On June 29, 2021 Kiromic BioPharma, Inc. (Nasdaq: KRBP) (the "Company"), an immuno-oncology target discovery and gene-editing company with a proprietary artificial intelligence neural network platform (Diamond AI) that is used to develop novel oncology therapeutics, reported the pricing of its underwritten public offering of 8,000,000 shares of its common stock at a public offering price of $5.00 per share, for gross proceeds of $40 million, before deducting underwriting discounts and commissions and other estimated offering expenses payable by the Company (Press release, Kiromic, JUN 29, 2021, View Source [SID1234584485]). In addition, the Company has granted the underwriters a 45-day option to purchase up to an additional 1,200,000 shares of common stock, solely to cover over-allotments. All of the shares of common stock are being offered by the Company.

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The offering is expected to close on or about July 2, 2021, subject to customary closing conditions.

ThinkEquity, a division of Fordham Financial Management, Inc., is acting as sole book-running manager for the offering.

The Company intends to use the net proceeds from the offering primarily for clinical trials for its ALEXIS-ISO-1 and ALEXIS-PRO-1 product candidates, GMP facility expansion, intellectual property protection and reinforcement, IND applications and IND enabling trials and working capital and the remainder for general corporate purposes.

A registration statement relating to the shares of common stock being sold in this offering was declared effective by the Securities and Exchange Commission (the "SEC") on June 29, 2021. The offering is being made only by means of a prospectus. Copies of the final prospectus may be obtained, when available, on the SEC’s website, www.sec.gov, or by contacting ThinkEquity, a division of Fordham Financial Management, Inc., 17 State Street, 22nd Floor, New York, New York 10004, by telephone at (877) 436-3673 or by email at [email protected].

This press release shall not constitute an offer to sell, or a solicitation of an offer to buy these securities, nor shall there be any sale of, these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

On June 29, 2021 Selexis SA and KBI Biopharma (KBI), both JSR Life Sciences companies, reported that they have signed service agreements with Immatics N.V. (NASDAQ: IMTX; "Immatics"), a clinical-stage biopharmaceutical company active in the discovery and development of T cell redirecting cancer immunotherapies (Press release, Selexis
, JUN 29, 2021, View Source [SID1234584484]). The agreements focus on using integrated services from Selexis and KBI as part of Immatics’ development of TCR Bispecifics, called TCER (T Cell Engaging Receptors), that simultaneously recruit, activate and stimulate the patient’s own T cells to detect, target and attack tumor cells. Under the agreements, Selexis will utilize its SUREtechnology Platform and KBI will leverage its advanced analytics, process, formulation and cGMP manufacturing for Immatics’ IMA402 program.

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"Immatics is pushing beyond the limitations of traditional antibody-based therapies by investigating targets beyond the cell surface to treat solid tumors," said Dirk Lange, chief executive officer at Selexis and president and chief executive officer at KBI Biopharma. "The integrated workflow between Selexis’ SUREtechnology Platform and KBI’s development approach and cGMP Manufacturing is designed to rapidly advance complex, novel product candidates towards investigational new drug submissions, while also providing a strong foundation for subsequent late-stage development and commercialization. Working together to support Immatics provides us a significant opportunity to demonstrate the power of our integrated expertise. We’re excited to work with Immatics as the company advances its TCR Bispecific candidate IMA402 towards the clinic."

Immatics is developing targeted T cell receptor (TCR)-based immunotherapies with an emphasis on solid tumors through two distinct therapeutic modalities: Adoptive Cell Therapies (ACTengine) and antibody-like TCR Bispecifics (TCER). Due to their different modes of action, these modalities are designed to expand the therapeutic value for patients across a broad range of tumor types and stages and to provide a meaningful impact on the lives of cancer patients.

"Having delivered preclinical proof-of-concept for our TCR Bispecifics program IMA402 and having moved this program into GMP process development is a major achievement of Immatics," said Sven Berger, CMC Project Leader at Immatics.

"We have chosen Selexis and KBI because of their expertise in the development and manufacturing of bispecific antibodies. We are looking forward to working with them on our path towards IND for IMA402," commented Michael Mølhøj, Head of CMC Biologics at Immatics.

Selexis’ modular SUREtechnology Platform facilitates the rapid, stable, and cost-effective production of virtually any recombinant protein and provides seamless integration of the biologics development continuum, spanning discovery to commercialization. KBI Biopharma will use the enriched pool and the high-performance research cell banks generated by Selexis for process, analytical, and formulation development, and manufacturing of pre-clinical and clinical supplies of Immatics’ TCR Bispecifics.

On June 29, 2021 Cancer Targeted Technology (CTT), a privately held Seattle-based biotechnology company, reported that it received a milestone payment from Advanced Accelerator Applications International S.A. (AAA), a Novartis company, triggered by the upcoming clinical trials of investigational 18F-CTT1057, a diagnostic PET imaging agent for prostate cancer (Press release, Cancer Targeted Technology, JUN 29, 2021, View Source [SID1234584483]). CTT1057 targets the biomarker, Prostate Specific Membrane Antigen (PSMA), which is over-expressed on most prostate cancer cells. Prior to licensing, CTT completed prostate cancer clinical trials of CTT1057 in adult males at University of California, San Francisco (UCSF), with encouraging safety and imaging results. Based on this clinical data, binding characteristics of the molecule, and solid patent protection, CTT1057 was licensed to AAA to undergo further development in the upcoming GuidePath and GuideView clinical studies.

