On March 3, 2021 Kiromic BioPharma, Inc. (Nasdaq: KRBP), an immuno-oncology target discovery and gene-editing company, with a proprietary artificial intelligence neural network platform (Diamond AI) to develop novel oncology therapeutics, reported its technology showcases at the recent American Association of Cancer Research ("AACR") 2021 meeting (Press release, Kiromic, MAY 3, 2021, View Source [SID1234579026]).
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Kiromic BioPharma is using cutting-edge artificial intelligence (AI) technology to select biomarkers to develop CAR-T therapy for solid tumors.
The Company believes that the use of AI will enable it to compress development timelines in ways which are not achievable by its peers who are not equipped with AI technology.
The American Association of Cancer Research recognized Kiromic’s innovation with its acceptance of 6 poster presentations at the recent conference on April 9-14, 2021.
Kiromic’s 6 posters showcased the company’s following technology platforms and advances:
CancerDiff, a deep data mining engine that harmonizes billions of data points across disease types and states, data types, data structures and data platforms and Diamond AI, a proprietary system which combs through billions of transcription data points across public and private RNA databases to present the best immunogenic peptide candidates for CAR-T;
CancerSplice, the Company’s 3D, isoform prediction engine, which examines billions of data points to select the best targets;
Validation of the Company’s AI technology in identifying NY-ESO-1, which is a very well-known target and served as an excellent validation of the Company’s engine’s accuracy;
Our company also demonstrated that our chPD1 receptor is effective on solid tumors in both in vitro and in vivo models with minimal toxicities;
We showed that our non-viral gene edit technology could have the same target specificity of Cas9 without the DNA destruction common to HIV integrase;
Finally we investigated NK as a potential adoptive cell therapy platform for CAR-T.
Dr. Maurizio Chiriva, PhD stated that, "Our mission is to become the leader in allogenic, off-the-shelf CAR-T in solid tumors. Our cutting-edge AI engine for biomarker identification and selection will support our development pathway going forward. We believe that our ability to deliver allogenic, off-the-shelf CAR-T for solid tumors is within reach and that our therapy will offer patients higher efficacy at lower costs. We expect to make this therapy a reality this year."
Mr. Gianluca Rotino, the Company’s Chief Strategy and Innovation Officer, noted that, "We are proud to have set a new record for the number of posters accepted for a single company by the prestigious American Association of Cancer Research (AACR 2021), who accepted 6 of our posters. These poster presentations also broke ground for the number of new technologies that Kiromic is bringing to the world of live-cell therapy (CAR-T).
"We believe that we are disrupting the industry with our innovative approach as summarized in the following table:
Kiromic’s approach
Industry standard
Targeting
AI driven and machine learning bio-informatics for targeting
Classic chemistry
Live Cell Type
Gamma Delta T cells for CAR-T
Peers’ NK, or Mesenchymal (stem cells)
Donor Tissue Type
Allogenic gamma delta T cells from healthy donors
Marketed therapies’ autologous T-cells from frail patients
Gene Editing
Non-viral, non-destructive to DNA
Industry standard CRISPR Cas9
GMP Manuf.
In-house Vivarium and GMP manufacturing for our clinical trials
Industry standard of using external Contract Manufacturers
"With these innovations, we believe that we are poised to lead the future for CAR-T in solid tumors. We expect to build on this lead with planned in-human dosing in the third quarter of 2021."
ABOUT KIROMIC POSTERS AT AACR (Free AACR Whitepaper) 2021
Session
Focus
Poster
Link to Poster at AACR (Free AACR Whitepaper)
BSB01.05
New Software for Data Analysis
247
Identification of an ovarian cancer selective splice variant of mesothelin utilizing the Kiromic proprietary search engine CancerDiff
CancerDiff:
Our deep data-mining engine which harmonizes billions of data points across:
— disease types and states
— data types,
— data structures, and
— data platforms.
Diamond AI:
Our system which combs through billions of transcription data points across public and private RNA databases to present the best immunogenic peptide candidates for CAR-T.
PO.IM02.01
Adoptive Cell Therapy
1534
Mesothelin isoform 2 is a novel target for allogenic CARγδT cell therapy in solid tumors
CancerSplice:
Our 3D, isoform prediction engine which examines billions of data points to select the best targets.
BSB01.04
New Algorithms
243
Identification of novel epitopes of NY-ESO-1 for solid malignancies by Kiromic proprietary search engine Diamond
NY-ESO-1:
How we got to NY-ESO-1 using our AI target selection engine. NY-EOS-1 is a very well-known target and served as an excellent validation of our engine’s accuracy.
PO.ET08.01
Gene and Vector-Based Therapy
1154
Site-specific gene editing with ABBIE for T-cell therapy
ABBIE:
We showed that our non-viral gene edit technology could have the same target specificity of Cas9 without the DNA destruction common to HIV integrase.
PO.IM02.01
Adoptive Cell Therapy
LB148
Gamma delta T cells engineered with a chimeric PD-1 receptor effectively control PD-L1 positive tumors in vitro and in vivo with minimal toxicities.
chPD1:
We demonstrated that our chPD1 receptor was effective on solid tumors in both in vitro and in vivo models with minimal toxicities.
PO.IM02.01
Adoptive Cell Therapy
1535
Allogenic CAR iNKT as a cell therapy platform targeting tumor antigen Isomesothelin
iNKT:
We investigated NK as a potential adoptive cell therapy platform for CAR-T.
About AACR (Free AACR Whitepaper) (American Association of Cancer Research)