On August 25, 2021 RenovoRx, Inc., a biopharmaceutical company and innovator in targeted cancer therapy, reported the pricing of its underwritten initial public offering of 1,850,000 units at a public offering price per unit of $9.00 (Press release, Renovorx, AUG 25, 2021, View Source [SID1234586890]). Each unit consists of one share of common stock and one warrant to purchase one share of common stock. The warrants have an exercise price of $10.80 per share and are exercisable for a period of five years after the issuance date. All of the units are being offered by RenovoRx. In addition, RenovoRx has granted the underwriters a 45-day option to purchase up to an additional 277,500 shares of its common stock and/or warrants to purchase up to an additional 277,500 shares of its common stock, at the initial public offering price, less the underwriting discounts and commissions.

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In connection with the offering, the Company’s common stock has been approved for listing on The Nasdaq Capital Market. The shares are expected to begin trading on The Nasdaq Capital Market on August 26, 2021, under the ticker symbol "RNXT." The offering is expected to close on August 30, 2021, subject to customary closing conditions.

RenovoRx Announces Pricing of Initial Public Offering

The gross proceeds to RenovoRx from the offering, before deducting the underwriting discounts and commissions and offering expenses, are expected to be $16.65 million.

Roth Capital Partners is acting as the sole book-running manager for the offering. Maxim Group LLC is acting as lead manager for the offering.

The securities described above are being offered by the Company pursuant to a registration statement on Form S-1 (Registration No. 333-258071) that was previously filed with the U.S. Securities and Exchange (the "SEC") and declared effective on August 25, 2021. This offering is being made only by means of a prospectus. A preliminary prospectus relating to and describing the terms of the offering has been filed with the SEC. Copies of the preliminary prospectus can be accessed through the SEC’s website at www.sec.gov. Copies of the final prospectus relating to the initial public offering can be obtained, when available, through the SEC’s website at www.sec.gov or from: Roth Capital Partners, LLC, 888 San Clemente Drive, Newport Beach, CA 92660, Attention: Equity Capital Markets at (800) 678-9147 or by email at [email protected].

This press release shall not constitute an offer to sell or a solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

On August 25, 2021 PharmaCyte Biotech, Inc. (NASDAQ: PMCB) (PharmaCyte or Company), a biotechnology company focused on developing cellular therapies for cancer and diabetes using its signature live-cell encapsulation technology, Cell-in-a-Box, reported that the Company will expand its product pipeline to again include its diabetes program and its malignant ascites program (Press release, PharmaCyte Biotech, AUG 25, 2021, View Source [SID1234586889]). Expanding the product pipeline was made possible after PharmaCyte closed on two public offerings, totaling approximately $90 million, including exercised warrants.

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The Chief Executive Officer of PharmaCyte, Kenneth L. Waggoner, said of the capital raises, "With the closing of two separate public offerings totaling approximately $90 million now complete, PharmaCyte can, for the first time in its history, operate comfortably in its development of treatments for hard-to-treat diseases without being constrained by financial resources.

"For a myriad of reasons, this is unquestionably good news for the Company, our shareholders and the patients we hope to treat. Most importantly, we now have the capital to complete the work necessary to satisfy the FDA’s requests to lift the clinical hold and receive an open Investigational New Drug application (IND) for our treatment in locally advanced, inoperable pancreatic cancer (LAPC). In addition, PharmaCyte is positioned to immediately move into a fully funded clinical trial in LAPC should the FDA lift the clinical hold. Also, because the Company is now well-capitalized, we can broaden our entire development pipeline, including our diabetes and malignant ascites programs.

"We were able to attract institutional investors to accomplish this substantial raise while maintaining our low-float, and we have no plans to raise additional capital any time soon."

Mr. Waggoner, discussing the expansion of the Company’s product pipeline, continued, "PharmaCyte remains laser focused on getting our leading product candidate, the treatment for LAPC, into a Phase 2b clinical trial. However, after deferring our diabetes and malignant ascites programs to dedicate every dollar to our treatment for LAPC, we are now ideally situated to reengage these two programs.

"We are excited to have the opportunity to continue what is very important work in the development of a treatment for Type 1 and insulin dependent Type 2 diabetes and for a treatment to delay the production and accumulation of malignant ascites fluid that results from abdominal tumors."

To learn more about PharmaCyte’s pancreatic cancer therapy and how it will work inside a patient’s body to treat locally advanced, inoperable pancreatic cancer, we encourage you to watch PharmaCyte’s documentary video at View Source

On August 25, 2021 NOXXON Pharma N.V. (Euronext Growth Paris: ALNOX), a biotechnology company focused on improving cancer treatments by targeting the tumor microenvironment (TME), reported that it will participate in the German Fall conference taking place from September 6 to September 7, 2021 (Press release, NOXXON, AUG 25, 2021, View Source [SID1234586888]). The capital market conference for small and mid-cap companies organized by Equity Forum will take place in the form of virtual one-on-one meetings.

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The conference aims at bringing together public company representatives across sectors with investors, analysts, financial journalists, intermediaries and financial industry experts. Around 100 companies will participate in this year’s summit to present their equity story. NOXXON’s CEO, Aram Mangasarian, will be available for meetings on both conference days. To schedule a meeting please contact the conference organizer or send an email to [email protected].

On August 25, 2021 Bavarian Nordic A/S (OMX: BAVA) reported its interim financial results and business progress for the first half of 2021 and releases its financial calendar for 2022 (Press release, Bavarian Nordic, AUG 25, 2021, View Source [SID1234586887]).

