IMV Inc. to Present at the Bloom Burton & Co. Healthcare Investor Virtual Conference

On April 13, 2021 IMV Inc. (Nasdaq: IMV; TSX: IMV), a clinical stage immuno-oncology company reported that IMV’s executive management team will be participating in the 2021 Bloom Burton & Co. Healthcare Investor Virtual Conference which will be held April 20 and April 21, 2021 (Press release, IMV, APR 13, 2021, View Source [SID1234577956]).

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IMV’s presentation details include:

Date: Tuesday, April 20, 2021
Time: 4:00 p.m. ET
There will be a live webcast of IMV’s presentation accessible in the ‘Events, Webcasts & Presentations’ page of IMV’s website. The webcast will then be archived following the live presentation and a copy of the presentation will be available www.imv-inc.com.

Cofactor Genomics Commences First Predictive Immune Modeling Clinical Trial to Bridge Precision Medicine Gap for Immunotherapy

On April 13, 2021 Cofactor Genomics, the company bridging the precision medicine gap, reported commencement of the first multicenter clinical trial of its OncoPrismTM diagnostic assay, using the company’s patented approach to generating multidimensional immune biomarkers (Press release, Cofactor Genomics, APR 13, 2021, View Source [SID1234577954]). Fifteen hospitals and healthcare networks, including Mayo Clinic, MultiCare Institute for Research and Innovation, and Revive Research Institute, are currently enrolling in the PREDAPT (Predicting Immunotherapy Efficacy From Analysis of Pre-treatment Tumor Biopsies) Trial to evaluate use of the OncoPrism test in patients with recurrent and metastatic squamous cell carcinoma of the head and neck (RM-HNSCC) to effectively predict a patient’s response to immunotherapy. The company expects additional sites to join the trial before the end of 2021.

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While the trial will initially recruit RM-HNSCC patients, the protocol is approved for recruitment of patients with 10 additional indications where independent market research has identified an unmet clinical need in predicting tumor response to immunotherapy. Specimens collected in the study will be analyzed at Cofactor’s CAP/CLIA accredited laboratory.

"Opening recruitment for the PREDAPT study is a significant milestone for Cofactor. It represents not only the world’s first Predictive Immune Modeling clinical validation study, but the first of many studies we intend to sponsor. These studies will lead to predictive diagnostics that are undeniably needed in the field, for therapies that are in development or those already on the market," stated David Messina, PhD, Cofactor’s Chief Operating Officer. "Physicians do not currently have adequate information to predict tumor response to immune checkpoint inhibitors, resulting in ineffective and inconsistent treatment. This is ultimately a heavy burden on both patients and the healthcare system that supports them; we intend to change that."

The study includes both retrospective and prospective specimen collection, but does not require any additional visits or surgery outside of standard care for enrolled patients. The PREDAPT trial builds on preliminary results recently presented that showed the performance of a multidimensional RNA biomarker built using the company’s Predictive Immune Modeling approach was more effective than the on-label PD-L1 immunohistochemistry (IHC) assay in predicting tumor response to anti-PD-1 therapy in RM-HNSCC.

PREDAPT is uniquely designed to be a decentralized study. To enable that, Cofactor has contracted Curebase as the CRO partner, who enables highly virtual clinical trials by offering a full-service CRO and eClinical Platform, complete with eConsent, electronic data capture, and remote monitoring capabilities. This enables individual investigators, who may be passionate about science and improving patient outcomes, the ability to participate in the clinical trial even if their hospital is unable to participate as a traditional clinical site. It has also enabled Cofactor to establish two major recruitment streams to ensure maximum diversity and streamlined recruitment, traditional clinical sites and direct-to-patient recruitment.

"The PREDAPT study is exactly what we had in mind when we built the Curebase platform. Using software-powered, decentralized research methods, we are proving with Cofactor that any patient can be part of a clinical trial no matter where they live," noted Tom Lemberg, CEO at Curebase.

Despite the thousands of new clinical trials that are started every year and the significant advances made in launching innovative therapies such as immunotherapies, physicians are still prescribing the wrong therapy to more than 80 percent of patients.1 The gap in matching these innovative therapies to the patients that will benefit (and avoiding those who will not respond or may have adverse reactions) is a major problem in healthcare.

"Technologies that are capable of playing matchmaker and bridging this gap are key," said Jarret Glasscock, PhD, Cofactor’s Chief Executive Officer. "The field of Predictive Immune Modeling is building this next generation of predictive diagnostics that are showing an enhanced ability to accurately predict patient response prior to treatment. We expect these technologies to not only improve patient treatment paths, but to also provide cost savings to the entire healthcare system."

Sites interested in joining this high impact study may contact [email protected] or express their interest here.

Herantis Pharma to Participate in the Upcoming Nordic Life Science Days

On April 13, 2021 Herantis Pharma Plc ("Herantis"), focusing on disease modifying therapies for debilitating neurodegenerative diseases, reported that Dr. Craig Cook, Chief Executive Officer, will hold 1×1 meetings and have a digital company presentation in the upcoming Nordic Life Science Days conference (Press release, Herantis Pharma, APR 13, 2021, View Source,c3324050 [SID1234577949]).

