Theratechnologies To Participate in Virtual Fireside Chat With Canaccord Genuity On May 20, 2021

On May 18, 2021 Theratechnologies Inc. (Theratechnologies) (TSX: TH) (NASDAQ: THTX), a biopharmaceutical company focused on the development and commercialization of innovative therapies, reported that Paul Levesque, President and Chief Executive Officer will participate in a virtual fireside chat hosted by Edward Nash at Canaccord Genuity on Thursday, May 20, 2021 at 2:00 p.m. ET (Press release, Theratechnologies, MAY 18, 2021, View Source [SID1234580212]).

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Institut Bergonié and Seven and Eight Biopharmaceuticals Inc. Announce the First Patient Treated in the AGADIR Study of BDB001 in Combination with Atezolizumab and Immunogenic Radiotherapy in Solid Tumors

On May 18, 2021 Institut Bergonié, a cancer center based in Bordeaux, and Seven and Eight Biopharmaceuticals Inc., a clinical stage biotechnology company specializing in immuno-oncology, reported the treatment of the first patient in their collaboration to study BDB001 (Press release, Seven and Eight Biopharmaceuticals, MAY 18, 2021, View Source [SID1234580211]). Institut Bergonié is the sponsor of the AGADIR Phase II protocol, "Atezolizumab combined with BDB001 and Immunogenic Radiotherapy in patients with advanced solid tumors" (NCT03915678), which will enroll patients with difficult-to-treat solid tumors across 10 clinical centers in France. The study is funded in a public-private partnership by a grant from the French National Cancer Institute (Institut National du Cancer, INCa) and the Fondation ARC (La Fondation ARC pour la recherche sur le cancer) (INCa-ARC_13579) and performed in collaboration with Roche, who will supply atezolizumab. BDB001 is a first-in-class Toll-like receptor 7/8 (TLR7/8) agonist, which is delivered intravenously, allowing for broader treatment of solid tumors compared to intratumoral TLR agonists in development.

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"We are delighted to begin this clinical study with BDB001. Our collaboration with Seven and Eight Biopharma allows us to explore a new and potentially valuable treatment option to our patients," declared Professor Antoine Italiano, Head of Early Phase Trials Unit, Institut Bergonié.

"This partnership with Institut Bergonié is a milestone in our development program for BDB001. The clinical trial expertise provided by Institut Bergonié and their collaborators will help us better understand the potential role for BDB001 as an immuno-oncology backbone in combination with checkpoint inhibitors and radiotherapy in the treatment of solid tumors," says Dr. Robert Andtbacka, Chief Medical Officer at Seven and Eight Biopharma Inc.

[Press release] InterSystems & Oncodesign partner for the optimization of data use to enhance and accelerate Drug Discovery processes in oncology

On May 18, 2021 InterSystems, a leader in healthcare data management, and Oncodesign (Paris:ALONC), a biopharmaceutical company specializing in precision medicine, reported the signing of a strategic partnership aimed at advancing research for new treatments in the field of oncology (Press release, Oncodesign, MAY 18, 2021, View Source [SID1234580210]).

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In a context characterized by an exponential growth of data volumes over the last 20 years, the quality and use of health and research data have become two critical issues for all healthcare stakeholders. The current health crisis has only reinforced the importance of an agile and decompartmentalized strategy for health data governance.

As part of this partnership, Oncodesign has chosen to combine its proprietary platform for the identification and validation of new therapeutic targets, called OncoSNIPER, with InterSystems’ unified health data management platform, known as InterSystems IRIS for Health. This alliance will allow both companies to develop and optimize essential synergies between the two platforms.

The InterSystems IRIS for Health data platform will be integrated into Oncodesign’s recently established Artificial Intelligence (AI) Business Unit for the storage and management of various preclinical and clinical data sources, which are highly valuable to each of the businesses involved in the drug discovery process. By analyzing and better exploiting the data consolidated through InterSystems IRIS for Health, Oncodesign’s AI BU will optimize the development of OncoSNIPER, notably through more accurate functioning of its algorithms. In addition, InterSystems will provide Oncodesign with the benefit of its international network of strategic academic partners generating health data (hospitals and universities), particularly in North America.

