On March 12, 2021 NOXXON Pharma N.V. (Euronext Growth Paris: ALNOX), a biotechnology company focused on improving cancer treatments by targeting the tumor microenvironment (TME), reported that the Data Safety Monitoring Board (DSMB) analyzed safety data from the initial four weeks of treatment of the first patient enrolled in the third and final dose cohort of the NOX-A12 plus radiotherapy brain cancer study (Press release, NOXXON, MAR 12, 2021, View Source [SID1234576595]). The DSMB concluded that it is safe and appropriate to continue patient recruitment according to the study protocol. The DSMB’s decision marks an important milestone in this trial as it enables the advancement and analysis of the final dose regimen, placing NOXXON on the path toward valuable data readouts anticipated later this year.

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The Phase 1/2 clinical study is testing three dose regimens of NOX-A12 (200, 400 and 600 mg/week), each combined with external-beam radiotherapy, in newly diagnosed brain cancer patients. Based on the DSMB’s confirmation, participating clinical centers have now initiated final patient recruitment for the last and highest dose group. After all patients in the third cohort have received four weeks of treatment with NOX-A12 and radiotherapy, the DSMB will reconvene for a final meeting to assess safety and tolerability. The outcome of this meeting will inform the recommended dose for the next randomized, controlled brain cancer trial which will lead to the registration of NOX-A12.

"We are pleased by the safety data confirmation of the DSMB, as it will allow our study to progress and the last patients to receive treatment at the highest planned dose of NOX-A12. This achievement brings us one step closer to a topline data readout for this cohort sometime around the end of Q3 2021," commented Aram Mangasarian, CEO of NOXXON. "As the study advances, we will be analyzing data which will be used to define the recommended dose and guide preparations for a potentially registrational Phase 2 study. The recent capital raise plus available financing vehicles secure NOXXON’s financial runway well into 2022, thereby allowing us to address operational matters crucial for the future of the company."

On March 12, 2021 CohBar, Inc. (NASDAQ: CWBR), a clinical stage biotechnology company developing mitochondria based therapeutics to treat chronic diseases and extend healthy lifespan, reported that CEO Steven Engle will participate in a fireside chat with Research Analyst Jason McCarthy at the Inaugural Emerging Growth Conference presented by M Vest LLC and Maxim Group LLC (Press release, CohBar, MAR 12, 2021, View Source [SID1234576594]). Mr. Engle will also present a company overview, which will be available on demand. The conference will be held virtually March 17 – 19, 2021.

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Maxim Emerging Growth Conference
Friday, March 19, 2021 at 2:30 PM ET
Webcast: The presentation may be accessed via webcast following the presentation, using the following link: https://www.m-vest.com/events/2021-emerging-growth-virtual-conference. Registration is required.

On March 12, 2021 Celsion Corporation (NASDAQ: CLSN), a clinical-stage development company focused on DNA-based immunotherapy and next-generation vaccines, reported that the Company will host a conference call at 11:00 a.m. EDT on Friday, March 19, 2021 to discuss financial results for the year ended December 31, 2020 and provide an update on clinical development programs with GEN-1, a DNA-based immunotherapy for the localized treatment of ovarian cancer and ThermoDox, a proprietary heat-activated liposomal encapsulation of doxorubicin under investigator-sponsored development for several cancer indications (Press release, Celsion, MAR 12, 2021, View Source [SID1234576593]). Celsion has two platform technologies for the development of novel nucleic acid-based immunotherapies and next generation infectious vaccines. The Company’s immunotherapy candidate, GEN-1, is currently in Phase II development for the localized treatment of advanced ovarian cancer.

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To participate in the call, interested parties may dial 1-800-353-6461 (Toll-Free/North America) or 1-334-323-0501 (International/Toll) and ask for the Celsion Corporation Fourth Quarter 2020 Earnings Call (Conference Code: 1175518) to register ten minutes before the call is scheduled to begin. The call will also be broadcast live on the internet at www.celsion.com. The call will be archived for replay on Friday, March 19, 2021 and will remain available until April 2, 2021. The replay can be accessed at 1-719-457-0820 or 1-888-203-1112 using Conference ID: 1175518. An audio replay of the call will also be available on the Company’s website, www.celsion.com, for 90 days after 2:00 p.m. EDT Friday, March 19, 2021.

