On June 29, 2021 Aptevo Therapeutics Inc. ("Aptevo") (NASDAQ:APVO), a clinical-stage biotechnology company focused on developing novel immuno-oncology therapeutics based on its proprietary ADAPTIR and ADAPTIR-FLEX platform technologies reported that the company has been added to the Russell Microcap Index at the conclusion of the 2021 annual reconstitution (Press release, Aptevo Therapeutics, JUN 29, 2021, View Source [SID1234584476]). Aptevo’s inclusion in the index became effective after the US market opened yesterday, June 28, 2021.

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Membership in the Russell Microcap Index, which remains in place for one year, means automatic inclusion in the appropriate growth and value style indexes. FTSE Russell determines membership for its Russell indexes primarily by objective, market-capitalization rankings and style attributes.

"We are pleased to be joining the Russell Microcap Index this year, as this inclusion represents increasing value to shareholders and opportunity for potential shareholders, after a year of significant achievement of clinical, pre-clinical and business goals," said Mr. Marvin White, President and CEO of Aptevo.

An immuno-oncology company, Aptevo is focused on discovering and developing novel therapeutics for difficult-to-treat hematologic malignances and solid tumors. Drug candidates are developed from the Company’s proprietary platforms, ADAPTIR and ADAPTIR-FLEX, which are capable of generating highly differentiated bispecific and multi-specific antibodies. The Company recently announced completion of the dose escalation part of a Phase 1b clinical trial with lead drug candidate APVO436 for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndrome. Interim results showed the drug was well tolerated and had a manageable side effect profile. The primary endpoint – identification of a recommended Phase 2 dose – was also achieved. The Company also announced activation of the expansion part of the trial, which will simultaneously evaluate APVO436 in five cohorts of 18 patients each (N=90) in both combination and monotherapy.

About the Russell Indexes
Russell indexes are widely used by investment managers and institutional investors for index funds and as benchmarks for active investment strategies. Approximately $10.6 trillion in assets are benchmarked against Russell’s US indexes. Russell indexes are part of FTSE Russell, a leading global index provider. For more information on the Russell Microcap Index and the Russell indexes reconstitution, go to the "Russell Reconstitution" section on the FTSE Russell website.

On June 29, 2021 Trillium Therapeutics Inc. (NASDAQ/TSX: TRIL), a clinical stage immuno-oncology company developing innovative therapies for the treatment of cancer, reported that it has dosed the first patient with TTI-621 (SIRPα-IgG1 Fc), an investigational checkpoint inhibitor of the innate immune system, in combination with doxorubicin in a Phase 1b/2 study in leiomyosarcoma (LMS) (Press release, Trillium Therapeutics, JUN 29, 2021, View Source [SID1234584474]).

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TTI-621 binds CD47, an innate immune checkpoint that binds SIRPα and delivers a "don’t eat me" signal to suppress macrophage phagocytosis. Overexpression of CD47 can allow tumor cells to escape immune surveillance. TTI-621 is a fusion protein consisting of the CD47 binding domain of SIRPα linked to the Fc region of human IgG1. It is designed to enhance phagocytosis and tumor cell destruction by blocking the CD47-SIRPα interaction and delivering an activating ("eat me") signal to macrophages. The IgG1 backbone can also activate NK cell-mediated anti-tumor activity. Published preclinical studies suggest that anti-CD47 agents may exhibit anti-tumor activity against LMS cells.

"The dosing of this patient marks the beginning of the first Phase 1b/2 solid tumor clinical trial for Trillium," commented Dr. Ingmar Bruns, Trillium’s Chief Medical Officer. "We’re committed to exploring solid tumors and build upon our potentially best-in-class initial hematologic malignancy datasets."

For newly diagnosed LMS patients, doxorubicin is considered part of standard of care. In this open-label Phase 1b/2 study, Trillium is adding TTI-621 to frontline doxorubicin and enrolling approximately 60 newly diagnosed LMS patients. The primary endpoints are safety and overall response rate.

"Metastisized LMS, the most common form of soft tissue sarcoma, is a serious disease with significant unmet need. We believe that the combination of TTI-621 and doxorubicin has the potential to provide benefit for these patients where few therapeutic options exist," added Dr. Bruns.

On June 29, 2021 MediciNova, Inc., a biopharmaceutical company traded on the NASDAQ Global Market (NASDAQ:MNOV) and the JASDAQ Market of the Tokyo Stock Exchange (Code Number: 4875), reported that Yuichi Iwaki, MD, PhD, President and Chief Executive Officer, and Geoffrey O’Brien, JD/MBA, Vice President and Executive Officer, will present a corporate overview at the Ladenburg Thalmann 2021 Virtual Healthcare Conference on Tuesday, July 13, 2021 at 4:30 pm ET. MediciNova will be available for one-on-one meetings at this conference and investors may request a one-on-one meeting through Ladenburg Thalmann.

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On June 29, 2021 Amplia Therapeutics Limited (ASX: ATX) ("Amplia" or the "Company")reported its Financial
Report for the Year Ended 31 March 2021 (Press release, Amplia Therapeutics, JUN 29, 2021, View Source;[email protected] [SID1234584472]).

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This ASX announcement was approved and authorised for release by the Board of Amplia Therapeutics.

On June 29, 2021 Intellia Therapeutics, Inc. (NASDAQ:NTLA), a leading clinical-stage genome editing company focused on developing curative therapeutics using CRISPR/Cas9 technology both in vivo and ex vivo, reported the pricing of an underwritten public offering of 4,137,931 shares of its common stock at a public offering price of $145.00 per share (Press release, Intellia Therapeutics, JUN 29, 2021, View Source [SID1234584471]). Intellia also granted the underwriters a 30-day option to purchase up to an additional 620,689 shares of its common stock. The gross proceeds from the offering, before deducting underwriting discounts and commissions and offering expenses, are expected to be approximately $600 million, excluding any exercise of the underwriters’ option to purchase additional shares. All of the shares in the offering are to be sold by Intellia.

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Goldman Sachs & Co. LLC, Jefferies, SVB Leerink, and Barclays are acting as joint book-running managers for the offering. Truist Securities is acting as co-manager for the offering. The offering is expected to close on or about July 2, 2021, subject to customary closing conditions.

The shares of common stock are being offered by Intellia pursuant to an effective shelf registration statement that was previously filed with the U.S. Securities and Exchange Commission (SEC). A preliminary prospectus supplement and accompanying prospectus relating to and describing the terms of the offering was filed with the SEC on June 28, 2021. The final prospectus supplement and accompanying prospectus relating to the offering will be filed with the SEC and may be obtained, when available, from: Goldman Sachs & Co. LLC, by mail at 200 West Street, New York, NY 10282, Attention: Prospectus Department, by telephone at (866) 471-2526, or by email at [email protected]; or Jefferies LLC, by mail at 520 Madison Avenue, 2nd Floor, New York, NY 10022, Attention: Equity Syndicate Prospectus Department, by telephone at (877) 547-6340, or by email at [email protected]; SVB Leerink LLC, by mail at One Federal Street, 37th Floor, Boston, MA 02110, Attention: Syndicate Department, by telephone at (800) 808-7525, ext. 6105, or by email at [email protected]; or Barclays Capital Inc., by mail at c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, by telephone at (888) 603-5847, or by email at [email protected]; or by accessing the SEC’s website at www.sec.gov.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.