NKMax America Announces Corporate Name Change to NKGen Biotech

On April 2, 2021 NKMax America, a biotechnology company harnessing the power of the body’s immune system through the development of Natural Killer (NK) cell therapies, reported that it has changed its corporate name to NKGen Biotech, Inc., which the Company believes best reflects its mission and strategic focus (Press release, NKMax America, APR 2, 2021, View Source [SID1234577554]). The name change is effective immediately.

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"We believe the name NKGen Biotech more accurately represents the direction our company is headed and our commitment to developing the next generation of natural killer cell immunotherapies with the potential to restore immune function in patients with cancer worldwide," said Stephen Chen, NKGen Biotech Chief Operating Officer and Chief Technical Officer.

Mr. Chen further commented, "Our clinical programs remain on track and we plan to report full data from our Phase 1 monotherapy trial of SNK01 in refractory solid tumors in the second quarter of 2021, while advancing our partnered combination programs with Merck KGaA and Affimed throughout the year. We are excited to embark on the next steps in our journey to become the leading player in NK cell therapeutics."

The Company’s lead drug candidate, SNK01, is an investigational autologous NK cell-based therapy which is currently being studied alone and in combination with other approved drugs for the treatment of cancer. NKGen Biotech also plans to file an IND for its allogeneic NK cell platform in 2022.

Boston Business Journal: Life sciences firm Locust Walk’s plans for its $175M SPAC

On April 2, 2021 Geoff Meyerson co-founded Locust Walk, a Boston-based life sciences consulting firm, on Sept. 15, 2008, the same day that Lehman Brothers filed for bankruptcy and Merrill Lynch sold itself to Bank of America (Press release, Locust Walk Partners, APR 2, 2021, View Source [SID1234577553]). Meyerson said he "figured the world didn’t need another investment bank," so he and his team found other ways to support biotech firms: advising on strategy, providing analytics, helping raise capital and preparing them for IPOs.

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Late last year, when the popularity of special-purpose acquisition companies, or SPACs, was exploding, Locust Walk was ready to jump in on the action. The firm filed to raise $130 million for Locust Walk Acquisition Corp., its first SPAC, in the fall. By mid-January, Locust Walk had secured $175 million for the vehicle and gone public on the Nasdaq.

Now, Locust Walk is using the same expertise it has developed over the last 12 years as it seeks a target for the SPAC.

"We basically used our engine that we built at Locust Walk to screen for the right types of companies, identify them, do due diligence and secure a deal," Meyerson said. "We’re kind of eating our own cooking."

Locust Walk is part of a rapidly growing group of companies and investment firms looking to strike gold via SPACs. RA Capital, MPM Capital, General Catalyst, Bain Capital Life Sciences and Omega Funds all launched SPACs of their own within the last year.

Also called blank-check companies, SPACs are formed with the purpose of using the proceeds from their initial public offerings to acquire one or more unspecified businesses, referred to as targets. SPACs have found a sweet spot in the Covid-19 era, offering a seemingly easier route to becoming a public company than a traditional IPO.

‘Not going anywhere’
Meyerson noted that even large, well-funded biotech firms are eyeing SPACs as a means to go public.

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"I think the biggest surprise we’ve had is we thought (those interested in SPACs) might be second-tier companies. We didn’t think some of the biggest companies would want to do that," Meyerson said. "We found that not to be the case. There are a lot of top-tier companies with plenty of investors that are seriously considering SPACs or have already merged with SPACs."

Meyerson declined to share many details about the criteria Locust Walk has outlined for a target for its SPAC. He said his team is looking for a biotech company of some kind, predominantly focused in the U.S., with a "great management team" that has raised adequate funding to support Locust Walk Acquisition Corp.’s $175 million raise. It is that amount of capital, Meyerson thinks, that sets Locust Walk apart from other SPACs in this space. With the exception of General Catalyst and Arch Venture Partners’ recently filed $500 million SPAC, most local biotech-focused SPACs are priced at around $100 million.

Meyerson doesn’t think the SPAC era is likely to be long-lived, however. The market might see a SPAC slowdown soon, or traditional IPOs may make a comeback. "There’s no way this pace can be sustained," he said.

Whatever the case, Locust is "not going anywhere," he said.

"We’re continuing to build and grow the core business. This is just one tool we offer to companies, and now, we can become more full-service, helping companies navigate the SPAC landscape because we’ve been a buyer," Meyerson said. "If the SPAC business continues, we’d like to continue to be a part of it as a SPAC issuer, but fundamentally, our job is to help biotech grow."

After name change and dropped IPO, IN8bio tries again to boost its cancer pipeline

On April 2, 2021 IN8bio reported that it has trod an unusual path to an IPO but now has revived its once-dropped attempt (Press release, In8bio, APR 2, 2021, View Source [SID1234577550]).

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The phase 1 New York biotech made its first attempt at an IPO last year for $75 million but dropped its plans in November. Now, five months down the line, it’s trying again for the slightly lower amount of $69 million.

It is hoping to funnel any raised cash into its pipeline of allogeneic gamma-delta T-cell therapies for cancers and its two lead candidates: INB-200, in an early test for newly diagnosed glioblastoma, and INB-100, also in phase 1, for leukemia patients undergoing hematopoietic stem cell transplantation. Top-line data for both are expected late this year and next, respectively.

The biotech’s immuno-oncology programs include activated and gene-modified adoptive cellular therapies that are designed to protect cells from chemotherapy and may also allow for new combinations of drugs to disrupt the tumor microenvironment and increase immunogenicity.

It aims to list on the Nasdaq under the ticker symbol "INAB" and comes after it changed its name last summer from Incysus Therapeutics to IN8bio.