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Event Details:

Nordic Life Science Days Digital

Dates: 20 – 23 April 2021

On 20 April 2021 all presentations will be available via a digital library, which is accessible to event participants only. Please contact the organizers at the Nordic Life Science Days if you wish to attend.

Evotec launches “beLAB2122”, translating academic innovation from leading German life science region in collaboration with Bristol Myers Squibb

On April 13, 2021 Evotec SE (Frankfurt Stock Exchange: EVT, MDAX/TecDAX, ISIN: DE0005664809) reported that the Company has launched beLAB2122, a translational $ 20 million BRIDGE in collaboration with Bristol-Myers Squibb Company (NYSE: BMY) (Press release, Evotec, APR 13, 2021, View Source;announcements/p/evotec-launches-belab2122-translating-academic-innovation-from-leading-german-life-science-region-in-collaboration-with-bristol-myers-squibb-6047 [SID1234577948]). beLAB2122 brings together leading academic institutions from the Rhine-Main-Neckar region of Germany with the goal of efficiently advancing first-in-class therapeutic options across all therapeutic areas and formats into investable drug discovery and early development projects.

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LET’S CALL EVOTEC | THOMAS HANKE ON BELAB2122 AND BRIDGES

Mediated and supported by BioRN, the Life Science Cluster Rhein Neckar, beLAB2122 for the first time brings together the European Molecular Biology Laboratory ("EMBL"), the German Cancer Research Center ("DKFZ"), the Goethe University Frankfurt, Heidelberg University and the University of Tübingen in one collaboration with industry partners. Evotec’s BRIDGE (Biomedical Research, Innovation & Development Generation Efficiency) collaborations provide an integrated fund and award framework to validate exciting academic projects in collaborations with pharma and funders which may lead to the formation of jointly owned new companies. Since 2016, Evotec has established several BRIDGE collaborations with a variety of academic, pharma, and venture capital partners across Europe and North America.

Evotec launches beLAB2122 in cooperation with Bristol Myers Squibb, Evotec’s long-standing collaborator in drug discovery across several therapeutic areas. Together the sponsors intend to tap into Europe’s foremost academic clusters of excellence in the life sciences, both validating and advancing innovative research in therapeutics and related technologies from academia to enable the formation of new, collectively owned spin-out companies.

Dr Werner Lanthaler, Chief Executive Officer of Evotec, said: "We are very excited about the launch of beLAB2122, a truly transformative framework that leverages first-class science from one of Europe’s leading life science cluster regions with lots of potential to generate medical progress. We look forward to unlocking this potential by using our ‘data-driven R&D Autobahn to Cures’ to further validate and develop these approaches to translate the promising early-stage research into the medicines of the future."

Dr Thomas Hanke, Head of Academic Partnerships at Evotec, added: "We are delighted to see the first BRIDGE in Germany becoming reality and look forward to working closely with our academic partners in the Rhine-Main-Neckar area and our colleagues at Bristol Myers Squibb to identify and accelerate the next generation of first-in-class therapeutics across all modalities and therapeutic areas. We would also like to particularly thank BioRN for continuously supporting beLAB2122."

Dr Rupert Vessey, Executive Vice President and President, Research and Early Development at Bristol Myers Squibb commented: "We are excited by the opportunity to support beLAB2122 in the translation of novel scientific research from these leading German academic institutions. Given their past experience with successful BRIDGEs, we believe Evotec is well-equipped to interpret the many lines of scientific inquiry resulting from this collaboration and use its proprietary platforms to deliver quality data that may one day lead to potentially novel therapies for patients."

Prof. Matthias Hentze, EMBL Director, said: „This collaboration has been established at a time of increasing awareness that the efficient and rapid translation of research outcomes is essential. beLAB2122 is a transformative collaboration to accelerate the validation of therapeutic concepts for the benefit of society. EMBL, as Europe’s leading molecular biology research institute, is delighted to be part of this initiative along with some of the most renowned institutes in the region and beyond. With Evotec and Bristol Myers Squibb this collaboration has world-renowned industrial sponsors to help bring successful ideas into the market and to foster cutting-edge research and innovation."

Dr Rainer Wessel, Chief Innovation Officer, German Cancer Research Center (DKFZ), added: "For DKFZ, a major goal is to foster transfer of our excellent research into highly innovative applications that benefit cancer patients world wide. The beLAB2122 collaboration is a major step in gaining critical mass and speed together with other scientific and commercial leaders to achieve that goal."

Prof. Dr Manfred Schubert-Zsilavecz, Vice President of Goethe University Frankfurt responsible for the Third Mission and Professor for Medicinal Chemistry, pointed out: "Pharmaceutical and translational medical research are two of the key strengths of Goethe University Frankfurt, and numerous of our research projects aim to contribute to closing the innovation gap in drug development. We are extremely happy to be part of the beLAB2122 research network in order to boost cooperation between academic and industrial research, for the sake of suffering patients."

