INmune Bio, Inc. Announces Participation at Upcoming Virtual Investor Conferences in March 2021

On March 8, 2021 INmune Bio, Inc. (NASDAQ: INMB) (the "Company" or "INmune"), a clinical-stage immunology company focused on developing treatments that harness a patient’s innate immune system to fight disease, reported that its management team is scheduled to participate in two upcoming virtual investor conferences in March 2021 (Press release, INmune Bio, MAR 8, 2021, View Source [SID1234576312]).

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33rd Annual Roth Virtual Conference

Panel Discussion: Therapeutics Against SARS-CoV-2 – Viral Variants Will Not Fade Away
Panel Date: Monday, March 15, 2021
Panel Time: 12:00 PM Eastern Time
Interested parties may register for the panel here

Oppenheimer 31st Annual Healthcare Conference

Presentation Date: Tuesday, March 16, 2021

Presentation Time: 1:10 PM Eastern Time
Interested parties may register for the panel here

Please contact your representative at either Roth or Oppenheimer to schedule a virtual one-on-one meeting with INmune Bio during the respective conference.

CHARLES RIVER LABORATORIES ANNOUNCES PLANNED OFFERING OF $1 BILLION OF SENIOR NOTES

On March 8, 2021 Charles River Laboratories International, Inc. (NYSE: CRL) reported that it intends to offer $1 billion aggregate principal amount of senior notes due 2029 and 2031 (the "notes") in an unregistered offering, subject to market conditions (Press release, Charles River Laboratories, MAR 8, 2021, View Source [SID1234576305]).

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Charles River intends to use the gross proceeds of the offering of the notes to redeem its 5.5% senior notes due 2026 (the "2026 notes"), to fund, along with borrowings under its senior credit facilities, a portion of the purchase price for its proposed acquisition of Cognate BioServices, Inc., and to pay fees and expenses in connection with the offering, the redemption of the 2026 notes, and the amendment of its senior credit facilities.

The notes have not been, and will not be, registered under the Securities Act of 1933, as amended (the "Securities Act"), or under the securities laws of any other jurisdiction. Unless they are registered, the notes may be offered only in transactions that are exempt from registration under the Securities Act and applicable state securities laws. The notes will be offered only to persons reasonably believed to be qualified institutional buyers under Rule 144A under the Securities Act and to non-U.S. persons outside the United States under Regulation S of the Securities Act.

This press release does not constitute an offer to sell or a solicitation of an offer to buy the notes, nor shall there be any sale of the notes in any state or jurisdiction in which such an offer, solicitation, or sale would be unlawful prior to registration or qualification under the securities laws of any such jurisdiction.

Avid Bioservices, Inc. Announces Proposed $125 Million Offering of Exchangeable Senior Notes

On March 8, 2021 Avid Bioservices, Inc. (NASDAQ:CDMO) (NASDAQ:CDMOP) (the "company"), a dedicated biologics contract development and manufacturing organization (CDMO) working to improve patient lives by providing high quality development and manufacturing services to biotechnology and pharmaceutical companies, reported that its wholly-owned subsidiary, Avid SPV, LLC (the "Issuer"), intends to sell, subject to market and other conditions, $125 million aggregate principal amount of exchangeable senior notes due 2026 (the "notes") in a private placement to qualified institutional buyers pursuant to Rule 144A under the Securities Act of 1933, as amended (the "Securities Act") (Press release, Avid Bioservices, MAR 8, 2021, View Source [SID1234576260]). The Issuer also intends to grant the initial purchasers of the notes a 13-day option to purchase up to an additional $18.75 million aggregate principal amount of the notes.

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The notes will be senior, unsecured obligations of the Issuer, will be fully and unconditionally guaranteed by the company on a senior, unsecured basis, and will accrue interest payable semi-annually in arrears. The notes will mature on March 15, 2026, unless earlier repurchased, redeemed or exchanged. Holders of the notes will have the right to exchange their notes for shares of the company’s common stock in certain circumstances and during specified periods. The notes will be settled in cash, shares of the company’s common stock or a combination of cash and shares of the company’s common stock, at the Issuer’s election.

The Issuer expects to make an intercompany loan to the company of all of the net proceeds from this offering. The company intends to use a portion of such loan to pay the cost of the capped call transactions described below, and to use up to approximately $41.3 million of such loan to redeem all of the company’s outstanding 10.50% Series E Convertible Preferred Stock (assuming such redemption occurs on April 10, 2021, all such shares remain outstanding through such date and none of such shares are converted into the company’s common stock prior to such redemption). The company intends to use the remainder of such loan for working capital and other general corporate purposes. If the initial purchasers exercise their option to purchase additional notes, the Issuer expects to make an intercompany loan to the company of all of the net proceeds from the sale of additional notes, which the company intends to use to pay the cost of additional capped call transactions and for working capital and other general corporate purposes. The company may also use a portion of the net proceeds from such loans for the acquisition of, or investment in, technologies, solutions or businesses that complement the company’s business, although it has no commitments to enter into any such acquisitions or investments at this time.

