On September 12, 2021 Precision BioSciences, Inc. (Nasdaq: DTIL), a clinical stage biotechnology company developing allogeneic CAR T and in vivo gene correction therapies with its ARCUS genome editing platform, reported that it will present at the H.C. Wainwright 23rd Annual Global Investment Conference, being held from September 13-15, 2021 (Press release, Precision Biologics, SEP 12, 2021, View Source [SID1234587545]).

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The pre-recorded presentation will be made available for on-demand viewing starting Monday, September 13, 2021 at 7:00 a.m. ET on the Company’s website, www.precisionbiosciences.com, in the Investors & Media section under Events and Presentations. An archived replay of the webcast will be available for approximately 90 days.

On September 12, 2021 MacroGenics, Inc. (Nasdaq: MGNX), a biopharmaceutical company focused on developing and commercializing innovative monoclonal antibody-based therapeutics for the treatment of cancer, reported poster presentations relating to multiple investigational product candidates at the European Society for Medical Oncology (ESMO) (Free ESMO Whitepaper) Virtual Conference, taking place September 16-21, 2021 (Press release, MacroGenics, SEP 12, 2021, View Source [SID1234587532]).

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Posters will be available on September 16, 2021. Details are as follows:

620P – MGC018, an Anti-B7-H3 Antibody-Drug Conjugate (ADC), in Patients with Advanced Solid Tumors: Preliminary Results of Phase 1 Cohort Expansion
Preliminary clinical results from the Phase 1 cohort expansion study of MGC018 in patients with metastatic castration-resistant prostate cancer and non-small cell lung cancer will be presented in this poster. The abstract submitted to ESMO (Free ESMO Whitepaper) included data as of May 3, 2021, while the final poster will include updated results as of August 16, 2021.
Presentation Topic: Genitourinary tumours, prostate

1379P – Margetuximab with Retifanlimab in HER2+, PD-L1+ First-Line Unresectable/Metastatic Gastroesophageal Adenocarcinoma (GEA): MAHOGANY Cohort A
Results from Cohort A Part 1 of the Phase 2/3 MAHOGANY clinical trial of margetuximab in combination with retifanlimab in treatment-naïve patients with locally advanced or metastatic gastroesophageal adenocarcinoma (GEA) who are positive for both HER2 and PD-L1 will be presented in this poster. The efficacy data and safety cutoff dates for this poster were July 19, 2021 and August 3, 2021, respectively.
Presentation Topic: Oesophagogastric cancer

627P – Phase 2 Neoadjuvant Trial of the Anti-B7-H3 Antibody, Enoblituzumab, in Men with Localized Prostate Cancer: Safety, Efficacy, and Immune Correlates
Results of a Phase 2 neoadjuvant trial of enoblituzumab in men with localized prostate cancer will be presented in this poster by Johns Hopkins University School of Medicine.
Presentation Topic: Genitourinary tumours, prostate

926TiP – Phase 2 Trial of Enoblituzumab Plus Retifanlimab or Tebotelimab in First-Line Treatment of Patients with Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
A trial-in-progress poster regarding the Phase 2 study of enoblituzumab, an Fc‐engineered, anti‐B7‐H3 monoclonal antibody, will be presented.
Presentation Topic: Head and neck cancer, excluding thyroid

The abstracts referenced above were submitted to ESMO (Free ESMO Whitepaper) in May 2021 and are available on the ESMO (Free ESMO Whitepaper) website. The posters will be available for on-demand viewing on the ESMO (Free ESMO Whitepaper) website and on the "Events & Presentations" page in the Investor Relations section of MacroGenics’ website at View Source on or around September 16, 2021.

On September 10, 2021 Immunocore Holdings plc (Nasdaq: IMCR), a late-stage biotechnology company pioneering the development of a novel class of T cell receptor (TCR) bispecific immunotherapies designed to treat a broad range of diseases, including cancer, infectious and autoimmune disease, reported that management will present at the following investor conferences in September (Press release, Immunocore, SEP 10, 2021, View Source [SID1234590901]).

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H.C. Wainwright 23rd Annual Global Investment Conference
Fireside Chat available on demand starting at 7:00 a.m. ET on Monday, September 13, 2021
Oppenheimer Fall Healthcare Life Sciences & MedTech Summit
Fireside Chat: Wednesday, September 22, 2021 at 2:05 p.m. ET
The investor conferences will each be held in a virtual format and a live webcast of each presentation can be accessed in the ‘Investors’ section of Immunocore’s website at www.immunocore.com. For conferences that offer replays, presentations will be made available for a limited time.

On September 10, 2021 T-Cure Bioscience, Inc., a privately held company focused on developing T cell receptor (TCR) therapy products for the treatment of solid tumors, reported that the management will present virtually at the following upcoming healthcare conferences (Press release, T-Cure Bioscience, SEP 10, 2021, View Source [SID1234590211]):

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5th Annual Cell Gene Therapy World Asia 2021, Singapore

Gang Zeng, Ph.D., Chief Executive Officer, will present virtually on Wednesday, September 16, 2021, at 11:30 am. (Singapore Time). The title of his presentation is "Targeting Solid Tumors with Novel TCR-T Strategies"
2021 Baird Global Healthcare Conference

Erika von Euw, Ph.D. Senior Director of Translational Research, and Gang Zeng, Ph.D. will give a presentation on T-Cure Bioscience on Wednesday, September 15, at 3:10 p.m. (EDT).
2021 Oppenheimer Fall Healthcare Life Sciences & MedTech Summit

Erika von Euw, PhD, and Gang Zeng, Ph.D. will give a presentation on T-Cure Bioscience on Thursday, September 23, at 12:25 pm (EDT).

On September 10, 2021 Apollomics Inc., an innovative biopharmaceutical company committed to the discovery and development of mono- and combination oncology therapies, reported the successful dosing of the first patient in a Phase I clinical study of APL-102 in patients with advanced solid tumors (Press release, Apollomics, SEP 10, 2021, View Source [SID1234587921]). The Phase I trial is designed to assess the safety, tolerability and pharmacokinetics of APL-102 delivered via an oral capsule.

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"APL-102 is an internally discovered and developed tyrosine kinase inhibitor targeting multiple oncogenic drivers, and we are excited about advancing it for clinical testing to explore its potential for treating a number of solid tumors;" said Guo-Liang Yu, PhD, Co-Founder, Chairman and Chief Executive Officer. "APL-102 is the first of several novel assets planned for clinical development to further expand Apollomics’ clinical pipeline in oncology."

About APL-102

APL-102 is an oral, small molecule multi kinase inhibitor (MTKi) targeting several key oncogenic drivers. APL-102 inhibits several receptor tyrosine kinases (RTKs), including: angiogenesis via vascular endothelial growth factor receptors (VEGFRs), mitogen-activated protein kinase (MAPK) pathway via B-RAF and C-RAF; and colony stimulating factor 1 receptor (CSF1R).

Preclinical studies have demonstrated broad and potent antitumor activity in patient-derived xenograft mouse models of liver, breast, colorectal, gastric, esophageal and lung cancers. APL-102 has also shown favorable preclinical pharmacokinetic (PK) and safety profiles with no serious off-target activity observed. APL-102 has the potential to be used as a single agent or in combination with other oncology agents.

Apollomics retains worldwide rights to APL-102.