Prof. Dr Matthias Weidemüller, Vice-Rector Innovation and Transfer, Heidelberg University, affirmed: "Heidelberg University is excited to be part of the Evotec BRIDGE collaboration beLAB2122. It is of fundamental importance that our cutting-edge research be translated into applications on a broader scale. This collaboration brings together leading institutions in the Rhine-Main-Neckar region that conduct research at the forefront of life science. I am positive that – within the BRIDGE framework – we can generate added momentum for converting scientific achievements into future therapeutics."

Prof. Dr Peter Grathwohl, Vice-President of Research and Innovation of the University of Tübingen, joined: "The University of Tübingen is delighted to be part of beLAB2122. The transfer of research results to application is very important to us: In the future, we want to provide excellent opportunities for our researchers to contribute their expertise to concrete collaboration projects with sponsors in economy and industry."

The name beLAB2122 refers to the Rhine, Main, and Neckar rivers which connect the member institutions with one another and which total 2,122 kilometres in length. For further information on beLAB2122, please visit www.belab2122.org.

ZN-C3 IS CURRENTLY BEING EVALUATED IN PATIENTS WITH ADVANCED SOLID TUMORS AND OVARIAN CANCER

On April 12, 2021 Zentalis Pharmaceuticals, Inc. (Nasdaq: ZNTL), a clinical-stage biopharmaceutical company focused on discovering and developing small molecule therapeutics targeting fundamental biological pathways of cancers, reported a clinical collaboration agreement with GlaxoSmithKline ("GSK") in which Zentalis will evaluate the combination of ZN-c3, Zentalis’ oral WEE1 inhibitor product candidate, and ZEJULA (niraparib), GSK’s poly (ADP-ribose) polymerase (PARP) inhibitor, in patients with advanced epithelial ovarian cancer (Press release, Zentalis Pharmaceuticals, APR 12, 2021, View Source [SID1234643100]). Zentalis is currently conducting clinical studies with ZN-c3 both as a monotherapy and in combination with certain standard of care therapies.

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"This clinical collaboration and supply agreement with GSK allows us to investigate the broader potential of our WEE1 inhibitor when used as part of a combination treatment with niraparib, a PARP inhibitor," commented Dr. Anthony Sun, Chairman and Chief Executive Officer of Zentalis Pharmaceuticals. "As demonstrated in our preclinical studies, ZN-c3 is designed to have significant advantages over other investigational WEE1 inhibitor therapies. We believe this combination has the potential to meaningfully improve the outcomes for patients with ovarian cancer."

PARP inhibitors prevent DNA damage repair in cancer cells. Similar to PARP, WEE1 plays a role in cellular regulation and repair, allowing cells with DNA damage to repair and survive. Inhibition of WEE1 causes dysregulation of DNA replication and subsequently induces apoptosis. Based on these complementary mechanisms of action, the use of WEE1 and PARP inhibitors could potentially have synergistic anti-tumor activity.

More than 300,000 women worldwide are diagnosed with ovarian cancer each year, leading to over 180,000 fatalities1. While substantial progress has been made in the treatment of this disease, there is an urgency to address the remaining unmet need through the development of innovative combination treatments.

Under the terms of the non-exclusive collaboration, Zentalis is responsible for conducting the study with GSK providing all required doses of niraparib. Zentalis maintains full ownership of ZN-c3.

1www.cancerresearch.org

About ZN-c3

ZN-c3 is an oral inhibitor of WEE1 in development for the treatment of advanced solid tumors. The inhibition of WEE1, a DNA damage response protein, aims to generate sufficient DNA damage in cancer cells, causing cell death, thereby preventing tumor growth and potentially causing tumor regression. Zentalis is currently conducting a Phase 1/2 clinical trial in patients with advanced solid tumors and reported initial data from the Phase 1 portion at the AACR (Free AACR Whitepaper) Annual Meeting 2021. In addition, the Company is also conducting a Phase 1b trial evaluating ZN-c3 in combination with chemotherapy in patients with advanced ovarian cancer, with plans to initiate a Phase 1/2 trial in combination with GSK’s niraparib in patients with advanced ovarian cancer, a Phase 1/2 trial in combination with chemotherapy in osteosarcoma and a Phase 2 trial investigating ZN-c3 as a monotherapy in patients with uterine serous carcinoma in 2021.

About ZEJULA (niraparib)

GSK’s ZEJULA (niraparib) is an FDA and EMA-approved oral, once-daily poly (ADP-ribose) polymerase inhibitor that is currently being evaluated in multiple pivotal trials. GSK is building a robust niraparib clinical development programme by assessing activity across multiple tumour types and by evaluating several potential combinations of niraparib with other therapeutics. The ongoing development programme for niraparib includes several combination studies, including Phase III studies in ovarian and non-ovarian indications.