Entry into a Material Definitive Agreement.

On August 20, 2021, Athenex, Inc. (the "Company") reported that it entered into a sales agreement (the "Sales Agreement") with SVB Leerink LLC (the "Agent"), in connection with the offer and sale of up to $100,000,000 of shares of the Company’s common stock, par value $0.001 per share ("ATM Shares") (Filing, 8-K, Athenex, AUG 20, 2021, View Source [SID1234586781]). The ATM Shares to be offered and sold under the Sales Agreement will be issued and sold pursuant to a registration statement on Form S-3 (File No. 333-258185), dated July 27, 2021 that was subsequently amended on August 5, 2021 and became effective with the Securities and Exchange Commission (the "Commission") on August 12, 2021. A prospectus supplement relating to the offering of the ATM Shares was filed with the Commission on August 20, 2021 (the "Prospectus Supplement").

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Subject to the terms and conditions of the Sales Agreement, the Agent will use commercially reasonable efforts, consistent with its normal trading and sales practices and applicable state and federal law, rules and regulations and the rules of the Nasdaq Stock Market, LLC ("Nasdaq"), to sell ATM Shares from time to time based upon the Company’s instructions, including any price, time or size limits or other customary parameters or conditions the Company may impose.

The Company is not obligated to make any sales of ATM Shares, and Agent is not required to sell any specific number or dollar amount of shares of the ATM Shares under the Sales Agreement. The Company or the Agent may suspend or terminate the offering of ATM Shares upon notice to the other party and subject to other conditions.

Under the Sales Agreement, the Agent may sell ATM Shares by any method permitted by law deemed to be an "at the market offering" as defined in Rule 415 of the Securities Act of 1933, as amended (the "Securities Act"), and the rules and regulations thereunder, including, without limitation, sales made directly on or through Nasdaq, on or through any other existing trading market for the Company’s shares of common stock or to or through a market maker. If expressly authorized by the Company, the Agent may also sell ATM Shares in privately negotiated transactions. The Company agreed to pay the Agent a commission equal to 3.0% of the gross proceeds from the sales of ATM Shares pursuant to the Sales Agreement.

The Sales Agreement contains customary representations, warranties and agreements by the Company, customary conditions to closing, indemnification obligations of the Company and the Agent against certain liabilities, including for liabilities under the Securities Act, and termination provisions. The provisions of the Sales Agreement, including the representations and warranties contained therein, are not for the benefit of any party other than the parties to such agreement and are not intended as a document for investors and the public to obtain factual information about the current state of affairs of the Company. Rather, investors and the public should look to other disclosures contained in the Company’s filings with the Commission.

The foregoing description of the Sales Agreement is a summary of its material terms, does not purport to be complete, and is qualified in its entirety by reference to the Sales Agreement, a copy of which is filed as Exhibit 1.1 to this Current Report on Form 8-K and is incorporated herein by reference.

Health Kick: Prescient Therapeutics’ YTD share price soars +220% after progress in clinical studies and CAR-T platform

On August 20, 2021 Prescient is a clinical stage oncology company reported that developing personalised medicine approaches to cancer, including targeted therapies, cell therapy enhancements and next generation CAR-T therapies (Press release, Prescient Therapeutics, AUG 20, 2021, View Source;utm_medium=rss&utm_campaign=health-kick-prescient-therapeutics-ytd-share-price-soars-220-after-progress-in-clinical-studies-and-car-t-platform [SID1234586777]).

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Encouraging progress through clinical trials of Prescient’s foundational assets PTX-100 and PTX-200 (with the PTX-100 trial progressing to expansion cohort last week following successful Phase 1b) and CAR-T safety and manufacturing milestone with OmniCAR.

The company made headlines in late July with news of its strong finish to the June.

Nordic Nanovector ASA: Invitation to Second Quarter and First Half 2021 Results Presentation Webcast

On August 20, 2021 Nordic Nanovector ASA (OSE: NANOV) reported that it will report its results for the second quarter and first half 2021 on Friday, 27 August 2021 (Press release, Nordic Nanovector, AUG 20, 2021, View Source [SID1234586766]).

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A presentation by Nordic Nanovector’s senior management team will be webcast live the same day beginning at 8:30am CEST.

The webcast can be accessed from www.nordicnanovector.com in the section: Investors & Media and a recording will also be available on this page after the event.

The results report and the presentation will be available at www.nordicnanovector.com in the section: Investors & Media/Reports and Presentation/Interim Reports/2021 from 7:00am CEST the same day.

ND CLEARANCE RECEIVED FROM THE US FOOD AND DRUG ADMINISTRATION
(FDA) FOR CHM 1101 (CLTX CAR T) FOR GLIOBLASTOMA

On August 20, 2021 Chimeric Therapeutics (ASX:CHM, "Chimeric" or the "Company"), a clinical-stage cell therapy company, reported that the US Food and Drug Administration (FDA) has cleared an Investigational New Drug (IND) application for CHM 1101 (CLTX CAR T) for patients with recurrent/relapsed Glioblastoma (Press release, Chimeric Therapeutics, AUG 20, 2021, View Source [SID1234586748]).