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Paul Chaplin, President & Chief Executive Officer of Bavarian Nordic said: "We are very pleased to confirm the successful execution of our commercial strategy with nearly 30 Rabipur/RabAvert and Encepur markets now transferred to Bavarian Nordic. Our objective during this transition was to stop the historical market share losses before the acquisition of these products, start gaining more ground and increase the awareness of Bavarian Nordic among health care professionals and we are pleased that we today can tick all these boxes, despite that the markets are still impacted by COVID-19. Both the rabies and TBE markets are still suffering from a low level of international travel and limited availability of physicians for non-COVID vaccinations in certain markets and due to this alone, we are firming up our financial guidance for 2021 to reflect the lower end of the previously guided intervals.

So far this year, we also received new orders for our Ebola and smallpox vaccines and saw very important advancements in our pipeline assets with our promising COVID-19 vaccine candidate, ABNCoV2 entering Phase 2 after reporting highly promising clinical results. The recent agreement with the Danish Ministry of Health to provide aid for developing ABNCoV2 is a strong recognition of the technology and Bavarian Nordic to develop a highly promising general booster against COVID-19. With this funding, together with our existing commitment to fund the program to the end of Phase 2, we have sufficient funds to execute the existing plans to develop ABNCoV2 through to licensure. We look forward to reporting the Phase 2 results for ABNCoV2, as well as additional pivotal results from the RSV human challenge trial later this year."

Financial highlights

Total revenue in first half year was DKK 905 million comprised of DKK 877 million from combined product sales and DKK 28 million from contract work.
Revenue in second quarter totaled DKK 370 million comprised of DKK 146 million from sale of Encepur, DKK 127 million from sale of Rabipur/RabAvert, DKK 89 million from sale of Mvabea to Janssen and DKK 8 million from contract work.
EBITDA in first half year was a loss of DKK 8 million.
Strong cash position of DKK 2,208 million at the end of the first half, excluding unutilized credit facilities of DKK 243 million and after deduction of repo pledged securities.
Full-year guidance maintained at the lower end of the previously guided ranges, due to the continued COVID-19 impact on the TBE and rabies markets. Thus, revenue of approximately DKK 1,900 million, EBITDA of approximately DKK 100 million and securities, cash and cash equivalents at year-end of approximately DKK 1,400 million are expected.

Events in the second quarter

In April, new preclinical results for the COVID-19 vaccine candidate, ABNCoV2 were announced, confirming its potential to offer broad protection against variants of the SARS-CoV2 virus.
In April, Bavarian Nordic received a new Ebola supply order from Janssen, valued at approximately USD 28 million. Manufacturing and delivery will occur during 2021. The Johnson & Johnson Ebola vaccine regimen, which includes Mvabea from Bavarian Nordic also received Prequalification from the World Health Organization, which along with the July 2020 approval from the European Commission, will help accelerate its registration in countries where Ebola is a persistent public health threat.
In May, the US government exercised the final USD 12 million option remaining under the USD 202 million order for JYNNEOS awarded in April 2020.
In May, Bavarian Nordic entered an agreement with Dynavax on marketing and distribution of their HEPLISAV B hepatitis B vaccine in Germany.
Events after the reporting date

In August, Bavarian Nordic entered a funding agreement with the Danish Ministry of Health, under which the Company will be eligible to receive up to DKK 800 million to further advance the development of ABNCoV2 as a booster vaccine for COVID-19.
In August, Bavarian Nordic initiated a Phase 2 clinical trial of ABNCoV2 to investigate the vaccine’s potential as a universal booster vaccine for individuals with existing immunity from prior COVID-19 disease or vaccination.
In August, initial results from the first-in-human trial of ABNCoV2 were reported, showing that the vaccine candidate was well tolerated and induced a strong antibody response, superior to current approved vaccines. Importantly, a strong neutralization response was demonstrated against SARS-CoV2 variants, including the Delta variant.
The Company has today published its financial calendar for 2022, which is available on page 8 in this report.
Conference call and webcast
The management of Bavarian Nordic will host a conference call today at 2 pm CET (8 am EST) to present the interim results followed by a Q&A session. A listen-only version of the call can be accessed via View Source To join the Q&A session, use one of the following dial-in numbers: Denmark: +45 32 72 80 42, UK: +44 (0) 844 571 8892, USA: +1 631-510-7495. Participant code is 8569159.

On August 25, 2021 Neuren Pharmaceuticals Limited ("Neuren" or the "Company") reported this financial report, including the interim consolidated financial statements, for the six months ended 30 June 2020, with the six months ended 30 June 2019 as the comparative period.

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2. Results for announcement to the market

The Group’s net loss after tax for the half-year ended 30 June 2020 was $4.8 million, compared with $7.9 million for the half-year ended 30 June 2019, predominately due to a decrease of $2.7 million in research and development costs. This was due to lower expenditure for manufacturing and non-clinical activities relating to the Rett Syndrome Phase 3 trial, partially offset by an increase in expenditure in 2020 for the NNZ-2591 non-clinical studies and Phase 1 trial, including manufacture of the required drug.

A more detailed discussion of the activities undertaken in the period is set out in the Directors’ Report contained in the attached Interim Report.

3. Net Tangible Assets per Security

4. Entities over which control has been gained or lost during the period: None.

5. Details of dividends Not applicable.

6. Details of dividend reinvestment plans Not applicable.

7. Details of associates and joint venture entities None.

8. Accounting standards The interim financial statements have been prepared in accordance with generally accepted accounting practice in New Zealand and NZ IAS 34 Interim Financial Reporting.

9. Auditors review
The interim financial statements have been subject to independent review by the Company’s auditors. The unqualified review report is included in the attached Interim Report