For InterSystems, this partnership is part of a strategic approach to healthcare players through its access to Oncodesign’s solid expertise in drug discovery and reflects its historical commitment to oncology. With a solid domestic network, InterSystems has been working for many years with major cancer centers (known as CLCC in France) through its patient administrative and clinical management solution, InterSystems TrakCare (especially in Dijon, Nice and Reims), as well as with the Toulouse University Cancer Institute – Oncopole (IUCT-O) with InterSystems HealthShare, for comprehensive patient management and better coordination of the various private and public players in the region. The company has also made its expertise in health data exploitation available to innovative partners such as the start-up MyPL and the Guerbet Group.

For Michel Amous, Regional Director EMEA at InterSystems: "We are delighted to begin this partnership with Oncodesign, which has been a major player in the biotechnology industry for 25 years. Our goal is to provide them with our expertise in optimizing data platforms to build a new intelligent architecture for oncology research. The pooling of health data – scattered, heterogeneous but so valuable – is not just a simple operational consolidation. It is a project with strategic scope aimed at aggregating the various sources of data available to Oncodesign in order to improve communication between them. This dynamic governance will enable Oncodesign to remain at the forefront of biopharmaceutical innovation and ultimately to commercialize new therapeutic solutions to better serve the public interest. "

For Oncodesign, this partnership is the second step in its strategic development based around AI after the launch in 2017 of the OncoSNIPER project (clinical trial of 600 patients with 3 oncology indications and 16 partners). After generating large amounts of heterogeneous clinical data, the company needs to structure the available data using the InterSystems IRIS for Health data platform, before implementing the algorithms needed to select sub-populations of patients with treatment-resistant cancers.

Philippe Genne, Chairman and CEO of Oncodesign, stated: "We have known the InterSystems teams well for several years, and we are therefore very pleased to formalize our collaboration through this ambitious partnership. Our expertise at Oncodesign is in developing new treatments and InterSystems’ is in leveraging data to accelerate the digital transformation of companies. Together, we will be able to pool our respective fields of expertise in order to make our drug discovery process in precision medicine more reliable and even faster. Traditionally, the lead optimization phase alone can last up to 3 years and cost between 10 and 12 million euros with random results in the medium term (1/10 success rate). Today, artificial intelligence is changing the game: the exploitation of data gives us the possibility to make more informed choices in increasingly rapid timeframes. "

This collaboration will bring together several distinct and complementary fields of expertise, including data science, artificial intelligence, pharmacology, chemistry, biology and clinical research. The two companies share a common goal: to harness the power of data to develop and industrialize new therapeutic solutions in the field of oncology.

On May 21st next, Oncodesign will inaugurate its new headquarters in Dijon (Bâtiment Jean Mermoz – 18 rue Jean Mazen), which will house its AI teams. On the same day, the company will also launch its new development strategy based on AI approaches.

Milestone reached in the clinical development of TG-1801 (NI-1701)

On May 18, 2021 Light Chain Bioscience | Novimmune SA reported that under its global collaboration agreement with TG Therapeutics (NSDAQ: TGTX) a predefined milestone was reached in the clinical development of TG-1801 (NI-1701), a bispecific antibody targeting CD19 and CD47 (Press release, Light Chain Bioscience, MAY 18, 2021, View Source [SID1234580208]).

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"We are excited with the progress of TG-1801 in the current Phase I clinical trial in Australia by our partner TG Therapeutics, as well as the recent approval of an IND and start of Phase I in the US. TG-1801 is the first bispecific antibody allowing for selective CD47 targeting on tumor cells, a unique mechanism of action that we are deploying in other internal and partnered bispecific programs for the treatment of cancer" said Nicolas Fischer CEO of Light Chain Bioscience. "The clinical progress of TG-1801 brings further validation to our bispecific kappa-lambda body format that maintains the native structure of a human IgG."

Labcorp to Speak at UBS Global Healthcare Virtual Conference

On May 18, 2021 Labcorp (NYSE: LH), a leading global life sciences company, reported that members of the executive management team will participate in a virtual fireside chat at the UBS Global Healthcare Virtual Conference on Monday, May 24 at 3:00 p.m. ET (Press release, LabCorp, MAY 18, 2021, View Source [SID1234580207]).

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A live webcast of the presentation will be available via the Investor Relations section of the company’s website at www.Labcorp.com and archived for replay.