In connection with the pricing of the notes, the company expects to enter into privately negotiated capped call transactions with one or more of the initial purchasers and/or their respective affiliates or other financial institutions (the "option counterparties"). The capped call transactions are expected to cover, subject to customary adjustments, the number of shares of the company’s common stock that will initially underlie the notes. The capped call transactions are expected to reduce or offset the potential dilution of the company’s common stock as a result of any exchange of the notes and/or offset any potential cash payments the Issuer is required to make in excess of the principal amount of exchanged notes, as the case may be, with such reduction and/or offset subject to a cap. If the initial purchasers exercise their option to purchase additional notes, the company expects to enter into additional capped call transactions with the option counterparties.

In connection with establishing their initial hedges of the capped call transactions, the option counterparties and/or their respective affiliates may purchase shares of the company’s common stock and/or enter into various derivative transactions with respect to the company’s common stock concurrently with, or shortly after, the pricing of the notes, including with certain investors in the notes. This activity could increase (or reduce the size of any decrease in) the market price of the company’s common stock or the notes at that time.

In addition, the option counterparties and/or their respective affiliates may modify their hedge positions by entering into or unwinding various derivatives with respect to the company’s common stock and/or purchasing or selling the company’s common stock or other securities in secondary market transactions following the pricing of the notes and prior to the maturity of the notes (and are likely to do so on each exercise date for the capped call transactions, which are expected to occur during the 40 trading day period beginning on the 41st scheduled trading day prior to the maturity date of the notes). This activity could also cause or avoid an increase or decrease in the market price of the company’s common stock or the notes, which could affect the ability of noteholders to exchange the notes, and, to the extent the activity occurs during any observation period related to an exchange of notes, it could affect the number of shares of the company’s common stock and value of the consideration that holders of the notes will receive upon exchange of the notes.

Neither the notes, nor any shares of the company’s common stock potentially issuable upon exchange of the notes, have been, nor will be, registered under the Securities Act or any state securities laws and, unless so registered, may not be offered or sold in the United States absent registration or an applicable exemption from, or in a transaction not subject to, the registration requirements of the Securities Act and other applicable securities laws.

This press release is neither an offer to sell nor a solicitation of an offer to buy any securities, nor shall it constitute an offer, solicitation or sale of the securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such jurisdiction. The notes will be offered to qualified institutional buyers pursuant to Rule 144A under the Securities Act.

Acorda Therapeutics to Present at H.C. Wainwright Global Life Sciences Virtual Conference

On March 8, 2021 Acorda Therapeutics, Inc. (NASDAQ: ACOR) reported that Ron Cohen, M.D., President and Chief Executive Officer, will present during the March 9th & 10th H.C. Wainwright Global Life Sciences Virtual Conference (Press release, Acorda Therapeutics, MAR 8, 2021, View Source [SID1234576258]). For more information about the conference, please visit the event website at View Source

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Wugen Announces Exclusive Partnership Agreement With Alpha Biopharma in Asia For Cell Therapies to Treat Cancer

On March 8, 2021 Wugen Inc., a clinical-stage biotechnology company developing novel universal natural killer (NK) and T-cell therapies for the treatment of cancer, reported that it has entered into an exclusive license and collaboration agreement with Shanghai-based Alpha Biopharma Inc. to manufacture, develop, and commercialize its allogeneic cell products in Asia, including mainland China, Hong Kong, Macao, Taiwan region and Singapore (Press release, Wugen, MAR 8, 2021, View Source [SID1234576256]). The products included in the agreement incorporate Wugen’s proprietary technology to manufacture universal "off-the-shelf" Memory NK and CAR-T cells for the treatment of solid tumors, T-cell malignancies, Acute Myeloid Leukemia, and Multiple Myeloma.

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"We are looking forward to collaborating with the experienced and accomplished team at Alpha Biopharma, a company committed to the clinical development of innovative drugs in China," said John McKearn, Ph.D., CEO of Wugen. "This agreement represents a significant milestone for Wugen’s clinical progress as it allows us to extend our pipeline of novel cell therapies to geographies with substantial unmet needs and position our clinical programs for expedited global approvals."

"This collaboration will generate significant synergies in both clinical development and future commercialization. We will bring Wugen’s leading next-generation cell therapies to China to fulfill the tremendous unmet medical need in combating cancer," said Eric Zhang, CEO of Alpha Biopharma. "We will leverage our strength to accelerate clinical development, manufacturing, and regulatory activities in China now and commercialization upon approval."

Per the agreement, Alpha Biopharma will be responsible for the development and commercialization of the products in the defined territory, including manufacturing, clinical, regulatory, marketing and sales activities. Alpha Biopharma and Wugen will equally share profits and losses related to the development and commercialization of products in the territory, as well as sharing data to support territory and global approvals.

Currently approved cellular therapies have been shown to effectively treat B-cell cancers, but there remains a significant unmet need for treating other cancers. Wugen is using its proprietary platform to manufacture "off-the-shelf" Memory NK and CAR-T therapies, providing several advantages over current autologous therapies, including robust manufacturing, lower cost of goods, and enhanced safety profile.