Taiho Oncology To Present Phase 2 Data for Futibatinib (TAS-120) in Advanced Intrahepatic Cholangiocarcinoma at Virtual AACR Annual Meeting 2021

On April 2, 2021 Taiho Oncology, Inc. reported that Phase 2 clinical data, along with preclinical and Phase 1 clinical data for futibatinib (TAS-120) will be presented during the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2021 Week 1, taking place virtually from April 10-15, 2021 (Press release, Taiho, APR 2, 2021, View Source [SID1234577548]). Futibatinib is a covalently-binding FGFR inhibitor being investigated for the potential treatment of patients with previously treated locally advanced or metastatic cholangiocarcinoma harboring FGFR2 gene rearrangements including gene fusions. Key presentations include:

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Primary results of phase 2 FOENIX-CCA2: the irreversible FGFR1-4 inhibitor futibatinib in intrahepatic cholangiocarcinoma (iCCA) with FGFR2 fusions/rearrangements: Lipika Goyal, MD, MPhil, Massachusetts General Hospital Cancer Center (Presentation Number CT010). Results will be shared online as an oral plenary presentation from 2:00 – 3:45 PM ET on April 11, 2021.
Acquired resistance to ATP-competitive and irreversible FGFR inhibitors (FGFRi’s): A library-based approach: Hiroshi Sootome, MS, Manager, Translational Research Planning & Management group, Taiho Pharmaceutical Co., Ltd. (1117). Results will be shared online as a poster presentation from 8:30 AM – 11:59 PM ET on April 10, 2021.
Effect of futibatinib on QT/QTc interval: a randomized, controlled, double-blind study: Ikuo Yamamiya, PhD, Associate Director, Bioanalytics & DMPK, Taiho Oncology, Inc. (CT128). Results will be shared online as a poster presentation from 8:30 AM – 11:59 PM ET on April 10, 2021.
Evaluation of potential drug-drug interactions (DDIs) between futibatinib and CYP3A inhibitors/inducers, CYP3A substrates, or proton pump inhibitors (PPIs): Ikuo Yamamiya, PhD, Associate Director, Bioanalytics & DMPK, Taiho Oncology, Inc. (CT125). Results will be shared online as a poster presentation from 8:30 AM – 11:59 PM ET on April 10, 2021.
Please visit Taiho Oncology’s virtual Medical Booth when the exhibit opens on April 10, 2021.

"We are pleased to present these clinical and pre-clinical data for futibatinib in patients with advanced intrahepatic cholangiocarcinoma (iCCA) who have failed at least one line of therapy, including primary results from the Phase 2 FOENIX-CCA2 trial," said Martin J. Birkhofer, MD, Senior Vice President and Chief Medical Officer, Taiho Oncology, Inc. "These data add to the body of evidence for futibatinib and support this investigational compound as a potential treatment option for patients with iCCA whose disease has progressed following previous therapies."

The U.S. Food and Drug Administration (FDA) granted Breakthrough Therapy Designation (BTD) for futibatinib for the treatment of patients with previously treated locally advanced or metastatic cholangiocarcinoma harboring FGFR2 gene rearrangements, including gene fusions, in February 2021 based on efficacy and safety results from the FOENIX-CCA2 study. The FDA Office of Orphan Drug Development granted futibatinib orphan drug status for the treatment of cholangiocarcinoma in May 2018.

About Futibatinib (TAS-120)
Futibatinib (TAS-120) is an investigational, oral, potent, selective, and irreversible small-molecule inhibitor of FGFR1, 2, 3 and 4 being studied as a potential treatment for patients with advanced solid tumors with FGFR1-4 genetic aberrations, including cholangiocarcinoma, who were previously treated with chemotherapy or other therapies. Futibatinib selectively and irreversibly binds to the ATP binding pocket of FGFR1-4 resulting in the inhibition of FGFR-mediated signal transduction pathways, reduced tumor cell proliferation and increased tumor cell death in tumors with FGFR1-4 genetic aberrations.

About Cholangiocarcinoma
Cholangiocarcinoma (CCA), also known as bile duct cancer, is not common. About 8,000 people in the U.S. are diagnosed with CCA each year.1 This includes both intrahepatic (inside the liver) and extrahepatic (outside the liver) cancers. CCA can occur at younger ages, but it is seen mainly in older people. The average age of people in the U.S. diagnosed with cancer of the intrahepatic bile ducts is 70, and for cancer of the extrahepatic bile ducts it is 72.1 The five-year survival rates of intrahepatic CCA (all SEER stages combined) is 9%.2

The main treatment for CCA is surgery. Radiation therapy and chemotherapy may be used if the cancer cannot be entirely removed with surgery and in cases where the edges of the tissues removed at the operation show cancer cells (also called a positive margin). Both stage III and stage IV cancers cannot be completely removed surgically. Currently, standard treatment options are limited to radiation, palliative therapy, liver transplantation, surgery, chemotherapy and interventional radiology.3

Evogene Files Annual Report for the Year Ended December 31, 2020

On April 2, 2021 Evogene Ltd. (NASDAQ: EVGN) (TASE: EVGN), a leading computational biology company focused on revolutionizing product discovery and development in multiple life-science based industries, reported that it has filed its annual report on Form 20-F for the fiscal year ended December 31, 2020 with the U.S. Securities and Exchange Commission (the "SEC") (Press release, Evogene, APR 2, 2021, View Source [SID1234577547]).

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The annual report, which contains the Company’s audited consolidated financial statements, can be accessed on the SEC website at View Source as well as via the Company’s website at View Source The Company will deliver a hard copy of its annual report, including its complete audited consolidated financial statements, free of charge, to its shareholders upon request to the Company Media Contact: [email protected].