On April 9, 2021 Nuvo Pharmaceuticals Inc. (TSX:MRV; OTCQX:MRVFF) d/b/a Miravo Healthcare (Miravo or the Company), a Canadian focused healthcare company with global reach and a diversified portfolio of commercial products, reported Jesse Ledger, Miravo’s President & Chief Executive Officer and Mary-Jane Burkett, Miravo’s Vice President & Chief Financial Officer will be presenting at upcoming investor conferences (Press release, Nuvo Pharmaceuticals, APR 9, 2021, View Source [SID1234580415]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Bloom Burton & Co. Healthcare Investor Conference

The Bloom Burton & Co. Healthcare Investor Conference brings together U.S., Canadian and international investors who are interested in the latest developments in the Canadian healthcare sector. Attendees will have an opportunity to obtain corporate updates from the premier Canadian publicly traded and private companies through presentations and private meetings.

Miravo Healthcare Presentation

DATE: Wednesday, April 21st, 2021
TIME: 10:00 a.m. EST
LINK: Conference Registration

Planet MicroCap Showcase

The Planet MicroCap Showcase VIRTUAL EVENT brings together the most promising companies and the top dealmakers in MicroCap Finance for three (3) days of company presentations, 1:1 meetings and educational panels in The Premier Virtual Event in MicroCap Finance.

Miravo Healthcare Presentation

DATE: Thursday, April 22nd, 2021
TIME: 10:00 a.m. EST
LINK: Miravo Presentation

On April 9, 2021 Werewolf Therapeutics reported that now wants an IPO (Press release, Werewolf Therapeutics, APR 9, 2021, View Source [SID1234577882]).

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The early-stage biotech is working on shape-shifting cytokine drugs, i.e., ones that deliver the promise of cytokines without their nasty side effects. Known as Indukines, Werewolf’s candidates are "switched off" when they’re given to patients and activate only when they arrive in cancer cells.

Cytokines, such as interleukin-2, emerged decades ago as promising cancer treatments. But they evolved as signaling molecules and not as drugs, so it’s no surprise that they’re missing some key pharmaceutical features that would make them good medicines.

"These mechanisms are a very powerful way to stimulate the immune system to attack tumors, but unfortunately, a number of cytokines can activate the immune system in an adverse way where it can attack normal tissues," Werewolf CEO Daniel Hicklin, Ph.D., said in January. Werewolf’s protein engineering technology is designed to limit its drugs’ effects on healthy tissues.

The biotech, which is preclinical but wants the cash to chase these drugs into the clinic, got off a $72 million raise in January just over a year after it nabbed $56 million series A back in November 2019. Now, according to its SEC-1 filing, it wants a $100 million IPO, though don’t be surprised if, like so many other biotechs over the past year, it ends up getting more than that.

Its two leading assets, WTX-124 and WTX-330, are seeking INDs with the FDA from next year, according to its filing, after which it plans to conduct phase 1/1b trials in patients with multiple tumor types both as standalone treatments and in combination with an immune checkpoint inhibitor.

It also has a third asset, WTX-613, which is much further back in the pipeline, with clinical trials not slated until 2023. This drug is designed to be a systemically delivered, conditionally activated interferon alpha, or IFN-a, molecule for the treatment of solid tumors and blood cancers.

Other players hoping to make better cytokines for cancer treatment include Synthekine, which launched in September with $82 million, and Bright Peak Therapeutics, which debuted in July with $35 million.

And Sanofi bet big on the approach in December 2019 when it inked a $2.5 billion deal to acquire Synthorx, with some early data dropping this weekend at the American Association for Cancer Research (AACR) (Free AACR Whitepaper).

On April 9, 2021 Bionomics Limited (ASX: BNO,OTCQB:BNOEF) (Bionomics) reported that it has completed its 1 for 6 pro rata non–renounceable entitlement offer that was announced on 8 March 2021 (Entitlement Offer) and concurrent placement that was announced on 17 March 2021 (Concurrent Placement) which collectively raised approximately A$22.9 million (Press release, Bionomics, APR 9, 2021, View Source [SID1234577811]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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The Entitlement Offer closed at 5.00pm (Adelaide time) on 30 March 2021 and raised approximately A$20.4 million from the offer of approximately 140.9 million new fully paid ordinary shares in Bionomics (New Shares) at the offer price of A$0.145 per New Share.

The Entitlement Offer was well supported by eligible shareholders who applied for approximately 85.6 million shares aggregating to approximately A$12.4 million of New Shares pursuant to their entitlements (representing a take up rate of approximately 60.7%).

Eligible shareholders subscribed for a further approximately 70.3 million additional New Shares in excess of their entitlement (up to a maximum of 100% of their entitlement) aggregating to approximately A$10.2 million in excess of their entitlement through the Oversubscription Facility. Applications under the Oversubscription Facility were in excess of the approximately 55.3 million shares or A$8 million shortfall and were scaled back in accordance with the terms of the Entitlement Offer on a pro rata basis.

