NOXXON Announces Data Safety Monitoring Board Validates NOX-A12 Highest Dose in Phase 1/2 Brain Cancer Trial

On May 10, 2021 NOXXON Pharma N.V. (Paris:ALNOX) (Euronext Growth Paris: ALNOX), a biotechnology company focused on improving cancer treatments by targeting the tumor microenvironment (TME), reported that an independent Data Safety Monitoring Board (DSMB) has confirmed that the highest dose of NOX-A12 in combination with radiotherapy in the ongoing Phase 1/2 study in patients with brain cancer is safe and that the trial should continue as planned.

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The study investigates three dose regimens of NOX-A12 (200, 400 and 600 mg/week), each combined with external-beam radiotherapy in newly diagnosed brain cancer patients. The DSMB recommendation to proceed followed the analysis of safety data stipulated in the study protocol after all three patients in the third – and last – cohort completed at least four weeks of treatment at the highest dose.

"We are pleased that the DSMB analysis has concluded that the highest dose of NOX-A12 in this Phase 1/2 study in brain cancer patients is safe. We look forward to continuing to investigate this exciting potential treatment and continue to expect top-line data for Cohort 2 end-May and Cohort 3 in November 2021," commented Aram Mangasarian, CEO of NOXXON.

Ultimovacs to Discuss ASCO UV1 Phase I Data in Webcast and Investor Meetings

On May 10, 2021 Ultimovacs ASA ("Ultimovacs") (OSE ULTI), a clinical stage leader in immune stimulatory vaccines for cancer, reported that its management team will discuss data from the abstract of a poster presentation at the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) 2021 Annual Meeting at a series of investor events in May, beginning with a live corporate webcast on Thursday May 20, 2021 (Press release, Ultimovacs, MAY 10, 2021, View Source [SID1234579614]).

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The abstract is titled "A Phase I Clinical Trial Investigating the Telomerase Vaccine UV1 in Combination with Pembrolizumab in Patients with Advanced Melanoma". It provides an overview of the open-label, single-arm study investigating the safety and tolerability for the combination of Ultimovacs’ universal cancer vaccine, UV1, with the checkpoint inhibitor pembrolizumab in patients with metastatic malignant melanoma.

The ASCO (Free ASCO Whitepaper) abstract will be made available on the company website on Wednesday, May 19th at 23:00 CEST and will be presented at the ASCO (Free ASCO Whitepaper) 2021 Annual Meeting to be held virtually Friday, June 4, 2021 through Tuesday, June 8, 2021. The full poster presentation from the ASCO (Free ASCO Whitepaper) Annual Meeting will be available on the Ultimovacs website on 4 June 2021.

Details of the investor events:

Event: Live Corporate Webcast
Date/Time: Thursday May 20, 10:00 CEST
Presenter: Carlos de Sousa, CEO. The webcast will be available on the company website, and it will be possible to post questions during the presentation through the webcast.
Webcast Link

Event: Radforsk’s Podcast RADIUM
Date/Time: Thursday May 20, 14:00 CEST
Presenter: Carlos de Sousa, CEO; Jens Bjørheim, CMO. The podcast will be available on the company website.
Podcast Link

Event: 7th Annual Immuno-Oncology Innovation Forum, SACHS associates (18-20th May, 2021)
Date/Time: Thursday May 20, 19:25 CEST
Presenter: Carlos de Sousa, CEO
Meeting link

Event: ABG Sundal Collier Life Science Summit 2021 (held virtually)
Date/Time: Tuesday May 25, 16:00 CEST
Presenter: Carlos de Sousa, CEO

Event: Biostock Life Science Spring Summit (held virtually)
Date/Time: May 26-27
Presenter: Carlos de Sousa, CEO
Meeting link

TYME Announces Abstract Selected for Publication at the 2021 American Society of Clinical Oncology Annual Meeting

On May 10, 2021 TYME Technologies, Inc. (Nasdaq: TYME) (the "Company" or "Tyme"), an emerging biotechnology company developing cancer metabolism-based therapies (CMBTs), reported that its abstract featuring data from the Company’s investigational therapy, SM-88, has been selected for publication at the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting being held virtually June 4-8, 2021 (Press release, TYME, MAY 10, 2021, View Source [SID1234579613]).

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Details about the abstract selected for publication can be found below:

Title: Phase II Study of SM-88 in Ewing’s and Other Sarcomas
Abstract Number: e23505
Authors: Giuseppe Del Priore, MD, MPH, Victoria S. Chua, Kitty Zheng, Ted Kim, Semmie Kim, Sant P. Chawla, MD
Session: Publication Only – Sarcoma

The Publication Only abstracts are under embargo until 5:00 p.m. ET on May 19, 2021. For more information about the Annual Meeting, please visit: asco.org.

