On August 23, 2021 Philochem, a wholly owned subsidiary of Philogen S.p.A., a publicly-listed company, InterX, Inc., a privately-owned company, and Scripps Research, a non-profit American medical research facility, reported the signature of a research collaboration to discover new small molecule therapeutics using Philochem’s and Scripps’ proprietary DNA-Encoded Chemical Library (DEL) technology and InterX´s proprietary computational chemical biology software platform (Press release, Philogen, AUG 23, 2021, View Source [SID1234586806]).

This collaboration brings together Nobel laureates Roger Kornberg and Michael Levitt with leading DEL technology scientists Richard Lerner and Dario Neri. The team will collaborate on the development of a best-in-class targeting agent for metastatic prostate cancer, a disease that affects millions of patients worldwide.

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Prof. Richard Lerner is Institute Professor at Scripps Research, one of the world’s leading Institutions in chemical and biomedical research. He first postulated the principle of DEL technology in 1992.

On August 23, 2021 HUTCHMED (China) Limited ("HUTCHMED") (Nasdaq/AIM: HCM; HKEX: 13) reported that HUTCHMED has been selected as a constituent stock of several indexes administered by Hang Seng Indexes Company Limited ("Hang Seng"), including the Hang Seng Composite Index, in accordance with the latest index series release by Hang Seng, with effect from Monday, September 6, 2021 (Press release, Hutchison China MediTech, AUG 23, 2021, View Source [SID1234586805]).

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The Hang Seng Composite Index offers a comprehensive Hong Kong market benchmark that covers about the top 95th percentile of the total market capitalization of companies listed on the Main Board of The Stock Exchange of Hong Kong Limited. HUTCHMED has also been selected for six other indexes of Hong Kong-listed stocks, including the Hang Seng Healthcare Index and the Hang Seng Hong Kong-Listed Biotech Index.

In addition to the above indexes of stocks listed in Hong Kong, Hang Seng has also selected HUTCHMED for inclusion in six cross-market indexes, including the Hang Seng Stock Connect China 500 Index, which aims to measure the overall performance of the 500 largest Chinese companies in terms of market capitalization listed in Hong Kong and/or mainland China that are eligible for Northbound or Southbound trading under the Stock Connect schemes.

On June 8, 2021 Australian cancer diagnosis and treatment hopeful Clarity Pharmaceuticals reported that it has hired investment banks Jefferies and Bell Potter to manage an initial public offering that could value it at about $300 million (Press release, Clarity Pharmaceuticals, JUN 23, 2021, View Source [SID1234586804]).

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It is understood Clarity Pharmaceuticals has told investors it is preparing offer documents for a $60 million-odd raising at about a $250 million pre-money valuation, with funds raised used for clinical trials and to commercialise its products.

On August 22, 2021 BerGenBio ASA (OSE:BGBIO), a clinical-stage biopharmaceutical company developing novel, selective AXL inhibitors for severe unmet medical need, reported the appointment of Martin Olin as new Chief Executive Officer from 8 September 2021 (Press release, BerGenBio, AUG 22, 2021, View Source [SID1234586803]).

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Following twelve years as CEO of BerGenBio, Richard Godfrey has decided to step down as CEO of the Company with immediate effect to pursue other business interests. Rune Skeie, Chief Financial Officer of BerGenBio, will assume the role of interim CEO until 8 September 2021.

Mr Olin brings more than 20 years of executive experience in the pharmaceutical and biotechnology industry to BerGenBio. He previously served as CEO of Symphogen, a biotechnology company focused on the development of protein drugs based on recombinant monoclonal antibody mixtures, acquired by Servier in 2020.

Before joining Symphogen in 2012, Mr. Olin was a senior partner with SLS Invest, a Scandinavian based healthcare focused private equity fund. Previously, he held managerial positions in Novo Nordisk including Finance Director, EMEA. Most recently he has served as Managing Partner of Nordic Eye, a Copenhagen based Venture Capital firm.

Sveinung Hole, Chairman of BerGenBio, commented: "Martin brings vast experience as a leader in the life sciences industry with a proven track record of success. BerGenBio has reached a critical phase, with its lead candidate bemcentinib demonstrating promising data and progress in Lung cancer, Leukemia and potentially COVID-19. The Board agrees that Martin is ideally qualified to lead BerGenBio into the next phase of its development.

I would like to thank Richard both personally and on behalf of the BerGenBio team for his dedicated work to the Company over the past twelve years. Richard has played a pivotal role in establishing BerGenBio as a clinical stage company and has guided the Company throughout the challenging backdrop of the global COVID-19 pandemic. We wish him every success in the future."

Martin Olin, Chief Executive Officer of BerGenBio commented, "BerGenBio has pioneered the understanding of AXL biology and the potential of AXL inhibition as a cornerstone therapy for the treatment of serious diseases. I am very excited to join the Company and look forward to working with the board and team to continue the progression of our lead candidate bemcentinib, as well as the pipeline of drug candidates, through further clinical development and ultimately to the patients we believe will benefit from them."

Richard Godfrey said: "I have thoroughly enjoyed my past twelve years at BerGenBio and will keenly watch the progress with bemcentinib as it progresses through the exciting next steps. Now is a natural time for me to hand over to Martin. I wish the Board and whole team every success for the future."

On August 22, 2021 Kintor Pharmaceutical Limited ("Kintor Pharma", HKEX: 9939), a clinical-stage biotechnology company developing innovative small molecule and biological therapeutics, reported that the company’s stock has been included in the Hang Seng Composite Index, effective September 6, 2021 (Press release, Suzhou Kintor Pharmaceuticals, AUG 22, 2021, View Source [SID1234586799]).

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Hang Seng Composite Index (HSCI) is one of the important indexes in the Hong Kong equity market. This index offers a comprehensive Hong Kong market benchmark that covers the top 95th percentile of the total market capitalization of companies listed on the Main Board of the Stock Exchange of Hong Kong. Adopting the free-float-adjusted market capitalization methodology, the HSCI can be used as a basis for index funds, mutual funds as well as performance benchmarks.

Dr. Youzhi Tong, Founder, Chairman, and CEO of Kintor Pharma, commented, "The inclusion of Kintor Pharma as a constituent stock of the HSCI reflects the recognition and confidence in our company’s business and development prospects from the capital markets. This inclusion indicates that Kintor Pharma’s stock is eligible for trading via the Hong Kong-Shanghai Stock Connect link between China’s mainland markets and the Hong Kong Exchange. We believe the liquidity of our stock and expansion of our investors base will benefit from this event. We will further advance the progress of our R&D, clinical operations and commercialization efforts, in this way, to continue innovation on therapeutics for patients and maximize value for our shareholders."