Commenting on the outcome, Bionomics’ Executive Chairman, Dr Errol De Souza said, "Following on from the strong support received under the Company’s oversubscribed capital raise in February 2021, the success of the Entitlement Offer and Concurrent Placement demonstrates the confidence of Bionomics’ shareholders in the direction of the Company and the opportunities presented by progressing the development programme for BNC210 for the treatment of PTSD. We remain on track to starting the Phase 2b BNC210 PTSD trial in mid-2021".

As announced on 17 March 2021, Bionomics also conducted the Concurrent Placement concurrently with the Entitlement Offer pursuant to which certain investors were entitled to apply for new shares at the same price and on the same pro rata basis as was offered to subscribers under the Entitlement Offer. The investors to whom this Concurrent Placement offer was extended were those who participated in the Bionomics placement announced on 9 February 2021 and which completed on 2 March 2021, but who were unable to participate in the Entitlement Offer due to having a registered address outside of Australia or New Zealand.

The Concurrent Placement which was made on substantially the same terms as the Entitlement Offer raised approximately A$2.5 million from the offer of approximately 17.2 million new fully paid ordinary shares in Bionomics (New Concurrent Shares) at the offer price of A$0.145 per New Concurrent Share. New Concurrent Shares applied for under the Concurrent Placement were scaled back on a pro rata basis in the same manner as shareholders who applied under the Entitlement Offer.

The New Concurrent Shares issued under the Concurrent Placement were allocated from Bionomics’ expanded placement capacity following the Entitlement Offer.

Allotment of New Shares and New Concurrent Shares under the Entitlement Offer and the Concurrent Placement occurred on Thursday, 8 April 2021.

New Shares and Concurrent New Shares issued under the Entitlement Offer and the Concurrent Placement rank equally in all respects with existing shares. Shareholders should confirm their holding before trading in New Shares and Concurrent New Shares.

On April 9, 2021 Bausch Health Companies Inc. (NYSE/TSX: BHC) ("Bausch Health") reported that it will release its first-quarter 2021 financial results on Tuesday, May 4, 2021 (Press release, Bausch Health, APR 9, 2021, View Source [SID1234577810]). Bausch Health will host a conference call and live web cast at 8:00 a.m. EDT to discuss the results and provide a business update. All materials will be made available on the Investor Relations section of the Bausch Health website prior to the start of the call.

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On April 9, 2021 Bold Therapeutics, a clinical-stage biopharmaceutical company developing BOLD-100, a first-in-class anti-cancer agent, reported that Sandra Van Schaeybroeck, PhD (Queen’s University Belfast) will be presenting research supporting BOLD-100 as a potential anti-resistance therapy for difficult-to-treat cancers, specifically BRAF-mutant colorectal cancer (Press release, Bold Therapeutics, APR 9, 2021, View Source [SID1234577809]).

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Van Schaeybroeck’s AACR (Free AACR Whitepaper) poster presentation "Targeting the DNA repair pathway with BOLD-100 in BRAF-mutant colorectal cancer" (Poster# 1183, Session PO.ET04.03 on April 10) highlights the promising research conducted by the Drug Resistance Group at the Patrick G. Johnston Centre for Cancer Research at Queen’s University Belfast, which investigated BOLD-100’s mechanism-of-action and identified promising treatment combinations in difficult-to-treat BRAF-mutant colorectal cancers.

Colon cancer is one of the most frequently diagnosed malignancies in adults, responsible for approximately 11% of all new cases of cancers worldwide and one-third of cancer deaths. BRAF-mutant colorectal cancers comprise 10% of those patients, and this subgroup has morphological, clinical, and therapeutic characteristics that differ substantially from patients without this genetic alteration. Importantly, there is no established standard of care for BRAF-mutant colorectal cancer, which is associated with a particularly poor prognosis and a median OS of less than 12 months versus more than 30 months for BRAF wild type metastatic colorectal cancer (mCRC), with V600E BRAF-mutated colorectal cancer being the most challenging subtype.

"BOLD-100 has a unique and complex mechanism-of-action and has potential in various challenging cancer subtypes, such as V600E BRAF-mutated colorectal cancer," stated Van Schaeybroeck. "This study further elucidated the mechanism-of-action for BOLD-100 and identified potentially synergistic drug-drug combinations for future investigation."

The AACR (Free AACR Whitepaper) Annual Meeting provides an opportunity to discuss the latest discoveries in cancer research and highlights the work being done by institutions around the world. This year’s virtual conference is taking place April 10-15 and May 17-21.

"Bold Therapeutics has developed a global consortium of world-class academic collaborators to investigate the potential of BOLD-100 as a revolutionary first-in-class anti-cancer agent that targets both ER stress and DNA repair pathways," said Mark Bazett, PhD, Director of Preclinical Development at Bold Therapeutics. "We look forward to connecting with interested researchers at AACR (Free AACR Whitepaper) 2021 to further develop this novel therapy."

Bold Therapeutics is headquartered in Vancouver, British Columbia, Canada. BOLD-100 is currently being investigated in a Phase 1b/2 study in combination with FOLFOX in the treatment of advanced gastrointestinal cancers at six sites in Canada, with additional sites opening in the United States and South Korea in late 2021.