On March 12, 2021 Cyclacel Pharmaceuticals, Inc. (NASDAQ: CYCC, NASDAQ: CYCCP; "Cyclacel" or the "Company"), a biopharmaceutical company developing innovative medicines based on cancer cell biology, reported the pricing of an underwritten public offering of 1,807,143 shares of its common stock, offered at a price of $7.00 to the public. Additionally, the Company has granted the underwriters a 30-day option to purchase up to an additional 271,071 shares of common stock at the public offering price, less underwriting discounts and commissions (Press release, Cyclacel, MAR 12, 2021, View Source [SID1234576592]). All of the shares in the offering are being offered by the Company. The offering is expected to close on or about March 16, 2021, subject to customary closing conditions. The gross proceeds to the Company from this offering are expected to be approximately $12.65 million, before deducting underwriting discounts and commissions and other estimated offering expenses payable by the Company. This amount assumes no exercise of the underwriters’ option.

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Cyclacel intends to use the net proceeds from this offering to support the Company’s growth strategy and for working capital and general corporate purposes, including research and development expenses, and capital expenditures.

Oppenheimer & Co. Inc. is acting as the sole book-running manager, and Ladenburg Thalmann & Co. Inc., Roth Capital Partners, and Brookline Capital Markets, a division of Arcadia Securities, LLC are acting as co-managers for the public offering.

This offering is being made pursuant to an effective shelf registration statement on Form S-3 (No. 333-231923) previously filed with the U.S. Securities and Exchange Commission (the "SEC") and declared effective by the SEC on June 21, 2019. A preliminary prospectus supplement relating to the offering was filed with the SEC on March 11, 2021 and is available on the SEC’s website at www.sec.gov. The final prospectus supplement relating to the offering will be filed with the SEC and will also be available on the SEC’s web site at www.sec.gov. Before investing in the offering, you should read the prospectus supplement and the accompanying prospectus in their entirety as well as the other documents that the Company has filed with the SEC that are incorporated by reference in the prospectus supplement and the accompanying prospectus, which provide more information about the Company and the offering. Copies of the final prospectus supplement and accompanying prospectus, when available, may also be obtained from Oppenheimer & Co. Inc., Attention: Syndicate Prospectus Department, 85 Broad Street, 26th Floor, New York, NY, 10004, by telephone at (212) 667-8055, or by email at [email protected].

This press release shall not constitute an offer to sell or the solicitation of an offer to buy nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

On March 12, 2021 Bavarian Nordic A/S (OMX: BAVA, OTC: BVNRY) ("Bavarian Nordic" or the "Company") reported it has in connection with the directed issue and private placement registered with the Danish Business Authority, a capital increase of a nominal value of DKK 51,500,000 (5,150,000 shares of DKK 10 each) (the "New Shares"), representing 8.81 % of the registered share capital prior to the capital increase (the "Offering") (Press release, Bavarian Nordic, MAR 12, 2021, View Source [SID1234576591]).

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The New Shares have been issued under a temporary ISIN code and are expected to be admitted to trading and official listing under the permanent ISIN code DK0015998017 on Nasdaq Copenhagen A/S with effect from 15 March 2021.

After registration of the share capital increase, the share capital of Bavarian Nordic amounts to nominally DKK 636,001,120 divided into 63,600,112 shares of DKK 10 each. The total number of voting rights in Bavarian Nordic are 63,600,112.

The New Shares rank pari passu with the Company’s existing shares and carry the same dividend and other rights. Each New Share carries one vote at the Company’s general meetings.

Reference is made to company announcements no. 4 and 5 of 9 and 10 March 2021.

The amendments to the Company’s articles of association required by the capital increase have been registered today with the Danish Business Authority and an updated version can be found at bavarian-nordic.com.

MANAGERS
Danske Bank A/S, Jefferies International Limited, Jefferies GmbH and Nordea Danmark, filial af Nordea Bank Abp, Finland are acting as Joint Global Coordinators and Joint Bookrunners (together the "Joint Global Coordinators" and "Joint Bookrunners") in connection with the Offering. Nordea Danmark, filial af Nordea Bank Abp, Finland acts as settlement agent for the Offering.

Kromann Reumert and Latham & Watkins LLP act as Danish and U.S. legal advisors respectively to the Company. Plesner acts as Danish legal advisors to the Joint Global Coordinators and Joint Bookrunners.