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"This licensing deal with AAA is an important collaboration for CTT and we are very excited to see CTT1057 moving forward as a potential new imaging agent for prostate cancer," stated Dr. Beatrice Langton-Webster, CTT’s Chief Executive Officer. The milestone payments, along with an NIH SBIR Phase IIB grant, are the key assets that CTT is using to advance its new radiolabeled small molecule drug CTT1403, a companion radiotherapeutic to CTT1057. Features that make the phosphoramidate PSMA-binding scaffold unique include irreversible binding to PSMA and excellent uptake by PSMA-expressing tumor cells. CTT1057 and CTT1403 are a theranostic pair that can both diagnose and treat solid tumors that express PSMA and are being studied together in the current CTT1403 therapeutic clinical trial (NCT03822871) that CTT is conducting with lead investigator Dr. Rahul Aggarwal at UCSF. The unique chemical structures of CTT’s drugs were conceived by Dr. Cliff Berkman, Professor of Chemistry at Washington State University (WSU).

On June 29, 2021 Synaffix B.V., a biotechnology company focused on commercializing its clinical-stage platform technology that enables antibody-drug conjugates (ADCs) with best-in-class therapeutic index, reported the signing of a non-exclusive, target-specific license agreement with Innovent Biologics Inc., a leading biopharmaceutical company developing innovative medicines for the treatment of major diseases (Press release, Synaffix, JUN 29, 2021, View Source [SID1234584482]).

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Under the terms of the agreement, Synaffix will provide all the necessary proprietary ADC technologies including GlycoConnect, HydraSpace and one of its toxSYN linker-payloads, to enable Innovent to rapidly progress one of its antibodies as a best-in-class ADC candidate. The deal is the culmination of a successful initial proof-of-concept research period between the companies.

Upon signature, Innovent is granted the rights to deploy the above ADC technologies for one therapeutic molecule. Innovent will be responsible for the research, development, manufacturing and commercialization of the ADC product. Synaffix will closely support Innovent’s research activities and will be responsible for manufacturing components that are specifically related to its proprietary technologies.

Synaffix is eligible to receive an upfront payment, milestone payments related to certain development and sales performance achievements, as well as royalties on potential future commercial sales of the ADC product.

Dr. Yongjun Liu, President of Innovent said:

"We are excited to collaborate with Synaffix as Innovent is expanding its pipeline into the ADC space. Our collaboration with Synaffix adds a promising new ADC candidate to our preclinical pipeline through leveraging Synaffix’s validated, differentiated and innovative ADC technology platform and Innovent’s strong antibody capabilities. Based on Synaffix’s seamless partnering model, we could rapidly combine Synaffix’s ADC technologies with Innovent’s antibody, generate compelling research data and keep moving the project ahead swiftly."

Peter van de Sande, CEO of Synaffix said:

"This is the fourth commercial licensing deal that illustrates the potential of the Synaffix platform to increase the competitive position of our partners within the ADC space. Innovent is an ideal partner for Synaffix due to its strategic focus on innovative medicines and strong R&D capability for high quality biologic drugs. We look forward to working closely together on this exciting development program."

"Central to enhancing our value proposition has been the addition of multiple new proprietary linker-payloads to our ADC technology portfolio. In addition to our well-understood, clinical-stage technologies, GlycoConnect and HydraSpace, our proprietary toxSYN linker-payload platform facilitates any company with an antibody to develop its own highly-competitive ADC."

About The Synaffix ADC Platform Technology
Synaffix’s proprietary ADC technology platform consists of GlycoConnect, HydraSpace and toxSYN linker-payload technologies. Both GlycoConnect and HydraSpace are clinical-stage technologies that enable best-in-class ADCs with significantly enhanced efficacy and tolerability.

GlycoConnect is a conjugation technology that exploits the native antibody glycan for site-specific and stable payload attachment and is tunable to DAR1, DAR2 or DAR4 formats.

HydraSpace is a compact and highly polar spacer technology that is designed to further enhance therapeutic index, particularly with hydrophobic payloads.

toxSYN is a platform of multiple unique linker-payloads that span key, validated mechanisms-of-action for ADC product development.

The combination of these three technologies provides developers with a "one stop" and easy-to-use ADC technology platform, allowing any antibody developer to develop its own proprietary ADC and any ADC developer to expand its pipeline further and increase its competitive position.

In September 2020, Synaffix was recognized with first place in the "Best ADC Platform Technology" award category at the World ADC Awards ceremony following a global review of technologies, voting by industry peers and final evaluation by a panel of independent industry experts.

On June 29, 2021 Takeda Pharmaceutical Company Limited ("Takeda") (TSE:4502/NYSE:TAK) reported that it has filed its Annual Report on Form 20-F for the fiscal year ended March 31, 2021 (the "Annual Report") with the U.S. Securities and Exchange Commission (the "SEC") (Press release, Takeda, JUN 29, 2021, View Source [SID1234584481]). Takeda filed the Annual Report with the SEC on June 29, 2021, and the Annual Report can be accessed on Takeda’s website at: View Source

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In addition, Takeda will also provide a hard copy of the Annual Report, which includes its most recent complete audited financial statements free of charge to any shareholder upon request. Please contact Takeda Investor Relations by e-mail at [email protected].

Additionally, Takeda also published today its 2021 Annual Integrated Report for the fiscal year ended March 31, 2021. It can be accessed on Takeda’s website at: View Source