZF1/3 for the treatment of hematologic malignancies such as multiple myeloma and non-Hodgkin lymphomas, including peripheral T cell lymphoma and mantle cell lymphoma.

Submit an IND application for CFT8634 in 2H 2021. CFT8634 is an orally bioavailable BiDAC (Bifunctional Degradation Activating Compound) targeting BRD9 for the treatment of synovial sarcoma and SMARCB1-deleted solid tumors.

Advance our BRAF program into IND-enabling studies in 2021. The goal of our BRAF program is to develop an orally bioavailable BiDAC targeting BRAF V600E for the treatment of genetically defined, solid tumors including locally advanced or metastatic melanoma and non-small cell lung cancer (NSCLC). Our BRAF program is partnered with Roche.

Advance our RET program into IND-enabling studies in 2021. The goal of our RET program is to develop an orally bioavailable BiDAC targeting genetically altered RET for the treatment of solid tumors, including relapsed or refractory NSCLC and sporadic medullary thyroid cancers that are resistant to RET inhibitors.
RECENT HIGHLIGHTS

In addition, the Company also provided an update on recent progress:

IND Submitted for CFT7455: In December 2020, C4T submitted an IND application for its lead candidate, CFT7455, targeting IKZF1/3 for the treatment of relapsed or refractory non-Hodgkin lymphomas and multiple myeloma.

Continued to Strengthen Leadership Team: Kelly Schick has been appointed chief people officer. Ms. Schick will be joining C4T in January 2021 from AMAG Pharmaceuticals, where she served as senior vice president, chief human resources officer and head of corporate engagement. In addition, Kendra Adams was appointed senior vice president, communications and investor relations. Ms. Adams joined C4T in November 2020 from Agios Pharmaceuticals where she served as vice president, external communications and investor relations.

Completed Upsized Initial Public Offering: In October 2020, C4T completed an upsized initial public offering of 11.0 million shares of common stock, including the full exercise of the underwriters’ over-allotment option, at a price of $19.00 per share. Net proceeds from the offering were $191.1 million.
CASH GUIDANCE
Unaudited cash, cash equivalents and short-term investments as of December 31, 2020, were approximately $370 million. C4T expects its cash, cash equivalents and short-term investments, including payments anticipated to be received under existing collaboration agreements, will be sufficient to fund its operating plan to the end of 2023.

UPCOMING INVESTOR EVENTS

January 14, 2021 – C4T will present at the 39th Annual J.P. Morgan Healthcare Conference
March 16, 2021 – C4T will participate in the Guggenheim Targeted Protein Degradation Day

On January 6, 2021 Purple Biotech Ltd. Presented the Corporate Presentation (Press release, Purple Biotech, JAN 6, 2021, View Source [SID1234573601]).

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