ITM and Chengdu Gaotong Isotope Co. Ltd. Form Joint Venture to Expand Access to ITM’s Diagnostic and Therapeutic Radioisotopes in China

On September 13, 2021 ITM AG, a leading radiopharmaceutical biotech company, reported that it has signed a strategic long-term agreement to create a Joint Venture with Chengdu Gaotong Isotope Co. Ltd., the leading provider of radiopharmaceuticals and nuclear services in China and a subsidiary of ITM’s collaboration partner China Isotope and Radiation Corporation (CIRC) (Press release, ITM Isotopen Technologien Munchen, SEP 13, 2021, View Source [SID1234587673]). The newly formed company is planned to start operations in Q4 2021 and will be located in Chengdu, China. It will focus its operations on the supply of ITM’s EndolucinBeta (n.c.a. 177Lu) and Gallium Generators to the rapidly emerging Chinese radiopharmaceutical industry. ITM hereby also increases its footprint in China with a second in country location after having established its first subsidiary in Shanghai earlier this year. The Joint Venture will be led by both companies with the goal of scaling and securing access to ITM’s state-of-the-art medical radioisotopes in China.

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"China is an important market for us and this Joint Venture represents our commitment to the region as well as our global efforts to bring a new generation of targeted radiopharmaceuticals to patients with hard-to-treat cancers worldwide," said Steffen Schuster, CEO of ITM. "We are committed to further expanding our successful, long-term partnership with CIRC and are looking forward to increasing our global footprint in China. Next to our own clinical development of targeted radiotherapeutics and diagnostics through our Chinese subsidiary, the new Joint Venture with Gaotong will also help facilitate market access and build new partnerships for our therapeutic radioisotope EndolucinBeta and our Gallium generators for precision oncology treatments with the growing Chinese radiopharmaceutical industry as a whole."

"The demand for innovative, precise and high-quality treatment options for cancer patients in China continues to increase. Together with ITM, we are working toward addressing this need," said Mr. Wang Suohui, the General Manager of CIRC. "We established a collaboration with ITM over ten years ago and strengthened our partnership in 2019 to locally manufacture and distribute ITM’s EndolucinBeta and Gallium Generators. We are excited to establish this Joint Venture as the next step in our common development and look forward to working with ITM in providing increasing quantities of high-quality medical radioisotopes to Chinese hospitals and industry and to further improving access for precise cancer radiotherapeutics and diagnostics for patients."

The Joint Venture follows the existing strategic partnership between ITM and CIRC which was initially formed in 2010 and further extended in November 2019. As part of the newly-formed Joint Venture, ITM and CIRC will also work on securing and scaling the supply of diagnostic and therapeutic radioisotopes as a robust basis for the clinical development and commercialization of targeted radiotherapeutics and diagnostics in China both independently and together with local pharmaceutical partners. Further details of the agreement were not disclosed.

2seventy bio Announces Upcoming Investor Events

On September 13, 2021 2seventy bio, the planned oncology spin-off of bluebird bio (NASDAQ: BLUE) reported that it will host a series of investor events to share further detail on its research pipeline and strategy (Press release, bluebird bio, SEP 13, 2021, View Source [SID1234587672]).

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Session One: An Introduction to 2seventy’s Pipeline; focus on AML [DARIC33] and Next-Gen Multiple Myeloma Strategy
September 21, 2021, 11:00am-12:00pm ET
Session Two: Focus on bNHL [bbT369] and Solid Tumor Strategy
September 22, 2021, 1:00-2:00pm ET
To access the live webcasts and dial-in information for 2seventy bio’s presentations, please visit the "Events & Presentations" page within the Investors & Media section of the bluebird bio website at View Source Replays of the webcasts will be available on the bluebird bio website for 90 days following the events.

Kinnate Biopharma Inc. Presents Preclinical Data on its Lead FGFR Inhibitor Candidate at the JCA-AACR Precision Cancer Medicine International Conference

On September 13, 2021 Kinnate Biopharma Inc. (Nasdaq: KNTE) ("Kinnate"), a biopharmaceutical company focused on the discovery and development of small molecule kinase inhibitors for difficult-to-treat, genomically defined cancers, reported results from preclinical studies evaluating its lead Fibroblast Growth Factor Receptor (FGFR) inhibitor candidate, KIN-3248 (Press release, Kinnate Biopharma, SEP 13, 2021, View Source [SID1234587665]). These findings were presented during a virtual poster session at the joint JCA-AACR Precision Cancer Medicine International Conference that took place September 10-12, 2021.

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KIN-3248 is a next-generation, irreversible, small molecule pan-FGFR inhibitor designed to target cancer-associated FGFR2 and FGFR3 gene alterations, which are common oncogenic drivers seen in human cancers. KIN-3248 was developed to address both primary FGFR2 and FGFR3 oncogenic alterations and those predicted to drive acquired resistance to current FGFR-targeted therapies, including gatekeeper, molecular brake, and activation loop mutations observed in cancers such as intrahepatic cholangiocarcinoma (ICC) and urothelial carcinoma (UC). Kinnate anticipates filling an Investigational New Drug (IND) application for KIN-3248 with the U.S. Food and Drug Administration (FDA) in the first half of 2022.

"We are very pleased with the progress of our FGFR program, and these positive preclinical data are an important indicator of the potential anti-tumor activity of KIN-3248," said Eric Martin, Ph.D., SVP, Translational Research and Medicine at Kinnate. "In preclinical studies, we have demonstrated inhibitory activity across a wide range of clinically relevant mutations that drive primary disease and acquired resistance. We believe that by addressing these mutations and broadly covering multiple FGFR isoforms, KIN-3248 may be able to overcome challenges associated with currently approved FGFR inhibitors and provide a meaningful increase in the duration of response."

The poster presentation, delivered by Aleksandra Franovic, Ph.D., Senior Director of Translational Medicine at Kinnate, highlights data which show that in biochemical and cellular assays, KIN-3248 exhibited nanomolar potency against all four wild-type FGFR family members but not against other non-FGFR kinases. Importantly, KIN-3248 was active against mutations associated with resistance to FGFR inhibitors both in the clinic and in experimental models, including the FGFR2 and FGFR3 gatekeeper (V565X and V555M, respectively), molecular brake (N550X and N540X, respectively), and activation loop (L618V and K650M, respectively) mutations with less than a five-fold difference in IC50 values relative to corresponding wild-type receptors. In addition, dose-dependent inhibition of FGFR2- and FGFR3-driven human in vivo xenografts, including one with an acquired gatekeeper mutation, was attained with once-daily KIN-3248 treatment and was well tolerated. This efficacy was accompanied by both pharmacodynamic biomarker modulation and downstream pathway inhibition.

Kinnate’s poster presentation, titled "The next-generation FGFR inhibitor, KIN-3248, is active against acquired FGFR2 and FGFR3 gatekeeper and molecular brake drug resistance mutations," is available for on-demand viewing and can be accessed via: View Source

Corporate Presentation dated September 13, 2021

On September 13, 2021, Moleculin Biotech, Inc. Presented the Corporate presentation (Press release, Moleculin, SEP 13, 2021, View Source [SID1234587664]).

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Updated 2021 Corporate Presentation

On September 13, 2021 Xenetic Biosciences, Inc. Presented the Corporate Presentation (Presentation, Xenetic Biosciences, SEP 13, 2021, View Source [SID1234587663]).

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