On April 7, 2021 PTC Therapeutics, Inc. (NASDAQ: PTCT) reported that it has been named a winner of the 2021 "Don Clifton Strengths-Based Culture Award" from Gallup (Press release, PTC Therapeutics, APR 7, 2021, View Source [SID1234577668]). The award recognizes organizations with strong workplace cultures that get the best out of their employees by focusing and developing their strengths and placing them at the center of how they work every day.

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"We are honored to accept this award and appreciate the recognition that at PTC we have built an engaging and innovative work environment that is collaborative and committed to develop our employees," said Stuart W. Peltz, Ph.D., Chief Executive Officer of PTC Therapeutics. "While the past year has presented many challenges due to the COVID-19 pandemic, our team has proven that we can work smarter and go farther together. At PTC we say that science is our foundation, and our culture is our heart."

About the Don Clifton Strengths-Based Culture Award
Don Clifton, professor of educational psychology at the University of Nebraska-Lincoln, invented the CliftonStrengths assessment, which helps companies bring the power of strengths-based development into the workplace.1 To honor this, Gallup introduced the "Don Clifton Strengths-Based Culture" Award. A panel of judges reviewed many companies and identified six that successfully integrate the Clifton StrengthsFinder methodology into its performance management framework as well as support employees in discovering and operating in their strengths.

On April 7, 2021 Ziopharm Oncology, Inc. ("Ziopharm" or the "Company") (Nasdaq: ZIOP), reported it will be presenting a poster at the upcoming American Association for Cancer Research (AACR) (Free AACR Whitepaper) Virtual 2021 Annual Meeting (Press release, Ziopharm, APR 7, 2021, View Source [SID1234577667]).

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The poster highlights work evaluating the ability of the non-viral Sleeping Beauty transposon/transposase gene transfer system to re-direct the specificity of T cells towards p53 and KRAS neoantigens and characterizing the resultant engineered TCR-T cell populations for specificity and function.

The poster is entitled "Hotspot mutations in KRAS and TP53 targeted by TCR-T cells genetically modified with the Sleeping Beauty transposon/transposase system."

The work summarized in the poster demonstrates that multiple TCRs with unique specificities targeting recurrent p53 and KRAS substitutions in frequent HLA haplotypes could be stably expressed using Sleeping Beauty transposition to re-direct peripheral blood T cells towards tumor cells.

Dr. Raffaele Baffa, MD, PhD, Chief Medical Officer of Ziopharm said, "We are pleased to share this update on our TCR-T directed work with the scientific community. The Company is working tirelessly on our Phase I/II clinical study for our TCR-T Library, and the work presented in this poster provides us with increased confidence in the scientific rationale behind the trial."

The poster will be presented as part of Session PO.IM02.01 – Adoptive Cell Therapy. The abstract for the poster can be found on the AACR (Free AACR Whitepaper) website using this link. The poster will be available for conference participants beginning at 8:30am ET on Saturday, April 10, 2021 and will also be posted on the Ziopharm Oncology website in the Investors section, using this link.

On April 7, 2021 Artios Pharma Limited (Artios), a leading DNA Damage Response (DDR) company exploiting synthetic lethality to develop a broad pipeline of precision medicines for the treatment of cancer, reported a global research collaboration with Novartis to discover and validate next generation DDR targets to enhance Novartis’ Radioligand Therapies (RLT) (Press release, Artios Pharma, APR 7, 2021, View Source [SID1234577665]).

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Under the three-year collaboration, Artios and Novartis will perform target discovery and validation, and Novartis will select up to three exclusive DDR targets, and receive worldwide rights on these targets to be utilized with its RLT’s.

Dr. Niall Martin, Chief Executive Officer at Artios Pharma, said: "This collaboration expands the reach of our discovery platform, leveraging our DDR expertise and target knowledge to enhance the potential of radioligand therapies. We are thrilled to work with Novartis, and this combined with our recent collaboration with Merck KGaA provides important validation of the power of the internal discovery capabilities at Artios. From a strategic perspective, this collaboration is an ideal fit which maximizes the application of our platform to areas beyond our current focus as we independently advance our pipeline of novel DDR candidates. We look forward to continued momentum as a clinical-stage precision medicine company, building upon our recently initiated Phase 1 study of ART0380, our potential best-in-class ATR inhibitor, with the expected entry of our first-in-class Pol Theta program into the clinic before year end."

Under the terms of the agreement, Novartis will make an up-front payment of US$20 million and provide near term research funding to support the collaboration. Artios will be eligible to receive discovery, development, regulatory and sales-based milestones, in addition to royalty payments on net sales of products commercialized by Novartis. The collaboration does not include Artios’ lead programs, ART0380, which is currently in clinical development, or ART4215, a first-in-class Pol Theta inhibitor.

Novartis’ RLT delivers targeted radiation to a specific subset of cancer cells, with minimal effect on surrounding healthy cells. RLT has been shown to improve overall survival and quality of life, particularly in the setting of cancers with bone metastases.

On April 7, 2021 CTI BioPharma Corp. (NASDAQ: CTIC) reported that management will provide a corporate overview at the 20th Annual Needham Virtual Healthcare Conference at 3:00 p.m. EST (Press release, CTI BioPharma, APR 7, 2021, View Source [SID1234577661]). The conference will be held in a virtual meeting format.

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Presentation details:

Event: 20th Annual Needham Virtual Healthcare Conference
Date: Wednesday, April 14, 2021
Time: 3:00 p.m. EST

The presentation will be webcast live and available for replay from the Investors section of CTI BioPharma’s website at www.ctibiopharma.com.

On April 7, 2021 BioCryst Pharmaceuticals, Inc. (Nasdaq:BCRX) reported that the company will present at the 20th Annual Needham Virtual Healthcare Conference on Wednesday, April 14, 2021 at 8:45 a.m. ET (Press release, BioCryst Pharmaceuticals, APR 7, 2021, View Source [SID1234577660]).

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Links to a live audio webcast and replay of this presentation may be accessed in the Investors section of BioCryst’s website at http://www.biocryst.com.