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CHM 1101 (CLTX CAR T) is a novel CAR T cell therapy that uniquely utilizes Chlorotoxin as its tumour targeting domain. CHM 1101 has shown promising preclinical safety and efficacy and is currently being studied in a single site phase 1 clinical trial.

"The FDA clearance of our IND is a critical milestone for Chimeric as it enables us to expand the development program for CHM 1101 (CLTX CAR T)," said Jennifer Chow, COO Chimeric Therapeutics. "Our first step will be to open new phase 1 clinical trial sites under the current study protocol. This will allow us to accelerate the phase 1 CHM 1101 clinical trial, which will be particularly important as we head towards the expansion phase of the protocol."

With this foundational IND, Chimeric will also further advance plans for a phase 1 basket trial in solid tumours and a phase 2 registration trial in Glioblastoma.

Chlorotoxin is derived from scorpion toxin, which binds preferentially to unique targets on brain cancer cells. CLTX CAR T cells do not target healthy cells and has not elicited adverse side effects when delivered intracranial and through IV routes in brain cancer mouse models. At the same time it has shown to bind to a higher percentage of Glioblastoma tumours than immunotherapies against other targets. Glioblastoma is the most common and aggressive type of brain tumour, with overall survival following first recurrence estimated at only 5-8 months

KYAN Therapeutics Announces Collaboration with Institute of Molecular and Cell Biology for Accelerated Drug Discovery and Development of Nucleic Acids

On August 19, 2021 KYAN Therapeutics, Inc. (KYAN), a developer of optimised therapeutics, reported that the company and the Agency of Science, Technology & Research (A*STAR)’s Institute of Molecular and Cell Biology (IMCB), a premier cell and molecular biology institute, have entered into a collaboration to discover and develop next-generation nucleic acid therapeutics for oncology (Press release, KYAN Therapeutics, AUG 19, 2021, View Source [SID1234632308]). The aim is to develop specific drug combinations that can achieve high clinical response rates and elicit durable responses.

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Nucleic acid therapeutics is an emerging field of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA)-based therapies that are able to treat diseases by inducing long lasting effects by targeting the genes in the genome. This means more effective treatments for diseases such as cancers. In particular, splice-switching oligonucleotides (SSOs), being amenable to complete chemical modifications for in vivo stability and specificity, possess superior specificity and lower toxicity than conventional small molecule drugs, and exhibit more predictable drug treatment and response compared to other nucleic acid modalities.

Leveraging on both parties’ expertise and proprietary platform technologies, the collaboration tackles the challenges in identifying and prioritising effective drug target combos, and developing therapeutics that are able to selectively affect a particular type of cells leading to a desirable effect. KYAN brings to the collaboration, proprietary combination design technology and expertise in cancer therapy, that has been validated in humans and across multiple diseases. A team led by Dr Dave Keng Boon Wee, Principal Investigator, at IMCB, has developed an accurate rational design platform empowering an unprecedented speed of identifying and optimisation of highly specific and effective SSOs, which will be useful to speed up the drug discovery and the development process. Leveraging IMCB’s extensive experience in optimising SSOs for high specificity and efficacy leading to clinical translation, IMCB is well positioned to provide clinically ready SSOs for further development.

"Tailoring the right drug combinations is key for better patient outcomes. We look forward to working with KYAN to implement the drug target combinations by discovering and developing precise RNA therapeutics," stated Dr Wee. "This could potentially open up treatment avenues for more than 50 per cent of cancer patients that have not responded to existing therapies, leading to better health outcomes. The partnership also helps to solidify Singapore’s position as a global innovation hub."

With IMCB’s expertise in the SSO discovery process and KYAN’s accurate and efficient computational optimisation platform, the collaboration has already yielded novel insights into how to develop more effective synthetic lethality treatment approaches. IMCB and KYAN will synergize their efforts to develop new classes of nucleic acid therapeutics towards difficult to treat gastrointestinal cancers, beginning with liver cancer. By focusing on cancers with high prevalence in Asia, this collaboration seeks to transform how cancer is treated both in Singapore and abroad.

"Being the medical hub of Asia, we hope that this collaboration could identify alternative treatment approaches especially for cancers like liver cancer, which has high prevalence in this region but limited therapeutic options. Having easy access to liver cancer patient samples in Singapore would aid in stratifying potential patient responders based on the identified optimal combination of RNA therapeutics" adds Dr Masturah Rashid, Head of Research and Development at KYAN Therapeutics.

The issuer is solely responsible for the content of this announcement.