About SM-88

SM-88 is an oral investigational modified proprietary tyrosine derivative that is believed to interrupt the metabolic processes of cancer cells by breaking down the cells’ key defenses and leading to cell death through oxidative stress and exposure to the body’s natural immune system. Clinical trial data have shown that SM-88 has demonstrated encouraging tumor responses across 15 different cancers, including pancreatic, lung, breast, prostate and sarcoma cancers with minimal serious grade 3 or higher adverse events. SM-88 is an investigational therapy that is not approved for any indication in any disease.

LianBio Appoints Yizhe Wang, Ph.D., as Chief Executive Officer

On May 10, 2021 LianBio, a biotechnology company dedicated to bringing paradigm-shifting medicines to patients in China and other major Asian markets, reported Yizhe Wang, Ph.D., has been named Chief Executive Officer and appointed to the Board of Directors, effective May 17, 2021 (Press release, LianBio, MAY 10, 2021, View Source [SID1234579611]).

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"Yizhe is a strategic leader with decades of experience developing, launching and managing the product lifecycle of transformative drugs in China, the U.S. and Europe," said Konstantin Poukalov, Managing Director, Perceptive Advisors and Executive Chairman, LianBio. "With his proven leadership guiding late-stage assets to market in China, LianBio is well positioned for our next phase of growth as we continue to advance our pipeline and partner with leading global biopharmaceutical companies to expand their reach into China and other Asian markets."

Throughout Dr. Wang’s career as a pharmaceutical executive in China and the United States, he has built and overseen high-growth business units and played a key role in the development, approval and commercialization of more than 25 innovative medicines. With past experience spanning commercial, R&D and strategic leadership roles at Eli Lilly and GlaxoSmithKline (GSK), he brings to LianBio expertise in accelerating drug development and executing commercial launches.

"I am honored to join LianBio to scale the company’s next-generation approach to sourcing, developing and commercializing innovative drugs in the region," said Dr. Wang. "As LianBio continues to advance a portfolio of world class programs across therapeutic areas, I look forward to partnering with the founding team to address the medical needs of patients in China and throughout Asia."

Dr. Wang joins LianBio from Eli Lilly, where he most recently served as Global Brand Development Leader, Lilly Oncology. In 2020, Dr. Wang served as Global Platform Lead for anti-COVID Therapy, Lilly Research Lab, where he led a new operating model integrating discovery, development and launch resulting in the EUA of bamlanivimab. Previously, Dr. Wang was SVP, Head of BioMedicines and Oncology Businesses, Lilly China, where he was a member of the Global Oncology and Biomedicines Business Unit lead teams, and China Executive Committee. In this role, he oversaw a 1,000-person organization, delivered double digit sales growth and launched multiple new products, including Tyvyt, Elunate, Taltz and Olumiant. Prior to Eli Lilly, Dr. Wang was at GSK for 15 years where he held product and commercial strategy roles of increasing responsibility in the U.S. (2003-2012), U.K. (2012-2014) and China (2014-2018), ultimately serving as Head of GSK China Pharmaceuticals’ Respiratory Business Unit. Earlier in his career, he was a researcher at Bristol Myers Squibb.

Dr. Wang received a doctorate in organic chemistry from Yale University. He also earned a master’s degree in business administration from the Wharton School at the University of Pennsylvania and a bachelor’s degree in chemistry from Ramapo College of New Jersey.

Promega, Exact Sciences Partnering to Help Jumpstart Colorectal Cancer Screenings

On May 10, 2021 Promega Corporation reported that Serious runners and casual walkers alike are invited to join a month-long Get Your Rear in Gear – Madison run/walk virtual event during May to raise money and awareness for colorectal cancer screening efforts (Press release, Promega, MAY 10, 2021, View Source [SID1234579609]). Colorectal cancer is the nation’s No. 2 cancer killer, but it is up to 95% preventable with proper screening. The number of people being screened has dropped drastically worldwide since the start of the COVID-19 pandemic. The event is aimed to help encourage this important, life-saving health screening.

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"It is imperative that patients are encouraged to get back in with their primary doctor to get screening tests they may have missed," says Dr. Sam Lubner, an oncologist at the University of Wisconsin Carbone Cancer Center. "Without accurate diagnosis as early as possible, all of the advancements we have made in cancer research cannot be brought to bear for patients."

Get Your Rear in Gear – Madison is presented by Promega and Exact Sciences with the support of the Colon Cancer Coalition. This inaugural event is one of nearly 40 held annually across the country planned by local volunteers. Money raised will go to UW Carbone Cancer Center programs aimed at increasing colon cancer screening and early detection.

Registration is open during the entire month of May at www.ColonCancerCoalition.org/Madison. Event participation for colorectal cancer patients and survivors is free. Fundraising by participants is encouraged, but not required.